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Cited by 217Bone health and osteoporosis researchMenopause: Health Impacts and TreatmentsEstrogen and related hormone effects

THE METABOLIC EFFECTS OF STEROID HORMONES IN OSTEOPOROSIS

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Reifenstein, Edward C., Albright, Fuller·1947·Journal of Clinical Investigation
DOI 10.1172/jci101787PMC PMC435644
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Abstract

In a previous communication from this clinic (1), three metabolic studies on the effect of estradiol benzoate on the calcium and phosphorus metabolisms of patients with post-menopausal osteoporosis were published in abstract form.The first objective of the present paper is to report these studies in detail, supplemented by 2 additional studies: one in which testosterone propionate by itself, and in combination with estradiol benzoate, was used; and another in which diethylstilbestrol by itself, and in combination with progesterone, was employed.The subject of the 1 The expense of these studies was defrayed by grants from the Josiah Macy, Jr. Foundation, from the Rocke- feller Foundation, and from the National Research Coun- cil (Committee for Researchin the Problems of Sex).A bed supported by the Mallinckrodt Chemical Company on the Metabolic Ward was used for part of these studies. 2 Presented in part at the twenty-sixth annual meeting of the Association for the Study of Internal Secretions, Atlantic City, New Jersey, June 8, 1942, in connection with a symposium on "Relation of Endocrines to Skeletal Development"; an outline of this presentation may be found in: Reifenstein, E. C., Jr.; Albright, F.; Parson, W.; and Bloomberg, E.: The effect of estradiol benzoate and of testosterone propionate and of combinations of both on post-menopausal osteoporosis and senile osteo- porosis, Endocrinology, 30: S1024 (1942).Also presented in part at the first annual meeting of the Amnerican Federation for Clinical Research, Minneapolis, Minn., April 20, 1942.Preliminary reports of part of these data may be found in: Albright, F.;

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  1. Albright, F., Bloomberg, E., and Smith, P. H., Post- menopausal osteoporosis. Tr. Assoc. Am. Physi- cians, 1940, 55, 298.
  2. Albright, F., Burnett, C. H., Cope, O., and Parson, W., Acute atrophy of bone (osteoporosis) simulat- ing hyperparathyroidism. J. Clin. Endocrinol., 1941, 1, 711.
  3. Albright, F., Cushing's syndrome. Its pathological physiology, its relationship to the adrenogenital syndrome, and its connection with the problem of the reaction of the body to injurious agents ("alarm reaction" of Selye). The Harvey Lecture Series, 1942-1943, 38, 123.
  4. Reifenstein, E. C., Jr., Kinsell, L. W., and Albright, F., Observations on the use of the serum phos- phorus level as an index of pituitary growth hor- mone activity; the effect of estrogen therapy in acromegaly. Endocrinol., 1946, 39, 71. Also Con- ference on Metabolic Aspects of Convalescence In- cluding Bone and Wound Healing. Trans. of 12th Meeting, February 4-5, 1946, p. 97; distributed by Josiah Macy, Jr. Foundation, New York.
  5. Abels, J. C., and Dobriner, K., Conference on Meta- bolic Aspects of Convalescence Including Bone and Wound Healing, Transactions of Seventh Meeting, June 9-10, 1944, p. 122; distributed by Josiah Macy, Jr. Foundation, New York.
  6. Farquharson, R. F., Salter, W. T., Tibbets, D. M., and Aub, J. C., Studies of calcium and phosphorus metabolism. XII. The effect of the ingestion of acid-producing substances. J. Clin. Invest., 1931, 10, 221.
  7. Howard, J. E., Parson, W., and Bigham, R. S., Jr., Studies on fracture convalescence. III. The uri- nary excretion of calcium and phosphorus. Bull. Johns Hopkins Hosp., 1945, 77, 291.
  8. Browne, J. S. L., Conference on Metabolic Aspects of Convalescence Including Bone and Wound Heal- ing, Transactions of the Fifth Meeting, October 8-9, 1943, p. 91; distributed by Josiah Macy, Jr. Foundation, New York.
  9. Reifenstein, E. C., Jr., and Albright, F., Conferences on Metabolic Aspects of Convalescence Including Bone and Wound Healing, Transactions of the Fifth Meeting, October 8-9, 1943, p. 79; distributed by Josiah Macy, Jr. Foundation, New York.
  10. Fremont-Smith, M., Graham, R. M., Janzen, L. T., and Meigs, J. V., The vaginal smear in the diag- nosis of uterine cancer. J. Clin. Endocrinol., 1945, 5, 40.
  11. Fraser, R. W., Forbes, A. P., Albright, F., Sulko- witch, H., and Reifenstein, E. C., Jr., Colorimetric assay of 17-ketosteroids in urine; a survey of the use of this test in endocrine investigation, diagno- sis, and therapy. J. Clin. Endocrinol., 1941, 1, 234.
  12. Reifenstein, E. C., Jr., Albright, F., Parson, W., and Bloomberg, E., The effect of estradiol benzoate, of testosterone propionate, and of combinations of both on post-menopausal osteoporosis and senile osteoporosis. Endocrinol., 1942, 30, S1024.
  13. Reifenstein, E. C., Jr., and Albright, F., Conferences on Metabolic Aspects of Convalescence Including Bone and Wound Healing, Transactions of First Meeting, September 11-12, 1942, p. 37; Transac- tions of Second Meeting, December 11-12, 1942, p. 69 and 96; and Transactions of Fourth Meeting, June 11-12, 1943, p. 77; distributed by Josiah Macy, Jr. Foundation, New York.
  14. Reifenstein, E. C., Jr., and Albright, F., Conferences on Metabolic Aspects of Convalescence Including Bone and Wound Healing, Transactions of Third Meeting, March 12-13, 1943, p. 63; and Transac- tions of Fourth Meeting, June 11-12, 1943, p. 77; distributed by Josiah Macy, Jr. Foundation, New York.
  15. Reifenstein, E. C., Jr., and Albright, F., Conferences on Metabolic Aspects of Convalescence Including Bone and Wound Healing, Transactions of Fourth Meeting, June 11-12, 1943, p. 77; distributed by Josiah Macy, Jr. Foundation, New York.
  16. Albright, F., and MacMahon, H. E., Clinical Patho- logical Conference. Bull. New Eng. Med. Center, 1941, 3, 35.

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Authors
Reifenstein, E. C., & Albright, F.
Affiliations
Harvard University (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1947-01-01
Volume
26
Issue
1
Pages
24-56
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci101787
PMC
PMC435644
OpenAlex
W2097522558
Cited by
217
References
13
Citations by year
2026: 2 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 6
FWCI
39.94
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Massachusetts General Hospital
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
postmenopausal osteoporosis, senile osteoporosis, steroid hormones, estradiol benzoate, testosterone propionate, diethylstilbestrol, progesterone, calcium metabolism, phosphorus metabolism, hormone therapy
MeSH terms
Atrophy, Bone and Bones, Hormones, Humans, Metabolism, Osteoporosis

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