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Cited by 865

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Liver and kidney metabolism during prolonged starvation

Open access
Owen, Oliver E., Felig, Philip, Morgan, Alfred P., Wahren, John, Cahill, George F.·1969·Journal of Clinical Investigation
DOI 10.1172/jci106016
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Abstract

This study quantifies the concentrations of circulating insulin, growth hormone, glucose, free fatty acids, glycerol, beta-hydroxybutyrate, acetoacetate, and alpha amino nitrogen in 11 obese subjects during prolonged starvation. The sites and estimated rates of gluconeogenesis and ketogenesis after 5-6 wk of fasting were investigated in five of the subjects. Blood glucose and insulin concentrations fell acutely during the 1st 3 days of fasting, and alpha amino nitrogen after 17 days. The concentration of free fatty acids, beta-hydroxybutyrate, and acetoacetate did not reach a plateau until after 17 days. Estimated glucose production at 5-6 wk of starvation is reduced to approximately 86 g/24 hr. Of this amount the liver contributes about one-half and the kidney the remainder. Approximately all of the lactate, pyruvate, glycerol, and amino acid carbons which are removed by liver and kidney are converted into glucose, as evidenced by substrate balances across these organs.

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Metadata

Authors
Owen, O. E., Felig, P., Morgan, A. P., Wahren, J., & Cahill, G. F.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1969-03-01
Volume
48
Issue
3
Pages
574-583
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci106016
OpenAlex
W2025481353
Cited by
865
References
3
FWCI
39.38
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.