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Cited by 233Asthma and respiratory diseasesOccupational exposure and asthmaChronic Obstructive Pulmonary Disease (COPD) Research

Outcomes of childhood asthma to the age of 50 years

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Tai, Andrew, Tran, Haily, Roberts, Mary, Clarke, Nadeene, Gibson, Anne-Marie, Vidmar, Suzanna, Wilson, John, Robertson, Colin F.·2014·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2013.12.1033
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Abstract

Background In 1964, The Melbourne Asthma Study was established to describe the spectrum and natural history of childhood asthma.Objective To describe the clinical and lung function outcome of childhood asthma to the age of 50 years.Method Subjects were invited to complete an interviewer-administered questionnaire, skin prick testing, and measurement of lung function from the age of 7 years to the age of 50 years at 7-year intervals.Results Of 458 survivors (from the original 484 subjects at recruitment), 346 subjects (76%) participated, of whom, 197 completed lung function measurement. Asthma remission at the age of 50 years was 64% in those with wheezy bronchitis, 47% for those with persistent asthma, and 15% for those with severe asthma in childhood. Multivariable analysis identified severe asthma in childhood (odds ratio [OR] 11.9 [95% CI, 3.4-41.8]), female sex (OR 2.0 [95% CI, 1.1-3.6]), and childhood hay fever (OR 2.0 [95% CI, 1.0-4.0]) as risk factors for "current asthma" at age 50 years. There was no evidence of a difference in the rate of decline in FEV1 (mL/y, 95% CI) between the severe asthma group (15 mL/y [95% CI, 9-22 mL/y]) and all the other recruitment groups: control (16 mL/y [95% CI, 12-20 mL/y]), mild wheezy bronchitis (14 mL/y [95% CI, 8-19 mL/y]), wheezy bronchitis (16 mL/y [95% CI, 11-20 mL/y]), and persistent asthma (19 mL/y [95% CI, 13-24 mL/y]).Conclusion The clinical and lung function outcome in adult life is strongly determined by asthma severity in childhood. The reduced lung function seen in adults is established in childhood and does not appear to decline more rapidly in adult years despite continuing symptoms.

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  • Lung function deficits in those with early onset adult asthma may result from both the tracking of reduced lung function from childhood and additional loss from a greater rate of decline in adulthood.

    “Lung function deficits in those with early onset adult asthma may result from both the tracking of reduced lung function from childhood and additional loss from a greater rate of decline in adulthood (167, 171).”

    From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [171]

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Authors
Tai, A., Tran, H., Roberts, M., Clarke, N., Gibson, A.-M., Vidmar, S., Wilson, J., & Robertson, C. F.
Affiliations
  • Women's and Children's Hospital (AU)
  • Murdoch Children's Research Institute (AU)
  • Royal Children's Hospital (AU)
  • The University of Melbourne (AU)
  • The Alfred Hospital (AU)
Corresponding author
Tai, Andrew
ORCID
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2014-06
Volume
133
Issue
6
Pages
1572-1578.e3
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2013.12.1033
OpenAlex
W2066168750
Cited by
233
References
38
Citations by year
2026: 7 · 2025: 13 · 2024: 22 · 2023: 22 · 2022: 12 · 2021: 23 · 2020: 22 · 2019: 26 · 2018: 15 · 2017: 23 · 2016: 14 · 2015: 27 · 2014: 6
FWCI
15.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
childhood asthma, adult asthma, asthma remission, lung function decline, FEV1, asthma severity, wheezy bronchitis, persistent asthma, allergic rhinitis, natural history of asthma
MeSH terms
Adolescent, Adult, Asthma, Child, Female, Humans, Longitudinal Studies, Male, Middle Aged, Surveys and Questionnaires, Respiratory Function Tests, Skin Tests, Smoking, Outcome Assessment, Health Care, Young Adult

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