The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
Open accessAbstract
TGF-βs are potent inhibitors of epithelial cell proliferation.However, in established carcinomas, autocrine/paracrine TGF-β interactions can enhance tumor cell viability and progression.Thus, we studied the effect of a soluble Fc:TGF-β type II receptor fusion protein (Fc:TβRII) on transgenic and transplantable models of breast cancer metastases.Systemic administration of Fc:TβRII did not alter primary mammary tumor latency in MMTV-Polyomavirus middle T antigen transgenic mice.However, Fc:TβRII increased apoptosis in primary tumors, while reducing tumor cell motility, intravasation, and lung metastases.These effects correlated with inhibition of Akt activity and FKHRL1 phosphorylation.Fc:TβRII also inhibited metastases from transplanted 4T1 and EMT-6 mammary tumors in syngeneic BALB/c mice.Tumor microvessel density in a mouse dorsal skin window chamber was unaffected by Fc:TβRII.Therefore, blockade of TGF-β signaling may reduce tumor cell viability and migratory potential and represents a testable therapeutic approach against metastatic carcinomas.
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TGF-β Signaling in Tumor Suppression and Cancer Progression
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Cited by
Korpal, M., Lee, E. S., Hu, G., & Kang, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800074200 · Cited by 1,645
Targeting the TGFβ signalling pathway in disease
Akhurst, R. J., & Hata, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3810 · Cited by 1,466
Strategies for MMP inhibition in cancer: innovations for the post-trial era
Overall, C. M., & López-Otín, C. (2002) · Nature Reviews Cancer · doi:10.1038/nrc884 · Cited by 1,349
Interactions between cancer stem cells and their niche govern metastatic colonization
Malanchi, I., Santamaria-Martínez, A., Susanto, E., Peng, H., Lehr, H.-A., Delaloye, J.-F., & Huelsken, J. (2012) · Nature · doi:10.1038/nature10694 · Cited by 1,339
Role of tissue stroma in cancer cell invasion
De Wever, O., & Mareel, M. (2003) · The Journal of Pathology · doi:10.1002/path.1398 · Cited by 1,042
Metadata
- Authors
- Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S., Gotwals, P. J., Koteliansky, V., & Arteaga, C. L.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-06-15
- Volume
- 109
- Issue
- 12
- Pages
- 1551-1559
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4229714030
- Cited by
- 415
- References
- 4
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S., Gotwals, P. J., Koteliansky, V., & Arteaga, C. L. (2002). Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases. Journal of Clinical Investigation. https://doi.org/10.1172/jci0215234
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