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Cited by 294

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Metabolism in immunoreactive parathyroid hormone in the dog. The role of the kidney and the effects of chronic renal disease.

Open access
Hruska, K A, Kopelman, R, Rutherford, W E, Klahr, S, Slatopolsky, E, Greenwalt, A, Bascom, T, Markham, J·1975·Journal of Clinical Investigation
DOI 10.1172/jci108077
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Abstract

The role of the kidney in the metabolism of parathyroid hormone (PTH) was examined in the dog. Studies were performed in awake normal and uremic dogs after administration of bovine parathyroid hormone (b-PTH) or synthetic amino terminal tetratricontapeptide of b-PTH (syn b-PTH 1-34). The renal clearance of immunoreactive PTH was determined from the product of renal plasma flow and the percent extraction of PTH immunoreactivity by the kidney. Blood levels of circulating immunoreactive PTH were determined by radioimmunoassay. The normal dog kidney extracted 20 plus or minus 1% of the immunoreactive b-PTH delivered to it, and renal clearance (RC) of immunoreactivity was 60 ml/min. When RC was compared to an estimate of total metabolic clearance (MCR) of immunoreactivity, it accounted for 61% of the total. Both MCR and RC were markedly decreased in dogs with chronic renal disease. However, the percent extraction of immunoreactive PTH was unchanged in chronic renal disease, and the observed decrease in RC was due to changes in renal plasma flow. The largest portion of the reduction in total MCR was accounted for by the decrease in RC, and there was no compensation for the decrease in RC by extrarenal sites of PTH metabolism.

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Metadata

Authors
Hruska, K. A., Kopelman, R., Rutherford, W. E., Klahr, S., Slatopolsky, E., Greenwalt, A., Bascom, T., & Markham, J.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1975-07-01
Volume
56
Issue
1
Pages
39-48
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci108077
OpenAlex
W2153655978
Cited by
294
References
10
FWCI
21.67
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Metabolism in immunoreactive parathyroid hormone in the dog. The role of the kidney and the effects of chronic renal disease. https://app.cochat.ai/papers/10.1172/jci108077
The paper
Hruska, K. A., Kopelman, R., Rutherford, W. E., Klahr, S., Slatopolsky, E., Greenwalt, A., Bascom, T., & Markham, J. (1975). Metabolism in immunoreactive parathyroid hormone in the dog. The role of the kidney and the effects of chronic renal disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci108077

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.