The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Induction of ICAM-1 Expression on Human Airway Epithelial Cells by Inflammatory Cytokines: Effects on Neutrophil-Epithelial Cell Adhesion
Abstract
Inflammation of the human airways in diseases such as chronic bronchitis, cystic fibrosis with Pseudomonas endobronchial infection, and possibly asthma during late-phase reactions involves a local influx of neutrophils (PMN) that may participate in airway epithelial injury. PMN-mediated cellular injury is most efficient under conditions of PMN-target cell adhesion. PMN express adhesive glycoproteins of the CD11/CD18 family that are counter-receptors for intercellular adhesion molecule-1 (ICAM-1), found on various cell types. We proposed that adherence by PMN to human airway epithelial cells via ICAM-1 might be an important mechanism in inflammatory airway diseases. We found that although PMN adhere poorly (less than 5%) to monolayers of human tracheal epithelial cells (TEC) in primary culture, they adhere readily (45 to 50%) to an SV40-immortalized line of human TEC, designated 9HTEo-. We also found 6-fold greater surface expression of ICAM-1 on 9HTEo- compared with primary TEC. Blocking surface ICAM-1 on 9HTEo- cells with specific monoclonal antibody inhibited PMN adherence by about 50%. Thus, ICAM-1 plays a major role in this adherence, although it is possible that other epithelial ligands contribute also. Antibodies to CD11a, CD11b, and CD18 on PMN also inhibited PMN-epithelial adherence. Treatment of primary TEC monolayers with the proinflammatory cytokines interleukin-1 (IL-1) or tumor necrosis factor-alpha (TNF-alpha) caused a 3- to 4-fold increase in both cell surface ICAM-1 expression and support of PMN adhesion.(ABSTRACT TRUNCATED AT 250 WORDS)
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Cited by
Intercellular adhesion molecule-1
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Transepithelial Migration of Neutrophils
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JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation
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Metadata
- Authors
- Tosi, M. F., Stark, J. M., Smith, C. W., Hamedani, A., Gruenert, D. C., & Infeld, M. D.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-08
- Volume
- 7
- Issue
- 2
- Pages
- 214-221
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W1991312386
- Cited by
- 278
- References
- 24
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Induction of ICAM-1 Expression on Human Airway Epithelial Cells by Inflammatory Cytokines: Effects on Neutrophil-Epithelial Cell Adhesion. https://app.cochat.ai/papers/10.1165/ajrcmb/7.2.214
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- Tosi, M. F., Stark, J. M., Smith, C. W., Hamedani, A., Gruenert, D. C., & Infeld, M. D. (1992). Induction of ICAM-1 Expression on Human Airway Epithelial Cells by Inflammatory Cytokines: Effects on Neutrophil-Epithelial Cell Adhesion. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/ajrcmb/7.2.214
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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