Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study
Open accessAbstract
Background Together with smoking, the lung function attained in early adulthood is one of the strongest predictors of chronic obstructive pulmonary disease. We aimed to investigate whether lung function in early adulthood is, in turn, affected by airway function measured shortly after birth. Methods Non-selected infants were enrolled at birth in the Tucson Children's Respiratory Study between 1980 and 1984. We measured maximal expiratory flows at functional residual capacity (Vmax(FRC)) in 169 of these infants by the chest compression technique at a mean of 2.3 months (SD 1.9). We also obtained measurements of lung function for 123 of these participants at least once at ages 11, 16, and 22 years. Indices were forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and forced expiratory flow between 25% and 75% of FVC (FEF25-75), both before and after treatment with a bronchodilator (180 microg of albuterol). Findings Participants who had infant Vmax(FRC) in the lowest quartile also had lower values for the FEV1/FVC ratio (-5.2%, p<0.0001), FEF25-75 (-663 mL/s, p<0.0001), and FEV1 (-233 mL, p=0.001) up to age 22, after adjustment for height, weight, age, and sex, than those in the upper three quartiles combined. The magnitude and significance of this effect did not change after additional adjustment for wheeze, smoking, atopy, or parental asthma. Interpretation Poor airway function shortly after birth should be recognised as a risk factor for airflow obstruction in young adults. Prevention of chronic obstructive pulmonary disease might need to start in fetal life.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
How lungs develop before birth and during childhood shapes lung function across life.
“Because lung development in utero and in childhood contributes to life-long trajectories of lung function,”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [317]
Nicotine exposure before birth might raise later-life risk of asthma and COPD in middle-aged and older people.
“the effects of prenatal exposure to nicotine could have negative effects on respiratory health in middle-aged and older adults, including increased risk of asthma and chronic obstructive pulmonary disease (COPD).(315-317)”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [317]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Outcome of Asthma and Wheezing in the First 6 Years of Life
Morgan, W. J., Stern, D. A., Sherrill, D. L., Guerra, S., Holberg, C. J., Guilbert, T. W., Taussig, L. M., Wright, A. L., & Martinez, F. D. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-525oc · Cited by 650 · see citing works
Self-citationDecline in Lung Function in the Busselton Health Study
James, A. L., Palmer, L. J., Kicic, E., Maxwell, P. S., Lagan, S. E., Ryan, G. F., & Musk, A. W. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-230oc · Cited by 397 · see citing works
Effect of pneumonia and whooping cough in childhood on adult lung function
Johnston, I. D. A., Strachan, D. P., & Anderson, H. R. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802263380904 · Cited by 169 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983 · see citing works
Self-citationVogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0218pp · Cited by 3,187 · see citing works
Patterns of growth and decline in lung function in persistent childhood asthma
McGeachie, M. J., Yates, K. P., Zhou, X., Guo, F., Sternberg, A. L., Van Natta, M. L., Wise, R. A., Szefler, S. J., Sharma, S., Kho, A. T., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1513737 · Cited by 608 · see citing works
Early lung development: lifelong effect on respiratory health and disease
Stocks, J., Hislop, A., & Sonnappa, S. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70118-8 · Cited by 390 · see citing works
The Origins of Asthma and Chronic Obstructive Pulmonary Disease in Early Life
Martinez, F. D. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200808-092rm · Cited by 242 · see citing works
McEvoy, C. T., Schilling, D., Clay, N., Jackson, K., Go, M. D., Spitale, P., Bunten, C., Leiva, M., Gonzales, D., Hollister-Smith, J., et al. (2014) · JAMA · doi:10.1001/jama.2014.5217 · Cited by 217 · see citing works
Guilbert, T. W., Bacharier, L. B., & Fitzpatrick, A. M. (2014) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2014.06.022 · Cited by 216 · see citing works
Trajectories of lung function during childhood
Belgrave, D. C. M., Buchan, I., Bishop, C., Lowe, L., Simpson, A., & Custovic, A. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1700oc · Cited by 184 · see citing works
Pneumonia in childhood and impaired lung function in adults: a longitudinal study
Chan, J. Y. C., Stern, D. A., Guerra, S., Wright, A. L., Morgan, W. J., & Martinez, F. D. (2015) · Pediatrics · doi:10.1542/peds.2014-3060 · Cited by 180 · see citing works
Self-citationLong term sequelae from childhood pneumonia; systematic review and meta-analysis
Edmond, K., Scott, S., Korczak, V., Ward, C., Sanderson, C., Theodoratou, E., Clark, A., Griffiths, U., Rudan, I., & Campbell, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031239 · Cited by 175 · see citing works
England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181 · see citing works
Prenatal Nicotine Exposure Alters Lung Function and Airway Geometry through α7 Nicotinic Receptors
Wongtrakool, C., Wang, N., Hyde, D. M., Roman, J., & Spindel, E. R. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0028oc · Cited by 147 · see citing works
Outcomes of childhood asthma and wheezy bronchitis. A 50-year cohort study
Tagiyeva, N., Devereux, G., Fielding, S., Turner, S., & Douglas, G. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201505-0870oc · Cited by 128 · see citing works
Perret, J. L., Dharmage, S. C., Matheson, M. C., Johns, D. P., Gurrin, L. C., Burgess, J. A., Marrone, J., Markos, J., Morrison, S., Feather, I., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201205-0788oc · Cited by 128 · see citing works
Risk factors of new-onset asthma in adults: a population-based international cohort study
Antó, J. M., Sunyer, J., Basagaña, X., Garcia‐Esteban, R., Cerveri, I., De Marco, R., Heinrich, J., Janson, C., Jarvis, D., Kogevinas, M., et al. (2010) · Allergy · doi:10.1111/j.1398-9995.2009.02301.x · Cited by 122 · see citing works
Lødrup Carlsen, K. C., Mowinckel, P., Hovland, V., Håland, G., Riiser, A., & Carlsen, K.-H. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.020 · Cited by 59 · see citing works
Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma
McGeachie, M. J., Yates, K. P., Zhou, X., Guo, F., Sternberg, A. L., Van Natta, M. L., Wise, R. A., Szefler, S. J., Sharma, S., Kho, A. T., et al. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201602-0250oc · Cited by 25 · see citing works
Immunologic Impact of Nutrient Depletion in Chronic Obstructive Pulmonary Disease
Herzog, R., & Cunningham-Rundles, S. (2011) · Current Drug Targets · doi:10.2174/138945011794751500 · Cited by 23 · see citing works
- Authors
- Stern, D. A., Morgan, W. J., Wright, A. L., Guerra, S., & Martinez, F. D.
- Affiliations
- University of Arizona (US)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 370
- Issue
- 9589
- Pages
- 758-764
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC2831283
- OpenAlex
- W2013981256
- Cited by
- 615
- References
- 3
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 41 · 2023: 33 · 2022: 30 · 2021: 28 · 2020: 31 · 2019: 34 · 2018: 36 · 2017: 39 · 2016: 32 · 2015: 42 · 2014: 41 · 2013: 30 · 2012: 36
- FWCI
- 29.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p50hl014136-25)
- National Heart, Lung, and Blood Institute (HL-14136, R01HL056177, HL-56177)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- lung function, early adulthood, chronic obstructive pulmonary disease, airflow obstruction, maximal expiratory flow, functional residual capacity, forced expiratory volume, forced expiratory flow, bronchodilator response, salbutamol, childhood wheezing, atopy, parental asthma, smoking, Tucson Children's Respiratory Study
- MeSH terms
- Adolescent, Adult, Child, Female, Forced Expiratory Flow Rates, Humans, Infant, Longitudinal Studies, Male, Respiratory Tract Diseases, Time Factors, Pulmonary Disease, Chronic Obstructive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
