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Cited by 358

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Early Neurodegeneration in the Retina of Type 2 Diabetic Patients

Open access
van Dijk, Hille W., Verbraak, Frank D., Kok, Pauline H. B., Stehouwer, Marilette, Garvin, Mona K., Sonka, Milan, DeVries, J. Hans, Schlingemann, Reinier O., Abràmoff, Michael D.·2012·Investigative Opthalmology & Visual Science
DOI 10.1167/iovs.11-8997
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Abstract

PURPOSE: The purpose of this study was to determine whether diabetes type 2 causes thinning of retinal layers as a sign of neurodegeneration and to investigate the possible relationship between this thinning and duration of diabetes mellitus, diabetic retinopathy (DR) status, age, sex, and glycemic control (HbA1c). METHODS: Mean layer thickness was calculated for retinal layers following automated segmentation of spectral domain optical coherence tomography images of diabetic patients with no or minimal DR and compared with controls. To determine the relationship between layer thickness and diabetes duration, DR status, age, sex, and HbA1c, a multiple linear regression analysis was used. RESULTS: In the pericentral area of the macula, the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) were thinner in patients with minimal DR compared to controls (respective difference 1.9 μm, 95% confidence interval [CI] 0.3-3.5 μm; 5.2 μm, 95% CI 1.0-9.3 μm; 4.5 μm, 95% CI 2.2-6.7 μm). In the peripheral area of the macula, the RNFL and IPL were thinner in patients with minimal DR compared to controls (respective difference 3.2 μm, 95% CI 0.1-6.4 μm; 3.3 μm, 95% CI 1.2-5.4 μm). Multiple linear regression analysis showed DR status to be the only significant explanatory variable (R = 0.31, P = 0.03) for this retinal thinning. CONCLUSIONS: This study demonstrated thinner inner retinal layers in the macula of type 2 diabetic patients with minimal DR than in controls. These results support the concept that early DR includes a neurodegenerative component.

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Metadata

Authors
van Dijk, H. W., Verbraak, F. D., Kok, P. H. B., Stehouwer, M., Garvin, M. K., Sonka, M., DeVries, J. H., Schlingemann, R. O., & Abràmoff, M. D.
Venue
Investigative Opthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Published
2012-05-14
Volume
53
Issue
6
Pages
2715
ISSN
  • 0146-0404 (ISSN-L)
  • 1552-5783
DOI
10.1167/iovs.11-8997
OpenAlex
W2081407214
Cited by
358
References
20
FWCI
15.04
Type
journal article
Language
en
Open access
green

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