The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Respiratory and Limb Muscle Weakness Induced by Tumor Necrosis Factor- α: Involvement of Muscle Myofilaments
Abstract
The respiratory and limb skeletal muscles become weakened in sepsis, congestive heart failure, and other inflammatory diseases. A potential mediator of muscle weakness is tumor necrosis factor (TNF)-alpha, a cytokine that can stimulate muscle wasting and also can induce contractile dysfunction without overt catabolism. This study addressed the latter process. Murine diaphragm and limb muscle (flexor digitorum brevis [FDB]) preparations were used to determine the relative sensitivities of these muscles to TNF-alpha. Intact muscle fibers were isolated from FDB and microinjected with indo-1 to measure changes in sarcoplasmic calcium regulation. We found that TNF-alpha depressed tetanic force of the diaphragm and FDB to comparable degrees across a range of stimulus frequencies. In isolated muscle fibers, TNF-alpha decreased tetanic force without altering tetanic calcium transients or resting calcium levels. We conclude that (1) TNF-alpha compromises contractile function of diaphragm and limb muscle similarly, and (2) TNF-alpha decreases force by blunting the response of muscle myofilaments to calcium activation.
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Cites
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582 · cited 1×
“Circulating TNF- levels are elevated in patients with chronic obstructive lung disease (13), heart failure (14), sepsis (15), transplant rejection (16, 17) and other inflammatory diseases that cause secondary muscle weakness (18–20).”
BackgroundMechanisms underlying changes of tetanic [Ca2+]i and force in skeletal muscle
WESTERBLAD, H., & ALLEN, D. G. (1996) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1996.196000.x · Cited by 64
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Manini, T. M., & Clark, B. C. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr010 · Cited by 875
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The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich, O., Reid, M. B., Van den Berghe, G., Vanhorebeek, I., Hermans, G., Rich, M. M., & Larsson, L. (2015) · Physiological Reviews · doi:10.1152/physrev.00028.2014 · Cited by 396
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Metadata
- Authors
- Reid, M. B., Lännergren, J., & Westerblad, H.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-08-15
- Volume
- 166
- Issue
- 4
- Pages
- 479-484
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1845511895
- Cited by
- 322
- References
- 2
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reid, M. B., Lännergren, J., & Westerblad, H. (2002). Respiratory and Limb Muscle Weakness Induced by Tumor Necrosis Factor- α: Involvement of Muscle Myofilaments. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.2202005
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