The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Maturation of the Infant Respiratory Microbiota, Environmental Drivers, and Health Consequences. A Prospective Cohort Study
Open accessAbstract
RATIONALE: Perinatal and postnatal influences are presumed important drivers of the early-life respiratory microbiota composition. We hypothesized that the respiratory microbiota composition and development in infancy is affecting microbiota stability and thereby resistance against respiratory tract infections (RTIs) over time. OBJECTIVES: To investigate common environmental drivers, including birth mode, feeding type, antibiotic exposure, and crowding conditions, in relation to respiratory tract microbiota maturation and stability, and consecutive risk of RTIs over the first year of life. METHODS: In a prospectively followed cohort of 112 infants, we characterized the nasopharyngeal microbiota longitudinally from birth on (11 consecutive sample moments and the maximum three RTI samples per subject; in total, n = 1,121 samples) by 16S-rRNA gene amplicon sequencing. MEASUREMENTS AND MAIN RESULTS: Using a microbiota-based machine-learning algorithm, we found that children experiencing a higher number of RTIs in the first year of life already demonstrate an aberrant microbial developmental trajectory from the first month of life on as compared with the reference group (0-2 RTIs/yr). The altered microbiota maturation process coincided with decreased microbial community stability, prolonged reduction of Corynebacterium and Dolosigranulum, enrichment of Moraxella very early in life, followed by later enrichment of Neisseria and Prevotella spp. Independent drivers of these aberrant developmental trajectories of respiratory microbiota members were mode of delivery, infant feeding, crowding, and recent antibiotic use. CONCLUSIONS: Our results suggest that environmental drivers impact microbiota development and, consequently, resistance against development of RTIs. This supports the idea that microbiota form the mediator between early-life environmental risk factors for and susceptibility to RTIs over the first year of life.
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Cites
Non‐parametric multivariate analyses of changes in community structure
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Cited by
The dynamic lung microbiome in health and disease
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Early-Life Formation of the Microbial and Immunological Environment of the Human Airways
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Metadata
- Authors
- Bosch, A. A. T. M., Piters, W. A. A. D. S., van Houten, M. A., Chu, M. L. J. N., Biesbroek, G., Kool, J., Pernet, P., de Groot, P.-K. C. M., Eijkemans, M. J. C., Keijser, B. J. F., Sanders, E. A. M., & Bogaert, D.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-12-15
- Volume
- 196
- Issue
- 12
- Pages
- 1582-1590
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2727392759
- Cited by
- 325
- References
- 32
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Bosch, A. A. T. M., Piters, W. A. A. D. S., van Houten, M. A., Chu, M. L. J. N., Biesbroek, G., Kool, J., Pernet, P., de Groot, P.-K. C. M., Eijkemans, M. J. C., Keijser, B. J. F., Sanders, E. A. M., & Bogaert, D. (2017). Maturation of the Infant Respiratory Microbiota, Environmental Drivers, and Health Consequences. A Prospective Cohort Study. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201703-0554oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
