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Cited by 311

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Role of the Sympathetic Nervous System in Regulating Renin and Aldosterone Production in Man *

Open access
Gordon, Richard D., Küchel, Oto, Liddle, Grant W., Island, Donald P.·1967·Journal of Clinical Investigation
DOI 10.1172/jci105561
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Abstract

Several lines of evidence have been developed indicating that the sympathetic nervous system may play a role in mediating the renal and adrenocortical secretory responses to upright posture and sodium deprivation. Despite concurrent increases in arterial blood pressure, the plasma renin activity of normal subjects increased both in response to the infusion of catecholamines (norepinephrine: epinephrine, 10:1) and in response to stimulation of the sympathetic nervous system by cold. Aldosterone excretion was also increased by catecholamine infusion. In normal subjects the stimuli of upright posture and of sodium depletion both resulted in increases in urinary catecholamines, plasma renin activity, and urinary aldosterone. A patient with severe autonomic insufficiency did not experience normal elevations of urinary catecholamines, plasma renin activity, or urinary aldosterone in response to upright posture or sodium deprivation, despite a substantial fall in arterial blood pressure. When orthostatic hypotension was prevented by infusion of catecholamines, however, increases in plasma renin activity and in aldosterone excretion were observed. We suggest that both upright posture and sodium depletion lead to decreases in effective plasma volume and increases in sympathetic nervous system activity. This increase in sympathetic activity is then responsible for an increase in renal afferent arteriolar constriction, leading to an increase in renin secretion and, ultimately, an increase in aldosterone secretion.

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Metadata

Authors
Gordon, R. D., Küchel, O., Liddle, G. W., & Island, D. P.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1967-04-01
Volume
46
Issue
4
Pages
599-605
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci105561
OpenAlex
W1971348433
Cited by
311
References
18
FWCI
27.12
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Role of the Sympathetic Nervous System in Regulating Renin and Aldosterone Production in Man *. https://app.cochat.ai/papers/10.1172/jci105561
The paper
Gordon, R. D., Küchel, O., Liddle, G. W., & Island, D. P. (1967). Role of the Sympathetic Nervous System in Regulating Renin and Aldosterone Production in Man *. Journal of Clinical Investigation. https://doi.org/10.1172/jci105561

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.