Transepithelial Migration of Neutrophils

Zemans, Rachel L.; Colgan, Sean P.; Downey, Gregory P.

doi:10.1165/rcmb.2008-0348tr

Cited by 339Neutrophil, Myeloperoxidase and Oxidative MechanismsCell Adhesion Molecules ResearchInflammation biomarkers and pathways

Transepithelial Migration of Neutrophils

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Zemans, Rachel L., Colgan, Sean P., Downey, Gregory P.·2009·American Journal of Respiratory Cell and Molecular Biology

DOI 10.1165/rcmb.2008-0348trPMC PMC2677434

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Abstract

The primary function of neutrophils in host defense is to contain and eradicate invading microbial pathogens. This is achieved through a series of swift and highly coordinated responses culminating in ingestion (phagocytosis) and killing of invading microbes. While these tasks are usually performed without injury to host tissues, in pathologic circumstances such as sepsis, potent antimicrobial compounds can be released extracellularly, inducing a spectrum of responses in host cells ranging from activation to injury and death. In the lung, such inflammatory damage is believed to contribute to the pathogenesis of diverse lung diseases, including acute lung injury and the acute respiratory distress syndrome, chronic obstructive lung disease, and cystic fibrosis. In these disorders, epithelial cells are targets of leukocyte-derived antimicrobial products, including proteinases and oxidants. Herein, we review the mechanisms involved in the physiologic process of neutrophil transepithelial migration, including the role of specific adhesion molecules on the leukocyte and epithelial cells. We examine the responses of the epithelial cells to the itinerant leukocytes and their cytotoxic products and the consequences of this for lung injury and repair. This paradigm has important clinical implications because of the potential for selective blockade of these pathways to prevent or attenuate lung injury.

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Increasing numbers of recruited neutrophils can promote the development of edema, enhanced disease severity, prolonged inflammation, and pulmonary tissue damage.
“Increasing numbers of recruited neutrophils can promote the development of edema, enhanced disease severity, prolonged inflammation, and pulmonary tissue damage (125, 126).”
From Aging and Lung Disease (2020) · cites this paper as [126]
Increased and prolonged neutrophil recruitment in the COPD lung can have devastating effects on lung parenchyma and can enhance disease severity, prolong inflammation, and cause further tissue damage.
“Increased and prolonged neutrophil recruitment in the COPD lung can have devastating effects on lung parenchyma and can enhance disease severity, prolong inflammation, and cause further tissue damage (107, 125, 126).”
From Aging and Lung Disease (2020) · cites this paper as [126]

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Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354 · see citing works
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738 · see citing works
Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration
Martín-Padura, I., Lostaglio, S., Schneemann, M., Williams, L., Romano, M., Fruscella, P., Panzeri, C., Stoppacciaro, A., Ruco, L., Villa, A., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.117 · Cited by 1,387 · see citing works
Matrix metalloproteinases: effectors of development and normal physiologyPreprint
Vu, T. H., & Werb, Z. (2000) · Genes & Development · doi:10.1101/gad.815400 · Cited by 1,236 · see citing works
Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.
Sacks, T., Moldow, C. F., Craddock, P. R., Bowers, T. K., & Jacob, H. S. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109031 · Cited by 1,101 · see citing works
Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.
Smith, C. W., Marlin, S. D., Rothlein, R., Toman, C., & Anderson, D. C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114111 · Cited by 1,091 · see citing works
The Neutrophil NADPH Oxidase
BABIOR, B. M., Lambeth, J. D., & Nauseef, W. M. (2002) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2642 · Cited by 911 · see citing works
Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthma
Wegner, C. D., Gundel, R. H., Reilly, P. L., Haynes, N., Letts, L. G., & Rothlein, R. (1990) · Science · doi:10.1126/science.1967851 · Cited by 898 · see citing works
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).
Diamond, M., Staunton, D. E., de Fougerolles, A. R., Stacker, S. A., García‐Aguilar, J., Hibbs, M. L., & Springer, T. A. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.3129 · Cited by 881 · see citing works
Neutrophils in Human Diseases
Malech, H. L., & Gallin, J. I. (1987) · New England Journal of Medicine · doi:10.1056/nejm198709103171107 · Cited by 840 · see citing works
Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome
Gadek, J. E., DeMichele, S. J., Karlstad, M. D., Pacht, E. R., Donahoe, M., Albertson, T. E., Van Hoozen, C., Wennberg, A. K., Nelson, J. L., & Noursalehi, M. (1999) · Critical Care Medicine · doi:10.1097/00003246-199908000-00001 · Cited by 757 · see citing works
How human neutrophils kill and degrade microbes: an integrated view
Nauseef, W. M. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00550.x · Cited by 756 · see citing works
JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes
Ostermann, G., Weber, K. S. C., Zernecke, A., Schröder, A., & Weber, C. (2002) · Nature Immunology · doi:10.1038/ni755 · Cited by 644 · see citing works
Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice
Lindberg, F. P., Bullard, D. C., Caver, T. E., Gresham, H. D., Beaudet, A. L., & Brown, E. J. (1996) · Science · doi:10.1126/science.274.5288.795 · Cited by 606 · see citing works
Noninvasive Markers in the Assessment of Intestinal Inflammation in Inflammatory Bowel Diseases: Performance of Fecal Lactoferrin, Calprotectin, and PMN-Elastase, CRP, and Clinical Indices
Langhorst, J., Elsenbruch, S., Koelzer, J., Rueffer, A., Michalsen, A., & Dobos, G. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01556.x · Cited by 588 · see citing works
Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.
Weiss, S. J., Young, J. K., LoBuglio, A., et al. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110307 · Cited by 577 · see citing works
Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.
Smedly, L. A., Tonnesen, M. G., Sandhaus, R. A., Haslett, C., Guthrie, L. A., Johnston, R. B., Henson, P. M., & Worthen, G. S. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112426 · Cited by 566 · see citing works
Human junction adhesion molecule regulates tight junction resealing in epithelia
Liu, Y., Nusrat, A., Schnell, F. J., Reaves, T. A., Walsh, S. V., Pochet, M., & Parkos, C. A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.13.2363 · Cited by 525 · see citing works
High Bronchoalveolar Levels of Tumor Necrosis Factor and Its Inhibitors, Interleukin-1, Interferon, and Elastase, in Patients with Adult Respiratory Distress Syndrome after Trauma, Shock, or Sepsis
Suter, P. M., Suter, S., Girardin, E. P., Roux‐Lombard, P., Grau, G. E., & Dayer, J. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.5.1016 · Cited by 516 · see citing works
Elastolytic Activity in Pulmonary Lavage Fluid from Patients with Adult Respiratory-Distress Syndrome
Lee, C. T., Fein, A. M., Lippmann, M. L., Holtzman, H., Kimbel, P., & Weinbaum, G. (1981) · New England Journal of Medicine · doi:10.1056/nejm198101223040402 · Cited by 516 · see citing works
JAM-A regulates permeability and inflammation in the intestine in vivo
Laukoetter, M. G., Nava, P., Lee, W. Y., Severson, E. A., Capaldo, C., Babbin, B. A., Williams, I. R., Koval, M. H., Peatman, E., Campbell, J. A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071416 · Cited by 512 · see citing works
Physiological roles for ecto-5’-nucleotidase (CD73)
Colgan, S. P., Eltzschig, H. K., Eckle, T. D. L. G., & Thompson, L. F. (2006) · Purinergic Signalling · doi:10.1007/s11302-005-5302-5 · Cited by 496 · see citing works
Self-citation
Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.
Xu, H., Gonzalo, J. A., St‐Pierre, Y., Williams, I. R., Kupper, T. S., Cotran, R. S., Springer, T. A., & Gutierrez‐Ramos, J. C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.95 · Cited by 483 · see citing works
Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.
Harlan, J. M., Killen, P. D., Harker, L. A., Striker, G. E., & Wright, D. G. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110390 · Cited by 430 · see citing works
Endogenous pro‐resolving and anti‐inflammatory lipid mediators: a new pharmacologic genus
Serhan, C. N., & Chiang, N. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707489 · Cited by 428 · see citing works
The Junctional Adhesion Molecule 3 (JAM-3) on Human Platelets is a Counterreceptor for the Leukocyte Integrin Mac-1
Santoso, S., Sachs, U. J., Kroll, H., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020267 · Cited by 427 · see citing works
Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation
Haworth, O., Cernadas, M., Yang, R., Serhan, C. N., & Levy, B. D. (2008) · Nature Immunology · doi:10.1038/ni.1627 · Cited by 425 · see citing works
The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome
Pugin, J., Verghese, G. M., Widmer, M.-C., & Matthay, M. A. (1999) · Critical Care Medicine · doi:10.1097/00003246-199902000-00036 · Cited by 421 · see citing works
Role of Gelatinase B and Elastase in Human Polymorphonuclear Neutrophil Migration Across Basement Membrane
Delclaux, C., Delacourt, C., d’Ortho, M., Boyer, V., Lafuma, C., & HARF, A. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.14.3.8845180 · Cited by 421 · see citing works
Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing
Ashcroft, G. S., Lei, K.-J., Jin, W., Longenecker, G., Kulkarni, A. B., Greenwell‐Wild, T., Hale‐Donze, H., McGrady, G., Song, X.-Y., & Wahl, S. M. (2000) · Nature Medicine · doi:10.1038/80489 · Cited by 417 · see citing works
Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP
Feng, D., Nagy, J. A., Pyne, K., Dvorak, H. F., & Dvořàk, A. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.6.903 · Cited by 412 · see citing works
CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits.
Doerschuk, C. M., Winn, R. K., Coxson, H. O., & Harlan, J. M. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.6.2327 · Cited by 408 · see citing works
Morphologic Changes in Pulmonary Oxygen Toxicity
Crapo, J. D. (1986) · Annual Review of Physiology · doi:10.1146/annurev.ph.48.030186.003445 · Cited by 405 · see citing works
Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury
Abraham, E. H., Carmody, A., Shenkar, R., & Arcaroli, J. J. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1137 · Cited by 403 · see citing works
Tyrosine phosphorylation and dissociation of occludin–ZO-1 and E-cadherin–β-catenin complexes from the cytoskeleton by oxidative stress
Rao, R., Basuroy, S., Rao, V. U., KARNAKY, K. J., & Gupta, A. K. (2002) · Biochemical Journal · doi:10.1042/bj20011804 · Cited by 402 · see citing works
In vivo damage of rat lungs by oxygen metabolites.
Johnson, K. J., Fantone, J. C., Kaplan, J., & Ward, P. A. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110149 · Cited by 359 · see citing works
Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease.
McKenzie, S. J., Baker, M. S., Buffinton, G. D., & Doe, W. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118757 · Cited by 349 · see citing works
Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction.
Parkos, C. A., Delp, C., Arnaout, M. A., et al. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115473 · Cited by 349 · see citing works
Neutrophil elastase inhibition in acute lung injury: Results of the STRIVE study
Zeiher, B. G., Artigas, A., Vincent, J., Dmitrienko, A. A., Jackson, K. A., Thompson, B., & Bernard, G. R. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000133332.48386.85 · Cited by 348 · see citing works
Soluble Fas Ligand Induces Epithelial Cell Apoptosis in Humans with Acute Lung Injury (ARDS)
Matute‐Bello, G., Liles, W. C., Steinberg, K. P., Kiener, P. A., Mongovin, S. M., Chi, E. Y., Jonas, M., & Martin, T. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.2217 · Cited by 347 · see citing works
Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin.
Wiener-Kronish, J. P., Albertine, K. H., & Matthay, M. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115388 · Cited by 337 · see citing works
Loosening tight junctions. Lessons from the intestine.
Madara, J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113987 · Cited by 335 · see citing works
Matrix Metalloproteinase-9 Knockout Confers Resistance to Corneal Epithelial Barrier Disruption in Experimental Dry Eye
Pflugfelder, S. C., Farley, W. J., Luo, L., Chen, L. Z., de Paiva, C. S., de Koo, L. C. O., Li, D., & Fini, M. E. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62232-8 · Cited by 332 · see citing works
Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.
Martin, T. R., Pistorese, B. P., Chi, E. Y., Goodman, R. B., & Matthay, M. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114338 · Cited by 330 · see citing works
Matrix metalloproteinase levels are elevated in inflammatory bowel disease
Baugh, M. D., Perry, M. J., Hollander, A. P., Davies, D. R., Cross, S. S., Lobo, A., Taylor, C. J., & EVANS, G. S. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70339-2 · Cited by 327 · see citing works
Leukocyte Elastase
Lee, W. L., & Downey, G. P. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2103040 · Cited by 325 · see citing works
Self-citation
Oxidant-Antioxidant Balance in Acute Lung Injury*
Lang, J. D., McArdle, P. J., O’Reilly, P. J., & Matalon, S. (2002) · CHEST Journal · doi:10.1378/chest.122.6_suppl.314s · Cited by 300 · see citing works
Unique Structural Features That Influence Neutrophil Emigration Into the Lung
Burns, A. R., Smith, C. W., & Walker, D. C. (2003) · Physiological Reviews · doi:10.1152/physrev.00023.2002 · Cited by 298 · see citing works
Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia
Folz, R. J., Abushamaa, A. M., & Suliman, H. B. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3816 · Cited by 289 · see citing works
Fas and Fas Ligand Are Up-Regulated in Pulmonary Edema Fluid and Lung Tissue of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome
Albertine, K. H., Soulier, M. F., Wang, Z., Ishizaka, A., Hashimoto, S., Zimmerman, G. A., Matthay, M. A., & Ware, L. B. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64455-0 · Cited by 288 · see citing works
Effects of polymorphonuclear leukocyte transmigration on the barrier function of cultured intestinal epithelial monolayers.
Nash, S. V., Stafford, J., & Madara, J. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113167 · Cited by 285 · see citing works
Leukocyte Recruitment in the Cerebrospinal Fluid of Mice with Experimental Meningitis Is Inhibited by an Antibody to Junctional Adhesion Molecule (Jam)
Maschio, A. D., Luigi, A. D., Martín-Padura, I., Brockhaus, M., Bartfai, T., Fruscella, P., Adorini, L., Martino, G., Furlan, R., Simoni, M. G. D., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.9.1351 · Cited by 283 · see citing works
Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium.
Luscinskas, F. W., Brock, A., Arnaout, M. A., & Gimbrone, M. A. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.7.2257 · Cited by 282 · see citing works
Induction of ICAM-1 Expression on Human Airway Epithelial Cells by Inflammatory Cytokines: Effects on Neutrophil-Epithelial Cell Adhesion
Tosi, M. F., Stark, J. M., Smith, C. W., et al. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/7.2.214 · Cited by 279 · see citing works
Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).
Diamond, M., Alon, R., Parkos, C. A., Quinn, M. T., & Springer, T. A. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.6.1473 · Cited by 279 · see citing works
Role of Inducible Nitric Oxide Synthase in Endotoxin-induced Acute Lung Injury
Kristof, A. S., Goldberg, P., Laubach, V. E., & Hussain, S. N. A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.6.9802100 · Cited by 277 · see citing works
Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging
Gitter, A. H., Wullstein, F., Fromm, M., & Schulzke, J. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.29694 · Cited by 270 · see citing works
Targeted Deletion of Metalloproteinase 9 Attenuates Experimental Colitis in Mice: Central Role of Epithelial-Derived MMP
Castaneda, F. E., Walia, B., Vijay–Kumar, M., Patel, N. R., Roser, S., Kolachala, V. L., Rojas, M., Wang, L., Oprea, G. M., Garg, P., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.09.017 · Cited by 267 · see citing works
Cellular Oxygen Toxicity
Kazzaz, J. A., Xu, J., Palaia, T. A., Mantell, L. L., Fein, A. M., & Horowitz, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15182 · Cited by 263 · see citing works
Nitric Oxide and Nitrotyrosine in the Lungs of Patients with Acute Respiratory Distress Syndrome
Sittipunt, C., Steinberg, K. P., RUZINSKI, J. T., Myles, C., Zhu, S., Goodman, R. B., Hudson, L. D., Matalon, S., & MARTIN, T. R. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.2.2004187 · Cited by 261 · see citing works
Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical.
Varani, J., Fligiel, S., Till, G. O., et al. (1985) · PubMed · Cited by 261 · see citing works
Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury.
Bardales, R. H., Xie, S. S., Schaefer, R. F., & Hsu, S. M. (1996) · Europe PMC (PubMed Central) · Cited by 258 · see citing works
Oxygen Toxicity in Mouse Lung: Pathways to Cell Death
Barazzone‐Argiroffo, C., Horowitz, S., Donati, Y. R. A., Rodríguez, I., & Piguet, P. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.19.4.3173 · Cited by 258 · see citing works
Membrane-Bound Matrix Metalloproteinase-8 on Activated Polymorphonuclear Cells Is a Potent, Tissue Inhibitor of Metalloproteinase-Resistant Collagenase and Serpinase
Owen, C. A., Hu, Z., López-Otı́n, C., & Shapiro, S. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7791 · Cited by 257 · see citing works
Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.
Shasby, D. M., VanBenthuysen, K. M., Tate, R. M., Shasby, S. S., McMurtry, I. F., & Repine, J. E. (1982) · PubMed · doi:10.1164/arrd.1982.125.4.443 · Cited by 250 · see citing works
Role of Oxidants in Lung Injury During Sepsis
Guo, R., & Ward, P. A. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1785 · Cited by 246 · see citing works
Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats
Steinberg, J. M., Halter, J. M., Schiller, H. J., DaSilva, M., LANDAS, S. K., Gatto, L. A., Maisi, P. S., Sorsa, T. A., Rajamäki, M. M., Lee, H., et al. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00089-1 · Cited by 246 · see citing works
Oxidative Stress Affects the Junctional Integrity of Retinal Pigment Epithelial Cells
Bailey, T. A., Kanuga, N., Romero, I. A., Greenwood, J., Luthert, P. J., & Cheetham, M. E. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0351 · Cited by 245 · see citing works
Protection from Lethal Apoptosis in Lipopolysaccharide-Induced Acute Lung Injury in Mice by a Caspase Inhibitor
Kawasaki, M., Kuwano, K., Hagimoto, N., Matsuba, T., Kunitake, R., Tanaka, T., Maeyama, T., & Hara, N. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64570-1 · Cited by 244 · see citing works
Proteolysis by Neutrophils
Campbell, E. J., Senior, R. M., McDonald, J. A., Cox, D. L., Greco, J. M., & Landis, J. A. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110681 · Cited by 243 · see citing works
Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease
Keshavarzian, A., Banan, A., Farhadi, A., Komanduri, S., Mutlu, E., Zhang, Y., & Fields, J. Z. (2003) · Gut · doi:10.1136/gut.52.5.720 · Cited by 237 · see citing works
Neutrophil-mediated Pulmonary Vascular Injury: Synergistic Effect of Trace Amounts of Lipopolysaccharide and Neutrophil Stimuli on Vascular Permeability and Neutrophil Sequestration in the Lung
Worthen, G. S., Haslett, C., Rees, A. J., et al. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.1.19 · Cited by 229 · see citing works
Mechanisms and Consequences of Neutrophil Interaction with the Endothelium
Zarbock, A., & Ley, K. F. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070502 · Cited by 228 · see citing works
Apoptosis and Epithelial Injury in the Lungs
Martin, T. R., Hagimoto, N., Nakamura, M., & Matute-Bello, G. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200504-031ac · Cited by 225 · see citing works
Increased Hydrogen Peroxide in the Expired Breath of Patients with Acute Hypoxemic Respiratory Failure
Sznajder, J. I., Fraiman, A., Hall, J. B., Sanders, W., Schmidt, G. A., Crawford, G., Nahum, A., Factor, P. H., & Wood, L. D. H. (1989) · CHEST Journal · doi:10.1378/chest.96.3.606 · Cited by 225 · see citing works
H 2 O 2 -mediated permeability: role of MAPK and occludin
Kevil, C. G., Oshima, T., Alexander, B., Coe, L. L., & Alexander, J. S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.1.c21 · Cited by 222 · see citing works
Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins
Carden, D. L., Xiao, F., Moak, C., Willis, B. H., Robinson-Jackson, S. A., & Alexander, S. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.2.h385 · Cited by 222 · see citing works
Transendothelial migration of neutrophils involves integrin-associated protein (CD47).
Cooper, D., Lindberg, F. P., Gamble, J. R., Brown, E. J., & Vadas, M. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3978 · Cited by 219 · see citing works
Signal Regulatory Protein (SIRPα), a Cellular Ligand for CD47, Regulates Neutrophil Transmigration
Liu, Y., Bühring, H., Zen, K., Burst, S. L., Schnell, F. J., Williams, I. R., & Parkos, C. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109720200 · Cited by 217 · see citing works
CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia.
Parkos, C. A., Colgan, S. P., Liang, T. W., Nusrat, A., Bacarra, A. E., Carnes, D. K., & Madara, J. L. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.132.3.437 · Cited by 216 · see citing works
Self-citation
Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes
Navaratna, D., McGuire, P. G., Menicucci, G., & Das, A. (2007) · Diabetes · doi:10.2337/db06-1694 · Cited by 211 · see citing works
Two leukocyte receptors (CD11a/CD18 and CD11b/CD18) mediate transient adhesion to endothelium by binding to different ligands.
Lo, S. K., van Seventer, G. A., Levin, S. M., & Wright, S. D. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.10.3325 · Cited by 204 · see citing works
Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice.
Kumasaka, T., Quinlan, W. M., Doyle, N. A., Condon, T. P., Sligh, J. E., Takei, F., Beaudet, A. L., Bennett, C. F., & Doerschuk, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118679 · Cited by 201 · see citing works
Reactive Oxygen Species and Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase Mediate Hyperoxia-Induced Cell Death in Lung Epithelium
Zhang, X., Shan, P., Sasidhar, M., Chupp, G. L., Flavell, R. A., Choi, A. M. K., & Lee, P. J. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0156oc · Cited by 201 · see citing works
Neutrophil Migration Into the Gingival Sulcus Is Associated With Transepithelial Gradients of Interleukin‐8 and ICAM‐1
Tonetti, M. S., Imboden, M. A., & Lang, N. P. (1998) · Journal of Periodontology · doi:10.1902/jop.1998.69.10.1139 · Cited by 196 · see citing works
Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3
Kale, G., Naren, A. P., Sheth, P., & Rao, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00167-0 · Cited by 196 · see citing works
Role of CD44 and Hyaluronan in Neutrophil Recruitment
Khan, A. I., Kerfoot, S. M., Heit, B., Liu, L., Andonegui, G., Ruffell, B., Johnson, P., & Kubes, P. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7594 · Cited by 195 · see citing works
Neutrophil-mediated epithelial injury during transmigration: role of elastase
Ginzberg, H. H., Cherapanov, V., Dong, Q., Cantin, A. M., McCulloch, C. A., Shannon, P. T., & Downey, G. P. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.3.g705 · Cited by 194 · see citing works
Self-citation
Matrix Metalloproteinases and TIMP in Acute Respiratory Distress Syndrome
Ricou, B., Nicod, L. P., Lacraz, S. F., et al. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.2.8756805 · Cited by 192 · see citing works
The Role of CD47 in Neutrophil Transmigration
Liu, Y., Merlin, D., Burst, S. L., Pochet, M., Madara, J., & Parkos, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104138200 · Cited by 191 · see citing works
Alveolar Cell Death in Hyperoxia‐Induced Lung Injury
Pagano, A., & Barazzone‐Argiroffo, C. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1299.074 · Cited by 185 · see citing works
Neutrophil Migration across Tight Junctions Is Mediated by Adhesive Interactions between Epithelial Coxsackie and Adenovirus Receptor and a Junctional Adhesion Molecule-like Protein on Neutrophils
Zen, K., Liu, Y., McCall, I. C., Wu, T., Lee, W., Babbin, B. A., Nusrat, A., & Parkos, C. A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0036 · Cited by 185 · see citing works
The Junctional Adhesion Molecule-C Promotes Neutrophil Transendothelial Migration in Vitro and in Vivo
Chavakis, T., Keiper, T., Matz, R. L., Hersemeyer, K., Sachs, U. J., Nawroth, P. P., Preissner, K. T., & Santoso, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404676200 · Cited by 184 · see citing works
Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall.
Huber, A., & Weiss, S. J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113992 · Cited by 184 · see citing works
Higher Concentrations of Matrix Metalloproteinases in Bronchoalveolar Lavage Fluid of Patients With Adult Respiratory Distress Syndrome
TORII, K., Iida, K., Miyazaki, Y., Saga, S., Kondoh, Y., Taniguchi, H., Taki, F., Takagi, K., Matsuyama, M., & Suzuki, R. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001287 · Cited by 184 · see citing works
Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase.
The University of North Carolina at Chapel Hill University Libraries (2020) · PubMed · doi:10.17615/0gv1-ew66 · Cited by 183 · see citing works
Plasma Hypoxanthine Levels in ARDS: Implications for Oxidative Stress, Morbidity, and Mortality
Quinlan, G. J., Lamb, N. J., Tilley, R., Evans, T. W., & Gutteridge, J. M. C. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.2.9032182 · Cited by 181 · see citing works
Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation*
Alexander, J. S., & Elrod, J. W. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00057.x · Cited by 179 · see citing works
Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion.
Huang, G. T. ‐., Eckmann, L., Savidge, T., & Kagnoff, M. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118825 · Cited by 178 · see citing works
Severity of Elastase-Induced Emphysema Is Decreased in Tumor Necrosis Factor-α and Interleukin-1β Receptor-Deficient Mice
Lucey, E. C., Keane, J., Kuang, P., et al. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780397 · Cited by 176 · see citing works
Role of NADPH Oxidase in the Mechanism of Lung Neutrophil Sequestration and Microvessel Injury Induced by Gram-Negative Sepsis: Studies in p47 phox −/− and gp91 phox −/− Mice
Gao, X.-P., Standiford, T. J., Rahman, A., Newstead, M. W., Holland, S. M., Dinauer, M. C., Liu, Q.-H., & Malik, A. B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.8.3974 · Cited by 176 · see citing works
‘Putting the squeeze’ on the tight junction: understanding cytoskeletal regulation
Turner, J. R. (2000) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2000.0180 · Cited by 174 · see citing works
Plasma Elastase Levels and the Development of the Adult Respiratory Distress Syndrome
Donnelly, S. C., MacGREGOR, I. R., Zamani, A., Gordon, M. W., Robertson, C. E., Steedman, D. J., Little, K., & Haslett, C. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.151.5.7735596 · Cited by 173 · see citing works
Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury☆
Fligiel, S., Standiford, T. J., Fligiel, H., Tashkin, D. P., Strieter, R. M., Warner, R., JOHNSON, K., & Varani, J. (2006) · Human Pathology · doi:10.1016/j.humpath.2005.11.023 · Cited by 172 · see citing works
Proteolytic Cleavage of ICAM-1 by Human Neutrophil Elastase
Champagne, B., Tremblay, P., Cantin, A. M., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6398 · Cited by 168 · see citing works
Increased Levels of Nitrate and Surfactant Protein a Nitration in the Pulmonary Edema Fluid of Patients with Acute Lung Injury
Zhu, S., Ware, L. B., Geiser, T., Matthay, M. A., & Matalon, S. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.1.2005068 · Cited by 168 · see citing works
Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms.
Lo, S. K., Everitt, J. I., Gu, J., & Malik, A. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115681 · Cited by 167 · see citing works
Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion.
Cai, T., & Wright, S. D. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.4.1213 · Cited by 166 · see citing works
Oxidant-induced disruption of intestinal epithelial barrier function: role of protein tyrosine phosphorylation
Rao, R., Baker, R. D., Baker, S. S., Gupta, A., & Holycross, M. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.4.g812 · Cited by 164 · see citing works
Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion.
Colgan, S. P., Parkos, C. A., Delp, C., Arnaout, M. A., & Madara, J. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.3.785 · Cited by 163 · see citing works
Self-citation
Matrix metalloproteinases in inflammatory bowel disease: Boon or a bane?
Ravi, A., Garg, P., & Sitaraman, S. V. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20011 · Cited by 163 · see citing works
Neutrophil Sequestration and Migration in Localized Pulmonary Inflammation: Capillary Localization and Migration across the Interalveolar Septum
Downey, G. P., Worthen, G. S., Henson, P. M., et al. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.1.168 · Cited by 161 · see citing works
Self-citation
Delayed Neutrophil Elastase Inhibition Prevents Subsequent Progression of Acute Lung Injury Induced by Endotoxin Inhalation in Hamsters
Kawabata, K., Hagio, T., MATSUMOTO, S., Nakao, S., Orita, S.-I., Aze, Y., & Ohno, H. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.6.9904047 · Cited by 159 · see citing works
Science review: apoptosis in acute lung injury.
Matute‐Bello, G., & Martin, T. R. (2003) · Critical Care · doi:10.1186/cc1861 · Cited by 158 · see citing works
Direct Cytotoxicity of Polymorphonuclear Leukocyte Granule Proteins to Human Lung-derived Cells and Endothelial Cells
Okrent, D. G., Lichtenstein, A. K., & Ganz, T. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.1.179 · Cited by 158 · see citing works
Expression and Polarization of Intercellular Adhesion Molecule-1 on Human Intestinal Epithelia: Consequences for CD11b/CD18-Mediated Interactions with Neutrophils
Parkos, C. A., Colgan, S. P., Diamond, M., Nusrat, A., Liang, T. W., Springer, T. A., & Madara, J. (1996) · Molecular Medicine · doi:10.1007/bf03401908 · Cited by 156 · see citing works
Self-citation
Role of Stromelysin 1 and Gelatinase B in Experimental Acute Lung Injury
Warner, R. L., Beltrán, L., Younkin, E. M., Lewis, C. S., Weiss, S. J., Varani, J., & Johnson, K. J. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.5.4160 · Cited by 156 · see citing works
Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption
Musch, M. W., Walsh-Reitz, M. M., & Chang, E. B. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00301.2005 · Cited by 152 · see citing works
Regulation of Leukocyte Transmigration: Cell Surface Interactions and Signaling Events
Liu, Y., Shaw, S. K., Ma, S., Yang, L., Luscinskas, F. W., & Parkos, C. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.7 · Cited by 152 · see citing works
Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability
Chin, A. C., Vergnolle, N., MacNaughton, W. K., Wallace, J. L., Hollenberg, M. D., & Buret, A. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831452100 · Cited by 149 · see citing works
Epithelial Deposition of Immunoglobulin G1 and Activated Complement (C3b and Terminal Complement Complex) in Ulcerative Colitis
Halstensen, T. S., Mollnes, T. E., Garred, P., FAUSA, O., & Brandtzæg, P. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90343-y · Cited by 145 · see citing works
Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways
Parkos, C., Colgan, S., Delp, C., et al. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.4.757 · Cited by 142 · see citing works
Self-citation
JAM-C Is a Component of Desmosomes and a Ligand for CD11b/CD18-mediated Neutrophil Transepithelial Migration
Zen, K., Babbin, B. A., Liu, Y., Whelan, J. B., Nusrat, A., & Parkos, C. A. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-04-0317 · Cited by 139 · see citing works
Selective induction of intercellular adhesion molecule-1 by interferon-gamma in human airway epithelial cells
Look, D. C., Rapp, S. R., Keller, B. T., et al. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.263.1.l79 · Cited by 139 · see citing works
Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL-8 production
Watering, S. V., Mannesse-Lazeroms, S. P. G., Dijkman, J. H., et al. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.62.2.217 · Cited by 139 · see citing works
Hyperoxia-induced signal transduction pathways in pulmonary epithelial cells
Zaher, T. E., Miller, E. J., Morrow, D. M. P., Javdan, M., & Mantell, L. L. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.021 · Cited by 138 · see citing works
Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine.
Bailey, C. J., Hembry, R. M., Alexander, A., et al. (1994) · Journal of Clinical Pathology · doi:10.1136/jcp.47.2.113 · Cited by 136 · see citing works
Leukocyte–epithelial interactions
Zen, K., & Parkos, C. A. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00103-0 · Cited by 135 · see citing works
Phenotyping and Cytokine Regulation of the BEAS-2B Human Bronchial Epithelial Cell: Demonstration of Inducible Expression of the Adhesion Molecules VCAM-1 and ICAM-1
Atsuta, J., Sterbinsky, S. A., Plitt, J., et al. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.5.2685 · Cited by 134 · see citing works
Impaired Swallowing Reflex in Patients With Obstructive Sleep Apnea Syndrome
Teramoto, S., Sudo, E., Matsuse, T., Ohga, E., Ishii, T., Ouchi, Y., & Fukuchi, Y. (1999) · CHEST Journal · doi:10.1378/chest.116.1.17 · Cited by 134 · see citing works
Physiology and Pathophysiology of Neutral Proteinases of Human Granulocytes
HAVEMANN, K., & Gramse, M. (1984) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-9355-3_1 · Cited by 132 · see citing works
JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells
Moog‐Lutz, C., Riant, F., Guibal, F. C., et al. (2003) · Blood · doi:10.1182/blood-2002-11-3462 · Cited by 131 · see citing works
CD44 Deficiency Leads to Enhanced Neutrophil Migration and Lung Injury in Escherichia coli Pneumonia in Mice
Wang, Q., Teder, P., Judd, N. P., Noble, P. W., & Doerschuk, C. M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64498-7 · Cited by 131 · see citing works
Protein carbonyl measurements show evidence of early oxidative stress in critically ill patients
Winterbourn, C. C., Buss, H., Chan, T., Plank, L. D., Clark, M. A., & Windsor, J. A. (2000) · Critical Care Medicine · doi:10.1097/00003246-200001000-00024 · Cited by 131 · see citing works
Junctional Adhesion Molecule-C Regulates the Early Influx of Leukocytes into Tissues during Inflammation
Aurrand‐Lions, M., Lamagna, C., Dangerfield, J. P., Wang, S., Herrera, P. L., Nourshargh, S., & Imhof, B. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6406 · Cited by 131 · see citing works
Neutrophil migration across model intestinal epithelia: Monolayer disruption and subsequent events in epithelial repair
Nusrat, A., Parkos, C. A., Liang, T., et al. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9352851 · Cited by 129 · see citing works
Proteinase-Activated Receptor-1 Mediates Elastase-Induced Apoptosis of Human Lung Epithelial Cells
Suzuki, T., Moraes, T. J., Vachon, E., Ginzberg, H. H., Huang, T.-T., Matthay, M. A., Hollenberg, M. D., Marshall, J., McCulloch, C. A., Abreu, M. T. H., et al. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0109oc · Cited by 129 · see citing works
Self-citation
Neutrophil Emigration in the Lungs, Peritoneum, and Skin Does Not Require Gelatinase B
Betsuyaku, T., Shipley, J. M., Liu, Z., & Senior, R. M. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.6.3558 · Cited by 129 · see citing works
Matrix Metalloproteinase Inhibitor Prevents Acute Lung Injury After Cardiopulmonary Bypass
Carney, D. E., Lutz, C. J., Picone, A., Gatto, L. A., Ramamurthy, N. S., Golub, L. M., Simon, S. R., Searles, B. E., Paskanik, A. M., Snyder, K. P., et al. (1999) · Circulation · doi:10.1161/01.cir.100.4.400 · Cited by 128 · see citing works
Quantitation of ICAM-1 expression in mouse lung during pneumonia.
Burns, A. R., Takei, F., & Doerschuk, C. M. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.7.3189 · Cited by 127 · see citing works
Mechanisms of cell death induced by the neutrophil antimicrobial peptides α-defensins and LL-37
Aarbiou, J., Tjabringa, G. S., Verhoosel, R. M., Ninaber, D. K., White, S. R., Peltenburg, L. T. C., Rabe, K. F., & Hiemstra, P. S. (2006) · Inflammation Research · doi:10.1007/s00011-005-0062-9 · Cited by 125 · see citing works
Activated neutrophils disrupt endothelial monolayer integrity by an oxygen radical-independent mechanism.
Jm, H., Schwartz, B. R., Reidy, M. A., et al. (1985) · PubMed · Cited by 122 · see citing works
Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury
Corada, M., Chimenti, S., Cera, M. R., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500147102 · Cited by 122 · see citing works
Monocyte Migration Through the Alveolar Epithelial Barrier: Adhesion Molecule Mechanisms and Impact of Chemokines
Rosseau, S., Selhorst, J., Wiechmann, K., Leissner, K., Maus, U. A., Mayer, K., Grimminger, F., Seeger, W., & Lohmeyer, J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.427 · Cited by 121 · see citing works
Reduced Expression of Junctional Adhesion Molecule and Platelet/Endothelial Cell Adhesion Molecule-1 (CD31) at Human Vascular Endothelial Junctions by Cytokines Tumor Necrosis Factor-α Plus Interferon-γ Does Not Reduce Leukocyte Transmigration Under Flow
Shaw, S. K., Perkins, B. N., Lim, Y.-C., Liu, Y., Nusrat, A., Schnell, F. J., Parkos, C. A., & Luscinskas, F. W. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63078-7 · Cited by 119 · see citing works
Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease
Naito, Y., Takagi, T., & Yoshikawa, T. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-007-2096-y · Cited by 118 · see citing works
Regulation of Neutrophil Activation in Acute Lung Injury
Downey, G. P., Dong, Q., Kruger, J., et al. (1999) · CHEST Journal · doi:10.1016/s0012-3692(15)30668-1 · Cited by 118 · see citing works
Self-citation
Purification and characterization of defensins from cystic fibrosis sputum
Soong, L. B., Ganz, T., Ellison, A. R., et al. (1997) · Inflammation Research · doi:10.1007/s000110050114 · Cited by 117 · see citing works
Nitric oxide as a mediator of oxidant lung injury due to paraquat.
Berisha, H., PAKBAZ, H., Absood, A., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7445 · Cited by 115 · see citing works
Tissue Inhibitor of Metalloproteinase-1 Deficiency Amplifies Acute Lung Injury in Bleomycin-Exposed Mice
Kim, K. H., Burkhart, K. M., Chen, P., Frevert, C. W., Randolph‐Habecker, J., Hackman, R. C., Soloway, P. D., & Madtes, D. K. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0111oc · Cited by 115 · see citing works
Neutrophil Migration through Preexisting Holes in the Basal Laminae of Alveolar Capillaries and Epithelium during Streptococcal Pneumonia
Walker, D. C., Behzad, A. R., & Chu, F. S. F. (1995) · Microvascular Research · doi:10.1006/mvre.1995.1067 · Cited by 114 · see citing works
Neutrophil Transepithelial Migration and Epithelial Barrier Function in IBD
Chin, A. C., & Parkos, C. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.018 · Cited by 114 · see citing works
Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome.
Idell, S., Kucich, U., Fein, A. M., Kueppers, F., James, H. L., Walsh, P. N., Weinbaum, G., Colman, R. W., & Cohen, A. B. (1985) · PubMed · doi:10.1164/arrd.1985.132.5.1098 · Cited by 110 · see citing works
Lung Liquid Clearance and Na,K-ATPase During Acute Hyperoxia and Recovery in Rats
OLIVERA, W. G., Ridge, K. M., & Sznajder, J. I. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.4.7551375 · Cited by 110 · see citing works
Inhibition of matrix metalloproteinase-9 prevents neutrophilic inflammation in ventilator-induced lung injury
Kim, J. H., Suk, M. H., Yoon, D. W., Lee, S. H., Hur, G. Y., Jung, K. H., Jeong, H. C., Lee, S. Y., Lee, S. Y., Suh, I. B., et al. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00270.2005 · Cited by 110 · see citing works
Blocking Neutrophil Influx Reduces DNA Damage in Hyperoxia-Exposed Newborn Rat Lung
Auten, R. L., Whorton, M. H., & Mason, S. N. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.4.4708 · Cited by 109 · see citing works
Differential Effects of CD18, CD29, and CD49 Integrin Subunit Inhibition on Neutrophil Migration in Pulmonary Inflammation
Ridger, V. C., Wagner, B. E., Wallace, W. A., & Hellewell, P. G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3484 · Cited by 109 · see citing works
Permeability of human HT‐29/B6 colonic epithelium as a function of apoptosis
Bojarski, C., Gitter, A. H., Bendfeldt, K., et al. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00541.x · Cited by 108 · see citing works
Apoptosis and DNA damage in type 2 alveolar epithelial cells cultured from hyperoxic rats
Buckley, S., Barsky, L. W., Driscoll, B., Weinberg, K. I., Anderson, K. D., & Warburton, D. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.5.l714 · Cited by 106 · see citing works
Neutrophil Elastase
Shapiro, S. D. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.3.f233 · Cited by 105 · see citing works
The Role of Up-Regulated Serine Proteases and Matrix Metalloproteinases in the Pathogenesis of a Murine Model of Colitis
Tarlton, J. F., Whiting, C. V., Tunmore, D., Bregenholt, S., Reimann, J., Claësson, M. H., & Bland, P. W. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64831-6 · Cited by 103 · see citing works
Effect of a Specific Neutrophil Elastase Inhibitor, ONO-5046, on Endotoxin-Induced Acute Lung Injury
Sakamaki, F., Ishizaka, A., Urano, T., et al. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.1.8542148 · Cited by 102 · see citing works
Renal expression of intercellular adhesion molecule-1 in different forms of glomerulonephritis
Lhotta, K., Neumayer, H. P., Joannidis, M., et al. (1991) · Clinical Science · doi:10.1042/cs0810477 · Cited by 102 · see citing works
Apoptosis in lung injury and remodeling
Li, X., Shu, R., Filippatos, G. S., & Uhal, B. D. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00519.2004 · Cited by 101 · see citing works
Gelatinases in epithelial lining fluid of patients with adult respiratory distress syndrome
Delclaux, C., d’Ortho, M., Delacourt, C., et al. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.272.3.l442 · Cited by 101 · see citing works
O2 metabolites and neutrophil elastase synergistically cause edematous injury in isolated rat lungs
Baird, B. R., Cheronis, J. C., Sandhaus, R. A., et al. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.6.2224 · Cited by 100 · see citing works
Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion
Zhang, H., Porro, G. A., Orzech, N., Mullen, B. M., Liu, M., & Slutsky, A. S. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.5.l947 · Cited by 99 · see citing works
Role of VASP in reestablishment of epithelial tight junction assembly after Ca2+ switch
Lawrence, D. W., Comerford, K. M., & Colgan, S. P. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00288.2001 · Cited by 97 · see citing works
Self-citation
The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome.
Cochrane, C. G., Spragg, R. G., Revak, S. D., et al. (1983) · PubMed · doi:10.1164/arrd.1983.127.2p2.s25 · Cited by 97 · see citing works
Leukocyte Adhesion Deficiency: Clinical and Postmortem Observations
Hawkins, H. K., Heffelfinger, S. C., & Anderson, D. C. (1992) · Pediatric Pathology · doi:10.3109/15513819209023288 · Cited by 95 · see citing works
Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats
Auten, R. L., Mason, S. N., Tanaka, D. T., Welty‐Wolf, K. E., & Whorton, M. H. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.2.l336 · Cited by 95 · see citing works
Neutrophils and lung injury: getting it right
Martin, T. R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci17302 · Cited by 93 · see citing works
Differential effects of α- and β-defensin on cytokine production by cultured human bronchial epithelial cells
Sakamoto, N., Mukae, H., Fujii, T., et al. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00076.2004 · Cited by 93 · see citing works
Escherichia coli induces transuroepithelial neutrophil migration by an intercellular adhesion molecule-1-dependent mechanism
Agace, W. W., Patarroyo, M. E., Svensson, M., et al. (1995) · Infection and Immunity · doi:10.1128/iai.63.10.4054-4062.1995 · Cited by 92 · see citing works
Absence of inflammatory lung injury in rabbits challenged intravascularly with complement-derived chemotactic factors.
Webster, R. O., Larsen, G. L., Mitchell, B. C., et al. (1982) · PubMed · doi:10.1164/arrd.1982.125.3.335 · Cited by 91 · see citing works
The selective and superoxide-independent disruption of intestinal epithelial tight junctions during leukocyte transmigration.
Nash, S. V., Stafford, J., & Madara, J. L. (1988) · PubMed · Cited by 91 · see citing works
E-cadherin expression in intestinal epithelium.
Doǧan, A., Wang, Z. D., & Spencer, J. (1995) · Journal of Clinical Pathology · doi:10.1136/jcp.48.2.143 · Cited by 90 · see citing works
Migration of Neutrophils across Human Pulmonary Endothelial Cells Is Not Blocked by Matrix Metalloproteinase or Serine Protease Inhibitors
Mackarel, A. J., Cottell, D. C., Russell, K. J., et al. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.6.3539 · Cited by 88 · see citing works
Neutrophil Transepithelial Migration: Evidence for Sequential, Contact-Dependent Signaling Events and Enhanced Paracellular Permeability Independent of Transjunctional Migration
Edens, H. A., Levi, B. P., Jaye, D. L., Walsh, S. V., Reaves, T. A., Turner, J. R., Nusrat, A., & Parkos, C. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.476 · Cited by 88 · see citing works
Neutrophils and lung injury: getting it right
Martin, T. R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0217302 · Cited by 88 · see citing works
Intercellular adhesion molecule-1 (ICAM-1)-dependent and ICAM-1-independent adhesive interactions between polymorphonuclear leukocytes and human airway epithelial cells infected with parainfluenza virus type 2
Tosi, M. F., Stark, J. M., Hamedani, A., Smith, C. W., Gruenert, D. C., & Huang, Y. T. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.10.3345 · Cited by 87 · see citing works
CD11b/CD18-Dependent Interactions of Neutrophils with Intestinal Epithelium Are Mediated by Fucosylated Proteoglycans
Zen, K., Liu, Y., Cairo, D., & Parkos, C. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.5270 · Cited by 87 · see citing works
Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis
Medina, C., Videla, S., Radomski, A. S., et al. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpheart.00036.2002 · Cited by 86 · see citing works
Patterns for RANTES Secretion and Intercellular Adhesion Molecule 1 Expression Mediate Transepithelial T Cell Traffic Based on Analyses In Vitro and In Vivo
Taguchi, M., Sampath, D., Koga, T., Castro, M., Look, D. C., Nakajima, S., & Holtzman, M. J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.1927 · Cited by 85 · see citing works
Intercellular Adhesion Molecule-1 Expression on the Alveolar Epithelium and Its Modification by Hyperoxia
Kang, B., Crapo, J. D., Wegner, C. D., et al. (1993) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/9.4.350 · Cited by 84 · see citing works
Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract.
Hanby, A. M., Chinery, R., Poulsom, R., Playford, R. J., & Pignatelli, M. N. (1996) · Europe PMC (PubMed Central) · Cited by 83 · see citing works
Transport Governs Flow-Enhanced Cell Tethering through L-Selectin at Threshold Shear
Yago, T., Zarnitsyna, V. I., Klopocki, A. G., et al. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.090969 · Cited by 82 · see citing works
Protection Against Acute Lung Injury by Intravenous or Intratracheal Pretreatment with EPI-HNE-4, a New Potent Neutrophil Elastase Inhibitor
Delacourt, C., Hérigault, S., Delclaux, C., et al. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.3.4611 · Cited by 82 · see citing works
Disparate Role of the β2-Integrin CD18 in the Local Accumulation of Neutrophils in Pulmonary and Cutaneous Inflammation in the Rabbit
Hellewell, P. G., Young, S. K., Henson, P. M., et al. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.10.4.7510985 · Cited by 80 · see citing works
CYTOKINE REGULATION OF ICAM-1 EXPRESSION ON HUMAN RENAL TUBULAR EPITHELIAL CELLS IN VITRO
Ishikura, H., Takahashi, C., Kanagawa, K., HIRATA, H., Imai, K., & Yoshiki, T. (1991) · Transplantation · doi:10.1097/00007890-199106000-00024 · Cited by 79 · see citing works
The Role of Metalloelastase in Immune Complex-Induced Acute Lung Injury
Warner, R. L., Lewis, C. S., Beltrán, L., Younkin, E. M., Varani, J., & Johnson, K. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64685-8 · Cited by 79 · see citing works
Antiadhesive Role of Apical Decay-accelerating Factor (CD55) in Human Neutrophil Transmigration across Mucosal Epithelia
Lawrence, D. W., Bruyninckx, W. J., Louis, N. A., Lublin, D. M., Stahl, G. L., Parkos, C. A., & Colgan, S. P. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030380 · Cited by 79 · see citing works
Self-citation
Deficiency in Neutrophil Elastase Does Not Impair Neutrophil Recruitment to Inflamed Sites
Hirche, T. O., Atkinson, J. J., Bahr, S. M., et al. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0253oc · Cited by 78 · see citing works
Pulmonary epithelial cells facilitate TNF-alpha-induced neutrophil chemotaxis. A role for cytokine networking.
Smart, S. J., & Casale, T. B. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.8.4087 · Cited by 77 · see citing works
Matrix Metalloproteinase-9–Deficient Dendritic Cells Have Impaired Migration through Tracheal Epithelial Tight Junctions
Ichiyasu, H., McCormack, J. M., McCarthy, K. M., Dombkowski, D., Preffer, F. I., & Schneeberger, E. E. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0370oc · Cited by 77 · see citing works
A Novel Oral Neutrophil Elastase Inhibitor (ONO-6818) Inhibits Human Neutrophil Elastase-induced Emphysema in Rats
Kuraki, T., Ishibashi, M., Takayama, M., Shiraishi, M., & Yoshida, M. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2103118 · Cited by 77 · see citing works
The effect of neutrophil migration on epithelial permeability.
Milks, L. C., Conyers, G. P., & Cramer, E. B. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.6.2729 · Cited by 77 · see citing works
Transendothelial Neutrophil Migration
Cepinskas, G., Noseworthy, R., & Kvietys, P. R. (1997) · Circulation Research · doi:10.1161/01.res.81.4.618 · Cited by 77 · see citing works
Complement Inhibition Attenuates Human Lung Transplant Reperfusion Injury
Zamora, M. R., Davis, R. D., Keshavjee, S. H., et al. (1999) · CHEST Journal · doi:10.1378/chest.116.suppl_1.46s · Cited by 75 · see citing works

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Research works printed but not linked: 3

[123]Ma S, Shaw SK, Yang L, Jones T, Liu Y, Nusrat A, Parkos CA, Luscinskas FW. Dynamics of junctional adhesion moleule 1 (JAM1) during leukocyte transendothelial migration under flow in vitro. FASEB J 2003;1189:1758. [Google Scholar]
[151]Shapiro SD. Neutrophil elastase: path clearer, pathogen killer, or just pathologic? Am J Respir Cell Mol Biol 2002;26:266–268. [DOI] [PubMed] [Google Scholar]
[175]Iwamoto M, Koji T, Makiyama K, Kobayashi N, Nakane PK. Apoptosis of crypt epithelial cells in ulcerative colitis. J Pathol 1996;180:152–159. [DOI] [PubMed] [Google Scholar]

Sorted by citations

The acute respiratory distress syndrome
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Mayadas, T. N., Cullere, X., & Lowell, C. A. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-164023 · Cited by 1,356 · see citing works
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Poorly soluble particulates: Searching for a unifying denominator of nanoparticles and fine particles for DNEL estimation
Pauluhn, J. (2011) · Toxicology · doi:10.1016/j.tox.2010.10.009 · Cited by 124 · see citing works

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Direct Chemotaxis and Leucocyte‐Induced Chemotaxis of Polymorphonuclear Leucocytes
Bäck, O., Bandmann, U., Norberg, B., et al. (1978) · Scandinavian Journal of Haematology · doi:10.1111/j.1600-0609.1978.tb02435.x · Cited by 15 · see citing works
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Authors: Zemans, R. L., Colgan, S. P., & Downey, G. P.
Affiliations: National Jewish Health (US)
University of Colorado Denver (US)
ORCID: Zemans, Rachel L.
Colgan, Sean P.
Downey, Gregory P.
Venue: American Journal of Respiratory Cell and Molecular Biology
Publisher: Oxford University Press (OUP)
Published: 2009-05-01
Volume: 40
Issue: 5
Pages: 519-535
ISSN: 1044-1549 (ISSN-L)
1535-4989
DOI: 10.1165/rcmb.2008-0348tr
PMC: PMC2677434
OpenAlex: W2080138182
Cited by: 339
References: 284
Citations by year: 2026: 10 · 2025: 8 · 2024: 14 · 2023: 12 · 2022: 26 · 2021: 24 · 2020: 21 · 2019: 18 · 2018: 14 · 2017: 19 · 2016: 26 · 2015: 18 · 2014: 13 · 2013: 32 · 2012: 19
FWCI: 1.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (DE13499, DK-50189)
National Heart, Lung, and Blood Institute (HL090669, R01HL060569, HL-60569, R01HL090669)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-50189)
National Institute of Dental and Craniofacial Research (DE13499, P01DE013499)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: neutrophils, epithelial cells, adhesion molecules, lung injury, acute lung injury, acute respiratory distress syndrome, cystic fibrosis, chronic obstructive pulmonary disease, sepsis, oxidizing agents, epithelial damage, lung repair, host defense
MeSH terms: Animals, Cell Adhesion, Cell Movement, Epithelial Cells, Humans, Ligands, Neutrophils, Acute Lung Injury

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Transepithelial Migration of Neutrophils

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