The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The Significance of Vascular and Neural Apoptosis to the Pathology of Diabetic Retinopathy
Open accessAbstract
The most striking features of diabetic retinopathy are the vascular abnormalities that are apparent by fundus examination. There is also strong evidence that diabetes causes apoptosis of neural and vascular cells in the retina. Thus, there is good reason to define diabetic retinopathy as a form of chronic neurovascular degeneration. In keeping with the gradual onset of retinopathy in humans, the rate of cell loss in the animal models is insidious, even in uncontrolled diabetes. This is not surprising given that a sustained high rate of cell loss without regeneration would soon lead to catastrophic tissue destruction. The consequences of ongoing cell death are difficult to detect, and even the quantification of cumulative cell loss requires painstaking histology and microscopy. This subtle cell loss raises the issue of the relevance of the phenomenon to the progression of diabetic retinopathy and the ultimate loss of vision. Neuronal function may be compromised in advance of apoptosis, contributing to an early deterioration of vision. Here we review some of the evidence supporting apoptotic cell death as a contributing mechanism of diabetic retinopathy, explore some of the potential causes, and discuss the potential links between apoptosis and loss of visual function in diabetic retinopathy.
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Cites
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
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Nitrogen shuttling between neurons and glial cells during glutamate synthesis
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Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
Diabetic retinopathy: current understanding, mechanisms, and treatment strategies
Duh, E. J., Sun, J. K., & Stitt, A. W. (2017) · JCI Insight · doi:10.1172/jci.insight.93751 · Cited by 1,057
Kur, J., Newman, E. A., & Chan-Ling, T. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.04.004 · Cited by 678
Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives
Simó, R., & Hernández, C. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.09.005 · Cited by 490
Early Neurodegeneration in the Retina of Type 2 Diabetic Patients
van Dijk, H. W., Verbraak, F. D., Kok, P. H. B., Stehouwer, M., Garvin, M. K., Sonka, M., DeVries, J. H., Schlingemann, R. O., & Abràmoff, M. D. (2012) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.11-8997 · Cited by 358
Plastic roles of pericytes in the blood–retinal barrier
Park, D. Y., Lee, J., Kim, J., Kim, K., Hong, S., Han, S., Kubota, Y., Augustin, H. G., Ding, L., Kim, J. W., et al. (2017) · Nature Communications · doi:10.1038/ncomms15296 · Cited by 322
Brain and Retinal Pericytes: Origin, Function and Role
Trost, A., Lange, S., Schroedl, F., Bruckner, D., Motloch, K. A., Bogner, B., Kaser-Eichberger, A., Strohmaier, C., Runge, C., Aigner, L., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00020 · Cited by 244
From oxygen to erythropoietin: Relevance of hypoxia for retinal development, health and disease
Caprara, C., & Grimm, C. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.11.003 · Cited by 176
Scott, I. U., Jackson, G. R., Quillen, D. A., Larsen, M., Klein, R., Liao, J., Holfort, S., Munch, I. C., & Gardner, T. W. (2014) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2014.93 · Cited by 59
Self-citation
Metadata
- Authors
- Barber, A. J., Gardner, T. W., & Abcouwer, S. F.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2011-02-28
- Volume
- 52
- Issue
- 2
- Pages
- 1156
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2089183158
- Cited by
- 439
- References
- 6
- FWCI
- 28.54
- Type
- journal article
- Language
- en
- Open access
- green
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