The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The L:M cone ratio in males of African descent with normal color vision
Abstract
Among Caucasian males with normal color vision, long-wavelength-sensitive (L) cones outnumber middle-wavelength-sensitive (M) cones by nearly three to one, on average, and the L and the M cone opsin genes are arrayed on the X-chromosome with the L opsin gene being closest to an upstream enhancer element termed the locus control region (LCR). Interaction between an opsin gene promoter and the LCR is required to mediate normal opsin gene expression, and the relative proximity of the L opsin gene promoter (4,000 base pairs for L compared to 40,000 base pairs for the M opsin gene promoter) has been proposed to endow the L gene with the advantage in competing for interaction with the LCR, thereby accounting for the nearly 3:1 ratio of L:M cones. This proximal advantage hypothesis predicts that the L:M cone ratio will be similar among populations that share the same X-chromosome opsin gene array organization. Here, we tested this hypothesis by examining a sample of males of African descent and found them to have a significantly different average L:M ratio compared to Caucasian males, even though their X-chromosome opsin gene arrays were indistinguishable from arrays in males of Caucasian descent. How these observations might be reconciled is discussed.
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“it appears that the details of how the DNA is looped in the nucleus is a more important determinant of the relative access of L vs. M genes to the LCR, and thus the cone ratio, than the linear distances along the DNA (McMahon, Carroll, Awua, Neitz & Neitz, 2008).”
From The genetics of normal and defective color vision (2011) · cites this paper as McMahon et al., 2008
Citations
Cites
Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments
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Organization of the human trichromatic cone mosaic
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Self-citationThe Variation with Age of the Spectral Transmissivity of the Living Human Crystalline Lens
Said, F., & Weale, R. A. (2009) · Gerontologia · doi:10.1159/000210900 · Cited by 341
A locus control region adjacent to the human red and green visual pigment genes
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Molecular genetics of human blue cone monochromacy
Nathans, J., Davenport, C. M., Maumenee, I. H., Lewis, R. A., Hejtmancik, J. F., Litt, M., Lovrien, E., Weleber, R., Bachynski, B., Zwas, F., et al. (1989) · Science · doi:10.1126/science.2788922 · Cited by 255
Normal and Defective Colour Vision
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Cited by
The genetics of normal and defective color vision
Neitz, J., & Neitz, M. (2011) · Vision Research · doi:10.1016/j.visres.2010.12.002 · Cited by 377
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Metadata
- Authors
- McMahon, C., Carroll, J., Awua, S., Neitz, J., & Neitz, M.
- Venue
- Journal of Vision
- Published
- 2008-02-01
- Volume
- 8
- Issue
- 2
- Pages
- 5
- ISSN
- 1534-7362
- Cited by
- 21
- References
- 27
- Language
- en
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