The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Clinical and pathological investigation of patients with severe COVID-19
Open accessAbstract
BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has become a pandemic. This study addresses the clinical and immunopathological characteristics of severe COVID-19. METHODS: Sixty-nine patients with COVID-19 were classified into severe and nonsevere groups to analyze their clinical and laboratory characteristics. A panel of blood cytokines was quantified over time. Biopsy specimens from 2 deceased cases were obtained for immunopathological, ultrastructural, and in situ hybridization examinations. RESULTS: Circulating cytokines, including IL-8, IL-6, TNF-α, IP10, MCP1, and RANTES, were significantly elevated in patients with severe COVID-19. Dynamic IL-6 and IL-8 were associated with disease progression. SARS-CoV-2 was demonstrated to infect type II and type I pneumocytes and endothelial cells, leading to severe lung damage through cell pyroptosis and apoptosis. In severe cases, lymphopenia, neutrophilia, depletion of CD4+ and CD8+ T lymphocytes, and massive macrophage and neutrophil infiltrates were observed in both blood and lung tissues. CONCLUSIONS: A panel of circulating cytokines could be used to predict disease deterioration and inform clinical interventions. Severe pulmonary damage was predominantly attributed to both cytopathy caused by SARS-CoV-2 and immunopathologic damage. Strategies that prohibit pulmonary recruitment and overactivation of inflammatory cells by suppressing cytokine storm might improve the outcomes of patients with severe COVID-19.
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Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415
Self-citationPathological findings of COVID-19 associated with acute respiratory distress syndrome
Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30076-x · Cited by 8,545
Self-citationPyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
Shi, J., Gao, W., & Shao, F. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.10.004 · Cited by 3,088
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Metadata
- Authors
- Li, S., Jiang, L., Li, X., Lin, F., Wang, Y., Li, B., Jiang, T., An, W., Liu, S., Liu, H., Xu, P., Zhao, L., Zhang, L., Mu, J., Wang, H., Kang, J., Li, Y., Huang, L., Zhu, C., Zhao, S., Lu, J., Ji, J., & Zhao, J.
- Venue
- JCI Insight
- Published
- 2020-06-18
- Volume
- 5
- Issue
- 12
- ISSN
- 2379-3708 (ISSN-L)
- OpenAlex
- W3025129816
- Cited by
- 280
- References
- 3
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, S., Jiang, L., Li, X., Lin, F., Wang, Y., Li, B., Jiang, T., An, W., Liu, S., Liu, H., Xu, P., Zhao, L., Zhang, L., Mu, J., Wang, H., Kang, J., Li, Y., Huang, L., Zhu, C., . . . Zhao, J. (2020). Clinical and pathological investigation of patients with severe COVID-19. JCI Insight. https://doi.org/10.1172/jci.insight.138070
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