The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Changes in Collagen Orientation and Distribution in Keratoconus Corneas
Abstract
PURPOSE: To map the collagen orientation and relative distribution of collagen fibrillar mass in keratoconus corneal buttons. METHODS: Structural analysis was performed by obtaining synchrotron x-ray scattering patterns across the samples at 0.25-mm intervals. The patterns were analyzed to produce two-dimensional maps of the orientation of the lamellae and of the distribution of total and preferentially aligned lamellae. RESULTS: Compared with normal corneas, in keratoconus the gross organization of the stromal lamellae was dramatically changed, and the collagen fibrillar mass was unevenly distributed, particularly around the presumed apex of the cone. CONCLUSIONS: The development of keratoconus involves a high degree of inter- and probably intralamellar displacement and slippage that leads to thinning of the central cornea and associated changes in corneal curvature. This slippage may be promoted by a loss of cohesive forces and mechanical failure in regions where lamellae bifurcate.
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Citations
Cites
X-Ray Scattering Used to Map the Preferred Collagen Orientation in the Human Cornea and Limbus
Aghamohammadzadeh, H., Newton, R. H., & Meek, K. M. (2004) · Structure · doi:10.1016/j.str.2004.01.002 · Cited by 233
Self-citationInterlacing and cross-angle distribution of collagen lamellae in the human cornea
Radner, W., Zehetmayer, M., Aufreiter, R., & Mallinger, R. (1998) · Cornea · doi:10.1097/00003226-199809000-00012 · Cited by 153
A synchrotron X-ray diffraction study of bovine cornea stained with cupromeronic blue
Meek, K. M., Elliott, G. F., & Nave, C. (1986) · Collagen and Related Research · doi:10.1016/s0174-173x(86)80026-7 · Cited by 46
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Cited by
Abahussin, M., Hayes, S., Knox Cartwright, N. E., Kamma-Lorger, C. S., Khan, Y., Marshall, J., & Meek, K. M. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.09-3669 · Cited by 162
Self-citationThree-dimensional distribution of transverse collagen fibers in the anterior human corneal stroma
Winkler, M., Shoa, G., Xie, Y., Petsche, S. J., Pinsky, P. M., Juhasz, T., Brown, D. J., & Jester, J. V. (2013) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-13150 · Cited by 152
Mapping collagen organization in the human cornea: left and right eyes are structurally distinct
Boote, C., Hayes, S., Abahussin, M., & Meek, K. M. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-0893 · Cited by 137
Self-citationMorishige, N., Takagi, Y., Chikama, T.-I., Takahara, A., & Nishida, T. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-5657 · Cited by 80
Elastic microfibril distribution in the cornea: Differences between normal and keratoconic stroma
White, T. L., Lewis, P. N., Young, R. D., Kitazawa, K., Inatomi, T., Kinoshita, S., & Meek, K. M. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.03.002 · Cited by 76
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Metadata
- Authors
- Meek, K. M., Tuft, S. J., Huang, Y., Gill, P. S., Hayes, S., Newton, R. H., & Bron, A. J.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2005-06-01
- Volume
- 46
- Issue
- 6
- Pages
- 1948
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2139139663
- Cited by
- 509
- References
- 3
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
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