Cited by 189Stress Responses and CortisolAdrenal Hormones and DisordersNeuropeptides and Animal Physiology

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Arginine vasopressin potentiates adrenocorticotropin release induced by ovine corticotropin-releasing factor

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DeBold, C R, Sheldon, W R, DeCherney, G S, Jackson, R V, Alexander, A N, Vale, W, Rivier, J, Orth, D N·1984·Journal of Clinical Investigation

DOI 10.1172/jci111240PMC PMC425045

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Abstract

Arginine vasopressin (AVP) stimulates ACTH release in man and acts synergistically with synthetic ovine corticotropin-releasing factor (oCRF) in vitro. This study was designed to examine in man the combined effects of synthetic AVP (10 U intramuscularly) and oCRF (1 micrograms/kg intravenously) on ACTH release. Five normal male volunteers participated in five separate experiments: (a) AVP alone; (b) oCRF alone; (c) AVP followed by oCRF 15 min later; (d) simultaneous AVP and oCRF; and (e) insulin-induced hypoglycemia. Plasma immunoreactive ACTH (IR-ACTH) and IR-cortisol were measured for 4 h after injection of each hormone; basal levels for all subjects were less than or equal to 9 +/- 1.2 pg/ml and 4.9 +/- 0.4 micrograms/dl (mean +/- SE), respectively. AVP and oCRF, when given individually, caused rapid rises in IR-ACTH to similar peak levels of 25 +/- 6.6 and 33 +/- 4.6 pg/ml, respectively. AVP given 15 min before oCRF caused a 2.6-fold potentiation of the oCRF response, with a peak IR-ACTH of 85 +/- 4.6 pg/ml. AVP given at the same time as oCRF produced a fourfold potentiation of the peak IR-ACTH response to 132 +/- 11 pg/ml. These ACTH responses were far greater than those previously observed after 30-fold greater doses of oCRF alone. By way of comparison, insulin-induced hypoglycemia caused a peak IR-ACTH of 169 +/- 20 pg/ml. IR-ACTH returned to base line at 60-90 min after AVP alone, whereas the prolonged effect of oCRF was apparent whether it was given alone or in combination with AVP. The mean peak IR-cortisol responses to AVP, oCRF, and AVP given 15 min before oCRF were similar (16.5 +/- 0.9, 16.4 +/- 2.3, and 18.5 +/- 0.8 micrograms/dl, respectively), but the peak IR-cortisol responses to AVP and oCRF given simultaneously and to insulin-induced hypoglycemia were 1.5 and 1.7 times greater, respectively. IR-cortisol returned to base line within 2-3 h after AVP alone, but remained elevated for at least 4 h after oCRF alone or in combination with AVP. These results indicate that AVP acts synergistically with oCRF to release ACTH in man and suggest that AVP may play a physiologic role in modulating the ACTH response mediated by corticotropin-releasing factor.

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Authors: DeBold, C. R., Sheldon, W. R., DeCherney, G. S., Jackson, R. V., Alexander, A. N., Vale, W., Rivier, J., & Orth, D. N.
Affiliations: Vanderbilt University (US)
Salk Institute for Biological Studies (US)
ORCID: Vale, W
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1984-02-01
Volume: 73
Issue: 2
Pages: 533-538
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci111240
PMC: PMC425045
OpenAlex: W2007636157
Cited by: 189
References: 31
Citations by year: 2026: 1 · 2025: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 3
FWCI: 3.88
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2t32am007061-12)
Medical Research Council (19429)
National Health and Medical Research Council
National Cancer Institute
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: vasopressin, ACTH, ACTH release, corticotropin-releasing factor, ovine CRF, synergistic hormone interaction, cortisol, insulin-induced hypoglycemia, hypothalamic-pituitary-adrenal axis, stress response, plasma ACTH, plasma cortisol, human volunteers, dose-response relationship
MeSH terms: Adrenocorticotropic Hormone, Adult, Arginine Vasopressin, Corticotropin-Releasing Hormone, Drug Synergism, Humans, Hydrocortisone, Insulin, Kinetics, Male, Peptides, Vasopressins

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Arginine vasopressin potentiates adrenocorticotropin release induced by ovine corticotropin-releasing factor

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