CoChat
Sign Up
Cited by 155Electrolyte and hormonal disordersThermoregulation and physiological responsesIon Transport and Channel Regulation

The regulation of antidiuretic hormone release in man

Open access
Segar, William E., Moore, Ward W.·1968·Journal of Clinical Investigation
DOI 10.1172/jci105900PMC PMC297375
Open this paper in CoChat — free accountOpen PDF

Abstract

It has been postulated that alterations in the intravascular distribution of blood affect antidiuretic hormone (ADH) secretion in man. The studies reported here were designed to alter blood distribution by thermal and by positional change to test this thesis.HUMAN BLOOD ADH LEVELS HAVE BEEN SHOWN TO VARY WITH POSITION: a mean value of 0.4 +/- 0.6 (SD) muU/ml was obtained while the subject was supine, a value of 1.4 +/- 0.7 muU/ml while sitting, and 3.1 +/- 1.5 muU/ml while standing. In 79 control subjects, sitting comfortably for 30 min in a normal environment, a blood ADH level of 1.65 +/- 0.63 muU/ml was found. It is suggested that subjects assume this position during experiments in which blood is drawn for measurement of ADH levels.In eight seated subjects the ADH level rose from 1.6 +/- 0.4 to 5.2 +/- 0.8 muU/ml after a 2 hr exposure at 50 degrees C and fell to 1.0 +/- 0.26 muU/ml within 15 min at 26 degrees C.Six subjects with a mean ADH level of 2.2 +/- 0.58 muU/ml sat quietly in the cold (13 degrees C) for 1 hr, and the ADH level fell to 1.2 +/- 0.36 muU/ml. After 15 min at 26 degrees C, the level rose to 3.1 +/- 0.78 muU/ml. The serum sodium and osmolal concentrations remained constant during all studies.Water, sodium, and total solute excretion decreased during exposure to the heat, whereas the urine to plasma (U/P) osmolal ratio increased. During cold exposure, water, sodium, and total solute excretion increased, and there was a decrease in the U/P osmolal ratio.These data are interpreted as indicating that changes in activity of intrathoracic stretch receptors, in response to redistribution of blood, alter ADH secretion independently of changes in serum osmolality. The rapidity of change of blood ADH concentration indicates a great sensitivity and a prime functional role for the "volume receptors" in the regulation of ADH secretion.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci105900

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Moore, W. W., W. E. Segar, J. A. Johnson, and J. E. Zehr. 1967. Blood ADH levels in hydrated humans during infusion of hypertonic saline. Federation Proc. 26: 256. (Abstr.)
  2. Moore, W. W., W. E. Segar, J. A. Johnson, and J. E. Zehr. 1967. Blood ADH levels in hydrated humans during infusion of hypertonic saline. Federa- tion Proc. 26: 256. (Abstr.)

Cited by

Sorted by citations

Related

Authors
Segar, W. E., & Moore, W. W.
Affiliations
  • Indiana University Indianapolis (US)
  • Rockefeller Foundation (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1968-09-01
Volume
47
Issue
9
Pages
2143-2151
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci105900
PMC
PMC297375
OpenAlex
W154707947
Cited by
155
References
30
Citations by year
2026: 2 · 2025: 1 · 2023: 1 · 2021: 2 · 2020: 3 · 2019: 7 · 2018: 3 · 2016: 6 · 2014: 2 · 2013: 3 · 2012: 4
FWCI
10.16
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
vasopressin release, blood volume regulation, position change, heat exposure, cold exposure, volume receptors, serum osmolality, urine osmolality, thermoregulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review