The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Glucagon levels and metabolic effects in fasting man
Open accessAbstract
The role of glucagon in the metabolic adaptation to prolonged fasting in man has been examined. Plasma immunoreactive glucagon was determined during 6-wk fasts and during infusion of exogenous glucagon using an assay which minimized nonpancreatic immunoreactivity. Plasma glucagon concentrations rose twofold to a peak on the 3rd day of fasting and then declined thereafter to a level maintained at or above postabsorptive. Insulin concentration declined to a plateau by the 3rd day. Thus a persisting altered relationship of glucagon and insulin concentrations characterized the fasted state. A synergism of low insulin and relative or absolute elevation of glucagon levels is viewed as a hormonal mechanism controlling the rate of hepatic substrate extraction for gluconeogenesis. Glucagon was infused systemically into 4-6 wk fasted subjects at three dose levels. A marked sensitivity of individual plasma free amino acids to the induced elevations of plasma glucagon within the physiologic range was demonstrated. At higher concentrations, equivalent to those present in the portal vein, stimulation of hepatic gluconeogenesis occurred, and the effects on glucose, insulin, and growth hormone levels and on ketone metabolism were induced.
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Cites
Statistical methods: Applied to experiments in agriculture and biology (4th ed.).
Snedecor, G. W. (1950) · Iowa State University Press eBooks · doi:10.1037/13268-000 · Cited by 1,523
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
Self-citationLiver and kidney metabolism during prolonged starvation
Owen, O. E., Felig, P., Morgan, A. P., Wahren, J., & Cahill, G. F. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106016 · Cited by 865
Self-citationStudies of pancreatic alpha cell function in normal and diabetic subjects
Unger, R. H., Aguilar-Parada, E., Müller, W. A., & Eisentraut, A. M. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106297 · Cited by 837
Self-citationPlasma Amino Acid Levels and Insulin Secretion in Obesity
Felig, P., Marliss, E., & Cahill, G. F. (1969) · New England Journal of Medicine · doi:10.1056/nejm196910092811503 · Cited by 812
Self-citationAmino acid metabolism during prolonged starvation
Felig, P., Owen, O. E., Wahren, J., & Cahill, G. F. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106017 · Cited by 722
Self-citationAlanine: Key Role in Gluconeogenesis
Felig, P., Pozefsk, T., Marlis, E., & Cahill, G. F. (1970) · Science · doi:10.1126/science.167.3920.1003 · Cited by 595
Self-citationBenedict, F. G., Goodall, H. W., Ash, J. E., Langfeld, H. S., Kendall, A. I., & Higgins, H. L. (1915) · Carnegie Institution of Washington eBooks · doi:10.5962/t.174877 · Cited by 451
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Self-citationTHE EFFECTS OF TOTAL STARVATION UPON THE LEVELS OF CIRCULATING GLUCAGON AND INSULIN IN MAN*
Unger, R. H., Eisentraut, A. M., & Madison, L. L. (1963) · Journal of Clinical Investigation · doi:10.1172/jci104788 · Cited by 345
Self-citation
Cited by
Substrate Turnover during Prolonged Exercise in Man
Ahlborg, G., Felig, P., Hagenfeldt, L., Hendler, R., & Wahren, J. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107645 · Cited by 786
Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904187106 · Cited by 704
Mallinson, C. N., Bloom, S. R., Warin, A. P., Salmon, P. R., & Cox, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91343-9 · Cited by 505
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
Liu, Y., Dentin, R., Chen, D., Hedrick, S., Ravnskjaer, K., Schenk, S., Milne, J., Meyers, D. J., Cole, P., III, J. Y., et al. (2008) · Nature · doi:10.1038/nature07349 · Cited by 484
Effects of intermittent fasting on body composition and clinical health markers in humans
Tinsley, G. M., & La Bounty, P. M. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv041 · Cited by 382
Metadata
- Authors
- Marliss, E. B., Aoki, T. T., Unger, R. H., Soeldner, J. S., & Cahill, G. F.
- Venue
- Journal of Clinical Investigation
- Published
- 1970-12-01
- Volume
- 49
- Issue
- 12
- Pages
- 2256-2270
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2113530540
- Cited by
- 339
- References
- 32
- FWCI
- 44.29
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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