The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
What is dynapenia?
Open accessAbstract
Dynapenia (pronounced dahy-nuh-pē-nē-a, Greek translation for poverty of strength, power, or force) is the age-associated loss of muscle strength that is not caused by neurologic or muscular diseases. Dynapenia predisposes older adults to an increased risk for functional limitations and mortality. For the past several decades, the literature has largely focused on muscle size as the primary cause of dynapenia; however, recent findings have clearly demonstrated that muscle size plays a relatively minor role. Conversely, subclinical deficits in the structure and function of the nervous system and/or impairments in the intrinsic force-generating properties of skeletal muscle are potential antecedents to dynapenia. This review highlights in the contributors to dynapenia and the etiology and risk factors that predispose individuals to dynapenia. In addition, we address the role of nutrition in the muscular and neurologic systems for the preservation of muscle strength throughout the life span.
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Cites
Thinning of the Cerebral Cortex in Aging
Salat, D. H. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh032 · Cited by 1,851
Longitudinal study of muscle strength, quality, and adipose tissue infiltration
Delmonico, M. J., Harris, T. B., Visser, M., Park, S. W., Conroy, M. B., Velasquez-Mieyer, P., Boudreau, R., Manini, T. M., Nevitt, M., Newman, A. B., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28047 · Cited by 1,446
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Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
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“However, recent findings have suggested that basal muscle protein synthesis rates do not differ between young and old adults [89-94], and it is generally accepted that the difference in fasted rates of muscle protein synthesis or breakdown are not altered in healthy older adults [95].”
BackgroundSarcopenia: alternative definitions and associations with lower extremity function
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E., Goodpaster, B., Nevitt, M., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., et al. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51534.x · Cited by 981
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Dynapenia and aging: an update
Manini, T. M., & Clark, B. C. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr010 · Cited by 875
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“Similarly, several recent studies have reported a blunted muscle protein synthesis response after an acute bout of resistance exercise in older subjects [101-103].”
BackgroundNutritional recommendations for the management of sarcopenia
Morley, J. E., Argiles, J. M., Evans, W. J., Bhasin, S., Cella, D., Deutz, N. E. P., Doehner, W., Fearon, K. C. H., Ferrucci, L., Hellerstein, M. K., et al. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.04.014 · Cited by 664
Cited by
Sarcopenia and Cardiovascular Diseases
Damluji, A. A., Alfaraidhy, M., AlHajri, N., Rohant, N. N., Kumar, M., Al Malouf, C., Bahrainy, S., Ji Kwak, M., Batchelor, W. B., Forman, D. E., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.064071 · Cited by 645
on behalf of the SPRINTT Consortium, Marzetti, E., Calvani, R., Tosato, M., Cesari, M., Di Bari, M., Cherubini, A., Collamati, A., D’Angelo, E., Pahor, M., et al. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0704-5 · Cited by 438
Herold, F., Törpel, A., Schega, L., & Müller, N. G. (2019) · European Review of Aging and Physical Activity · doi:10.1186/s11556-019-0217-2 · Cited by 349
Live strong and prosper: the importance of skeletal muscle strength for healthy ageing
McLeod, M., Breen, L., Hamilton, D. L., & Philp, A. (2016) · Biogerontology · doi:10.1007/s10522-015-9631-7 · Cited by 274
Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength
Collins, B. C., Laakkonen, E. K., & Lowe, D. A. (2019) · Bone · doi:10.1016/j.bone.2019.03.033 · Cited by 227
Metadata
- Authors
- Clark, B. C., & Manini, T. M.
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 28
- Issue
- 5
- Pages
- 495-503
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W1982152979
- Cited by
- 414
- References
- 31
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- green
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