Hydrogen sulfide prevents and partially reverses ozone-induced features of lung inflammation and emphysema in mice
Abstract
Hydrogen sulfide (H2S), a novel signaling gasotransmitter in the respiratory system, may have antiinflammatory properties in the lung. We examined the preventive and therapeutic effects of H2S on ozone-induced features of lung inflammation and emphysema. C57/BL6 mice were exposed to ozone or filtered air over 6 weeks. Sodium hydrogen sulfide (NaHS), an H2S donor, was administered to the mice either before ozone exposure (preventive effect) or after completion of 6 weeks of ozone exposure (therapeutic effect). The ozone-exposed mice developed emphysema, measured by micro-computed tomography and histology, airflow limitation, measured by the forced maneuver system, and increased lung inflammation with augmented IL-1β, IL-18, and matrix metalloproteinase-9 (MMP-9) gene expression. Ozone-induced changes were associated with increased Nod-like receptor pyrin domain containing 3 (NLRP3)-caspase-1 activation and p38 mitogen-activated protein kinase phosphorylation and decreased Akt phosphorylation. NaHS both prevented and reversed lung inflammation and emphysematous changes in alveolar space. In contrast, NaHS prevented, but did not reverse, ozone-induced airflow limitation and bronchial structural remodeling. In conclusion, NaHS administration prevented and partially reversed ozone-induced features of lung inflammation and emphysema via regulation of the NLRP3-caspase-1, p38 mitogen-activated protein kinase, and Akt pathways.
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Rodent studies confirmed that the use of N-acetylcysteine and sulfide salt can help prevent or recover the lung impairment caused by ozone.
“For example, rodent studies confirmed that the use of N-acetylcysteine and sulfide salt can help prevent or recover the lung impairment caused by ozone (82, 83).”
From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [82]
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- Authors
- Li, F., Zhang, P., Zhang, M., Liang, L., Sun, X., Li, M., Tang, Y., Bao, A., Gong, J., Zhang, J., Adcock, I., Chung, K. F., & Zhou, X.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Duke University (US)
- Imperial College London (GB)
- Corresponding author
- Zhou, Xin
- ORCID
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-07-01
- Volume
- 55
- Issue
- 1
- Pages
- 72-81
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2226662974
- Cited by
- 40
- References
- 44
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 1
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University
- NIH Clinical Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- hydrogen sulfide, ozone exposure, lung inflammation, emphysema, NLRP3 inflammasome, caspase-1, p38 MAPK, Akt signaling, airflow obstruction, MMP-9, IL-1β, IL-18, sodium hydrosulfide
- MeSH terms
- Animals, Bronchi, Bronchoalveolar Lavage Fluid, Enzyme Activation, Hydrogen Sulfide, Mice, Inbred C57BL, Ozone, Phosphorylation, Pneumonia, Pulmonary Emphysema, Respiratory Function Tests, RNA, Messenger, Blotting, Western, Biomarkers, Oxidants, Caspase 1, GTPase-Activating Proteins, Imaging, Three-Dimensional, Intracellular Signaling Peptides and Proteins, p38 Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-akt, Caspase 3, X-Ray Microtomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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