Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis
Open accessAbstract
Pneumonia is a major cause of morbidity and mortality for which no new methods of treatment have entered clinical practice since the discovery of antibiotics. Innovations in the techniques of culture-independent microbial identification have shown that the lungs, previously deemed sterile in the absence of infection, contain diverse and dynamic communities of microbes. In this Personal View, we argue that these observations have shown the inadequacy of traditional conceptual models of lung microbiology and the pathogenesis of pneumonia, hampering progress in research and practice. We propose three new conceptual models to replace the traditional models of lung microbiology: an adapted island model of lung biogeography, the effect of environmental gradients on lung microbiota, and pneumonia as an emergent phenomenon propelled by unexplored positive feedback loops. We argue that the ecosystem of lung microbiota has all of the features of a complex adaptive system: diverse entities interacting with each other within a common space, showing interdependent actions and possessing the capacity to adapt to changes in conditions. Complex adaptive systems are fundamentally different in behaviour from the simple, linear systems typified by the traditional model of pneumonia pathogenesis, and need distinct analytical approaches.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The microbiome and alveolar injury can propel each other in a dysregulated feedback loop that spans the host-microbiome divide.
“The microbiome and alveolar injury can propel each other in a dysregulated feedback loop that spans the host–microbiome divide”
From The microbiome and critical illness (2016) · cites this paper as [113]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200405-644st · Cited by 5,870 · see citing works
Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
Boucher, H. W., Talbot, G. H., Bradley, J. S., Edwards, J. E., Gilbert, D. N., Rice, L. B., Scheld, M., Spellberg, B. J., & Bartlett, J. (2008) · Clinical Infectious Diseases · doi:10.1086/595011 · Cited by 4,978 · see citing works
The Acute Respiratory Distress Syndrome
Matthay, M. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605303342209 · Cited by 4,924 · see citing works
Early-warning signals for critical transitions
Scheffer, M., Bascompte, J., Brock, W. A., Brovkin, V., Carpenter, S. R., Dakos, V., Held, H., van Nes, E. H., Rietkerk, M., & Sugihara, G. (2009) · Nature · doi:10.1038/nature08227 · Cited by 4,854 · see citing works
The Acute Respiratory Distress Syndrome
Ware, L. B., & Matthay, M. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421806 · Cited by 4,666 · see citing works
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-92-3-460_4 · Cited by 4,593 · see citing works
QUORUM SENSING: Cell-to-Cell Communication in Bacteria
Waters, C. M., & Bassler, B. L. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131001 · Cited by 3,989 · see citing works
AN EQUILIBRIUM THEORY OF INSULAR ZOOGEOGRAPHY
MacArthur, R. H., & Wilson, E. O. (1963) · Evolution · doi:10.1111/j.1558-5646.1963.tb03295.x · Cited by 2,152 · see citing works
Robbins pathologic basis of disease
Cotran, R. S., Kumar, V., & Collins, T. (1989) · Medical Entomology and Zoology · Cited by 1,944 · see citing works
Disordered Microbial Communities in Asthmatic Airways
Hilty, M., Burke, C. M., Pedro, H., Cárdenas, P., Bush, A., Bossley, C. J., Davies, J. C., Ervine, A., Poulter, L. W., Pachter, L. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008578 · Cited by 1,818 · see citing works
Ecosystems and the Biosphere as Complex Adaptive Systems
Levin, S. A. (1998) · Ecosystems · doi:10.1007/s100219900037 · Cited by 1,726 · see citing works
The principles and practice of medicine
(1938) · The American Journal of Surgery · doi:10.1016/s0002-9610(38)91188-2 · Cited by 1,657 · see citing works
Resource Competition between Plankton Algae: An Experimental and Theoretical Approach
Tilman, D. G. (1977) · Ecology · doi:10.2307/1935608 · Cited by 1,241 · see citing works
Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract
Charlson, E. S., Bittinger, K., Haas, A. R., Fitzgerald, A. S., Frank, I., Yadav, A., Bushman, F. D., & Collman, R. G. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201104-0655oc · Cited by 1,144 · see citing works
Studying Complex Adaptive Systems
Holland, J. H. (2006) · Journal of Systems Science and Complexity · doi:10.1007/s11424-006-0001-z · Cited by 1,125 · see citing works
An Equilibrium Theory of Insular Zoogeography
MacArthur, R. H., & Wilson, E. O. (1963) · Evolution · doi:10.2307/2407089 · Cited by 1,048 · see citing works
Chang, J. Y., Antonopoulos, D. A., Kalra, A., Tonelli, A., Khalife, W. T., Schmidt, T. M., & Young, V. B. (2008) · The Journal of Infectious Diseases · doi:10.1086/525047 · Cited by 1,010 · see citing works
Analysis of the lung microbiome in the “healthy” smoker and in COPD.
Erb-Downward, J. R., Thompson, D. L., Han, M. K., Freeman, C. M., McCloskey, L., Schmidt, L. A., Young, V. B., Toews, G. B., Curtis, J. L., Sundaram, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016384 · Cited by 973 · see citing works
Risk of Community-Acquired Pneumonia and Use of Gastric Acid–Suppressive Drugs
Laheij, R. J. F. (2004) · JAMA · doi:10.1001/jama.292.16.1955 · Cited by 879 · see citing works
Cooperation and conflict in quorum-sensing bacterial populations
Diggle, S. P., Griffin, A. S., Campbell, G. S., & West, S. A. (2007) · Nature · doi:10.1038/nature06279 · Cited by 824 · see citing works
Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers
Morris, A., Beck, J. M., Schloss, P. D., Campbell, T. B., Crothers, K., Curtis, J. L., Flores, S. C., Fontenot, A. P., Ghedin, E., Huang, L., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201210-1913oc · Cited by 822 · see citing works
Inter-kingdom signalling: Communication between bacteria and their hosts
Hughes, D. T., & Sperandio, V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1836 · Cited by 761 · see citing works
Sugiyama, Y., Fukui, M., Kikuchi, M., Hasebe, K., Nakayama, A., Nishinari, K., Tadaki, S.-I., & Yukawa, S. (2008) · New Journal of Physics · doi:10.1088/1367-2630/10/3/033001 · Cited by 751 · see citing works
Pharyngeal aspiration in normal adults and patients with depressed consciousness
Huxley, E. J., Viroslav, J., Gray, W. R., & Pierce, A. K. (1978) · The American Journal of Medicine · doi:10.1016/0002-9343(78)90574-0 · Cited by 739 · see citing works
Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
Huang, Y. J., Nelson, C. E., Brodie, E., DeSantis, T. Z., Baek, M. S., Liu, J., Woyke, T., Allgaier, M., Bristow, J., Wiener-Kronish, J. P., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.048 · Cited by 706 · see citing works
Robbins Pathologic Basis of Disease
Morrison, A. B. (1999) · JAMA · doi:10.1001/jama.282.18.1776-a · Cited by 669 · see citing works
Page, S. E. (2010) · Princeton University Press eBooks · doi:10.1515/9781400835140 · Cited by 632 · see citing works
Pharyngeal aspiration in normal adults and patients with depressed consciousness
(1978) · The American Journal of Medicine · doi:10.1016/0002-9343(78)90607-1 · Cited by 607 · see citing works
The Lung Tissue Microbiome in Chronic Obstructive Pulmonary Disease
Sze, M. A., Dimitriu, P. A., Hayashi, S., Elliott, W. M., McDonough, J. E., Gosselink, J. V., Cooper, J. D., Sin, D. D., Mohn, W. W., & Hogg, J. C. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201111-2075oc · Cited by 552 · see citing works
Rello, J., Ausino, V., Ricart, M., Castella, J., & Prats, G. (1993) · CHEST Journal · doi:10.1378/chest.104.4.1230 · Cited by 481 · see citing works
Bowers, R. M., McLetchie, S., Knight, R. D., & Fierer, N. (2010) · The ISME Journal · doi:10.1038/ismej.2010.167 · Cited by 464 · see citing works
Quantitative Aspiration During Sleep in Normal Subjects
Gleeson, K., Maxwell, S. L., & Eggli, D. F. (1997) · CHEST Journal · doi:10.1378/chest.111.5.1266 · Cited by 448 · see citing works
Airway Microbiota and Pathogen Abundance in Age-Stratified Cystic Fibrosis Patients
Cox, M. J., Allgaier, M., Taylor, B., Baek, M. S., Huang, Y. J., Daly, R. A., Karaöz, U., Andersen, G. L., Brown, R., Fujimura, K. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011044 · Cited by 448 · see citing works
The lung microbiome in moderate and severe chronic obstructive pulmonary disease
Pragman, A. A., Kim, H. B., Reilly, C. S., Wendt, C., & Isaacson, R. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047305 · Cited by 437 · see citing works
The microbiome as a human organ
Baquero, F., & Nombela, C. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2012.03916.x · Cited by 418 · see citing works
The role of the bacterial microbiome in lung disease
Dickson, R. P., Erb‐Downward, J. R., & Huffnagle, G. B. (2013) · Expert Review of Respiratory Medicine · doi:10.1586/ers.13.24 · Cited by 412 · see citing works
Canani, R. B., Cirillo, P., Roggero, P., Romano, C., Malamisura, B., Terrin, G., Passariello, A., Manguso, F., Morelli, L., Guarino, A., et al. (2006) · PEDIATRICS · doi:10.1542/peds.2005-1655 · Cited by 395 · see citing works
Molyneaux, P. L., Mallia, P., Cox, M. J., Footitt, J., Willis-Owen, S. A. G., Homola, D., Trujillo-Torralbo, M.-B., Elkin, S., Kon, O. M., Cookson, W. O. C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201302-0341oc · Cited by 390 · see citing works
Charlson, E. S., Diamond, J. M., Bittinger, K., Fitzgerald, A. S., Yadav, A., Haas, A. R., Bushman, F. D., & Collman, R. G. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0693oc · Cited by 348 · see citing works
Probiotic Prophylaxis of Ventilator-associated Pneumonia: A Blinded, Randomized, Controlled Trial
Morrow, L. E., Kollef, M. H., & Casale, T. B. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1853oc · Cited by 347 · see citing works
Singh, S., Amin, A. V., & Loke, Y. K. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.550 · Cited by 344 · see citing works
Use of Proton Pump Inhibitors and the Risk of Community-Acquired Pneumonia
Gülmez, S. E. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.9.950 · Cited by 342 · see citing works
Agent‐based models in translational systems biology
An, G. C., Mi, Q., Dutta‐Moscato, J., & Yoram Vodovotz, B. (2009) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.45 · Cited by 324 · see citing works
Haase, T. W. (2011) · Journal of Comparative Policy Analysis Research and Practice · doi:10.1080/13876988.2011.541697 · Cited by 309 · see citing works
Lung Infection—A Public Health Priority
Mizgerd, J. P. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030076 · Cited by 293 · see citing works
Sources of Bacteria in Outdoor Air across Cities in the Midwestern United States
Bowers, R. M., Sullivan, A. P., Costello, E. K., Collett, J. L., Knight, R. D., & Fierer, N. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05498-11 · Cited by 266 · see citing works
Sunda, W. G., Graneli, E., & Gobler, C. J. (2006) · Journal of Phycology · doi:10.1111/j.1529-8817.2006.00261.x · Cited by 265 · see citing works
Marks, L. R., Davidson, B. A., Knight, P. R., & Hakansson, A. P. (2013) · mBio · doi:10.1128/mbio.00438-13 · Cited by 240 · see citing works
Ants at work: how an insect society is organized
(2000) · Choice Reviews Online · doi:10.5860/choice.37-4479 · Cited by 233 · see citing works
The Principles and Practice of Medicine
Osler, W. (1905) · AJN American Journal of Nursing · doi:10.2307/3403146 · Cited by 228 · see citing works
Microbiome Diversity in the Bronchial Tracts of Patients with Chronic Obstructive Pulmonary Disease
Cabrera‐Rubio, R., García-Núñez, M., Setó, L., Antó, J. M., Moyá, A., Monsó, E., & Mira, Á. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.00767-12 · Cited by 213 · see citing works
Clinical and Radiographic Correlates of Primary and Reactivation Tuberculosis
Geng, E. H., Kreiswirth, B. N., Burzynski, J., & Schluger, N. W. (2005) · JAMA · doi:10.1001/jama.293.22.2740 · Cited by 180 · see citing works
Spatial distribution of microbial communities in the cystic fibrosis lung
Willner, D., Haynes, M. R., Furlan, M., Schmieder, R., Lim, Y. W., Rainey, P. B., Rohwer, F., & Conrad, D. (2012) · The ISME Journal · doi:10.1038/ismej.2011.104 · Cited by 177 · see citing works
DISTRIBUTION AND DEPOSITION OF INHALED PARTICLES IN RESPIRATORY TRACT
Hatch, T. F. (1961) · Bacteriological Reviews · doi:10.1128/br.25.3.237-240.1961 · Cited by 174 · see citing works
Cough frequency, cough sensitivity and health status in patients with chronic cough
Birring, S. S., Matos, S., Patel, R. B., Prudon, B., Evans, D. H., & Pavord, I. D. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2005.09.023 · Cited by 166 · see citing works
Regional Differences in the Lung
West, J. B. (1978) · CHEST Journal · doi:10.1016/s0012-3692(15)37392-x · Cited by 163 · see citing works
Bruzzese, E., Raia, V., Spagnuolo, M. I., Volpicelli, M., Marco, G. D., Maiuri, L., & Guarino, A. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.01.004 · Cited by 162 · see citing works
Charlson, E. S., Bittinger, K. L., Chen, J., Diamond, J. M., Li, H., Collman, R. G., & Bushman, F. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042786 · Cited by 159 · see citing works
(2005) · Encyclopedia of Evaluation · doi:10.4135/9781412950558.n92 · Cited by 154 · see citing works
Munyard, P., & Bush, A. (1996) · Archives of Disease in Childhood · doi:10.1136/adc.74.6.531 · Cited by 147 · see citing works
The Effect of Proton Pump Inhibitors on the Human Microbiota
Vesper, B. J., Jawdi, A., Altman, K. W., Haines, G. K., Tao, L., & Radosevich, J. A. (2009) · Current Drug Metabolism · doi:10.2174/138920009787048392 · Cited by 145 · see citing works
Mini-review of the concentration variations found inthe alfresco atmospheric bacterial populations
Lighthart, B. (2000) · Aerobiologia · doi:10.1023/a:1007694618888 · Cited by 143 · see citing works
Culture-Independent Analysis of Aerosol Microbiology in a Metropolitan Subway System
Robertson, C. E., Baumgartner, L. K., Harris, J. K., Peterson, K. L., Stevens, M. J., Frank, D. N., & Pace, N. R. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.00331-13 · Cited by 131 · see citing works
Weiss, B., Bujanover, Y., Yahav, Y., Vilozni, D., Fireman, E. M., & Efrati, O. (2010) · Pediatric Pulmonology · doi:10.1002/ppul.21138 · Cited by 115 · see citing works
Regional differences in the lung.
Jb, W. (1978) · CHEST Journal · doi:10.1378/chest.74.4.426 · Cited by 112 · see citing works
Pseudomonas aeruginosa -Catecholamine Inotrope Interactions
Freestone, P. P., Hirst, R. A., Sandrini, S. M., Sharaff, F., Fry, H., Hyman, S., & O'Callaghan, C. (2012) · Chest · doi:10.1378/chest.11-2614 · Cited by 107 · see citing works
The internal surface area of the adult human lung.
Hasleton, P. S. (1972) · PubMed · Cited by 107 · see citing works
Ek, A., Larsson, K., Siljerud, S., & Palmberg, L. (1999) · Allergy · doi:10.1034/j.1398-9995.1999.00087.x · Cited by 102 · see citing works
THE RELATIONSHIP OF SINUSITIS AND BRONCHIECTASIS
QUINN, L. H., & MEYER, O. O. (1929) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1929.00620050048003 · Cited by 96 · see citing works
Longitudinal analysis of the lung microbiome in lung transplantation
Borewicz, K., Pragman, A. A., Kim, H. B., Hertz, M., Wendt, C. H., & Isaacson, R. E. (2012) · FEMS Microbiology Letters · doi:10.1111/1574-6968.12053 · Cited by 86 · see citing works
DISTRIBUTION AND DEPOSITION OF INHALED PARTICLES IN RESPIRATORY TRACT
Hatch, T. F. (1961) · Bacteriological Reviews · doi:10.1128/mmbr.25.3.237-240.1961 · Cited by 86 · see citing works
Differential effects of catecholamines on in vitro growth of pathogenic bacteria
Belay, T., & Sonnenfeld, G. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01683-1 · Cited by 78 · see citing works
Chen, Y., Legan, S. K., Mahan, A., Thornton, J., Xu, H., & Schwarz, M. A. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-1 · Cited by 71 · see citing works
Indirect assessment of mucosal surface temperatures in the airways: theory and tests
Ingenito, E. P., Solway, J., McFadden, E. R., Pichurko, B. M., Bowman, H. F., Michaels, D., & Drazen, J. M. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.5.2075 · Cited by 59 · see citing works
Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella Pneumoniae in mice
Patterson, C. M., Morrison, R. L., D’Souza, A., Teng, X. S., & Happel, K. I. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-40 · Cited by 46 · see citing works
Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise
Twigg, H. L., Morris, A. M., Ghedin, E., Curtis, J. L., Huffnagle, G. B., Crothers, K. A., Campbell, T., Flores, S. C., Fontenot, A. P., Beck, J. M., et al. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70117-6 · Cited by 37 · see citing works
The Changing Fate of Pneumonia as a Public Health Concern in 20th-Century America and Beyond
Podolsky, S. H. (2005) · American Journal of Public Health · doi:10.2105/ajph.2004.048397 · Cited by 32 · see citing works
STRUCTURE AND FUNCTION OF RESPIRATORY TRACT IN RELATION TO INFECTION
Wright, G. W. J. (1961) · Bacteriological Reviews · doi:10.1128/br.25.3.219-227.1961 · Cited by 31 · see citing works
Note sur la maladie nouvelle provoquée par la salive d'un enfant mort de la rage
Pasteur (1881) · Recueil de Médecine Vétérinaire · doi:10.3406/rmv.1881.2052 · Cited by 29 · see citing works
Iida, H., Matsuura, S., Shirakami, G., Tanimoto, K., & Fukuda, K. (2006) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03022209 · Cited by 24 · see citing works
Effect of Proton Pump Inhibitor Pantoprazole on Growth and Morphology of Oral Lactobacillus Strains
Altman, K. W., Chhaya, V., Hammer, N. D., Pavlova, S. I., Vesper, B. J., Tao, L., & Radosevich, J. A. (2008) · The Laryngoscope · doi:10.1097/mlg.0b013e318161f9bf · Cited by 24 · see citing works
Gilman, P. R. (2021) · Advances in Nursing Science · doi:10.1097/ans.0000000000000380 · Cited by 22 · see citing works
STRUCTURE AND FUNCTION OF RESPIRATORY TRACT IN RELATION TO INFECTION
Wright, G. W. J. (1961) · Bacteriological Reviews · doi:10.1128/mmbr.25.3.219-227.1961 · Cited by 15 · see citing works
Simulation and minimisation of the airway deposition of airborne bacteria
Balásházy, I., Horváth, A. Z., Sárkány, Z., Farkas, Á., & HOFMANN, W. (2009) · Inhalation Toxicology · doi:10.1080/08958370902736646 · Cited by 10 · see citing works
Clinical and Radiographic Correlates of Primary and Reactivation Tuberculosis
Geng, E. H., Kreiswirth, B. N., Burzynski, J., & Schluger, N. W. (2006) · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [8]Mason RJ Broaddus VC Martin T Murray and Nadel's textbook of respiratory medicine: 2-volume set 2010 Philadelphia Elsevier Health Sciences
- [41]Cohen J Cohen and Powderly: Infectious Diseases, 3/e 2010 St. Louis, MO, USA Mosby, Inc
- [56]Molyneaux PL Mallia P Cox MJ Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease Am J Respir Crit Care Med 2013 188 1224 1231 23992479 PMC3863728
Cited by
Sorted by citations
The Microbiome and the Respiratory Tract
Dickson, R. P., Erb-Downward, J. R., Martinez, F. J., & Huffnagle, G. B. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105238 · Cited by 953 · see citing works
Bassis, C. M., Erb-Downward, J. R., Dickson, R. P., Freeman, C. M., Schmidt, T. M., Young, V. B., Beck, J. M., Curtis, J. L., & Huffnagle, G. B. (2015) · mBio · doi:10.1128/mbio.00037-15 · Cited by 839 · see citing works
Torres, A., Cillóniz, C., Niederman, M. S., Menéndez, R., Chalmers, J. D., Wunderink, R. G., & van der Poll, T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00259-0 · Cited by 903 · see citing works
Mandell, L. A., & Niederman, M. S. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1714562 · Cited by 646 · see citing works
The Lung Microbiome: New Principles for Respiratory Bacteriology in Health and Disease
Dickson, R. P., & Huffnagle, G. B. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004923 · Cited by 562 · see citing works
Dickson, R. P., Erb-Downward, J. R., Freeman, C. M., McCloskey, L., Beck, J. M., Huffnagle, G. B., & Curtis, J. L. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201501-029oc · Cited by 567 · see citing works
Bacterial topography of the healthy human lower respiratory tract
Dickson, R. P., Erb-Downward, J. R., Freeman, C. M., McCloskey, L., Falkowski, N. R., Huffnagle, G. B., & Curtis, J. L. (2017) · mBio · doi:10.1128/mbio.02287-16 · Cited by 548 · see citing works
Self-citationThe respiratory tract microbiome and lung inflammation: a two-way street.
Huffnagle, G. B., Dickson, R. P., & Lukacs, N. W. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.108 · Cited by 535 · see citing works
Self-citationThe role of the microbiome in exacerbations of chronic lung diseases
Dickson, R. P., Martinez, F. J., & Huffnagle, G. B. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61136-3 · Cited by 495 · see citing works
The microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460 · see citing works
Lung microbiome: new insights into the pathogenesis of respiratory diseases
Li, R., Li, J., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01722-y · Cited by 466 · see citing works
Application of a Neutral Community Model To Assess Structuring of the Human Lung Microbiome
Venkataraman, A., Bassis, C. M., Beck, J. M., Young, V. B., Curtis, J. L., Huffnagle, G. B., & Schmidt, T. M. (2015) · mBio · doi:10.1128/mbio.02284-14 · Cited by 428 · see citing works
Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients
Dickson, R. P., Schultz, M. J., van der Poll, T., Schouten, L. R. A., Falkowski, N. R., Luth, J. E., Sjoding, M. W., Brown, C. A., Chanderraj, R., Huffnagle, G. B., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201907-1487oc · Cited by 365 · see citing works
Aliberti, S., Cruz, C. S. D., Amati, F., Sotgiu, G., & Restrepo, M. I. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00630-9 · Cited by 312 · see citing works
Desired Turbulence? Gut-Lung Axis, Immunity, and Lung Cancer
Bingula, R., Filaire, M., Radosevic‐Robin, N., Bey, M., Berthon, J., Bernalier‐Donadille, A., Vasson, M., & Filaire, E. (2017) · Journal of Oncology · doi:10.1155/2017/5035371 · Cited by 272 · see citing works
Dickson, R. P., Erb‐Downward, J. R., Falkowski, N. R., Hunter, E. M., Ashley, S. L., & Huffnagle, G. B. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201711-2180oc · Cited by 244 · see citing works
Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients
de Steenhuijsen Piters, W. A. A., Huijskens, E. G. W., Wyllie, A. L., Biesbroek, G., van den Bergh, M. R., Veenhoven, R. H., Wang, X., Trzciński, K., Bonten, M. J., Rossen, J. W. A., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2015.99 · Cited by 235 · see citing works
Man, W. H., van Houten, M. A., Mérelle, M. E., Vlieger, A. M., Chu, M. L. J. N., Jansen, N. J. G., Sanders, E. A. M., & Bogaert, D. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30449-1 · Cited by 213 · see citing works
Novel aspects of pathogenesis and regeneration mechanisms in COPD
Aldonytė, R., Bagdonas, E., Raudoniūtė, J., & Bružauskaitė, I. (2015) · International Journal of COPD · doi:10.2147/copd.s82518 · Cited by 219 · see citing works
Role of lung and gut microbiota on lung cancer pathogenesis
Zhao, Y., Liu, Y., Li, S., Peng, Z., Liu, X., Chen, J., & Zheng, X. (2021) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-021-03644-0 · Cited by 217 · see citing works
Advancing precision medicine for acute respiratory distress syndrome
Beitler, J. R., Thompson, B., Baron, R. M., Bastarache, J. A., Denlinger, L. C., Esserman, L. J., Gong, M. N., LaVange, L. M., Lewis, R. J., Marshall, J. C., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00157-0 · Cited by 213 · see citing works
Methods in Lung Microbiome Research
Carney, S. M., Clemente, J. C., Cox, M. J., Dickson, R. P., Huang, Y. J., Kitsios, G. D., Kloepfer, K. M., Leung, J. M., LeVan, T. D., Molyneaux, P. L., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0273tr · Cited by 189 · see citing works
The Lung Microbiome during Health and Disease
Yagi, K., Huffnagle, G. B., Lukacs, N. W., & Asai, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910872 · Cited by 180 · see citing works
Zumla, A. I., Al‐Tawfiq, J. A., Enne, V. I., Kidd, M., Drosten, C., Breuer, J., Müller, M. A., Hui, D. S. C., Maeurer, M. J., Bates, M., et al. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70827-8 · Cited by 175 · see citing works
The Microbiome in Cystic Fibrosis
Huang, Y. J., & LiPuma, J. J. (2015) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2015.10.003 · Cited by 165 · see citing works
Homeostasis and its disruption in the lung microbiome
Dickson, R. P., Erb‐Downward, J. R., & Huffnagle, G. B. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00279.2015 · Cited by 164 · see citing works
Bernasconi, E., Pattaroni, C., Koutsokera, A., Pison, C. M., Kessler, R., Benden, C., Soccal, P. M., Magnan, A., Aubert, J., Marsland, B. J., et al. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2424oc · Cited by 163 · see citing works
Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury
Zhou, X., & Liao, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.779620 · Cited by 153 · see citing works
“, 2015) may alter the lung microbiome that in turn perpetuates a positive-feedback loop of inflammation, injury, and further dysbiosis (Dickson et al., 2014).”
BackgroundThe lung tissue microbiota of mild and moderate chronic obstructive pulmonary disease
Pragman, A. A., Lyu, T., Baller, J. A., Gould, T. J., Kelly, R. F., Reilly, C. S., Isaacson, R. E., & Wendt, C. H. (2018) · Microbiome · doi:10.1186/s40168-017-0381-4 · Cited by 150 · see citing works
Early Life Microbiota and Respiratory Tract Infections
Piters, W. A. A. D. S., Binkowska, J. M., & Bogaert, D. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.07.004 · Cited by 148 · see citing works
Motile cilia create fluid-mechanical microhabitats for the active recruitment of the host microbiome
Nawroth, J. C., Guo, H., Koch, E. J., Heath-Heckman, E., Hermanson, J. C., Ruby, E. G., Dabiri, J. O., Kanso, E. A., & McFall‐Ngai, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706926114 · Cited by 117 · see citing works
Zumla, A. I., Memish, Z. A., Maeurer, M. J., Bates, M., Mwaba, P., Al‐Tawfiq, J. A., Denning, D. W., Hayden, F. G., & Hui, D. S. C. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70828-x · Cited by 104 · see citing works
Topography of the respiratory tract bacterial microbiota in cattle
McMullen, C., Alexander, T. W., Léguillette, R., Workentine, M. L., & Timsit, E. (2020) · Microbiome · doi:10.1186/s40168-020-00869-y · Cited by 102 · see citing works
Novel Approaches Are Needed to Develop Tomorrow’s Antibacterial Therapies
Spellberg, B. J., Bartlett, J., Wunderink, R. G., & Gilbert, D. N. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201410-1894oe · Cited by 99 · see citing works
The Oral-Lung Axis: The Impact of Oral Health on Lung Health
Gaeckle, N. T., Pragman, A. A., Pendleton, K. M., Baldomero, A. K., & Criner, G. J. (2020) · Respiratory Care · doi:10.4187/respcare.07332 · Cited by 96 · see citing works
Pneumonia prevention in the elderly patients: the other sides
Chebib, N., Cuvelier, C., Malézieux-Picard, A., Parent, T., Roux, X., Fassier, T., Müller, F., & Prendki, V. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01437-7 · Cited by 95 · see citing works
The Lung Microbiome and Its Role in Pneumonia
Wu, B. G., & Segal, L. N. (2018) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2018.07.003 · Cited by 92 · see citing works
The impact of lung microbiota dysbiosis on inflammation
Yang, D., Xing, Y., Song, X., & Qian, Y. (2019) · Immunology · doi:10.1111/imm.13139 · Cited by 100 · see citing works
Lung Microbiome in Asthma: Current Perspectives
Loverdos, K., Bellos, G., Kokolatou, L., Vasileiadis, I., Giamarellos‐Bourboulis, E. J., Pecchiari, M., Koulouris, N. G., Koutsoukou, A., & Rovina, N. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111967 · Cited by 88 · see citing works
Microbiome Changes during Tuberculosis and Antituberculous Therapy
Hong, B., Maulén, N. P., Adami, A. J., Granados, H., Balcells, M. E., & Cervantes, J. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00096-15 · Cited by 91 · see citing works
Future Research Directions in Pneumonia. NHLBI Working Group Report
Cruz, C. S. D., Wunderink, R. G., Christiani, D. C., Cormier, S. A., Crothers, K. A., Doerschuk, C. M., Evans, S. E., Goldstein, D. R., Khatri, P., Kobzik, L., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201801-0139ws · Cited by 89 · see citing works
Bovine respiratory microbiota of feedlot cattle and its association with disease
Chai, J., Capik, S. F., Kegley, E. B., Richeson, J. T., Powell, J. G., & Zhao, J. (2022) · Veterinary Research · doi:10.1186/s13567-021-01020-x · Cited by 93 · see citing works
The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract
Perdijk, O., Azzoni, R., & Marsland, B. J. (2023) · Physiological Reviews · doi:10.1152/physrev.00020.2023 · Cited by 88 · see citing works
Characterization of the upper and lower respiratory tract microbiota in Piedmontese calves
Nicola, I., Cerutti, F., Grego, E., Bertone, I., Gianella, P., D’Angelo, A., Peletto, S., & Bellino, C. (2017) · Microbiome · doi:10.1186/s40168-017-0372-5 · Cited by 83 · see citing works
2018 recommendations for the management of community acquired pneumonia
Corrêa, R. D. A., Costa, A. N., Lundgren, F. L. C., Michelin, L., de Figueiredo, M. R. F., Holanda, M. A., Gomes, M., Teixeira, P. J. Z., Martins, R. L. D. M., Silva, R., et al. (2018) · Jornal Brasileiro de Pneumologia · doi:10.1590/s1806-37562018000000130 · Cited by 81 · see citing works
Kitsios, G. D., Fitch, A. C., Manatakis, D. V., Rapport, S. F., Li, K., Qin, S., Huwe, J., Zhang, Y., Doi, Y., Evankovich, J. W., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01413 · Cited by 80 · see citing works
Huang, Y. J., Erb‐Downward, J. R., Dickson, R. P., Curtis, J. L., Huffnagle, G. B., & Han, M. K. (2016) · Translational research · doi:10.1016/j.trsl.2016.06.007 · Cited by 79 · see citing works
Sex and gender differences in community-acquired pneumonia
Corica, B., Tartaglia, F., D’Amico, T., Romiti, G. F., & Cangemi, R. (2022) · Internal and Emergency Medicine · doi:10.1007/s11739-022-02999-7 · Cited by 88 · see citing works
Human Lung Microbiome on the Way to Cancer
Kovaleva, O. V., Romashin, D. D., Zborovskaya, I. B., Давыдов, М. М., Сергеевич, Ш. М., & Gratchev, A. N. (2019) · Journal of Immunology Research · doi:10.1155/2019/1394191 · Cited by 75 · see citing works
Linking microbiota and respiratory disease
Hauptmann, M., & Schaible, U. E. (2016) · FEBS Letters · doi:10.1002/1873-3468.12421 · Cited by 77 · see citing works
Inhaled corticosteroids and pneumonia in chronic obstructive pulmonary disease
Finney, L., Berry, M. P. R., Singanayagam, A., Elkin, S., Johnston, S. L., & Mallia, P. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70169-9 · Cited by 75 · see citing works
The Lung Microbiome and Pneumonia
Pettigrew, M. M., Tanner, W. D., & Harris, A. D. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa702 · Cited by 70 · see citing works
Feikin, D. R., Hammitt, L. L., Murdoch, D. R., O’Brien, K. L., & Scott, J. A. G. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix143 · Cited by 70 · see citing works
Mansbach, J. M., Luna, P. N., Shaw, C. A., Hasegawa, K., Petrosino, J. F., Piedra, P. A., Sullivan, A. F., Espinola, J. A., Stewart, C. J., & Camargo, C. A. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.10.034 · Cited by 69 · see citing works
Microbiota dysbiosis in lung cancer: evidence of association and potential mechanisms
Xu, N., Wang, L., Li, C., Ding, C., Li, C., Fan, W., Chen, C., & Gu, B. (2020) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-156 · Cited by 71 · see citing works
The Microbiome and the Pathophysiology of Asthma
Sullivan, A., Hunt, E. B., MacSharry, J. A., & Murphy, D. M. (2016) · Respiratory Research · doi:10.1186/s12931-016-0479-4 · Cited by 69 · see citing works
Kullberg, R. F. J., de Brabander, J., Boers, L. S., Biemond, J. J., Nossent, E. J., Heunks, L. M. A., Vlaar, A. P. J., Bonta, P. I., van der Poll, T., Duitman, J., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202202-0274oc · Cited by 63 · see citing works
Bingula, R., Filaire, E., Molnar, I., Delmas, E., Berthon, J., Vasson, M., Bernalier‐Donadille, A., & Filaire, M. (2020) · Respiratory Research · doi:10.1186/s12931-020-01392-2 · Cited by 61 · see citing works
Sun, J., Ding, X., Liu, S., Duan, X., Liang, H., & Sun, T. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01902-5 · Cited by 61 · see citing works
Ewan, V. C., Sails, A. D., Walls, A. W. G., Rushton, S., & Newton, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123622 · Cited by 60 · see citing works
The Nasopharyngeal Microbiota of Children With Respiratory Infections in Botswana
Kelly, M. S., Surette, M. G., Smieja, M., Pernica, J. M., Rossi, L., Luinstra, K., Steenhoff, A. P., Feemster, K. A., Goldfarb, D. A., Arscott‐Mills, T., et al. (2017) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001607 · Cited by 60 · see citing works
Lucas, S. K., Yang, R., Dunitz, J., Boyer, H. C., & Hunter, R. C. (2017) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2017.08.007 · Cited by 58 · see citing works
The emerging role of the microbiota in the ICU
Wolff, N. S., Hugenholtz, F., & Wiersinga, W. J. (2018) · Critical Care · doi:10.1186/s13054-018-1999-8 · Cited by 61 · see citing works
Intraalveolar catecholamines and the human lung microbiome
Dickson, R. P., Erb-Downward, J. R., Prescott, H. C., Martinez, F. J., Curtis, J. L., Lama, V. N., & Huffnagle, G. B. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201502-0326le · Cited by 59 · see citing works
Reconsidering ventilator-associated pneumonia from a new dimension of the lung microbiome
Fernández‐Barat, L., López-Aladid, R., & Torres, A. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102995 · Cited by 59 · see citing works
Smit, L. A. M., Boender, G. J., Piters, W. A. A. D. S., Hagenaars, T. J., Huijskens, E. G. W., Rossen, J. W. A., Koopmans, M., Nodelijk, G., Sanders, E. A. M., Yzermans, J. C., et al. (2017) · Pneumonia · doi:10.1186/s41479-017-0027-0 · Cited by 64 · see citing works
The Lung Microbiome in Idiopathic Pulmonary Fibrosis: A Promising Approach for Targeted Therapies
Fastrès, A., Felice, F., Roels, É., Moermans, C., Corhay, J.-L., Bureau, F., Louis, R. E., Clercx, C., & Guiot, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122735 · Cited by 59 · see citing works
Nonventilator hospital-acquired pneumonia: A call to action
Munro, S., Baker, D. L., Giuliano, K. K., Sullivan, S. C., Haber, J., Jones, B. E., Crist, M. B., Nelson, R. E., Carey, E., Lounsbury, O., et al. (2021) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2021.239 · Cited by 60 · see citing works
The microbiome at the pulmonary alveolar niche and its role in Mycobacterium tuberculosis infection
Adami, A. J., & Cervantes, J. (2015) · Tuberculosis · doi:10.1016/j.tube.2015.07.004 · Cited by 56 · see citing works
Lung Microbiota and Its Impact on the Mucosal Immune Phenotype
Wu, B. G., & Segal, L. N. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0005-2016 · Cited by 53 · see citing works
The bacterial microbiota in inflammatory lung diseases
Huffnagle, G. B., & Dickson, R. P. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.05.022 · Cited by 53 · see citing works
The human microbiota: novel targets for hospital-acquired infections and antibiotic resistance
Pettigrew, M. M., Johnson, J. K., & Harris, A. D. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.02.007 · Cited by 55 · see citing works
Biofilms in Ventilator-Associated Pneumonia
Fernández‐Barat, L., & Torres, A. (2016) · Future Microbiology · doi:10.2217/fmb-2016-0040 · Cited by 54 · see citing works
The respiratory microbiome and innate immunity in asthma
Huang, Y. J. (2014) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000124 · Cited by 52 · see citing works
Cruz, C. S. D., Evans, S. E., Restrepo, M. I., Dean, N. C., Torres, A., Amara‐Elori, I., Awasthi, S., Caler, E. V., Cao, B., Chalmers, J. D., et al. (2021) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202102-209st · Cited by 49 · see citing works
Shankar, J., Nguyen, M. H., Crespo, M. M., Kwak, E. J., Lucas, S. K., McHugh, K. J., Mounaud, S. H., Alcorn, J. F., Pilewski, J. M., Shigemura, N., et al. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13676 · Cited by 49 · see citing works
Gu, L., Deng, H., Ren, Z., Zhao, Y., Yu, S., Guo, Y., Dai, J., Chen, X., Li, K., Li, R., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02491 · Cited by 49 · see citing works
Gut microbiome and response to checkpoint inhibitors in non-small cell lung cancer—A review
Nagasaka, M., Sexton, R. E., Alhasan, R., Rahman, S. B., Azmi, A. S., & Sukari, A. W. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.102841 · Cited by 49 · see citing works
Species-level evaluation of the human respiratory microbiome
Ibironke, O. A., McGuinness, L. R., Lu, S., Wang, Y., Hussain, S., Weisel, C. P., & Kerkhof, L. J. (2020) · GigaScience · doi:10.1093/gigascience/giaa038 · Cited by 48 · see citing works
Association of sputum microbiota profiles with severity of community-acquired pneumonia in children
Pettigrew, M. M., Gent, J. F., Kong, Y., Wade, M., Gansebom, S., Bramley, A. M., Jain, S., Arnold, S. L. R., & McCullers, J. A. (2016) · BMC Infectious Diseases · doi:10.1186/s12879-016-1670-4 · Cited by 48 · see citing works
Lung microbiome and origins of the respiratory diseases
Belizário, J. E., Garay-Malpartida, M., & Faintuch, J. (2023) · Current Research in Immunology · doi:10.1016/j.crimmu.2023.100065 · Cited by 47 · see citing works
Respiratory microbiota and lower respiratory tract disease
Lanaspa, M., Bassat, Q., Medeiros, M. M., & Muñoz‐Almagro, C. (2017) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2017.1349609 · Cited by 47 · see citing works
The respiratory microbiome and nontuberculous mycobacteria: an emerging concern in human health
Thornton, C. S., Mellett, M., Jarand, J. M., Barss, L., Field, S. K., & Fisher, D. A. (2021) · European Respiratory Review · doi:10.1183/16000617.0299-2020 · Cited by 44 · see citing works
Mansbach, J. M., Hasegawa, K., Piedra, P. A., Avadhanula, V., Petrosino, J. F., Sullivan, A. F., Espinola, J. A., & Camargo, C. A. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy741 · Cited by 46 · see citing works
Cadena, A. M., Ma, Y., Ding, T., Bryant, M., Maiello, P. A., Geber, A. B., Lin, P. L., Flynn, J. L., & Ghedin, E. (2018) · Microbiome · doi:10.1186/s40168-018-0560-y · Cited by 44 · see citing works
Lung Microbiome in Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases
Amati, F., Stainer, A., Mantero, M., Gramegna, A., Simonetta, E., Suigo, G., Voza, A., Nambiar, A. M., Cariboni, U., Oldham, J. M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020977 · Cited by 45 · see citing works
Does lung microbiome play a causal or casual role in asthma?
Cicco, M. D., Pistello, M., Jacinto, T., Ragazzo, V., Piras, M., Freer, G., Pifferi, M., & Peroni, D. G. (2018) · Pediatric Pulmonology · doi:10.1002/ppul.24086 · Cited by 46 · see citing works
Microbiome in the pathogenesis of cystic fibrosis and lung transplant-related disease
Cribbs, S. K., & Beck, J. M. (2016) · Translational research · doi:10.1016/j.trsl.2016.07.022 · Cited by 44 · see citing works
Ecology of the respiratory tract microbiome
Pérez‐Cobas, A. E., Rodríguez-Beltrán, J., Baquero, F., & Coque, T. M. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.04.006 · Cited by 44 · see citing works
Lung cancer: a new frontier for microbiome research and clinical translation
Mur, L. A. J., Huws, S., Cameron, S. J. S., Lewis, P. D., & Lewis, K. E. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.866 · Cited by 43 · see citing works
From hype to hope: Considerations in conducting robust microbiome science
McGuinness, A. J., Stinson, L. F., Snelson, M., Loughman, A., Stringer, A. M., Hannan, A. J., Cowan, C. S. M., Jama, H. A., Caparros-Martin, J. A., West, M. L., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.022 · Cited by 43 · see citing works
Inhaled corticosteroids and the increased risk of pneumonia: what’s new? A 2015 updated review
Iannella, H. A., Luna, C. M., & WATERER, G. W. (2016) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465816630208 · Cited by 42 · see citing works
Peña-López, Y., Pujol, M., Campins, M., Antelo, A. G., Rodrigo‐Pendás, J. Á., Balcells, J., & Rello, J. (2016) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2016.09.021 · Cited by 41 · see citing works
Development of a Stable Lung Microbiome in Healthy Neonatal Mice
Kostrić, M., Milger, K., Krauss‐Etschmann, S., Engel, M., Vestergaard, G., Schloter, M., & Schöler, A. (2017) · Microbial Ecology · doi:10.1007/s00248-017-1068-x · Cited by 45 · see citing works
How human microbiome talks to health and disease
Cong, J., & Zhang, X. (2018) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-018-3263-1 · Cited by 43 · see citing works
Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients
Boutin, S., & Dalpke, A. H. (2017) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-016-0067-1 · Cited by 38 · see citing works
Cheng, M., Chen, Y., Wang, L., Chen, W., Yang, L., Shen, G., Xu, T., Shen, G., Tian, Z., & Hu, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-08264-8 · Cited by 38 · see citing works
The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?
Weinberg, F. D., Dickson, R. P., Nagrath, D., & Ramnath, N. (2020) · Cancers · doi:10.3390/cancers13010013 · Cited by 39 · see citing works
Infections and Immunotherapy in Lung Cancer: A Bad Relationship?
Belluomini, L., Caldart, A., Avancini, A., Dodi, A., Trestini, I., Kadrija, D., Sposito, M., Tregnago, D., Casali, M., Riva, S. T., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010042 · Cited by 39 · see citing works
Schneeberger, P. H. H., Zhang, C. Y. K., Santilli, J., Chen, B., Xu, W., Lee, Y., Wijesinha, Z., Reguera-Nuñez, E., Yee, N., Ahmed, M., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202110-2413oc · Cited by 38 · see citing works
- Authors
- Dickson, R. P., Erb-Downward, J. R., & Huffnagle, G. B.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Dickson, Robert P
- Venue
- The Lancet Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 2
- Issue
- 3
- Pages
- 238-246
- ISSN
- 2213-2600 (ISSN-L)
- PMC
- PMC4004084
- OpenAlex
- W2156749754
- Cited by
- 371
- References
- 84
- Citations by year
- 2026: 35 · 2025: 43 · 2024: 39 · 2023: 24 · 2022: 25 · 2021: 44 · 2020: 30 · 2019: 30 · 2018: 26 · 2017: 26 · 2016: 22 · 2015: 19 · 2014: 8
- FWCI
- 18.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (U01HL098961, L30 HL120241, T32HL00774921, R01HL114447, T32HL007749)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Keywords
- lung microbiome, pneumonia pathogenesis, island model, environmental gradients, complex adaptive systems, positive feedback loop, emergence
- MeSH terms
- Humans, Lung, Models, Biological, Pneumonia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
