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Increased thyroxine turnover and thyroidal function after stimulation of hepatocellular binding of thyroxine by phenobarbital
Open accessAbstract
Administration of phenobarbital to rats in a dosage schedule previously demonstrated to increase hepatocellular binding of thyroxine results in increased hormonal turnover, due both to increased deiodination and to fecal disposition of thyroxine iodine. The rate of biliary excretion of thyroxine iodine is roughly proportional to the hepatic content of exchangeable thyroxine. The enhanced peripheral disposition of thyroxine appears to lead to increased thyroidal function, as measured by isotopic iodine studies, and the maintenance of a normal nonradioactive serum PBI. On the other hand, thyroidectomized animals maintained on a constant replacement dose of L-thyroxine and treated with phenobarbital exhibit a marked fall in serum PBI. These findings suggest that increased thyroxine flux in phenobarbital-treated animals is secondary to primary stimulation of hepatocellular binding. Exchangeable intracellular thyroxine may thus be an important determinant of hormone turnover and, possibly, of hormonal action.
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“The effect of phenobarbital to increase T 4 and T3 metabolism has been documented in rodents (173) and humans (174,175), but effects on thyroid function are more notable in rats (172).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [173]
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ADAPTIVE INCREASES IN DRUG-METABOLIZING ENZYMES INDUCED BY PHENOBARBITAL AND OTHER DRUGS
Conney, A. H., Davison, C., Gastel, R., & Burns, J. J. (1960) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)25856-6 · Cited by 533
Proteins Associated with the Thyroid Hormones
ROBBINS, J. J., & Rall, J. E. (1960) · Physiological Reviews · doi:10.1152/physrev.1960.40.3.415 · Cited by 349
(1957) · PubMed · Cited by 198
Sterling, K., & CHODOS, R. B. (1956) · Journal of Clinical Investigation · doi:10.1172/jci103333 · Cited by 157
Gregerman, R. I., & Crowder, S. E. (1963) · Endocrinology · doi:10.1210/endo-72-3-382 · Cited by 97
Oppenheimer, J. H., Bernstein, G. S., & Hasen, J. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105577 · Cited by 91
Self-citationCavalieri, R. R., & SEARLE, G. L. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105409 · Cited by 87
Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages.
Braverman, L. W., Dawber, N. A., & Ingbar, S. H. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105434 · Cited by 74
Freinkel, N., Ingbar, S. H., Dowling, J. T., & Fine, B. R. (1957) · Journal of Clinical Investigation · doi:10.1172/jci103406 · Cited by 64
Surks, M. I., Beckwitt, H. J., & Chidsey, C. A. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-6-789 · Cited by 52
Self-citation
Cited by
Sorted by citations
Items 101–161 of 161
Roe, F. J. C. (1998) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(98)80006-7 · Cited by 11
Kato, Y., Haraguchi, K., Kubota, M., Seto, Y., Okura, T., Ikushiro, S., Koga, N., Yamada, S., & Degawa, M. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.029348 · Cited by 11
Problems in the Management of Hypothyroidism
Ladenson, P. W. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-352-1_8 · Cited by 11
Adsorption Equilibria of Thyroid Hormones in the Liver Cell
Wahl, R., Geiseler, D., & Kallee, E. (1977) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1977.tb11851.x · Cited by 11
Owen, N. V., Griffing, W. J., Hoffman, D. G., Gibson, W. R., & Anderson, R. C. (1971) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(71)80027-3 · Cited by 11
Kato, Y., Onishi, M., Haraguchi, K., Ikushiro, S., Ohta, C., Koga, N., Endo, T., Yamada, S., & Degawa, M. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.04.020 · Cited by 10
Reports of two cases of autoimmune thyroiditis while receiving anticonvulsant therapy
Nishiyama, S., Matsukura, M., Fujimoto, S., & Matsuda, I. (1983) · European Journal of Pediatrics · doi:10.1007/bf00441656 · Cited by 10
Atterwill, C. K., Poole, A., Jones, C. A., Jones, R., & Brown, C. G. (1989) · Food and Chemical Toxicology · doi:10.1016/0278-6915(89)90123-3 · Cited by 10
D’Azzò, G., Pinzello, G., Pace, F., Garofalo, P., Craxı̀, A., & Janní, A. (1985) · Journal of Endocrinological Investigation · doi:10.1007/bf03348508 · Cited by 10
BARBITURATE/THYROID-HORMONE INTERACTION
HOFFBRAND, B. I. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92717-x · Cited by 10
Mechanistic Studies on the Thyroid Toxicity Induced by Certain Drugs
Atterwill, C. K., & Brown, C. G. (1988) · Archives of toxicology. Supplement · doi:10.1007/978-3-642-73113-6_11 · Cited by 10
Thomas, G. A., & Williams, E. D. (1988) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(88)80061-2 · Cited by 10
Changes in Thyroidal Economy in Rats Bearing Transplantable Walker 256 Carcinomas*
Rosenbaum, R. L., Maturlo, S. J., & Surks, M. I. (1980) · Endocrinology · doi:10.1210/endo-106-5-1386 · Cited by 10
Self-citationPoole, A., Pritchard, D., Jones, R. B., Catto, L., & Leonard, T. B. (1990) · Archives of Toxicology · doi:10.1007/bf01977630 · Cited by 9
Vagenakis, A. G., & Braverman, L. E. (1976) · Pharmacology & Therapeutics Part C Clinical Pharmacology and Therapeutics · doi:10.1016/s0362-5486(76)80011-8 · Cited by 9
Effect of barbital on the pituitary-thyroid axis
Ching, M. (1981) · Journal of Endocrinological Investigation · doi:10.1007/bf03348300 · Cited by 9
The effect of different doses of rifampicin on thyroid hormone metabolism [proceedings]
Ee, O., & Studer, H. (1980) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1980.tb04845.x · Cited by 9
Weight-of-Biological Evidence Approach for Assessing Carcinogenicity
Burek, J. D., Patrick, D., & Gerson, R. J. (1988) · Springer eBooks · doi:10.1007/978-3-642-61364-7_11 · Cited by 8
Effects of diethofencarb on thyroid function and hepatic UDP-glucuronyltransferase activity in rats.
HOSOKAWA, S., Nakamura, J., MURAKAMI, M., INEYAMA, M., Watanabe, T., YOSHIOKA, K., Yamada, T., Seki, T., Okuno, Y., & YAMADA, H. (1992) · The Journal of Toxicological Sciences · doi:10.2131/jts.17.155 · Cited by 8
Poole, A., Jones, R. B., Pritchard, D., Catto, L., & Leonard, T. B. (1989) · Toxicology · doi:10.1016/0300-483x(89)90154-6 · Cited by 8
A possible mechanism for the decrease in serum thyroxine level by phenobarbital in rodents
Kato, Y., Suzuki, H., Haraguchi, K., Ikushiro, S., Ito, Y., Uchida, S., Yamada, S., & Degawa, M. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.09.024 · Cited by 8
Effects of Phenobarbital on Hypothalamic-Pituitary-Thyroid Axis in the Rat
Theodoropoulos, T. J., & Zolman, J. C. (1989) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198904000-00005 · Cited by 8
Thyroxine in blood and tissues.
HARLAND, W. A., & Orr, J. S. (1969) · PubMed · doi:10.1016/s0140-6736(69)92187-4 · Cited by 8
Greaves, P. (2007) · Elsevier eBooks · doi:10.1016/b978-044452771-4/50014-6 · Cited by 7
Greaves, P. (2012) · Elsevier eBooks · doi:10.1016/b978-0-444-53856-7.00013-0 · Cited by 6
Bürgi, H., & Labhart, A. (1974) · Springer eBooks · doi:10.1007/978-3-642-96158-8_6 · Cited by 6
Klaassen, C. D. (1977) · Comprehensive physiology · doi:10.1002/cphy.cp090134 · Cited by 6
Kato, Y., Onishi, M., Haraguchi, K., Ikushiro, S., Ohta, C., Koga, N., Endo, T., Yamada, S., & Degawa, M. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00440 · Cited by 5
Effects of Lersivirine on Canine and Rodent Thyroid Function
Houle, C. D., Finch, G. L., Mauthe, R. J., Potter, D. M., Walisser, J. A., Gardner, I. B., & DeWit, R. H. (2013) · Toxicologic Pathology · doi:10.1177/0192623313503516 · Cited by 5
Changes in Thyroid Function Tests During Phenobarbital Treatment in Late Pregnancy
Luoma, P. V., Heikkinen, J. E., & Ylöstalo, P. (1980) · International Journal of Gynecology & Obstetrics · doi:10.1002/j.1879-3479.1980.tb00188.x · Cited by 5
Serum triiodothyronine concentration in the iodine‐deficient rat
VOLPERT, E. M., & Werner, S. C. (1972) · American Journal of Anatomy · doi:10.1002/aja.1001350206 · Cited by 4
Bossens, K., Daminet, S., Duchateau, L., Rick, M., Ham, L. V., & Bhatti, S. F. M. (2016) · The Veterinary Journal · doi:10.1016/j.tvjl.2016.03.008 · Cited by 4
Perret, G. Y., Yin, Y., Nicolas, P., Vassy, R., Uzzan, B., & Louchahi, M. (1991) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1991.tb00747.x · Cited by 4
Kato, Y., Tamaki, S., Haraguchi, K., Ikushiro, S., Sekimoto, M., Ohta, C., Endo, T., Koga, N., Yamada, S., & Degawa, M. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.07.004 · Cited by 4
Recent Advances in the Biochemistry of Thyroid Regulation
Leeper, R. D. (1969) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)60262-0 · Cited by 3
Brown, C. G., Lee, D. M., Jones, C. A., & Atterwill, C. K. (1988) · Archives of toxicology. Supplement · doi:10.1007/978-3-642-73113-6_12 · Cited by 4
in Patients with Hepatic Cirrhosis
Chambers, J. B., & Buck, M. W. (1975) · Cited by 4
The Role of Thyroxine Binding in the Establishment of Thyroid Status
HARLAND, W. A., & Orr, J. S. (1969) · Scottish Medical Journal · doi:10.1177/003693306901401102 · Cited by 4
Bürgi, H., Labhart, A., Hedinger, C. E., Kistler, G., & Prader, A. (1978) · Springer eBooks · doi:10.1007/978-3-662-08098-6_6 · Cited by 4
BILIARY EXCRETION OF XENOBIOTICS
Klaassen, C. D. (1981) · Elsevier eBooks · doi:10.1016/b978-0-08-027350-1.50041-4 · Cited by 3
The in vitro Deiodination of Thyroxine and Triiodothyronine
SAKURADA, T., Suzuki, Y., SAITO, S., & TORIKAT, T. (1973) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.110.225 · Cited by 3
Boado, R. J., Ulloa, E., & Zaninovich, Á. A. (1982) · Journal of Endocrinological Investigation · doi:10.1007/bf03348326 · Cited by 3
Thyroxine in Blood and Tissues
(1969) · The Lancet · doi:10.1016/s0140-6736(69)91866-2 · Cited by 3
Aylward, S., Walker, T., & Atterwill, C. K. (1994) · Toxicology in Vitro · doi:10.1016/0887-2333(94)90151-1 · Cited by 2
Thyroid hypertrophic effect of semotiadil fumarate, a new calcium antagonist, in rats.
TSUCHIYA, Y., Ohno, H., Satoh, H., SUGAWARA, T., Kajimura, T., & Nomura, M. (2000) · The Journal of Toxicological Sciences · doi:10.2131/jts.25.121 · Cited by 1
Greaves, P. (2000) · Elsevier eBooks · doi:10.1016/b978-044450514-9/50012-7 · Cited by 1
Influence of Drugs on Thyroid Function Tests
Ananthakrishnan, S., & Pearce, E. N. (2010) · Endocrine updates · doi:10.1007/978-1-4419-1485-9_13 · Cited by 1
Nakamura, Y., Bellamy, G., & GREEN, W. (1981) · Endocrinology · doi:10.1210/endo-108-4-1519 · Cited by 1
Grossman, S. J. (1990) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(90)90028-j · Cited by 1
Endocrine Mechanisms in Tolerance to and Dependence on Alcohol
Cicero, T. J. (1983) · Springer eBooks · doi:10.1007/978-1-4613-3518-4_9 · Cited by 1
Gopinath, C. (1992) · Archives of toxicology. Supplement · doi:10.1007/978-3-642-77260-3_26 · Cited by 1
Katz, Y. S., Amir, Z., Pick, C. G., Weizman, R., Yana, J., & Gavish, M. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90492-8
The Effect of Iopanoic Acid on Thyrotropin Secretion in Patients with Cirrhosis of the Liver.
Tajiri, J., Naomi, S., Hamasaki, S.-I., MORITA, M., Higashi, K., & Sato, T. (1987) · Endocrinologia Japonica · doi:10.1507/endocrj1954.34.531
Evaluation of the effects of clomipramine on the canine hypothalamic-pituitary-thyroid axis
Gulikers, K. P. (2002) · VTechWorks (Virginia Tech)
Shimo, T., Saito, A., Aoki, Y., Mitsumori, K., Onodera, H., Takahashi, M., Takahashi, M., & Ueno, Y. (1995) · Journal of Toxicologic Pathology · doi:10.1293/tox.8.417
Takegawa, K., Mitsumori, K., Onodera, H., Shimo, T., Yasuhara, K., Takahashi, M., Mutai, M., Takahashi, M., Yanai, T., & Masegi, T. (1997) · Journal of Toxicologic Pathology · doi:10.1293/tox.10.91
Serum Thyroid Hormone Levels in Liver Diseases with Special
Yamanaka, T., Kenichi, I. D. O., Kimura, K., Saitoh, T., & 永井, 総. (1978) · Kanzo · doi:10.2957/kanzo.19.951
Thyroid Growth Immunoglobulins in Non-Toxic Goitre: A Comparison of Methods
Miller, H. (1999) · Enlighten: Theses (The University of Glasgow)
(2022) · American Registry of PathologyArlington, Virginia eBooks · doi:10.55418/9781933477251-3
Klaassen, C. D. (1997) · Comprehensive physiology · doi:10.1002/j.2040-4603.1997.tb01643.x
Problems in the Management of Hypothyroidism
Ocampo, E. L., & Surks, M. I. (1997) · doi:10.1007/978-1-4757-2594-0_9
Self-citation
Metadata
- Authors
- Oppenheimer, J. H., Bernstein, G., & Surks, M. I.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1968-06-01
- Volume
- 47
- Issue
- 6
- Pages
- 1399-1406
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC297295
- OpenAlex
- W2054942726
- Cited by
- 161
- References
- 22
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- phenobarbital, thyroxine, deiodination, biliary excretion, iodine, thyroid function, thyroidectomy, thyroxine replacement
- MeSH terms
- Animals, Bile, Blood Proteins, Chlordan, Iodine, Iodine Radioisotopes, Kidney, Liver, Male, Phenobarbital, Protein Binding, Thyroid Gland, Thyroidectomy, Thyroxine, Rats
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