The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis
Open accessAbstract
Rheumatoid arthritis (RA) is a debilitating disease characterized by persistent accumulation of leukocytes within the articular cavity and synovial tissue. Metabololipidomic profiling of arthritic joints from omega-3 supplemented mice identified elevated levels of specialized proresolving lipid mediators (SPM) including resolvin D1 (RvD1). Profiling of human RA synovial fluid revealed physiological levels of RvD1, which — once applied to human neutrophils — attenuated chemotaxis. These results prompted analyses of the antiarthritic properties of RvD1 in a model of murine inflammatory arthritis. The stable epimer 17 R -RvD1 (100 ng/day) significantly attenuated arthritis severity, cachexia, hind-paw edema, and paw leukocyte infiltration and shortened the remission interval. Metabololipidomic profiling in arthritic joints revealed 17 R -RvD1 significantly reduced PGE 2 biosynthesis, while increasing levels of protective SPM. Molecular analyses indicated that 17 R -RvD1 enhanced expression of genes associated with cartilage matrix synthesis, and direct intraarticular treatment induced chondroprotection. Joint protective actions of 17 R -RvD1 were abolished in RvD1 receptor–deficient mice termed ALX/fpr2/3 –/– . These investigations open new therapeutic avenues for inflammatory joint diseases, providing mechanistic substance for the benefits of omega-3 supplementation in RA.
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Cites
Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041
Self-citationResolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., Flower, R. J., Perretti, M., & Serhan, C. N. (2009) · Nature · doi:10.1038/nature08541 · Cited by 695
Self-citationInfection regulates pro-resolving mediators that lower antibiotic requirements
Chiang, N., Fredman, G., Bäckhed, F., Oh, S. F., Vickery, T., Schmidt, B. A., & Serhan, C. N. (2012) · Nature · doi:10.1038/nature11042 · Cited by 664
Self-citationChou, R. C., Kim, N. D., Sadik, C. D., Seung, E., Lan, Y., Byrne, M. H., Haribabu, B., Iwakura, Y., & Luster, A. D. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.018 · Cited by 342
Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs
Krishnamoorthy, S., Recchiuti, A., Chiang, N., Fredman, G., & Serhan, C. N. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.01.028 · Cited by 283
Self-citationDalli, J., Zhu, M., Vlasenko, N. A., Deng, B., Haeggström, J. Z., Petasis, N. A., & Serhan, C. N. (2013) · The FASEB Journal · doi:10.1096/fj.13-227728 · Cited by 283
Self-citationChiang, N., Shinohara, M., Dalli, J., Mirakaj, V., Kibi, M., Choi, A. M. K., & Serhan, C. N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202969 · Cited by 117
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Cited by
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
Serhan, C. N., & Levy, B. D. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97943 · Cited by 1,344
Self-citationSerhan, C. N. (2017) · The FASEB Journal · doi:10.1096/fj.201601222r · Cited by 555
Self-citationBioactive Lipids and Chronic Inflammation: Managing the Fire Within
Chiurchiù, V., Leuti, A., & Maccarrone, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00038 · Cited by 427
Fredman, G., Hellmann, J., Proto, J. D., Kuriakose, G., Colas, R. A., Dorweiler, B., Connolly, E. S., Solomon, R., Jones, D. M., Heyer, E. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms12859 · Cited by 411
Deng, C., Zhang, Q., He, P., Zhou, B., He, K., Sun, X., Lei, G., Gong, T., & Zhang, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-22454-z · Cited by 252
Metadata
- Authors
- Norling, L. V., Headland, S. E., Dalli, J., Arnardottir, H. H., Haworth, O., Jones, H. R., Irimia, D., Serhan, C. N., & Perretti, M.
- Venue
- JCI Insight
- Published
- 2016-04-21
- Volume
- 1
- Issue
- 5
- Pages
- e85922-e85922
- ISSN
- 2379-3708 (ISSN-L)
- OpenAlex
- W2341561827
- Cited by
- 174
- References
- 7
- FWCI
- 19.34
- Type
- journal article
- Language
- en
- Open access
- gold
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