Cited by 787Electrolyte and hormonal disordersNeuroendocrine regulation and behaviorClinical Laboratory Practices and Quality Control

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Development and Clinical Application of a New Method for the Radioimmunoassay of Arginine Vasopressin in Human Plasma

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Robertson, Gary L., Mahr, Ermelinda A., Athar, Shahid, Sinha, Tushar·1973·Journal of Clinical Investigation

DOI 10.1172/jci107423PMC PMC333039

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Abstract

A radioimmunoassay has been developed that permits reliable measurements of plasma arginine vasopressin (AVP) at concentrations as low as 0.5 pg/ml in sample volumes of 1 ml or less. Nonhormonal immunoreactivity associated with the plasma proteins is eliminated by acetone precipitation before assay, leaving unaltered a component that is immunologically and chromatographically indistinguishable from standard AVP. Storage of plasma results in a decline in AVP concentration and, thus, must be carefully regulated. The plasma AVP values obtained by our method approximate the anticipated levels and vary in accordance with physiologic expections. In recumbent normal subjects, plasma AVP ranged from (mean +/-SD) 5.4+/-3.4 pg/ml after fluid deprivation to 1.4+/-0.8 pg/ml after water loading, and correlated significantly with both plasma osmolality (r=0.52; P<0.001) and urine osmolality (r=0.77; P<0.001). After fluid restriction, plasma AVP was uniformly normal relative to plasma osmolality in patients with nephrogenic diabetes insipidus and primary polydipsia but was distinctly subnormal in all patients with pituitary diabetes insipidus. The infusion of physiologic amounts of posterior pituitary extract caused a dose-related rise in plasma vasopressin that afterwards declined at the expected rate (t(1/2)=22.5+/-4 min). We conclude that, when used appropriately, our radioimmunoassay method provides a useful way of assessing AVP function in man.

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Use of Polyethylene Glycol to Separate Free and Antibody-Bound Peptide Hormones in Radioimmunoassays†
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The regulation of antidiuretic hormone release in man
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A Radioimmunoassay for Parathyroid Hormone in Man
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Authors: Robertson, G. L., Mahr, E. A., Athar, S., & Sinha, T.
Affiliations: Larue Carter Hospital (US)
ORCID: Robertson, Gary L.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1973-09-01
Volume: 52
Issue: 9
Pages: 2340-2352
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci107423
PMC: PMC333039
OpenAlex: W1984984454
Cited by: 787
References: 26
Citations by year: 2026: 7 · 2025: 10 · 2024: 15 · 2023: 11 · 2022: 17 · 2021: 11 · 2020: 13 · 2019: 10 · 2018: 13 · 2017: 14 · 2016: 25 · 2015: 14 · 2014: 18 · 2013: 11 · 2012: 15
FWCI: 23.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Keywords: vasopressin, radioimmunoassay, acetone precipitation, plasma osmolality, urine osmolality, fluid deprivation, water loading, nephrogenic diabetes insipidus, primary polydipsia, posterior pituitary extract
MeSH terms: Acetone, Antibodies, Antigen-Antibody Reactions, Arginine, Blood Preservation, Blood Pressure, Chromatography, Gel, Chromatography, Ion Exchange, Cross Reactions, Diabetes Insipidus, Diuresis, Humans, Iodine Isotopes, Lysine, Methods, Osmolar Concentration, Oxytocin, Pituitary Hormones, Posterior, Radioimmunoassay, Trimethoprim, Urine, Vasopressins, Vasotocin

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Development and Clinical Application of a New Method for the Radioimmunoassay of Arginine Vasopressin in Human Plasma

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