CoChat
Sign Up
Cited by 128Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesOccupational exposure and asthma

Outcomes of childhood asthma and wheezy bronchitis. A 50-year cohort study

Open access
Tagiyeva, Nara, Devereux, Graham, Fielding, Shona, Turner, Stephen, Douglas, Graham·2016·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.201505-0870ocPMC PMC4731615
Open this paper in CoChat — free account

Abstract

RATIONALE: Cohort studies suggest that airflow obstruction is established early in life, manifests as childhood asthma and wheezy bronchitis, and continues into early adulthood. Although an association between childhood asthma and chronic obstructive pulmonary disease (COPD) in later life has been demonstrated, it is unclear if childhood wheezy bronchitis is associated with COPD. OBJECTIVES: To investigate whether childhood wheezy bronchitis increases the risk of COPD in the seventh decade. METHODS: A cohort of children recruited in 1964 at age 10 to 15 years, which was followed up in 1989, 1995, and 2001, was followed up again in 2014 when at age 60 to 65 years. Discrete time-to-event and linear mixed effects models were used. MEASUREMENTS AND MAIN RESULTS: FEV1 and FVC were measured. COPD was defined as post-bronchodilator FEV1/FVC <0.7. Childhood wheezing phenotype was related to 1989, 1995, 2001, and 2014 spirometry data. Three hundred thirty subjects, mean age 61 years, were followed up: 38 with childhood asthma; 53 with childhood wheezy bronchitis; and 239 control subjects (of whom 57 developed adulthood-onset wheeze between ages 16 and 46 yr). In adjusted multivariate analyses, childhood asthma was associated with an increased risk of COPD (odds ratio, 6.37; 95% confidence interval, 3.73-10.94), as was childhood wheezy bronchitis (odd ratio 1.81; 95% confidence interval, 1.12-2.91). The COPD risk increased with childhood asthma, and wheezy bronchitis was associated with reduced FEV1 that was evident by the fifth decade and not an accelerated rate of FEV1 decline. In contrast, adulthood-onset wheeze was associated with accelerated FEV1 decline. CONCLUSIONS: Childhood wheezy bronchitis and asthma are associated with an increased risk of COPD and reduced ventilatory function.

Integrity signals

Registry

Crossref · 10.1164/rccm.201505-0870oc

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A number of studies have reported that childhood asthma itself has no impact on adult lung function decline.

    “While a number of studies have reported that childhood asthma itself has no impact on adult lung function decline (154, 157, 158, 160), a study that collected childhood asthma status retrospectively has reported that it is associated with greater lung function decline, which may be related to recall bias (161).”

    From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [158]

  • Childhood asthma has been associated with adult lung function deficits and increased risk of COPD.

    “Childhood asthma has been associated with adult lung function deficits and increased risk of COPD (157–159).”

    From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [158]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Tagiyeva, N., Devereux, G., Fielding, S., Turner, S., & Douglas, G.
Affiliations
  • University of Aberdeen (GB)
  • Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom; and
  • Aberdeen Royal Infirmary (GB)
Corresponding author
Tagiyeva, Nara
ORCID
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2016-01-01
Volume
193
Issue
1
Pages
23-30
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.201505-0870oc
PMC
PMC4731615
OpenAlex
W1686816393
Cited by
128
References
26
Citations by year
2026: 5 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 17 · 2020: 17 · 2019: 11 · 2018: 14 · 2017: 22 · 2016: 15 · 2015: 1
FWCI
13.71
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Journal of Respiratory and Critical Care Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • CLOK (University of Central Lancashire) (acceptedVersion)
  • Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
Funders
Chest Heart and Stroke Scotland
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords
childhood asthma, wheezy bronchitis, chronic obstructive pulmonary disease, COPD risk, airflow obstruction, FEV1 decline, lung function, long-term outcomes
MeSH terms
Adolescent, Adult, Asthma, Bronchitis, Child, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Respiratory Sounds, Risk Factors, Vital Capacity, Cohort Studies, Age of Onset, Pulmonary Disease, Chronic Obstructive, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review