The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Liver and kidney metabolism during prolonged starvation
Open accessAbstract
This study quantifies the concentrations of circulating insulin, growth hormone, glucose, free fatty acids, glycerol, beta-hydroxybutyrate, acetoacetate, and alpha amino nitrogen in 11 obese subjects during prolonged starvation. The sites and estimated rates of gluconeogenesis and ketogenesis after 5-6 wk of fasting were investigated in five of the subjects. Blood glucose and insulin concentrations fell acutely during the 1st 3 days of fasting, and alpha amino nitrogen after 17 days. The concentration of free fatty acids, beta-hydroxybutyrate, and acetoacetate did not reach a plateau until after 17 days. Estimated glucose production at 5-6 wk of starvation is reduced to approximately 86 g/24 hr. Of this amount the liver contributes about one-half and the kidney the remainder. Approximately all of the lactate, pyruvate, glycerol, and amino acid carbons which are removed by liver and kidney are converted into glucose, as evidenced by substrate balances across these organs.
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Cites
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
Self-citationBagdade, J. D., Bierman, E. L., & Porte, D. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105646 · Cited by 672
Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay
Karam, J. H., Grodsky, G. M., Forsham, P. H., & McWilliams, N. B. (1963) · Diabetes · doi:10.2337/diab.12.3.197 · Cited by 591
Cited by
The key role of anaplerosis and cataplerosis for citric acid cycle function
Owen, O. E., Kalhan, S. C., & Hanson, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200006200 · Cited by 1,172
Nakae, J., Kitamura, T., Silver, D. L., & Accili, D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112876 · Cited by 652
Glucose metabolism during leg exercise in man
Wahren, J., Felig, P., Ahlborg, G., & Jorfeldt, L. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106772 · Cited by 598
Self-citationQuantitation of Hepatic Glycogenolysis And Gluconeogenesis in Fasting Humans With 13 C NMR
Rothman, D. L., Magnusson, I., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1991) · Science · doi:10.1126/science.1948033 · Cited by 546
Ho, K. Y., Veldhuis, J. D., Johnson, M. L., Furlanetto, R., Evans, W. S., Alberti, K. G., & Thorner, M. O. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113450 · Cited by 503
Metadata
- Authors
- Owen, O. E., Felig, P., Morgan, A. P., Wahren, J., & Cahill, G. F.
- Venue
- Journal of Clinical Investigation
- Published
- 1969-03-01
- Volume
- 48
- Issue
- 3
- Pages
- 574-583
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2025481353
- Cited by
- 865
- References
- 3
- FWCI
- 39.38
- Type
- journal article
- Language
- en
- Open access
- green
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