An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
Open accessAbstract
Chronic unresolved inflammation plays a causal role in the development of advanced atherosclerosis, but the mechanisms that prevent resolution in atherosclerosis remain unclear. Here, we use targeted mass spectrometry to identify specialized pro-resolving lipid mediators (SPM) in histologically-defined stable and vulnerable regions of human carotid atherosclerotic plaques. The levels of SPMs, particularly resolvin D1 (RvD1), and the ratio of SPMs to pro-inflammatory leukotriene B 4 (LTB 4 ), are significantly decreased in the vulnerable regions. SPMs are also decreased in advanced plaques of fat-fed Ldlr −/− mice. Administration of RvD1 to these mice during plaque progression restores the RvD1:LTB 4 ratio to that of less advanced lesions and promotes plaque stability, including decreased lesional oxidative stress and necrosis, improved lesional efferocytosis, and thicker fibrous caps. These findings provide molecular support for the concept that defective inflammation resolution contributes to the formation of clinically dangerous plaques and offer a mechanistic rationale for SPM therapy to promote plaque stability.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In advanced atherosclerotic lesions, the ratio of specialized pro-resolving mediators to pro-inflammatory lipids, especially leukotrienes, is strikingly low, providing a molecular explanation for defective resolution.
“In advanced atherosclerotic lesions, the ratio between specialized pro-resolving mediators and pro-inflammatory lipids (in particular leukotrienes) is strikingly low, providing a molecular explanation for the defective inflammation resolution features of these lesions.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [36]
The ratio of 5-LOX-derived SPMs, notably RvD1, to pro-inflammatory leukotrienes is lower in advanced versus early atherosclerotic lesions in both humans and hypercholesterolaemic mice.
“The ratio of 5-LOX-derived SPMs, notably RvD1, to pro-inflammatory leukotrienes is lower in advanced versus early atherosclerotic lesions in both humans and hypercholesterolaemic mice36.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [36]
Intraperitoneal injections of RvD1 to Western-diet-fed Ldlr-knockout mice with mid-stage atherosclerotic lesions restore RvD1 levels, increase efferocytosis, reduce oxidative stress, and induce a more stable plaque phenotype, suppressing progression to advanced lesions.
“intraperitoneal injections of RvD1 to Western-diet-fed Ldlr-knockout mice with mid-stage atherosclerotic lesions restore RvD1 levels in the lesions, increase efferocytosis, reduce oxidative stress in the lesions and induce a more stable plaque phenotype, thereby suppressing the progression of the mid-stage lesions to more advanced lesions36.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [36]
SPMs and IL-10 promote efferocytosis.
“Both SPMs and IL-10 promote efferocytosis36,93,181–185”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [36]
Treatment of Western-diet-fed Ldlr−/− mice with athero-targeted nanoparticles carrying an annexin A1-derived pro-resolving peptide Ac2-26 or with SPMs markedly suppressed formation of necrotic, thin-capped plaques.
“As summarized in this Review, treatment of Western-diet-fed Ldlr−/− mice with athero-targeted nanoparticles packaged with a pro-resolving peptide derived from annexin A1 (Ac2–26) or with SPMs markedly suppressed the formation of necrotic, thin-capped plaques36,38,99,109,118.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works
Pathology of the Vulnerable Plaque
Virmani, R., BURKE, A. P., Farb, A. A., & Kolodgie, F. D. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.065 · Cited by 2,358 · see citing works
Concept of Vulnerable/Unstable Plaque
Finn, A. V., Nakano, M., Narula, J., Kolodgie, F. D., & Virmani, R. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179739 · Cited by 1,193 · see citing works
A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation
Erickson, J. R., Joiner, M.-L. A., Guan, X., Kutschke, W., Yang, J., Oddis, C. V., Bartlett, R. K., Lowe, J. S., O'Donnell, S. E., Aykin-Burns, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.048 · Cited by 1,122 · see citing works
Macrophage death and defective inflammation resolution in atherosclerosis
Tabas, I. (2010) · Nature Reviews Immunology · doi:10.1038/nri2675 · Cited by 1,120 · see citing works
Self-citationn–3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia
The ORIGIN Trial Investigators (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1203859 · Cited by 929 · see citing works
Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions
Serhan, C. N., Yang, R., Martinod, K., Kasuga, K., Pillai, P. S., Porter, T. F., Oh, S. F., & Spite, M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081880 · Cited by 908 · see citing works
Self-citationLipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875 · see citing works
Resolvin D1 binds human phagocytes with evidence for proresolving receptors
Krishnamoorthy, S., Recchiuti, A., Chiang, N., Yacoubian, S., Lee, C., Yang, R., Petasis, N. A., & Serhan, C. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907342107 · Cited by 738 · see citing works
Infection regulates pro-resolving mediators that lower antibiotic requirements
Chiang, N., Fredman, G., Bäckhed, F., Oh, S. F., Vickery, T., Schmidt, B. A., & Serhan, C. N. (2012) · Nature · doi:10.1038/nature11042 · Cited by 664 · see citing works
Self-citationArachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis
Dwyer, J. H., Allayee, H., Dwyer, K. M., Fan, J., Wu, H., Mar, R., Lusis, A. J., & Mehrabian, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025079 · Cited by 614 · see citing works
Dalli, J., & Serhan, C. N. (2012) · Blood · doi:10.1182/blood-2012-04-423525 · Cited by 556 · see citing works
Inflammation and its Resolution as Determinants of Acute Coronary Syndromes
Libby, P., Tabas, I. A., Fredman, G., & Fisher, E. A. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302699 · Cited by 523 · see citing works
Self-citationDisruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
Cyrus, T., Witztum, J. L., Rader, D. J., Tangirala, R., Fazio, S., Linton, M. F., & Funk, C. D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5897 · Cited by 523 · see citing works
Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis
Schrijvers, D. M., De Meyer, G. R. Y., Kockx, M. M., Herman, A. G., & Martinet, W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000166517.18801.a7 · Cited by 509 · see citing works
Hastürk, H., Kantarcı, A., Goguet, E., Blackwood, A., Andry, C., Serhan, C. N., & Dyke, T. E. V. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.7021 · Cited by 462 · see citing works
Spanbroek, R., Gräbner, R., Lötzer, K., Hildner, M., Urbach, A., Rühling, K., Moos, M. P. W., Kaiser, B., Cohnert, T. U., Wahlers, T., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242716099 · Cited by 457 · see citing works
Perretti, M., Chiang, N., La, M., Fierro, I. M., Marullo, S., Getting, S. J., Solito, E., & Serhan, C. N. (2002) · Nature Medicine · doi:10.1038/nm786 · Cited by 449 · see citing works
Colas, R. A., Shinohara, M., Dalli, J., Chiang, N., & Serhan, C. N. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00024.2014 · Cited by 424 · see citing works
Self-citationTimmins, J. M., Özcan, L., Seimon, T. A., Li, G., Malagelada, C., Backs, J., Backs, T., Bassel‐Duby, R., Olson, E. N., Anderson, M. E., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38857 · Cited by 422 · see citing works
Self-citationMerched, A. J., Ko, K., Gotlinger, K. H., Serhan, C. N., & Chan, L. (2008) · The FASEB Journal · doi:10.1096/fj.08-112201 · Cited by 414 · see citing works
Serhan, C. N., Jain, A., Marleau, S., Clish, C. B., Kantarcı, A., Behbehani, B., Colgan, S. P., Stahl, G. L., Merched, A. J., Petasis, N. A., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6856 · Cited by 405 · see citing works
Fredman, G., Kamaly, N., Spolitu, S., Milton, J., Ghorpade, D. S., Chiasson, R., Kuriakose, G., Perretti, M., Farokhzad, O. C., & Tabas, I. A. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1065 · Cited by 360 · see citing works
Self-citationThorp, E., Cui, D., Schrijvers, D. M., Kuriakose, G., & Tabas, I. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.167197 · Cited by 357 · see citing works
Self-citationDefective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
Karp, C. L., Flick, L. M., Park, K. W., Softic, S., Greer, T. M., Keledjian, R., Yang, R., Uddin, J., Guggino, W. B., Atabani, S. F., et al. (2004) · Nature Immunology · doi:10.1038/ni1056 · Cited by 344 · see citing works
Li, G., Scull, C. M., Özcan, L., & Tabas, I. A. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201006121 · Cited by 306 · see citing works
Self-citationResolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs
Krishnamoorthy, S., Recchiuti, A., Chiang, N., Fredman, G., & Serhan, C. N. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.01.028 · Cited by 283 · see citing works
Self-citationWang, Y., Wang, G. Z., Rabinovitch, P. S., & Tabas, I. A. (2013) · Circulation Research · doi:10.1161/circresaha.114.302153 · Cited by 264 · see citing works
Self-citationDiminished Lipoxin Biosynthesis in Severe Asthma
Levy, B. D., Bonnans, C., Silverman, E. S., Palmer, L. J., Marigowda, G., & Israel, E. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200410-1413oc · Cited by 250 · see citing works
Qiu, H., Gabrielsen, A., Agardh, H. E., Wan, M., Wetterholm, A., Wong, C., Hedin, U., Swedenborg, J., Hansson, G. K., Samuelsson, B. O., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602414103 · Cited by 249 · see citing works
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone
He, B. J., Joiner, M.-L. A., Singh, M. V., Luczak, E. D., Dominic, P. S., Koval, O. M., Kutschke, W. J., Allamargot, C., Yang, J., Guan, X., et al. (2011) · Nature Medicine · doi:10.1038/nm.2506 · Cited by 239 · see citing works
Kain, V., Ingle, K. A., Colas, R. A., Dalli, J., Prabhu, S. D., Serhan, C. N., Joshi, M. D., & Halade, G. V. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.003 · Cited by 234 · see citing works
Self-citationAtherosclerosis – A matter of unresolved inflammation
Viola, J. R., & Soehnlein, O. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.013 · Cited by 227 · see citing works
Kamaly, N., Fredman, G., Fojas, J. J. R., Subramanian, M., Choi, W. I., Zepeda, K., Vilos, C., Yu, M., Gadde, S., Wu, J., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b01114 · Cited by 220 · see citing works
Self-citationHo, K. J., Spite, M., Owens, C. D., Lancero, H., Kroemer, A. H. K., Pande, R., Creager, M. A., Serhan, C. N., & Conte, M. S. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.091082 · Cited by 204 · see citing works
Self-citationHasturk, H., Abdallah, R., Kantarci, A., Nguyen, D., Giordano, N., Hamilton, J., & Van Dyke, T. E. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.115.305324 · Cited by 199 · see citing works
Fredman, G., Özcan, L., Spolitu, S., Hellmann, J. L., Spite, M. R., Backs, J., & Tabas, I. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410851111 · Cited by 193 · see citing works
Self-citationAngioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy.
Brezinski, D. A., Nesto, R. W., & Serhan, C. N. (1992) · Circulation · doi:10.1161/01.cir.86.1.56 · Cited by 193 · see citing works
The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease
Poeckel, D., & Funk, C. D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq016 · Cited by 185 · see citing works
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis
Norling, L. V., Headland, S. E., Dalli, J., Arnardottir, H. H., Haworth, O., Jones, H. R., Irimia, D., Serhan, C. N., & Perretti, M. (2016) · JCI Insight · doi:10.1172/jci.insight.85922 · Cited by 174 · see citing works
Impaired Phagocytosis in Localized Aggressive Periodontitis: Rescue by Resolvin E1
Fredman, G., Oh, S. F., Ayilavarapu, S., Hastürk, H., Serhan, C. N., & Dyke, T. E. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024422 · Cited by 154 · see citing works
Self-citationPhospholipase A 2 regulates eicosanoid class switching during inflammasome activation
Norris, P. C., Gosselin, D., Reichart, D. R., Glass, C. K., & Dennis, E. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404372111 · Cited by 152 · see citing works
Annexin A1 Counteracts Chemokine-Induced Arterial Myeloid Cell Recruitment
Drechsler, M., de Jong, R., Rossaint, J., Viola, J. R., Leoni, G., Wang, J. M., Grommes, J., Hinkel, R., Kupatt, C., Weber, C., et al. (2015) · Circulation Research · doi:10.1161/circresaha.116.305825 · Cited by 150 · see citing works
Elajami, T. K., Colas, R. A., Dalli, J., Chiang, N., Serhan, C. N., & Welty, F. K. (2016) · The FASEB Journal · doi:10.1096/fj.201500155r · Cited by 143 · see citing works
Self-citationHeller, E. A., Liu, E. H., Tager, A. M., Sinha, S., Roberts, J. D., Koehn, S. L., Libby, P., Aikawa, E. R., Chen, J. Q., Huang, P. L., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.545616 · Cited by 141 · see citing works
Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B 4 synthetic capacity
Luo, M., Jones, S. M., Peters-Golden, M. L., & Brock, T. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2133253100 · Cited by 135 · see citing works
Miyahara, T., Runge, S. J., Chatterjee, A., Chen, M., Mottola, G., Fitzgerald, J. M., Serhan, C. N., & Conte, M. S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225615 · Cited by 134 · see citing works
Fredman, G., Li, Y., Dalli, J., Chiang, N., & Serhan, C. N. (2012) · Scientific Reports · doi:10.1038/srep00639 · Cited by 122 · see citing works
Self-citationLipoxin A 4 and benzo‐lipoxin A 4 attenuate experimental renal fibrosis
Börgeson, E., Docherty, N. G., Murphy, M., Rodgers, K., Ryan, A., O’Sullivan, T. P., Guiry, P. J., Goldschmeding, R., Higgins, D. F., & Godson, C. (2011) · The FASEB Journal · doi:10.1096/fj.11-185017 · Cited by 120 · see citing works
Lee, H., & Surh, Y. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.002 · Cited by 119 · see citing works
Wan, J., Huang, L., Rong, R., Tan, R., Wang, J., & Kang, J. X. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.210054 · Cited by 107 · see citing works
Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques
Brooks, C. J. W., HARLAND, W. A., & Steel, G. (1966) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(66)90055-5 · Cited by 100 · see citing works
Rao, N. L., Dunford, P. J., Xue, X., Jiang, X., Lundeen, K. A., Coles, F., Riley, J. P., Williams, K. N., Grice, C. A., Edwards, J. P., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.115436 · Cited by 92 · see citing works
Lipoxin and resolvin biosynthesis is dependent on 5‐lipoxygenase activating protein
Lehmann, C., Homann, J., Ball, A., Blöcher, R., Kleinschmidt, T. K., Basavarajappa, D. K., Angioni, C., Ferreirós, N., Häfner, A., Rådmark, O., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-275487 · Cited by 84 · see citing works
Kusters, D. H. M., Chatrou, M. L. L., Willems, B. A. G., Saint‐Hubert, M. D., Bauwens, M., van der Vorst, E. P. C., Bena, S., Biessen, E. A. L., Perretti, M., Schurgers, L. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130484 · Cited by 70 · see citing works
Hill, E. M., Maclouf, J., Murphy, R. C., & Henson, P. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41633-x · Cited by 67 · see citing works
Titos, E., Clària, J., Planagumà, A., López‐Parra, M., González‐Périz, A., Gaya, J., Miquel, R., Arroyo, V., & Rodés, J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204747 · Cited by 67 · see citing works
Brock, T. G., Maydanski, E., McNish, R. W., & Peters-Golden, M. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105676200 · Cited by 62 · see citing works
Elias, I., Ferré, T., Vilà, L., MUÑOZ, S. A., Casellas, A., García, M., Molas, M., Agudo, J., Roca, C., Ruberte, J., et al. (2016) · Diabetes · doi:10.2337/db16-0040 · Cited by 59 · see citing works
Oxidative Stress and Coronary Plaque Stability
Channon, K. M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000042203.08210.17 · Cited by 49 · see citing works
17(R)-resolvin D1 ameliorates bleomycin-induced pulmonary fibrosis in mice
Yatomi, M., Hisada, T., Ishizuka, T., Koga, Y., Ono, A., Kamide, Y., Seki, K., Aoki‐Saito, H., Tsurumaki, H., Sunaga, N., et al. (2015) · Physiological Reports · doi:10.14814/phy2.12628 · Cited by 45 · see citing works
Nutrigenetic Disruption of Inflammation-Resolution Homeostasis and Atherogenesis
Merched, A. J., Serhan, C. N., & Chan, L. (2011) · Lifestyle Genomics · doi:10.1159/000326890 · Cited by 40 · see citing works
Harmon, E. Y., Fronhofer, V., Keller, R. S., Feustel, P. J., Zhu, X., Xu, H., Avram, D., Jones, D., Nagarajan, S., & Lennartz, M. R. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001232 · Cited by 34 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
Serhan, C. N., & Levy, B. D. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97943 · Cited by 1,344 · see citing works
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Self-citationAge and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267 · see citing works
Efferocytosis in health and disease
Doran, A. C., Yurdagul, A., & Tabas, I. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0240-6 · Cited by 1,066 · see citing works
Self-citationTargeting inflammation in atherosclerosis — from experimental insights to the clinic
Soehnlein, O., & Libby, P. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00198-1 · Cited by 1,042 · see citing works
Monocyte-macrophages and T cells in atherosclerosis
Tabas, I., & Lichtman, A. H. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.008 · Cited by 646 · see citing works
Self-citationSerhan, C. N. (2017) · The FASEB Journal · doi:10.1096/fj.201601222r · Cited by 553 · see citing works
Yurdagul, A., Subramanian, M., Wang, X., Crown, S. B., Ilkayeva, O. R., Darville, L., Kolluru, G. K., Rymond, C. C., Gerlach, B. D., Zheng, Z., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.001 · Cited by 525 · see citing works
Self-citationInflammation in atherosclerosis: pathophysiology and mechanisms
Ajoolabady, A., Praticò, D., Lin, L., Mantzoros, C. S., Bahijri, S., Tuomilehto, J. O., & Ren, J. T. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07166-8 · Cited by 510 · see citing works
Drugging the efferocytosis process: concepts and opportunities
Mehrotra, P., & Ravichandran, K. S. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00470-y · Cited by 459 · see citing works
Macrophages: The Good, the Bad, and the Gluttony
Ross, E. A., Devitt, A., & Johnson, J. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708186 · Cited by 436 · see citing works
Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?
Engelen, S. E., Robinson, A., Zurke, Y.-X., & Monaco, C. G. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00668-4 · Cited by 442 · see citing works
Bioactive Lipids and Chronic Inflammation: Managing the Fire Within
Chiurchiù, V., Leuti, A., & Maccarrone, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00038 · Cited by 427 · see citing works
Bioactive lipids, inflammation and chronic diseases
Leuti, A., Fazio, D., Fava, M., Piccoli, A., Oddi, S., & Maccarrone, M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.028 · Cited by 368 · see citing works
Resolution of inflammation: An organizing principle in biology and medicine
Panigrahy, D., Gilligan, M. M., Serhan, C. N., & Kashfi, K. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107879 · Cited by 345 · see citing works
Chiang, N., & Serhan, C. N. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.005 · Cited by 330 · see citing works
Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis
Yurdagul, A., Doran, A. C., Cai, B., Fredman, G., & Tabas, I. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00086 · Cited by 300 · see citing works
Self-citationWerz, O., Gerstmeier, J., Libreros, S., de la Rosa, X., Werner, M., Norris, P. C., Chiang, N., & Serhan, C. N. (2017) · Nature Communications · doi:10.1038/s41467-017-02538-5 · Cited by 298 · see citing works
Coronary Atherosclerotic Vulnerable Plaque: Current Perspectives
Stefanadis, C., Antoniou, C. K., Tsiachris, D., & Pietri, P. G. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005543 · Cited by 279 · see citing works
MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis
Cai, B., Thorp, E. B., Doran, A. C., Sansbury, B. E., Daemen, M. J. A. P., Dorweiler, B., Spite, M., Fredman, G., & Tabas, I. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90520 · Cited by 262 · see citing works
Self-citationThe role of non-resolving inflammation in atherosclerosis
Kasikara, C., Doran, A. C., Cai, B., & Tabas, I. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97950 · Cited by 266 · see citing works
Self-citationRegulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression
Sharma, M., Schlegel, M., Afonso, M., Brown, E. J., Rahman, K., Weinstock, A., Sansbury, B. E., Corr, E. M., van Solingen, C., Koelwyn, G., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316461 · Cited by 231 · see citing works
Self-citationNew pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration
Serhan, C. N., Chiang, N., & Dalli, J. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.08.002 · Cited by 246 · see citing works
Macrophage Death as a Pharmacological Target in Atherosclerosis
Martinet, W., Coornaert, I., Puylaert, P., & Meyer, G. R. Y. D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00306 · Cited by 223 · see citing works
Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis
Moore, K. J., Koplev, S., Fisher, E. A. A., Tabas, I. A., Björkegren, J., Doran, A. C., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2147 · Cited by 221 · see citing works
Self-citationCarcinogenesis: Failure of resolution of inflammation?
Fishbein, A., Hammock, B. D., Serhan, C. N., & Panigrahy, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107670 · Cited by 207 · see citing works
Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets
Meyer, G. R. Y. D., Zurek, M., Puylaert, P., & Martinet, W. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00957-0 · Cited by 214 · see citing works
Mediators of the Resolution of the Inflammatory Response
Sugimoto, M. A., Vago, J. P., Perretti, M., & Teixeira, M. M. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.01.007 · Cited by 201 · see citing works
Schebb, N. H., Kühn, H., Kahnt, A. S., Rund, K. M., O’Donnell, V. B., Flamand, N., Peters-Golden, M. L., Jakobsson, P., Weylandt, K. H., Rohwer, N., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.838782 · Cited by 202 · see citing works
Lei, A. A., Phang, V. W. X., Lee, Y. Z., Kow, A. S. F., Tham, C. L., Ho, Y.-C., & Lee, M. T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072940 · Cited by 207 · see citing works
“While atherosclerosis is primarily associated with local inflammation, systemic chronic low-grade inflammation plays a role in the development of atherosclerotic plaques at sites of minor arterial injuries and can promote the progression of existing plaques [66].”
Targeting IRE1 with small molecules counteracts progression of atherosclerosis
Tufanlı, Ö., Telkoparan‐Akillilar, P., Acosta‐Alvear, D., Kocatürk, B., Onat, U. İ., Hamid, S. M., Çimen, İ., Walter, P., Weber, C., & Erbay, E. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621188114 · Cited by 192 · see citing works
He, Z., Chen, W., Hu, K., Luo, Y., Zeng, W., He, X., Li, T., Ouyang, J., Li, Y., Xie, L., et al. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01687-1 · Cited by 190 · see citing works
The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation
Schilperoort, M., Ngai, D., Sukka, S. R., Avrampou, K., Shi, H., & Tabas, I. A. (2023) · Immunological Reviews · doi:10.1111/imr.13214 · Cited by 181 · see citing works
Self-citationCai, B., Kasikara, C., Doran, A. C., Ramakrishnan, R., Birge, R. B., & Tabas, I. (2018) · Science Signaling · doi:10.1126/scisignal.aar3721 · Cited by 175 · see citing works
Self-citationAmpomah, P. B., Cai, B., Sukka, S. R., Gerlach, B. D., Yurdagul, A., Wang, X., Kuriakose, G., Darville, L. N. F., Sun, Y., Sidoli, S., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00551-7 · Cited by 176 · see citing works
Self-citationBoosting Inflammation Resolution in Atherosclerosis
Fredman, G., & Tabas, I. A. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.01.018 · Cited by 173 · see citing works
Self-citationInflammation Resolution: Implications for Atherosclerosis
Doran, A. C. (2022) · Circulation Research · doi:10.1161/circresaha.121.319822 · Cited by 177 · see citing works
Lipidomics unveils the complexity of the lipidome in metabolic diseases
Lydic, T. A., & Goo, Y. (2018) · Clinical and Translational Medicine · doi:10.1186/s40169-018-0182-9 · Cited by 170 · see citing works
Leukotriene biosynthetic enzymes as therapeutic targets
Haeggström, J. Z. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97945 · Cited by 169 · see citing works
Regulation and Functions of 15-Lipoxygenases in Human Macrophages
Snodgrass, R. G., & Brüne, B. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00719 · Cited by 162 · see citing works
Fredman, G., & Serhan, C. N. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00984-x · Cited by 160 · see citing works
Self-citationGiannakis, N., Sansbury, B. E., Patsalos, A., Hays, T. T., Riley, C. O., Han, X., Spite, M. R., & Nagy, L. (2019) · Nature Immunology · doi:10.1038/s41590-019-0356-7 · Cited by 157 · see citing works
Self-citationProteomic Architecture of Human Coronary and Aortic Atherosclerosis
Herrington, D. M., Mao, C., Parker, S. J., Fu, Z., Yu, G., Chen, L., Venkatraman, V., Fu, Y., Wang, Y., Howard, T. D., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.034365 · Cited by 153 · see citing works
Simonetto, M., Infante, M., Sacco, R. L., Rundek, T., & Della‐Morte, D. (2019) · Nutrients · doi:10.3390/nu11102279 · Cited by 156 · see citing works
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase
Pein, H., Ville, A., Pace, S., Temml, V., Garscha, U., Raasch, M., Alsabil, K., Viault, G., Dinh, C. P., Guilet, D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06158-5 · Cited by 152 · see citing works
Souza, P. R., Marques, R. M., Gómez, E. A., Colas, R. A., Matteis, R. D., Zak, A., Patel, M., Collier, D., & Dalli, J. (2019) · Circulation Research · doi:10.1161/circresaha.119.315506 · Cited by 150 · see citing works
Self-citationThe walking dead: macrophage inflammation and death in atherosclerosis
Kavurma, M. M., Rayner, K. J., & Karunakaran, D. (2017) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000394 · Cited by 145 · see citing works
Role of Omega-3 Fatty Acids in Cardiovascular Disease: the Debate Continues
Sherratt, S. C. R., Libby, P., Budoff, M. J., Bhatt, D. L., & Mason, R. P. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01075-x · Cited by 132 · see citing works
Resolvin D1 promotes the targeting and clearance of necroptotic cells
Gerlach, B. D., Marinello, M., Heinz, J., Rymut, N., Sansbury, B. E., Riley, C. O., Sadhu, S., Hosseini, Z., Kojima, Y., Tang, D. D., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0370-1 · Cited by 128 · see citing works
Self-citationTargeting Neutrophils for Promoting the Resolution of Inflammation
Filep, J. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.866747 · Cited by 128 · see citing works
Kooij, G., Troletti, C. D., Leuti, A., Norris, P. C., Riley, I. R., Albanese, M., Ruggieri, S., Libreros, S., van der Pol, S. M. A., Hof, B. V. H., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.219519 · Cited by 121 · see citing works
Gromovsky, A. D., Schugar, R. C., Brown, A. L., Helsley, R. N., Burrows, A. C., Ferguson, D., Zhang, R., Sansbury, B. E., Lee, R. G., Morton, R. E., et al. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.309660 · Cited by 115 · see citing works
Self-citationResolvin D1 promotes efferocytosis in aging by limiting senescent cell‐induced MerTK cleavage
Rymut, N., Heinz, J., Sadhu, S., Hosseini, Z., Riley, C. O., Marinello, M., Maloney, J., MacNamara, K. C., Spite, M. R., & Fredman, G. (2019) · The FASEB Journal · doi:10.1096/fj.201902126r · Cited by 113 · see citing works
Self-citationThe role of the LTB4-BLT1 axis in health and disease
He, R., Chen, Y., & Cai, Q. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104857 · Cited by 113 · see citing works
Doran, A. C., Özcan, L., Cai, B., Zheng, Z., Fredman, G., Rymond, C. C., Dorweiler, B., Sluimer, J. C., Hsieh, J., Kuriakose, G., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94735 · Cited by 113 · see citing works
Self-citationDuan, J., Zhou, Y., Zhou, A., Guan, X., Liu, T., Yang, H., Xie, H., & Chen, P. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.08.020 · Cited by 112 · see citing works
The Role of Lipids and Lipoproteins in Atherosclerosis
Linton, M. F., Yancey, P. G., Davies, S. S., Jerome, W. G., Linton, E. F., Song, W., Doran, A. C., & Vickers, K. C. (2015) · Europe PMC (PubMed Central) · Cited by 108 · see citing works
Zaloga, G. P. (2021) · Nutrients · doi:10.3390/nu13020662 · Cited by 106 · see citing works
Norris, P. C., Skulas‐Ray, A. C., Riley, I. R., Richter, C. K., Kris‐Etherton, P. M., Jensen, G. L., Serhan, C. N., & Maddipati, K. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-36679-4 · Cited by 103 · see citing works
Through the layers: how macrophages drive atherosclerosis across the vessel wall
Susser, L. I., & Rayner, K. J. (2022) · Journal of Clinical Investigation · doi:10.1172/jci157011 · Cited by 99 · see citing works
Specialized pro-resolving mediators in cardiovascular diseases
Fredman, G., & Spite, M. R. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.02.003 · Cited by 98 · see citing works
Self-citationZhou, W., Liu, K., Zeng, L., He, J., Gao, X., Gu, X., Chen, X., Li, J. J., Wang, M., Wu, D., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.061900 · Cited by 95 · see citing works
2016 Russell Ross Memorial Lecture in Vascular Biology
Tabas, I. A. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308036 · Cited by 92 · see citing works
Self-citationLiu, T., Xiang, A., Peng, T., Doran, A. C., Tracey, K. J., Barnes, B. J., Tabas, I. A., Son, M., & Diamond, B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907490116 · Cited by 93 · see citing works
Self-citationLipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis
Brennan, E. P., Mohan, M., McClelland, A., de Gaetano, M., Tikellis, C., Marai, M., Crean, D., Dai, A., Beuscart, O., Derouiche, S., et al. (2018) · Diabetes · doi:10.2337/db17-1317 · Cited by 92 · see citing works
Caravaca, A. S., Gallina, A. L., Tarnawski, L., Shavva, V. S., Colas, R. A., Dalli, J., Malin, S., Hult, H., Arnardottir, H. H., & Olofsson, P. S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023285119 · Cited by 91 · see citing works
Self-citationMeriwether, D., Sulaiman, D., Volpe, C., Dorfman, A., Grijalva, V. R., Dorreh, N., Solórzano-Vargas, R. S., Wang, J., O’Connor, E., Papesh, J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123700 · Cited by 90 · see citing works
Targeting immune cell recruitment in atherosclerosis
Döring, Y., van der Vorst, E. P. C., & Weber, C. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01023-z · Cited by 90 · see citing works
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
Tizazu, A. M., Mengist, H. M., & Demeke, G. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00309-5 · Cited by 91 · see citing works
Carracedo, M., Artiach, G., Arnardottir, H. H., & Bäck, M. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00767-y · Cited by 92 · see citing works
Resolution metabolomes activated by hypoxic environment
Norris, P. C., Libreros, S., & Serhan, C. N. (2019) · Science Advances · doi:10.1126/sciadv.aax4895 · Cited by 85 · see citing works
Pro-resolving lipid mediators in vascular disease
Conte, M. S., Desai, T. A., Wu, B., Schaller, M. S., & Werlin, E. C. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97947 · Cited by 81 · see citing works
The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection
Arnardottir, H., Thul, S., Pawelzik, S., Karadimou, G., Artiach, G., Gallina, A. L., Mysdotter, V., Carracedo, M., Tarnawski, L., Caravaca, A. S., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142883 · Cited by 85 · see citing works
Fattori, V., Zaninelli, T. H., Rasquel-Oliveira, F. S., Casagrande, R., & Verri, W. A., Jr. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104549 · Cited by 80 · see citing works
Gómez, E. A., Colas, R. A., Souza, P. R., Hands, R., Lewis, M., Bessant, C., Pitzalis, C., & Dalli, J. (2020) · Nature Communications · doi:10.1038/s41467-020-19176-z · Cited by 81 · see citing works
Self-citationAnnexins in Translational Research: Hidden Treasures to Be Found
Schloer, S., Pajonczyk, D., & Rescher, U. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061781 · Cited by 79 · see citing works
Artiach, G., Carracedo, M., Plunde, O., Wheelock, C. E., Thul, S., Sjövall, P., Franco‐Cereceda, A., Laguna-Fernández, A., Arnardottir, H. H., & Bäck, M. (2020) · Circulation · doi:10.1161/circulationaha.119.041868 · Cited by 81 · see citing works
Hosseini, Z., Marinello, M., Decker, C., Sansbury, B. E., Sadhu, S., Gerlach, B. D., Ramos, R. B., Adam, A. P., Spite, M. R., & Fredman, G. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315758 · Cited by 79 · see citing works
Self-citationStotts, C., Corrales‐Medina, V., & Rayner, K. J. (2023) · Circulation Research · doi:10.1161/circresaha.122.321636 · Cited by 86 · see citing works
Filep, J. G., & Ariel, A. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00181.2020 · Cited by 75 · see citing works
Modified Lipoproteins Induce Arterial Wall Inflammation During Atherogenesis
Lorey, M. B., Öörni, K., & Kovanen, P. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.841545 · Cited by 80 · see citing works
Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells
Markworth, J. F., Brown, L. A., Lim, E. Y., Floyd, C., Larouche, J. A., Castor‐Macias, J. A., Sugg, K. B., Sarver, D. C., Macpherson, P. C. D., Davis, C. S., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.137713 · Cited by 75 · see citing works
Macrophage Responses to Environmental Stimuli During Homeostasis and Disease
Rasheed, A., & Rayner, K. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab004 · Cited by 79 · see citing works
Yin, P., Wang, X., Wang, S., Wei, Y., Feng, J., & Zhu, M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00466 · Cited by 73 · see citing works
Lipoxins Regulate the Early Growth Response–1 Network and Reverse Diabetic Kidney Disease
Brennan, E. P., Mohan, M., McClelland, A., Tikellis, C., Ziemann, M., Kaspi, A., Gray, S. P., Pickering, R. J., Tan, S. M., Shah, S. T. A., et al. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017101112 · Cited by 71 · see citing works
Colas, R. A., Souza, P. R., Walker, M. E., Burton, M., Zasłona, Z., Curtis, A. M., Marques, R. M., & Dalli, J. (2018) · Circulation Research · doi:10.1161/circresaha.117.312472 · Cited by 71 · see citing works
Self-citationDysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities
Stroope, C., Nettersheim, F. S., Coon, B. G., Finney, A. C., Schwartz, M. A., Ley, K. F., Rom, O., & Yurdagul, A. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01015-w · Cited by 72 · see citing works
Eating the dead to keep atherosclerosis at bay
Brophy, M. L., Dong, Y., Wu, H., Rahman, H. N. A., Song, K., & Chen, H. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00002 · Cited by 68 · see citing works
Resolvin D1 and D2 reduce SARS‐CoV‐2‐induced inflammatory responses in cystic fibrosis macrophages
Recchiuti, A., Patruno, S., Mattoscio, D., Isopi, E., Pomilio, A., Lamolinara, A., Iezzi, M., Pecce, R., & Romano, M. (2021) · The FASEB Journal · doi:10.1096/fj.202001952r · Cited by 65 · see citing works
Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation
Chen, J., Norling, L. V., & Cooper, D. (2021) · Cells · doi:10.3390/cells10040881 · Cited by 69 · see citing works
Cell death in the vessel wall: The good, the bad, the ugly
Rayner, K. J. (2017) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309229 · Cited by 64 · see citing works
Kotlyarov, S. N., & Котлярова, А. А. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031308 · Cited by 67 · see citing works
Resolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1
Mattè, A., Recchiuti, A., Federti, E., Koehl, B., Mintz, T., Nemer, W. E., Tharaux, P., Brousse, V. A. M., Andolfo, I., Lamolinara, A., et al. (2018) · Blood · doi:10.1182/blood-2018-07-865378 · Cited by 65 · see citing works
Macrophage fatty acid metabolism and atherosclerosis: The rise of PUFAs
Ménégaut, L., Jalil, A., Thomas, C., & Masson, D. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.10.002 · Cited by 65 · see citing works
Do patients benefit from omega-3 fatty acids?
Sherratt, S. C. R., Mason, R. P., Libby, P., Steg, P. G., & Bhatt, D. L. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad188 · Cited by 71 · see citing works
Chattopadhyay, R., Raghavan, S., & Rao, G. N. (2017) · Redox Biology · doi:10.1016/j.redox.2017.02.023 · Cited by 64 · see citing works
Wu, B., Mottola, G., Schaller, M. S., Upchurch, G. R., & Conte, M. S. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.07.005 · Cited by 64 · see citing works
Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
Wang, L., Li, H., Tang, Y., & Yao, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.585285 · Cited by 62 · see citing works
Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial)
Ramirez, J. L., Gasper, W. J., Khetani, S. A., Zahner, G. J., Hills, N. K., Mitchell, P. T., Sansbury, B. E., Conte, M. S., Spite, M. R., & Grenon, S. M. (2019) · Journal of Surgical Research · doi:10.1016/j.jss.2019.01.038 · Cited by 62 · see citing works
Self-citation
- Authors
- Fredman, G., Hellmann, J., Proto, J. D., Kuriakose, G., Colas, R. A., Dorweiler, B., Connolly, E. S., Solomon, R., Jones, D. M., Heyer, E. J., Spite, M., & Tabas, I.
- Affiliations
- Columbia University Irving Medical Center (US)
- Brigham and Women's Hospital (US)
- Johannes Gutenberg University Mainz (DE)
- Albany Medical College (US)
- Corresponding author
- Spite, Matthew
- Tabas, Ira
- ORCID
- Venue
- Nature Communications
- Published
- 2016-09-23
- Volume
- 7
- Issue
- 1
- Pages
- 12859-12859
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5036151
- OpenAlex
- W2523453502
- Cited by
- 411
- References
- 63
- Citations by year
- 2026: 27 · 2025: 30 · 2024: 43 · 2023: 34 · 2022: 58 · 2021: 55 · 2020: 46 · 2019: 42 · 2018: 43 · 2017: 29 · 2016: 3 · 2015: 1
- FWCI
- 40.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institutes of Health (HL119587, GM095467, HL132412)
- National Heart, Lung, and Blood Institute (F32HL116186, R01HL132412, R01HL127464, R00HL119587, K99HL119587, P01HL087123, R01HL075662, R01HL106173, T32HL007343)
- National Institute of General Medical Sciences (P01GM095467)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- specialized pro-resolving mediators, resolvin D1, leukotriene B4, atherosclerotic plaque instability, vulnerable plaque, inflammation resolution, carotid atherosclerosis, Ldlr-deficient mice, oxidative stress, efferocytosis, fibrous cap thickness, plaque necrosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
