Cited by 736Lipid metabolism and biosynthesisDiet and metabolism studiesCancer, Lipids, and Metabolism

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A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

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McGarry, J D, Mannaerts, G P, Foster, D W·1977·Journal of Clinical Investigation

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Abstract

Studied on the oxidation of oleic and octanoic acids to ketone bodies were carried out in homogenates and in mitochondrial fractions of livers taken from fed and fasted rats. Malonyl-CoA inhibited ketogenesis from the former but not from the latter substrate. The site of inhibition appeared to be the carnitine acyltransferase I reaction. The effect was specific and easily reversible. Inhibitory concentrations were in the range of values obtained in livers from fed rats by others. It is proposed that malonyl-CoA functions as both precursor for fatty acid synthesis and suppressor of fatty acid oxidation. As such, it might be an important element in the carbohydrate-induced sparing of fatty acid oxidation.

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Role of carnitine in hepatic ketogenesis.
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Hormonal control of ketogenesis. Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon.
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Cook, G. A., M. R. Lakshmanan, and R. L. Veech. 1977. The effect of glucagon on hepatic malonyl-CoA concen- tration and on lipid synthesis. Fed. Proc. 36: 672.

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Authors: McGarry, J. D., Mannaerts, G. P., & Foster, D. W.
Affiliations: University of Texas Health Science Center at Dallas (US)
ORCID: McGarry, J D
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1977-07-01
Volume: 60
Issue: 1
Pages: 265-270
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci108764
PMC: PMC372365
OpenAlex: W2126909426
Cited by: 736
References: 15
Citations by year: 2026: 14 · 2025: 15 · 2024: 22 · 2023: 22 · 2022: 38 · 2021: 18 · 2020: 26 · 2019: 17 · 2018: 29 · 2017: 23 · 2016: 24 · 2015: 14 · 2014: 21 · 2013: 18 · 2012: 19
FWCI: 9.19
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Fogarty International Center
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: malonyl-CoA, hepatic fatty acid oxidation, ketogenesis, oleic acid, octanoic acid, ketone bodies, fasting, liver mitochondria, fatty acid synthesis
MeSH terms: Animals, Caprylates, Carnitine, Coenzyme A, Fatty Acids, Ketone Bodies, Liver, Male, Malonates, Mitochondria, Liver, Models, Biological, Oleic Acids, Oxidation-Reduction, Rats

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A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

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