Immunoassay of plasma vasopressin in man
Open accessAbstract
A radioimmunoassay for arginine vasopressin has been developed that is sensitive to the hormone at 1 pg/ml. When plasma was filtered on G-25 Sephadex, immunoreactivity was detected in three regions. Endogenous arginine vasopressin was the third and smallest of the peaks and was recovered just after the salt. By combining gel filtration with immunoassay, we have made precise measurements of arginine vasopressin in a few milliliters of plasma.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Born et al. achieved plasma vasopressin of 20 pg/ml after 40 IU intranasal, higher than Robertson et al. reported for any patient, including those with pathologically elevated vasopressin; maximal urine concentrating ability in humans occurs at about 5 pg/ml.
“Born et al. achieved plasma concentrations of 20pg/ml after giving 40IU vasopressin (17).These are higher than Robertson et al. reported for any patient, including those with pathologically elevated vasopressin secretion; in man, maximal urine concentrating ability is achieved at a vasopressin concentration of ~5pg/ml (33).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [33]
Robertson et al. found that two vasopressin radioimmunoassays on unextracted plasma yielded values at least two orders of magnitude higher than those inferred from other evidence, and these values did not fluctuate in parallel with endogenous authentic vasopressin.
“Robertson et al. showed that two radioimmunoassays for vasopressin yielded measurements in unextracted plasma that were at least two orders of magnitude greater than those inferred from other evidence, and which did not fluctuate in parallel with endogenous authentic vasopressin (33,58).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [33]
High molecular weight factors in raw plasma interfere with the binding of antibodies to oxytocin and vasopressin, leading to high and erroneous readings.
“high molecular weight factors in raw plasma interfered with the binding of antibodies to the hormones, leading to high and erroneous readings”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [78]
Like the first radioimmunoassays of unextracted plasma, using an enzyme-linked immunoassay to measure plasma levels without extracting samples generates impossibly high and wholly erroneous measurements.
“Like the first radioimmunassays of unextracted plasma, this generates impossibly high and wholly erroneous measurements.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [78]
Robertson et al. resolved three peaks of immunoreactivity by filtering plasma on G-25 Sephadex; only the third and smallest was consistent with true vasopressin, being recovered in the same location as pure vasopressin.
“By filtering plasma samples on G‐25 Sephadex, they resolved three peaks of ‘immunoreactivity’, only the third and smallest of which was consistent with true vasopressin, being recovered in the same location as pure vasopressin 78.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [78]
The third peak reproduced the expected relationship with plasma osmotic pressure in normal adults, the expected high levels in nephrogenic diabetes insipidus, and the expected low levels in pituitary diabetes insipidus.
“The immunoreactivity in the third peak reproduced the expected relationship with plasma osmotic pressure in normal adults, the expected high levels in nephrogenic diabetes insipidus”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [78]
For peptide assays, interference mainly comes from plasma proteins that bind to the primary antibody, impairing its ability to bind hormone, leading to an excess of free label that is erroneously measured as a high concentration of hormone.
“For peptide assays, interference mainly comes from plasma proteins that bind to the primary antibody, impairing its ability to bind hormone, leading to an excess of free label that is erroneously measured as a high concentration of hormone 78 (Fig. 1).”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [78]
After accounting for plasma matrix interference, Robertson et al. calculated that normal plasma concentrations of vasopressin in man were approximately 1 pg/ml, increasing to approximately 10 pg/ml with dehydration.
“After accounting for the plasma matrix interference, Robertson et al. 78 calculated that normal plasma concentrations of vasopressin in man were approximately 1 pg/ml, increasing to approximately 10 pg/ml with dehydration.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [78]
The first peak accounted for a 67% loss of binding of antibody to vasopressin, and the second peak accounted for a further 30% loss; neither apparent immunoreactivity was displaced by excess cold vasopressin, indicating occlusion of antibody recognition rather than competitive binding.
“The first peak accounted for a 67% loss of binding of antibody to vasopressin, and the second peak accounted for a further 30% loss. Neither of these apparent ‘immunoreactivities’ were displaced by an excess of cold vasopressin, indicating that they did not involve competitive binding of vasopressin, but occlusion of antibody recognition of vasopressin.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [78]
In 1970, Robertson et al. described one of the first radioimmunoassays to measure plasma vasopressin in man; it was sensitive to 1 pg/ml (0.3 mU/ml) but when whole plasma was assayed, apparent concentrations were several hundredfold higher than anticipated, failed to fluctuate appropriately in response to physiological manipulation or disease states, and were not reduced substantially by dialysis.
“This assay was sensitive to 1 pg/ml (0.3 mU/ml) but, when whole plasma was assayed, apparent concentrations were ‘several hundredfold higher than anticipated, failed to fluctuate appropriately in response to physiological manipulation or in disease states, and were not reduced substantially by dialysis of the plasma under conditions that completely removed vasopressin’.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [78]
Analytical verification by HPLC with chromatographic separation can confirm that measurements reflect the actual peptide, although care is needed to ensure that all high molecular weight proteins are eluted from the column and are checked for assay interference; there should be quantitative agreement between the amount of hormone in the appropriate fraction and the level reported by the assay.
“Analytical verification by HPLC with chromatographic separation 78 can confirm that measurements reflect the actual peptide, although care is needed to ensure that all high molecular weight proteins are eluted from the column and are checked for assay interference. There should be quantitative agreement between the amount of hormone in the appropriate fraction, and the level reported by the assay.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [78]
Cites
Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
Hunter, W. M., & Greenwood, F. C. (1962) · Nature · doi:10.1038/194495a0 · Cited by 6,945 · see citing works
Adsporption phenomena on sephadex®
Janson, J. (1967) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)85920-3 · Cited by 197 · see citing works
"Big insulin": a new component of plasma insulin detected by immunoassay.
Roth, J., Görden, P., & Pastan, I. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.61.1.138 · Cited by 147 · see citing works
Melani, F., Rubenstein, A. H., & Steiner, D. F. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106259 · Cited by 104 · see citing works
Vasopressin, its bioassay and the physiological control of its release
Share, L. (1967) · The American Journal of Medicine · doi:10.1016/0002-9343(67)90090-3 · Cited by 90 · see citing works
The purification of synthetic oxytocin and analogues by gel filtration on Sephadex G-15
Manning, M., Wuu, T.-C., & Baxter, J. W. M. (1968) · Journal of Chromatography A · doi:10.1016/0021-9673(68)85065-4 · Cited by 78 · see citing works
Purification of Oxytocin and Vasopressin by Way of a Protein Complex
Acher, R., Light, A., & du Vigneaud, V. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68038-5 · Cited by 74 · see citing works
Roth, J., Glick, S. M., Klein, L. A., & Petersen, M. J. (1966) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-26-6-671 · Cited by 74 · see citing works
Inappropriate vasopressin secretion and carcinoma of the pancreas
Marks, L. J., Berde, B., Klein, L. A., Roth, J., Goonan, S. R., Blumen, D., & Nabseth, D. C. (1968) · The American Journal of Medicine · doi:10.1016/0002-9343(68)90196-4 · Cited by 55 · see citing works
Wu, W.-H., & Rockey, J. H. (1969) · Biochemistry · doi:10.1021/bi00835a005 · Cited by 40 · see citing works
[Changes of renal function in conditioned reflex polyuria to mercurial diuretics].
HELLER, J., & STULC, J. (1959) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Robertson, G. L., Mahr, E. A., Athar, S., & Sinha, T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107423 · Cited by 787 · see citing works
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · see citing works
The osmoregulation of vasopressin
Robertson, G. L., Shelton, R. L., & Athar, S. (1976) · Kidney International · doi:10.1038/ki.1976.76 · Cited by 524 · see citing works
The Regulation of Vasopressin Function in Health and Disease
Robertson, G. L. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-571133-3.50015-5 · Cited by 375 · see citing works
Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers
Leng, G., & Sabatier, N. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12413 · Cited by 237 · see citing works
“After accounting for the plasma matrix interference, Robertson et al. (78) calculated that normal plasma concentrations of vasopressin in man were approximately 1 pg/ml, increasing to approximately 10 pg/ml with dehydration.”
BackgroundMethodInfluentialDistribution, blood transport, and degradation of antidiuretic hormone in man.
Baumann, G., & Dingman, J. F. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108377 · Cited by 172 · see citing works
OSMOREGULATION OF VASOPRESSIN SECRETION AND THIRST IN HEALTH AND DISEASE
Baylis, P. H., & Thompson, C. J. (1988) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1988.tb03704.x · Cited by 146 · see citing works
A new extraction of arginine vasopressin from blood: The use of octadecasilyl-silica
Larochelle, F. T., North, W. G., & Stern, P. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00580849 · Cited by 145 · see citing works
Gray, D. A., & Simón, E. (1983) · Journal of Comparative Physiology B · doi:10.1007/bf00689924 · Cited by 133 · see citing works
Vincristine Neurotoxicity and Abnormal Secretion of Antidiuretic Hormone
Robertson, G. L. (1973) · Archives of Internal Medicine · doi:10.1001/archinte.1973.03650110061013 · Cited by 127 · see citing works
Physiological Roles of Peptides in the Nervous System
Barker, J. L. (1977) · Springer eBooks · doi:10.1007/978-1-4613-4130-7_11 · Cited by 117 · see citing works
Clinical disorders of water metabolism
Berl, T., Anderson, R. J., McDonald, K. M., & Schrier, R. W. (1976) · Kidney International · doi:10.1038/ki.1976.83 · Cited by 106 · see citing works
Radioimmunoassay of Vasopressin in Unextracted Plasma
Fyhrquist, F., Wallenius, M., & Hollemans, H. J. G. (1976) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517609081947 · Cited by 102 · see citing works
Role of plasma vasopressin in the impairment of water excretion in nephrotic syndrome
Usberti, M., Federico, S., Meccariello, S., Cianciaruso, B., Balletta, M., Pecoraro, C., Saccà, L., Ungaro, B., Pisanti, N., & Andreucci, V. E. (1984) · Kidney International · doi:10.1038/ki.1984.34 · Cited by 85 · see citing works
Diabetes Insipidus: Celebrating a Century of Vasopressin Therapy
Qureshi, S., Galiveeti, S., Bichet, D. G., & Roth, J. (2014) · Endocrinology · doi:10.1210/en.2014-1385 · Cited by 62 · see citing works
The syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
Bartter, F. C. (1973) · Disease-a-Month · doi:10.1016/s0011-5029(73)80002-1 · Cited by 62 · see citing works
Arginine Vasopressin in the Testis: An Intragonadal Peptide Control System*
Kasson, B. G., Adashi, E. Y., & Hsueh, A. J. W. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-2-156 · Cited by 58 · see citing works
Antibodies to Small Molecules: Biological and Clinical Applications
Butler, V. P., & Beiser, S. M. (1973) · Advances in immunology · doi:10.1016/s0065-2776(08)60734-8 · Cited by 56 · see citing works
THE DEVELOPMENT OF A RADIOIMMUNOASSAY FOR THE MEASUREMENT OF HUMAN PLASMA ARGININE VASOPRESSIN
BAYLIS, P. H., & HEATH, D. A. (1977) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1977.tb01300.x · Cited by 51 · see citing works
Oppong‐Damoah, A., Zaman, R. U., D’Souza, M. J., & Murnane, K. S. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.12.011 · Cited by 49 · see citing works
M�hring, J., Schoun, J., Simon-Oppermann, C., & Simón, E. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584258 · Cited by 47 · see citing works
Chiodera, P., Louis, F., & Legros, J. J. (1984) · Journal of Endocrinological Investigation · doi:10.1007/bf03351004 · Cited by 40 · see citing works
Radioimmunoassay of 8-arginine-vasopressin (antidiuretic hormone) in human plasma
HAMMER, M. (1978) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365517809104877 · Cited by 40 · see citing works
Sawyer, W. H., Deyrup‐Olsen, I., & Martin, A. W. (1984) · General and Comparative Endocrinology · doi:10.1016/0016-6480(84)90204-1 · Cited by 37 · see citing works
Koike, T. I., Neldon, H. L., McKay, D., & Rayford, P. L. (1986) · General and Comparative Endocrinology · doi:10.1016/0016-6480(86)90186-3 · Cited by 36 · see citing works
The Handling of Immunoreactive Vasopressin by the Isolated Perfused Rat Kidney
Rabkin, R., Share, L., Payne, P. A., YOUNG, J., & Crofton, J. T. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109279 · Cited by 31 · see citing works
Inappropriate secretion of antidiuretic hormone in a premature infant
Weinberg, J. A., Weitzman, R. E., Zakauddin, S., & Leake, R. D. (1977) · The Journal of Pediatrics · doi:10.1016/s0022-3476(77)80782-8 · Cited by 31 · see citing works
Hyperuricemia, a Concomitant of Congenital Vasopressin-Resistant Diabetes Insipidus in the Adult
Görden, P., Robertson, G. L., & Seegmiller, J. E. (1971) · New England Journal of Medicine · doi:10.1056/nejm197105132841903 · Cited by 30 · see citing works
Radioimmunoassay of urinary antidiuretic hormone in man: Stimulation–suppression tests
Fressinaud, P., Corvol, P. L., Ménard, J., & Allegrini, J. (1974) · Kidney International · doi:10.1038/ki.1974.97 · Cited by 27 · see citing works
Bisset, G. W. (1976) · doi:10.1007/978-1-349-02718-7_9 · Cited by 27 · see citing works
Diseases of the hypothalamus and pituitary gland
Edwards, C. R. W., & BESSER, G. M. (1974) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(74)80037-x · Cited by 26 · see citing works
Bichet, D. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804169-7.00008-8 · Cited by 25 · see citing works
INFLUENCE OF LOWER BODY NEGATIVE PRESSURE UPON ARGININE VASOPRESSIN RELEASE
Baylis, P. H., STOCKLEY, R. A., & Heath, D. A. (1978) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1978.tb03576.x · Cited by 24 · see citing works
Radioimmunoassay of posterior pituitary peptides: A review
ROBINSON, A. G., & FRANTZ, A. G. (1973) · Metabolism · doi:10.1016/0026-0495(73)90224-2 · Cited by 24 · see citing works
Hays, R. M., & Levine, S. D. (1974) · Kidney International · doi:10.1038/ki.1974.116 · Cited by 24 · see citing works
Novel and sensitive noncompetitive (two-site) immunoassay for haptens with emphasis on peptides
Ishikawa, E., Tanaka, K., & Hashida, S. (1990) · Clinical Biochemistry · doi:10.1016/0009-9120(90)90238-p · Cited by 21 · see citing works
Vasopressin and oxytocin in health and disease
Edwards, C. R. W. (1977) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(77)80065-0 · Cited by 20 · see citing works
Simple and rapid radioimmunoassay for the routine determination of vasopressin in plasma
Larose, P., Ong, H., & du Souich, P. (1985) · Clinical Biochemistry · doi:10.1016/s0009-9120(85)80075-8 · Cited by 19 · see citing works
El‐Nouty, F. D., Elbanna, I. M., & Johnson, H. D. (1978) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(78)83577-2 · Cited by 17 · see citing works
Radioimmunoassay of Polypeptide Hormones and Enzymes
Felber, J. P. (1974) · Methods of biochemical analysis · doi:10.1002/9780470110423.ch1 · Cited by 17 · see citing works
Beke, E., Gondran, C., Chovelon, B., Peyrin, É., Holzinger, M., & Ravelet, C. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.117306 · Cited by 16 · see citing works
Brooks, E., Bachmeier, C., Vorster, J., Sorbello, J., Peer, F., Chikani, V., Dimeski, G., Ungerer, J. P. J., Pretorius, C. J., & Inder, W. J. (2021) · Clinical Endocrinology · doi:10.1111/cen.14417 · Cited by 16 · see citing works
Zaelzer, C. A., Gizowski, C., Salmon, C. K., Murai, K. K., & Bourque, C. W. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00467.2017 · Cited by 14 · see citing works
Taussig, L. M., & Braunstein, G. D. (1973) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12724468 · Cited by 14 · see citing works
Weitzman, R. E., & Kleeman, C. R. (1979) · PubMed Central · Cited by 14 · see citing works
Radioimmunoassay for somatostatin
Utsumi, M., Makimura, H., Sakoda, M., & Baba, S. (1977) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.53.3_221 · Cited by 14 · see citing works
Distribution of free and antibody-bound peptide hormones in two-phase aqueous polymer systems
Desbuquois, B., & Aurbach, G. D. (1972) · Biochemical Journal · doi:10.1042/bj1260717 · Cited by 12 · see citing works
Hockaday, T. D. R. (1972) · BMJ · doi:10.1136/bmj.2.5807.210 · Cited by 12 · see citing works
Marchetti, J. (1973) · Cellular and Molecular Life Sciences · doi:10.1007/bf01926525 · Cited by 11 · see citing works
Electrocardiographic abnormalities and autonomic dysfunction in Guillain-Barre syndrome.
Palferman, T. G., Wright, I., & Doyle, D. (1982) · BMJ · doi:10.1136/bmj.284.6324.1231 · Cited by 10 · see citing works
Hashida, S., Tanaka, K., Yamamoto, N., Uno, T., Yamaguchi, K., & Ishikawa, E. (1991) · Analytical Letters · doi:10.1080/00032719108052957 · Cited by 10 · see citing works
Measurement of Plasma and Urinary Vasopressin by Immunoassay
Edwards, C. R. W. (1971) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591577106400819 · Cited by 9 · see citing works
The Hypothalamo-Neurohypophysial System and Reproduction
Swaab, D. F. (1972) · Progress in brain research · doi:10.1016/s0079-6123(08)64276-4 · Cited by 9 · see citing works
The Relationship of Antidiuretic Hormone to the Control of Volume and Tonicity in The Human
Scheiner, E. (1975) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)60247-4 · Cited by 9 · see citing works
Vasopressin and anesthesia surgery.
Wu, W.-J., & Zbuzek, V. K. (1982) · PubMed Central · Cited by 8 · see citing works
Iodination and purification of oxytocin
Wilson, N., & Greenhouse, V. Y. (1976) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)81032-8 · Cited by 7 · see citing works
Bichet, D. G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-380926-1.10008-2 · Cited by 6 · see citing works
Direct Detection of the Vasopressin Precursor
Gruber, K. A., & Morris, M. (1980) · Endocrine Research Communications · doi:10.3109/07435808009065958 · Cited by 6 · see citing works
Endocrine pancreatic carcinoma and syndrome of inappropriate secretion of antidiuretic hormone.
Kleibeuker, J. H., & Doorenbos, H. (1982) · BMJ · doi:10.1136/bmj.284.6324.1230 · Cited by 6 · see citing works
Study of different factors affecting arginine-vasopressinradioimmunoassay
Galard, R., Sanmartı́, A., Catalán, R., Schwartz, S., & Castellanos, J. M. (1985) · Clinica Chimica Acta · doi:10.1016/0009-8981(85)90026-9 · Cited by 6 · see citing works
Vasopressin and Water Metabolism
Robertson, G. L. (1978) · Springer eBooks · doi:10.1007/978-1-4684-2502-4_7 · Cited by 6 · see citing works
Forsling, M. L. (1971) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591577106401029 · Cited by 6 · see citing works
Edwards, C. R. W. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-475360-0.50027-4 · Cited by 5 · see citing works
The laboratory investigation of diabetes insipidus: A review
Boot, C. S. (2023) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/00045632231154391 · Cited by 3 · see citing works
Polyuria and Diabetes Insipidus
Bichet, D. G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381462-3.00046-x · Cited by 3 · see citing works
Glick, S. M., & Kagan, A. (1978) · Elsevier eBooks · doi:10.1016/b978-0-12-379260-0.50023-6 · Cited by 3 · see citing works
Pabst, H. W., & Hör, G. (1978) · Handbuch der medizinischen Radiologie · doi:10.1007/978-3-642-81170-8_18 · Cited by 3 · see citing works
Development of a Solid-Phase Radioimmunoassay for the Determination of Arginine-Vasopressin in Urine
Larose, P., Gutkowska, J., du Souich, P., & Ong, H. (1985) · Journal of Immunoassay · doi:10.1080/01971528508063030 · Cited by 2 · see citing works
The posterior pituitary and diabetes insipidus.
Beardwell, C. G. (1976) · Journal of Clinical Pathology · doi:10.1136/jcp.s1-7.1.68 · Cited by 2 · see citing works
Haaf, J. A. T., Terwela, D., van de Heijning, B. J. M., & Greidanus, T. B. V. W. (1992) · Journal of Controlled Release · doi:10.1016/0168-3659(92)90005-c · Cited by 2 · see citing works
Polyuria and Diabetes Insipidus
Bichet, D. G. (2008) · Elsevier eBooks · doi:10.1016/b978-012088488-9.50046-2 · Cited by 1 · see citing works
Vincent, J. C. (2010) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Moses, A. M., & Jones, C. (1996) · Elsevier eBooks · doi:10.1016/b978-012688460-9/50019-3
Evaluation of clinical disturbances of the hypothalamus
BESSER, G. M. (1978) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-03506-9_8
Applicability Of Copeptin As A Biomarker For Heart Failure
Naithani, M. (2011) · International Journal of Pharma and Bio Sciences
Antoniades, H. N. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-568403-3.50013-1
(1999) · Laboratory techniques in biochemistry and molecular biology · doi:10.1016/s0075-7535(08)70578-3
Kannan, C. R. (1987) · Springer eBooks · doi:10.1007/978-1-4613-1849-1_20
Mechanisms Underlying the Formation of Endolymphatic Hydrops and the Inner Ear Disorder
Kakigi, A. (2023) · Practica Oto-Rhino-Laryngologica · doi:10.5631/jibirin.116.399
Sweis, N. W. G., Tuazon, J. A., Cheema, Y., Rosa, R. M., Batlle, D., & Robertson, G. L. (2026) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00049.2026
The Hypothalamo-Neurohypophyseal System
Labhart, A. (1974) · Springer eBooks · doi:10.1007/978-3-642-96158-8_3
- Authors
- Robertson, G. L., Klein, L. A., Roth, J., & Gorden, P.
- Affiliations
- National Institutes of Health (US)
- NATIONAL CANCER INSTITUTE, NATIONAL INSTITUTES OF HEALTH, BETHESDA, MARYLAND 20014
- ORCID
- Robertson, Gary L.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1970-08
- Volume
- 66
- Issue
- 4
- Pages
- 1298-1305
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC335819
- OpenAlex
- W2030483106
- Cited by
- 83
- References
- 11
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2021: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, plasma vasopressin, radioimmunoassay, size exclusion chromatography, Sephadex G-25, immunoreactivity, human plasma, hormone measurement
- MeSH terms
- Adult, Arginine, Chromatography, Chromatography, Gel, Diabetes Insipidus, Female, Humans, Immune Sera, Immunoassay, Male, Polyuria, Vasopressins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
