The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthma
Abstract
Airway eosinophilia, epithelial desquamation, and hyperresponsiveness are characteristics of the airway inflammation underlying bronchial asthma. The contribution of intercellular adhesion molecule-1 (ICAM-1) to eosinophil migration and airway responsiveness was studied. ICAM-1 partially mediated eosinophil adhesion to endothelium in vitro and was upregulated on inflamed bronchial endothelium in vivo. ICAM-1 expression was also upregulated on inflamed airway epithelium in vitro and in vivo. In a primate model of asthma, a monoclonal antibody to ICAM-1 attenuated airway eosinophilia and hyperresponsiveness. Thus, antagonism of ICAM-1 may provide a therapeutic approach to reducing airway inflammation, hyperresponsiveness, and asthma symptoms.
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Cites
Mullarkey, M. F., Hill, J. S., & Webb, D. R. (1980) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(80)90196-7 · Cited by 243
Cited by
Rothenberg, M. E., & Hogan, S. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090720 · Cited by 1,356
Intercellular adhesion molecule-1
van de Stolpe, A., & van der Saag, P. T. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00202069 · Cited by 802
Interleukin-5, eosinophils, and disease
Sanderson, C. (1992) · Blood · doi:10.1182/blood.v79.12.3101.bloodjournal79123101 · Cited by 972
Pathophysiology of allergic inflammation
Barnes, P. J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01020.x · Cited by 361
Transepithelial Migration of Neutrophils
Zemans, R. L., Colgan, S. P., & Downey, G. P. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0348tr · Cited by 339
Metadata
- Authors
- Wegner, C. D., Gundel, R. H., Reilly, P., Haynes, N., Letts, L. G., & Rothlein, R.
- Venue
- Science
- Published
- 1990-01-26
- Volume
- 247
- Issue
- 4941
- Pages
- 456-459
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015037737
- Cited by
- 898
- References
- 1
- FWCI
- 58.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wegner, C. D., Gundel, R. H., Reilly, P., Haynes, N., Letts, L. G., & Rothlein, R. (1990). Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthma. Science. https://doi.org/10.1126/science.1967851
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
