The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
Open accessAbstract
Studied on the oxidation of oleic and octanoic acids to ketone bodies were carried out in homogenates and in mitochondrial fractions of livers taken from fed and fasted rats. Malonyl-CoA inhibited ketogenesis from the former but not from the latter substrate. The site of inhibition appeared to be the carnitine acyltransferase I reaction. The effect was specific and easily reversible. Inhibitory concentrations were in the range of values obtained in livers from fed rats by others. It is proposed that malonyl-CoA functions as both precursor for fatty acid synthesis and suppressor of fatty acid oxidation. As such, it might be an important element in the carbohydrate-induced sparing of fatty acid oxidation.
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“Some important players to consider in this regard include acetyl-CoA carboxylase (ACC2) (21), the mitochondrial lipid transporter CPT1A (13, 22), and metabolites such as acetyl-CoA and malonyl-CoA (23).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [23]
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Cites
Role of carnitine in hepatic ketogenesis.
McGarry, J., Robles-Valdés, C., & Foster, D. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.11.4385 · Cited by 260
Self-citationMcGarry, J. D., Meier, J. M., & Foster, D. W. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44471-2 · Cited by 246
Self-citationMcGarry, J., Wright, P. H., & Foster, D. W. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108038 · Cited by 227
Self-citationPalmityl-coa:carnitine palmityltransferase
Norum, K. R. (1964) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(64)90103-8 · Cited by 202
Lossow, W. J., & Chaikoff, I. L. (1955) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(55)90173-9 · Cited by 193
The Regulation of Ketogenesis from Octanoic Acid
McGarry, J., & Foster, D. W. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62443-3 · Cited by 183
Self-citationThe Concentration of Malonyl-Coenzyme A and the Control of Fatty Acid Synthesis in Vivo
Guynn, R. W., Veloso, D., & Veech, R. L. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44633-4 · Cited by 182
Hormonal Control of Ketogenesis
McGarry, J. (1977) · Archives of Internal Medicine · doi:10.1001/archinte.137.4.495 · Cited by 166
Self-citationKetone Body Metabolism in the Ketosis of Starvation and Alloxan Diabetes
McGarry, J., Guest, M. J., & Foster, D. W. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)63806-8 · Cited by 161
Self-citationThe Regulation of Ketogenesis from Oleic Acid and the Influence of Antiketogenic Agents
McGarry, J. D., & Foster, D. W. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61782-x · Cited by 150
Self-citationMaternal-fetal carnitine relationship and neonatal ketosis in the rat.
Robles-Valdés, C., McGarry, J., & Foster, D. W. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33051-x · Cited by 147
Self-citationPilkis, S. J., Riou, J. P., & Claus, T. H. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57012-0 · Cited by 107
Kopec, B., & Fritz, I. B. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43840-4 · Cited by 86
Dimarco, J., & Hoppel, C. L. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108042 · Cited by 71
THE ETIOLOGY OF DIABETIC ACIDOSIS
Mirsky, I. A. (1942) · JAMA · doi:10.1001/jama.1942.02830090008002 · Cited by 29
Flagged first, then by citations
Research works printed but not linked: 1
- Cook, G. A., M. R. Lakshmanan, and R. L. Veech. 1977. The effect of glucagon on hepatic malonyl-CoA concen- tration and on lipid synthesis. Fed. Proc. 36: 672.
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Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,228
Molecular mediators of hepatic steatosis and liver injury
Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772
The Mitochondrial Carnitine Palmitoyltransferase System — From Concept to Molecular Analysis
McGarry, J. D., & Brown, N. F. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00001.x · Cited by 1,616
Self-citationThe Science and Translation of Lactate Shuttle Theory
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Metadata
- Authors
- McGarry, J. D., Mannaerts, G. P., & Foster, D. W.
- Affiliations
- University of Texas Health Science Center at Dallas (US)
- ORCID
- McGarry, J D
- Venue
- Journal of Clinical Investigation
- Published
- 1977-07-01
- Volume
- 60
- Issue
- 1
- Pages
- 265-270
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC372365
- OpenAlex
- W2126909426
- Cited by
- 736
- References
- 15
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 22 · 2023: 22 · 2022: 38 · 2021: 18 · 2020: 26 · 2019: 17 · 2018: 29 · 2017: 23 · 2016: 24 · 2015: 14 · 2014: 21 · 2013: 18 · 2012: 19
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fogarty International Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- malonyl-CoA, hepatic fatty acid oxidation, ketogenesis, oleic acid, octanoic acid, ketone bodies, fasting, liver mitochondria, fatty acid synthesis
- MeSH terms
- Animals, Caprylates, Carnitine, Coenzyme A, Fatty Acids, Ketone Bodies, Liver, Male, Malonates, Mitochondria, Liver, Models, Biological, Oleic Acids, Oxidation-Reduction, Rats
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