The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Interleukin 6: at the interface of human health and disease
Open accessAbstract
Interleukin 6 (IL-6) is a pleiotropic cytokine executing a diverse number of functions, ranging from its effects on acute phase reactant pathways, B and T lymphocytes, blood brain barrier permeability, synovial inflammation, hematopoiesis, and embryonic development. This cytokine empowers the transition between innate and adaptive immune responses and helps recruit macrophages and lymphocytes to the sites of injury or infection. Given that IL-6 is involved both in the immune homeostasis and pathogenesis of several autoimmune diseases, research into therapeutic modulation of IL-6 axis resulted in the approval of a number of effective treatments for several autoimmune disorders like neuromyelitis optica spectrum disorder (NMOSD), rheumatoid arthritis, juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, giant cell arteritis (GCA), and cytokine release syndrome, associated with SARS-CoV2 pneumonia. This review discusses downstream inflammatory pathways of IL-6 expression and therapeutic applications of IL-6 blockade, currently investigated for the treatment of several other autoimmune conditions such as autoimmune encephalitis, autoimmune epilepsy, as well as myelin oligodendrocyte glycoprotein associated demyelination (MOGAD). This review further highlights the need for clinical trials to evaluate IL-6 blockade in disorders such neuropsychiatric lupus erythematosus (SLE), sarcoidosis and Behcet’s.
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IL-6 as a keystone cytokine in health and disease
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IL‐6: Regulator of Treg/Th17 balance
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Association of interleukin-6 (IL-6) with suicide attempt
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Metadata
- Authors
- Grebenciucova, E., & VanHaerents, S.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2023-09-28
- Volume
- 14
- Pages
- 1255533-1255533
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W4387183678
- Cited by
- 281
- References
- 107
- FWCI
- 28.99
- Type
- journal article
- Language
- en
- Open access
- gold
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- Grebenciucova, E., & VanHaerents, S. (2023). Interleukin 6: at the interface of human health and disease. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2023.1255533
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
