Cited by 317Hypothalamic control of reproductive hormonesCircadian rhythm and melatoninSleep and Wakefulness Research

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Human puberty. Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep

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Boyar, R. M., Rosenfeld, R. S., Kapen, S., Finkelstein, J. W., Roffwarg, H. P., Weitzman, E. D., Hellman, Leon·1974·Journal of Clinical Investigation

DOI 10.1172/jci107798PMC PMC301594

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Abstract

Plasma luteinizing hormone (LH) and testosterone (T) were measured by radioimmunoassay in nine pubertal boys and three sexually mature young men at 20-min intervals for 24 h. Plasma LH and T were also measured in one boy during a delayed sleep onset study. Polygraphic monitoring was carried out to identify precisely sleep onset. Wakefulness, and specific sleep stages. In all nine pubertal boys the plasma T concentration fluctuated and was significantly higher during normal nocturnal sleep as compared to daytime waking. This increased T secretion during sleep was temporally linked to the characteristic pubertal sleep augmentation of LH secretion. To define further the relationship of this increased T secretion to sleep, plasma LH and T were also measured in three of the pubertal boys after acute (1-day) reversal of the sleep-wake cycle. One of these boys was also studied after 3 days of sleep-wake cycle reversal. The results of these studies showed that plasma T was now augmented during the reversed daytime sleep period; the mean T concentrations during this period were significantly higher (P < 0.001) than during nocturnal waking in all four studies. Measurement of plasma LH and T in the three sexually mature young men showed episodic secretion of LH and T during both waking and sleep periods; there was no consistent significant augmentation of LH or T secretion during sleep. This study demonstrates that (a) in normal pubertal boys and sexually mature young men plasma T fluctuates episodically; (b) there is marked augmentation of T secretion during sleep in pubertal boys, which is dependent on increased LH secretion; (c) this pubertal LH-T secretory "program" is dependent on sleep, since it shifts with delayed sleep onset and reversal of the sleep-wake cycle; and (d) this demonstrable tropic effect of LH on T is evident only during puberty, since sexually mature young men fail to show any consistent relationship between LH and T secretion either awake or asleep.

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THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,724
Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
Hunter, W. M., & Greenwood, F. C. (1962) · Nature · doi:10.1038/194495a0 · Cited by 6,902
Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects
WEITZMAN, E. D., FUKUSHIMA, D., NOGEIRE, C., ROFFWARG, H., GALLAGHER, T. F., & HELLMAN, L. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-1-14 · Cited by 1,258
Self-citation
Growth hormone secretion during sleep
Takahashi, Y., KIPNIS, D. M., & Daughaday, W. H. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105893 · Cited by 799
Radioimmunoassay: A Method for Human Chorionic Gonadotropin and Human Luteinizing Hormone1
MIDGLEY, A. R. (1966) · Endocrinology · doi:10.1210/endo-79-1-10 · Cited by 760
Height and weight at menarche and a hypothesis of critical body weights and adolescent events
Frisch, R. E., & Revelle, R. (1970) · Science · doi:10.1126/science.169.3943.397 · Cited by 721
Growth at adolescence : with a general consideration of the effects of hereditary and environmental factors upon growth and maturation from birth to maturity
Tanner, J. M. (1962) · Medical Entomology and Zoology · Cited by 540
Radioimmunoassay for Human Follicle-Stimulating Hormone1
MIDGLEY, A. R. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-2-295 · Cited by 536
Synchronization of Augmented Luteinizing Hormone Secretion with Sleep during Puberty
BOYAR, R. M., Finkelstein, J. W., Roffwarg, H. P., Kapen, S., Weitzman, E. D., & HELLMAN, L. (1972) · New England Journal of Medicine · doi:10.1056/nejm197209212871203 · Cited by 496
Self-citation
Human Prolactin: 24-Hour Pattern with Increased Release during Sleep
Sassin, J. F., Frantz, A. G., Weitzman, E. D., & Kapen, S. (1972) · Science · doi:10.1126/science.177.4055.1205 · Cited by 460
Self-citation

Flagged first, then by citations

Show all 38 references

Sorted by citations

European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment
Boehm, U., Bouloux, P.-M., Dattani, M. T., de Roux, N., Dodé, C., Dunkel, L., Dwyer, A. A., Giacobini, P., Hardelin, J.-P., Juul, A., et al. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.112 · Cited by 874
Puberty : ontogeny, neuroendocrinology, physiology, and disorders
Styne, D. M., Grumbach, M. M., Dennis, M., Styne, J., & Melvin, M. N. (1998) · Time to knit · doi:10.1016/b978-1-4160-2911-3.50026-1 · Cited by 546
The Physiology of Gonadotropin-Releasing Hormone (GnRH) Secretion in Men and Women
Crowley, W. F., Filicori, M., Spratt, D. I., & Santoro, N. F. (1985) · Elsevier eBooks · doi:10.1016/b978-0-12-571141-8.50015-9 · Cited by 485
Gonadotropin-Releasing Hormone Deficiency in the Human (Idiopathic Hypogonadotropic Hypogonadism and Kallmann's Syndrome): Pathophysiological and Genetic Considerations
Seminara, S. B., Hayes, F. J., & Crowley, W. F. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.5.0344 · Cited by 419
Clinical Management of Congenital Hypogonadotropic Hypogonadism
Young, J., Xu, C., Papadakis, G. E., Acierno, J. S., Maione, L., Hietamäki, J., Raivio, T., & Pitteloud, N. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00116 · Cited by 425
Anorexia Nervosa
BOYAR, R. M., Katz, J. L., Finkelstein, J. W., Kapen, S., Weiner, H., Weitzman, E. D., & HELLMAN, L. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410242911701 · Cited by 394
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Induction of Puberty in Men by Long-Term Pulsatile Administration of Low-Dose Gonadotropin-Releasing Hormone
Hoffman, A. R., & Crowley, W. F. (1982) · New England Journal of Medicine · doi:10.1056/nejm198211113072003 · Cited by 352
Obesity, male infertility, and the sperm epigenome
Craig, J. R., Jenkins, T. G., Carrell, D. T., & Hotaling, J. M. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.02.115 · Cited by 341
CHANGES IN THE PITUITARY‐TESTICULAR SYSTEM WITH AGE
Baker, H. W. G., Burger, H., KRETSER, D. M. D., Hudson, B., O'connor, S., Wang, C.-L., MIROVICS, A., Court, J. M., Dunlop, M., & RENNIE, G. C. (1976) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1976.tb01964.x · Cited by 305
Testosterone, aggression, physical, and personality dimensions in normal adolescent males
Olweus, D., Mattsson, Å., Schalling, D., & Low, H. (1980) · Psychosomatic Medicine · doi:10.1097/00006842-198003000-00003 · Cited by 300
Reproductive ecology and life history of the human male
Bribiescas, R. G. (2001) · American Journal of Physical Anthropology · doi:10.1002/ajpa.10025 · Cited by 272
Gonadotropin Secretory Dynamics During Puberty in Normal Girls and Boys
Oerter, K. E., Uriarte, M., Rose, S. R., Barnes, K. M., & Cutler, G. B. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-5-1251 · Cited by 247
Predictors of Outcome of Long-Term GnRH Therapy in Men with Idiopathic Hypogonadotropic Hypogonadism
Pitteloud, N., Hayes, F. J., Dwyer, A. A., Boepple, P. A., Lee, H., & Crowley, W. F. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020518 · Cited by 241
Regulation of Peptide Hormone Receptors and Gonadal Steroidogenesis
Catt, K. J., Harwood, J. P., Clayton, R. N., Davies, T. F., Chan, V., Katikineni, M., NOZU, K., & Dufau, M. L. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-571136-4.50021-8 · Cited by 228
Short-Term Treatment of Idiopathic Precocious Puberty with a Long-Acting Analogue of Luteinizing Hormone-Releasing Hormone
Comite, F., Cutler, G. B., Rivier, J., Vale, W., Loriaux, D. L., & Crowley, W. F. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112243052602 · Cited by 225
A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial
Wickman, S., Sipilä, I., Ankarberg-Lindgren, C., Norjavaara, E., & Dunkel, L. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04895-9 · Cited by 216
The Role of Prior Pubertal Development, Biochemical Markers of Testicular Maturation, and Genetics in Elucidating the Phenotypic Heterogeneity of Idiopathic Hypogonadotropic Hypogonadism
Pitteloud, N., Hayes, F. J., Boepple, P. A., DeCruz, S., Seminara, S. B., MacLaughlin, D. T., & Crowley, W. F. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.1.8131 · Cited by 201
Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone
Spratt, D. I., O'Dea, L. S., Schoenfeld, D., Butler, J., Rao, P. N., & Crowley, W. F. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.5.e658 · Cited by 194
Management and outcome of central precocious puberty
Partsch, C., Heger, S., & Sippell, W. G. (2002) · Clinical Endocrinology · doi:10.1046/j.0300-0664.2001.01490.x · Cited by 190
Testicular Control of Follicle-Stimulating Hormone Secretion
Baker, H. W. G., Bremner, W. J., Burger, H., KRETSER, D. M. D., Dulmanis, A., EDDIE, L. W., Hudson, B., Keogh, E. J., Lee, V. W. K., & RENNIE, G. C. (1976) · Elsevier eBooks · doi:10.1016/b978-0-12-571132-6.50025-7 · Cited by 186
Sleep Is for Tissue Restoration
Adam, K., & Oswald, I. (1977) · Journal of the Royal College of Physicians of London · doi:10.1016/s0035-8819(25)02990-3 · Cited by 181
Mild hypogonadotropic hypogonadism in obese men
Strain, G. W., Zumoff, B., Kream, J., Strain, J. J., Deucher, R., Rosenfeld, R. S., Levin, J., & Fukushima, D. K. (1982) · Metabolism · doi:10.1016/0026-0495(82)90175-5 · Cited by 174
Self-citation
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Axelsson, J., Ingre, M., Åkerstedt, T., & Holmbäck, U. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0520 · Cited by 171
Male Hypogonadotropic Hypogonadism
Whitcomb, R. W., & Crowley, W. F. (1993) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30183-x · Cited by 166
Relationship of somatomedin-C concentrations to pubertal changes
Rosenfield, R. I., Furlanetto, R. W., & Bock, D. (1983) · The Journal of Pediatrics · doi:10.1016/s0022-3476(83)80465-x · Cited by 164
The association of testosterone, sleep, and sexual function in men and women
Andersen, M. L., Alvarenga, T. A., Mazaro‐Costa, R., Hachul, H., & Tufik, S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.060 · Cited by 161
The spectrum of abnormal patterns of gonadotropin-releasing hormone secretion in men with idiopathic hypogonadotropic hypogonadism: clinical and laboratory correlations
SPRATT, D. I., CARR, D. B., MERRIAM, G. R., SCULLY, R. E., RAO, P. N., & CROWLEY, W. F. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-2-283 · Cited by 153
Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male
Corradi, P. F., Corradi, R. B., & Greene, L. W. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.001 · Cited by 162
Plasma Testosterone, Aggressive Behavior, and Personality Dimensions in Young Male Delinquents
Mattsson, Å., Schalling, D., Olweus, D., Löw, H., & Svensson, J. (1980) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)61065-7 · Cited by 144
Age Variation of the 24-Hour Mean Plasma Concentrations of Androgens, Estrogens, and Gonadotropins in Normal Adult Men*
Zumoff, B., Strain, G. W., Kream, J., O'CONNOR, J., Rosenfeld, R. S., Levin, J., & Fukushima, D. K. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-3-534 · Cited by 143
Self-citation
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Zumoff, B., Freeman, R., Coupey, S. M., Saenger, P. H., MARKOWITZ, M. E., & Kream, J. (1983) · New England Journal of Medicine · doi:10.1056/nejm198311173092002 · Cited by 139
HYPOTHALAMIC‐PITUITARY‐GONADAL RELATIONSHIPS IN MAN FROM BIRTH TO PUBERTY
Forest, M. G., PERETTI, E. D., & Bertrand, J. (1976) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1976.tb01985.x · Cited by 137
Sleep as a Restorative Process and a Theory to Explain Why
Adam, K. (1980) · Progress in brain research · doi:10.1016/s0079-6123(08)60070-9 · Cited by 132
A Study of the Role of the Postnatal Testes in Determining the Ontogeny of Gonadotropin Secretion in the Male Rhesus Monkey (Macaca mulatto)*
PLANT, T. M. (1985) · Endocrinology · doi:10.1210/endo-116-4-1341 · Cited by 128
Subnormal Plasma Dehydroisoandrosterone to Cortisol Ratio in Anorexia Nervosa: A Second Hormonal Parameter of Ontogenic Regression*
Zumoff, B., Walsh, B. T., Katz, J. L., Levin, J., Rosenfeld, R. S., Kream, J., & Weiner, H. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-4-668 · Cited by 128
Self-citation
Diurnal rhythm of 17 beta-estradiol secretion throughout pubertal development in healthy girls: evaluation by a sensitive radioimmunoassay
Norjavaara, E., Ankarberg‐Lindgren, C., & Albertsson-Wikland, K. G. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923866 · Cited by 125
Puberty in Nonhuman Primates and Humans
Plant, T. M., & Witchel, S. F. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50045-2 · Cited by 125
The Relationship of Sleep and Sleep Stages to Neuroendocrine Secretion and Biological Rhythms in Man
Weitzman, E. D., BOYAR, R. M., Kapen, S., & HELLMAN, L. (1975) · Elsevier eBooks · doi:10.1016/b978-0-12-571131-9.50015-3 · Cited by 120
Self-citation
The Determination of Bio-Available Testosterone
Wheeler, M. J. (1995) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329503200401 · Cited by 119
Gonadotrophin replacement for induction of fertility in hypogonadal men
Dwyer, A. A., Raivio, T., & Pitteloud, N. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.10.005 · Cited by 114
Sleep as a Restorative Process: Human Clues
Oswald, I. (1980) · Progress in brain research · doi:10.1016/s0079-6123(08)60069-2 · Cited by 117
The effects of testosterone on sleep and sleep-disordered breathing in men: Its bidirectional interaction with erectile function
Andersen, M. L., & Tufik, S. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.12.003 · Cited by 118
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Golden, N. H., & Carlson, J. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1429.014 · Cited by 110
Age effects of follicle-stimulating hormone and pulsatile luteinizing hormone secretion across the menstrual cycle of premenopausal women
Reame, N. E., Kelche, R. P., Beitins, I. Z., Yu, M., Zawacki, C. M., & Padmanabhan, V. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636360 · Cited by 109
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Keenan, D. M., & Veldhuis, J. D. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.1.e157 · Cited by 107
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Shaw, N. D., Seminara, S. B., Welt, C. K., Au, M., Plummer, L., HUGHES, V. A., Dwyer, A. A., Martin, K. A., Quinton, R., Verónica Mericq, G., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2292 · Cited by 105
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WENNINK, J. M. B., de Waal, H. A. D., Schoemaker, R. C., SCHOEMAKER, H., & Schoemaker, J. (1989) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1989.tb01279.x · Cited by 106
Effect of Massive Weight Loss on Hypothalamic Pituitary-Gonadal Function in Obese Men*
STRAIN, G. W., ZUMOFF, B., MILLER, L. K., ROSNER, W., LEVIT, C., KALIN, M., HERSHCOPF, R. J., & ROSENFELD, R. S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-5-1019 · Cited by 103
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Concentration of Dihydrotestosterone and 3α-Androstanediol in Naturally Occurring and Androgen- Induced Prostatic Hyperplasia in the Dog
Moore, R. J., Gazak, J. M., Quebbeman, J. F., & Wilson, J. D. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109536 · Cited by 99
The physiology of male reproduction: Impact of drugs and their abuse on male fertility
Ajayi, A. F., & Akhigbe, R. E. (2020) · Andrologia · doi:10.1111/and.13672 · Cited by 100
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Ankarberg‐Lindgren, C., & Norjavaara, E. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510747 · Cited by 95
Neuroendocrine Regulation of Puberty
Ojeda, S. R., & Bilger, M. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-707-9_12 · Cited by 93
Diurnal Rhythms of Luteinizing Hormone, Follicle-Stimulating Hormone, and Testosterone Secretion before the Onset of Male Puberty1
Mitamura, R., Yano, K., Suzuki, N., Ito, Y., Makita, Y., & Okuno, A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5404 · Cited by 93
Testosterone-mediated sex differences in the face shape during adolescence: Subjective impressions and objective features
Marečková, K., Weinbrand, Z., Chakravarty, M. M., Lawrence, C., Aleong, R., Leonard, G. T., Perron, M., Pike, G. B., Richer, L., Veillette, S., et al. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.09.004 · Cited by 93
Circadian Rhythm of Serum Testosterone and Its Relation to Sleep: Comparison with the Variation in Serum Luteinizing Hormone, Prolactin, and Cortisol in Normal Men*
Miyatake, A., Morimoto, Y., OISHI, T., Hanasaki, N., Sugita, Y., Iijima, S., Teshima, Y., Hishikawa, Y., & Yamamura, Y. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-6-1365 · Cited by 89
Obesity and Male Infertility: A Practical Approach
Meikle, A., Reis, L., Gibson, M., Peterson, C., Carrell, D., & Hammoud, A. (2012) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1328877 · Cited by 88
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ROSS, J. L., Loriaux, D. L., & Cutler, G. B. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-2-288 · Cited by 88
A review of normal sleep and its disturbances in Parkinson’s disease
Pal, P. K., Calne, S. M., Samii, A., & Fleming, J. A. E. (1999) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(99)00011-5 · Cited by 86
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Butler, G. E., WALKER, R. F., WALKER, R. V., TEAGUE, P., Riad-Fahmy, D., & Ratcliffe, S. G. (1989) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1989.tb01431.x · Cited by 86
Interrelationships between Hormones, Behavior, and Affect during Adolescence: Understanding Hormonal, Physical, and Brain Changes Occurring in Association with Pubertal Activation of the Reproductive Axis. Introduction to Part III
Cameron, J. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.012 · Cited by 88
Clinical and Laboratory Heterogeneity in Idiopathic Hypogonadotropic Hypogonadism
BOYAR, R. M., WU, R. H. K., Kapen, S., HELLMAN, L., Weitzman, E. D., & Finkelstein, J. W. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-6-1268 · Cited by 81
Self-citation
Endogenous opiates modulate the pulsatile secretion of biologically active luteinizing hormone in man.
Veldhuis, J. D., Rogol, A. D., & Johnson, M. L. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111168 · Cited by 80
A Workshop on Pubertal Hormone Replacement Options in the United States
Drobac, S., Rubin, K., Rogol, A. D., & Rosenfield, R. L. (2006) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2006.19.1.55 · Cited by 80
Intravenous infusions of nutrients and sleep in the rat: an ischymetric sleep regulation hypothesis
Danguir, J., & Nicolaı̈dis, S. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.238.4.e307 · Cited by 80
Reproductive ageing in women
Djahanbakhch, O., Ezzati, M., & Zosmer, A. (2007) · The Journal of Pathology · doi:10.1002/path.2108 · Cited by 80
Ontogeny of Circadian Rhythms
Davis, F. C. (1981) · Springer eBooks · doi:10.1007/978-1-4615-6552-9_14 · Cited by 78
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Veldhuis, J. D. (1999) · Journal of Andrology · doi:10.1002/j.1939-4640.1999.tb02488.x · Cited by 77
Male pubertal development and the role of androgen therapy
Richmond, E. J., & Rogol, A. D. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0450 · Cited by 77
Peer pressure and risk-taking behaviors in children.
Lewis, C. E., & Lewis, M. A. (1984) · American Journal of Public Health · doi:10.2105/ajph.74.6.580 · Cited by 77
Circadian sleep and feeding patterns in the rat: possible dependence on lipogenesis and lipolysis
Danguir, J., & Nicolaı̈dis, S. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.238.3.e223 · Cited by 77
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Regulation of bile acid synthesis in man. Presence of a diurnal rhythm.
Duane, W. C., Levitt, D. G., Mueller, S. M., & Behrens, J. C. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111157 · Cited by 76
Abnormal levels of plasma hormones in men with prostate cancer: Evidence toward a “two‐disease” theory
Zumoff, B., Levin, J., Strain, G. W., Rosenfeld, R. S., O'Connor, J., Freed, S. Z., Kream, J., Whitmore, W. S., Fukushima, D. K., & HELLMAN, L. (1982) · The Prostate · doi:10.1002/pros.2990030607 · Cited by 75
Self-citation
Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic–pituitary axes)
López, M., Tena‐Sempere, M., & Diéguez, C. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.07.001 · Cited by 74
Evidence of a Role for Retinoic Acid (Vitamin A-Acid) in the Maintenance of Testosterone Production in Male Rats*
Appling, D. R., & Chytil, F. (1981) · Endocrinology · doi:10.1210/endo-108-6-2120 · Cited by 74
Abnormal hormone levels in men with coronary artery disease.
Zumoff, B., Troxler, R. G., O'Connor, J., Rosenfeld, R. S., Kream, J., Levin, J., Hickman, J. R., Sloan, A., Walker, W. J., Cook, R. L., et al. (1982) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.2.1.58 · Cited by 73
Self-citation
TRANSITION IN ENDOCRINOLOGY: Hypogonadism in adolescence
Dwyer, A. A., Phan-Hug, F., Hauschild, M., Elowe-Gruau, É., & Pitteloud, N. (2015) · European Journal of Endocrinology · doi:10.1530/eje-14-0947 · Cited by 75
Increase in first morning voided urinary luteinizing hormone levels precedes the physical onset of puberty
Demir, A., Voutilainen, R., Juul, A., Dunkel, L., Alfthan, H. V., Skakkebæk, N. E., & Stenman, U. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768859 · Cited by 70
CRYPTORCHIDISM
Gill, B., & Kogan, S. J. (1997) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(05)70554-x · Cited by 70
Androgens and male sexual function: A review of human studies
Schiavi, R. C., & White, D. (1976) · Journal of Sex & Marital Therapy · doi:10.1080/00926237608405324 · Cited by 70
Pulsatile Secretion of LH and FSH in Prepubertal and Early Pubertal Boys Revealed by Ultrasensitive Time-Resolved Immunofluorometric Assays
Dunkel, L., Alfthan, H. V., Stenman, U.-H., Tapanainen, P. J., & Perheentupa, J. (1990) · Pediatric Research · doi:10.1203/00006450-199003000-00003 · Cited by 68
Luteinizing Hormone Secretion Patterns in Boys at the Onset of Puberty Measured Using a Highly Sensitive Immunoradiometric Assay*
WENNINK, J. M. B., de Waal, H. A. D., van Kessel, H. I., Mulder, G. H., Foster, J. P., & Schoemaker, J. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-5-924 · Cited by 64
The function of sleep
Oswald, I. (1976) · Postgraduate Medical Journal · doi:10.1136/pgmj.52.603.15 · Cited by 64
Neuroendocrine Regulation of Puberty
Ojeda, S. R., & Terasawa, E. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50077-9 · Cited by 64
HYPOGONADOTROPIC HYPOGONADISM
Hayes, F. J., Seminara, S. B., & Crowley, W. F. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70039-6 · Cited by 62
Prepubertal and Pubertal Endocrinology
Winter, J. S. D. (1978) · Springer eBooks · doi:10.1007/978-1-4684-2622-9_7 · Cited by 61
Voice break in boys—temporal relations with other pubertal milestones and likely causal effects of BMI
Busch, A. S., Hollis, B., Day, F. R., Sørensen, K., Aksglæde, L., Perry, J. R. B., Ong, K. K., Juul, A., & Hagen, C. P. (2019) · Human Reproduction · doi:10.1093/humrep/dez118 · Cited by 61
Subnormal serum testosterone levels in male internal medicine residents
Singer, F. M., & Zumoff, B. (1992) · Steroids · doi:10.1016/0039-128x(92)90035-8 · Cited by 57
Long-Term Administration of Gonadotropin-Releasing Hormone in Men with Idiopathic Hypogonadotropic Hypogonadism
Spratt, D. I., FINKELSTEIN, J. S., O'DEA, L. S. L., BADGER, T. M., RAO, P. N., CAMPBELL, J. D., & CROWLEY, W. F. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-848 · Cited by 57
Self-citation
Normal testicular function and spermatogenesis
Shalet, S. M. (2009) · Pediatric Blood & Cancer · doi:10.1002/pbc.22000 · Cited by 56
INDUCTION OF PUBERTY BY PULSATILE GONADOTROPIN RELEASING HORMONE
Stanhope, R. G., Pringle, P. J., Brook, C. G. D., Adams, J., & Jacobs, H. S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92932-1 · Cited by 56
Circadian Rhythms in Gonadotropin Excretion in Prepubertal and Pubertal Children
Kulin, H. E., Moore, R. G., & Santner, S. J. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-4-770 · Cited by 56
Luteinizing Hormone-Releasing Hormone Analog Treatment of Boys with Hypothalamic Hamartoma and True Precocious Puberty
Comite, F., Pescovitz, O. H., Rieth, K. G., Dwyer, A. J., HENCH, K. D., McNEMAR, A., Loriaux, D. L., & Cutler, G. B. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-5-888 · Cited by 56
Short-term variations in plasma LH and testosterone in bull calves from birth to 1 year of age
Lacroix, A., & Pelletier, J. (1979) · Reproduction · doi:10.1530/jrf.0.0550081 · Cited by 55
Sleep-Wake Patterns of LH and Testosterone Release in Prepubertal Boys
Judd, H. L., PARKER, D. C., & Yen, S. S. C. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-44-5-865 · Cited by 55
Studies on the Regulation of the Onset of Steroid Hormone Biosynthesis in Fetal Rabbit Gonads*
George, F. W., Simpson, E. R., Milewich, L., & Wilson, J. D. (1979) · Endocrinology · doi:10.1210/endo-105-5-1100 · Cited by 51
Fertility induction in hypogonadotropic hypogonadal men
Prior, M., Stewart, J. A., McEleny, K. R., Dwyer, A. A., & Quinton, R. (2018) · Clinical Endocrinology · doi:10.1111/cen.13850 · Cited by 53
Neuroendocrine mechanisms mediating awakening of the human gonadotropic axis in puberty
Veldhuis, J. D. (1996) · Pediatric Nephrology · doi:10.1007/bf00866767 · Cited by 49
Effect of Fluoxymesterone on the Pituitary-Gonadal Axis: The Role of Testosterone-Estradiol-Binding Globulin
Vigersky, R. A., Easley, R. B., & Loriaux, D. L. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-1-1 · Cited by 50

Authors: Boyar, R. M., Rosenfeld, R. S., Kapen, S., Finkelstein, J. W., Roffwarg, H. P., Weitzman, E. D., & Hellman, L.
Affiliations: Montefiore Medical Center (US)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1974-09-01
Volume: 54
Issue: 3
Pages: 609-618
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci107798
PMC: PMC301594
OpenAlex: W2046659727
Cited by: 317
References: 38
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 9 · 2016: 11 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 5
FWCI: 15.63
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: puberty, luteinizing hormone, testosterone, sleep, nocturnal hormone secretion, sleep onset delay, pubertal boys
MeSH terms: Adolescent, Adult, Central Nervous System, Child, Electroencephalography, Humans, Luteinizing Hormone, Male, Periodicity, Puberty, Radioimmunoassay, Secretory Rate, Sleep, Sleep Deprivation, Testosterone, Time Factors

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Human puberty. Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep

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