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Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline

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Crouser, Elliott D., Maier, Lisa A., Wilson, Kevin C., Bonham, Catherine A., Morgenthau, Adam S., Patterson, Karen C., Abston, Eric, Bernstein, Richard C., Blankstein, Ron, Chen, Edward S., Culver, Daniel A., Drake, Wonder, Drent, Marjolein, Gerke, Alicia K., Ghobrial, Michael, Govender, Praveen, Hamzeh, Nabeel, James, W. Ennis, Judson, Marc A., Kellermeyer, Liz, Knight, Shandra, Koth, Laura L., Poletti, Venerino, Raman, Subha V., Tukey, Melissa H., Westney, Gloria E., Baughman, Robert P.·2020·American Journal of Respiratory and Critical Care Medicine

Abstract

Abstract Background The diagnosis of sarcoidosis is not standardized but is based on three major criteria: a compatible clinical presentation, finding nonnecrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative causes of granulomatous disease. There are no universally accepted measures to determine if each diagnostic criterion has been satisfied; therefore, the diagnosis of sarcoidosis is never fully secure. Methods Systematic reviews and, when appropriate, meta-analyses were performed to summarize the best available evidence. The evidence was appraised using the Grading of Recommendations, Assessment, Development, and Evaluation approach and then discussed by a multidisciplinary panel. Recommendations for or against various diagnostic tests were formulated and graded after the expert panel weighed desirable and undesirable consequences, certainty of estimates, feasibility, and acceptability. Results The clinical presentation, histopathology, and exclusion of alternative diagnoses were summarized. On the basis of the available evidence, the expert committee made 1 strong recommendation for baseline serum calcium testing, 13 conditional recommendations, and 1 best practice statement. All evidence was very low quality. Conclusions The panel used systematic reviews of the evidence to inform clinical recommendations in favor of or against various diagnostic tests in patients with suspected or known sarcoidosis. The evidence and recommendations should be revisited as new evidence becomes available.

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Metadata

Authors
Crouser, E. D., Maier, L. A., Wilson, K. C., Bonham, C. A., Morgenthau, A. S., Patterson, K. C., Abston, E., Bernstein, R. C., Blankstein, R., Chen, E. S., Culver, D. A., Drake, W., Drent, M., Gerke, A. K., Ghobrial, M., Govender, P., Hamzeh, N., James, W. E., Judson, M. A., Kellermeyer, L., Knight, S., Koth, L. L., Poletti, V., Raman, S. V., Tukey, M. H., Westney, G. E., & Baughman, R. P.
Venue
American Journal of Respiratory and Critical Care Medicine
Published
2020-04-15
Volume
201
Issue
8
Pages
e26-e51
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
OpenAlex
W3015330439
Cited by
1,086
References
2
FWCI
66.88
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. https://app.cochat.ai/papers/10.1164/rccm.202002-0251st
The paper
Crouser, E. D., Maier, L. A., Wilson, K. C., Bonham, C. A., Morgenthau, A. S., Patterson, K. C., Abston, E., Bernstein, R. C., Blankstein, R., Chen, E. S., Culver, D. A., Drake, W., Drent, M., Gerke, A. K., Ghobrial, M., Govender, P., Hamzeh, N., James, W. E., Judson, M. A., . . . Baughman, R. P. (2020). Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202002-0251st

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