The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cigarette Smoke–Related Oxidants and the Development of Sub-RPE Deposits in an Experimental Animal Model of Dry AMD
Abstract
PURPOSE: Oxidative injury to the retinal pigment epithelium (RPE) has been proposed to be an important injury stimulus relevant to the accumulation of subretinal deposits in age-related macular degeneration (AMD). Cigarette smoking is a major risk factor for AMD, and cigarette smoke-related tar contains high concentrations of a potent oxidant, hydroquinone (HQ). This study was an investigation of the effects of cigarette smoke (CS) and HQ in the development of sub-RPE deposits in an experimental mouse model. METHODS: Sixteen-month-old C57BL/6 female mice were fed a high-fat diet (HFD) for 4.5 months. Mice were divided into two major experimental groups, one to examine the effects of cigarette smoke and one to study the effects of a defined cigarette smoke component such as HQ. In the first group, mice eyes were exposed to blue-green light (positive controls) or to whole cigarette smoke. A third group with no intervention served as the negative control. In the second experimental group, animals received a purified diet with HQ (0.8%) with low or high fat content for 4.5 months. Mice in both groups were euthanatized at 4.5 months and eyes processed for transmission electron microscopy. RESULTS: As previously demonstrated by our laboratory and others, most mice fed an HFD without other oxidant exposure demonstrated normal morphology or, in a few cases, small nodular basal laminar deposits. Eyes of mice exposed to whole cigarette smoke or to HQ in the food demonstrated a variable degree of basal laminar deposits and diffusely thickened Bruch's membrane. The choriocapillaris endothelium was variably hypertrophic. CONCLUSIONS: Exposure to cigarette smoke or the smoke-related redox molecule, HQ, results in the formation of sub-RPE deposits, thickening of Bruch's membrane, and accumulation of deposits within Bruch's membrane. Smoke-related oxidants may be another oxidative injury stimulus to the choriocapillaris and RPE, and may explain the association between cigarette smoking and early AMD.
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Cites
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Relationship between RPE and Choriocapillaris in Age-Related Macular Degeneration
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“Espinosa-Heidmann and colleagues studied exposing mice to combinations of high fat diets, blue light, and whole cigarette smoke versus oral hydroquinone (Cousins et al., 2002; Espinosa-Heidmann et al., 2006).”
BackgroundRowan, S., Jiang, S., Korem, T., Szymanski, J., Chang, M.-L., Szelog, J., Cassalman, C., Dasuri, K., McGuire, C., Nagai, R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702302114 · Cited by 272
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SOD2 knockdown mouse model of early AMD
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Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)
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How does the macula protect itself from oxidative stress?
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Toll-like receptor polymorphisms and age-related macular degeneration
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Immunological aspects of RPE cell transplantation
Sugita, S., Mandai, M., Kamao, H., & Takahashi, M. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100950 · Cited by 77
Making Biological Sense of Genetic Studies of Age-Related Macular Degeneration
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Metadata
- Authors
- Espinosa-Heidmann, D. G., Suner, I. J., Catanuto, P., Hernandez, E. P., Marin-Castano, M. E., & Cousins, S. W.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2006-02-01
- Volume
- 47
- Issue
- 2
- Pages
- 729
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2171885105
- Cited by
- 181
- References
- 3
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- closed
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