The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Arginine vasopressin potentiates adrenocorticotropin release induced by ovine corticotropin-releasing factor
Open accessAbstract
Arginine vasopressin (AVP) stimulates ACTH release in man and acts synergistically with synthetic ovine corticotropin-releasing factor (oCRF) in vitro. This study was designed to examine in man the combined effects of synthetic AVP (10 U intramuscularly) and oCRF (1 micrograms/kg intravenously) on ACTH release. Five normal male volunteers participated in five separate experiments: (a) AVP alone; (b) oCRF alone; (c) AVP followed by oCRF 15 min later; (d) simultaneous AVP and oCRF; and (e) insulin-induced hypoglycemia. Plasma immunoreactive ACTH (IR-ACTH) and IR-cortisol were measured for 4 h after injection of each hormone; basal levels for all subjects were less than or equal to 9 +/- 1.2 pg/ml and 4.9 +/- 0.4 micrograms/dl (mean +/- SE), respectively. AVP and oCRF, when given individually, caused rapid rises in IR-ACTH to similar peak levels of 25 +/- 6.6 and 33 +/- 4.6 pg/ml, respectively. AVP given 15 min before oCRF caused a 2.6-fold potentiation of the oCRF response, with a peak IR-ACTH of 85 +/- 4.6 pg/ml. AVP given at the same time as oCRF produced a fourfold potentiation of the peak IR-ACTH response to 132 +/- 11 pg/ml. These ACTH responses were far greater than those previously observed after 30-fold greater doses of oCRF alone. By way of comparison, insulin-induced hypoglycemia caused a peak IR-ACTH of 169 +/- 20 pg/ml. IR-ACTH returned to base line at 60-90 min after AVP alone, whereas the prolonged effect of oCRF was apparent whether it was given alone or in combination with AVP. The mean peak IR-cortisol responses to AVP, oCRF, and AVP given 15 min before oCRF were similar (16.5 +/- 0.9, 16.4 +/- 2.3, and 18.5 +/- 0.8 micrograms/dl, respectively), but the peak IR-cortisol responses to AVP and oCRF given simultaneously and to insulin-induced hypoglycemia were 1.5 and 1.7 times greater, respectively. IR-cortisol returned to base line within 2-3 h after AVP alone, but remained elevated for at least 4 h after oCRF alone or in combination with AVP. These results indicate that AVP acts synergistically with oCRF to release ACTH in man and suggest that AVP may play a physiologic role in modulating the ACTH response mediated by corticotropin-releasing factor.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“On receipt of the neuronal signal from the amygdala and locus coeruleus, numerous neuropeptides are released from the hypothalamus, including arginine vasopressin (AVP) and stress-induced corticotropin-releasing factor/hormone (CRF/H) (90).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [90]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Namely, both in human (39, 43–47, 55) and in rat (26, 36–38, 40, 41), CRH reaction pathway is considered to be dominant in pituitary-adrenal regulation.”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [45]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Principles and Procedures of Statistics
Robinson, H. F. (1961) · Agronomy Journal · doi:10.2134/agronj1961.00021962005300050002x · Cited by 17,727
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965
Self-citationVale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
Self-citationCorticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965
RIVIER, C. L., Brownstein, M. J., Spiess, J., Rivier, J., & Vale, W. (1982) · Endocrinology · doi:10.1210/endo-110-1-272 · Cited by 555
Self-citationPrimary structure of corticotropin-releasing factor from ovine hypothalamus
Spiess, J., Rivier, J., Rivier, C., & Vale, W. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6517 · Cited by 424
Self-citationIsolation and sequence analysis of the human corticotropin‐releasing factor precursor gene.
Shibahara, S., Morimoto, Y., Furutani, Y., Notake, M., Takahashi, H. K., Shimizu, S., Horikawa, S., & Numa, S. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01499.x · Cited by 419
Corticotropin-Releasing Factor*
YASUDA, N., Greer, M. A., & Aizawa, T. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-2-123 · Cited by 322
Rapid radioimmunoassay for corticotropin in unextracted human plasma.
Nicholson, W. E., Davis, D. R., Sherrell, B. J., & Orth, D. N. (1984) · Clinical Chemistry · doi:10.1093/clinchem/30.2.259 · Cited by 280
Self-citationOrth, D. N., Jackson, R. V., DeCherney, G. S., DEBOLD, C. R., ALEXANDER, A. N., Island, D. P., Rivier, J., RIVIER, C. L., Spiess, J., & Vale, W. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110804 · Cited by 246
Self-citationPotentiation by Vasopressin of Corticotropin Release Induced by Corticotropin-Releasing Factor1
Yates, F. E., Russell, S. M., Dallman, M. F., Hedge, G. A., McCann, S. M., & DHARIWAL, A. P. S. (1971) · Endocrinology · doi:10.1210/endo-88-1-3 · Cited by 245
Corticotrophin releasing factor may be modulated vasopressin
Gillies, G. E., & Lowry, P. (1979) · Nature · doi:10.1038/278463a0 · Cited by 174
Site of Action of Vasopressin in Causing Corticotropin Release1
Hedge, G. A., Yates, M. B., Marcus, R., & Yates, F. E. (1966) · Endocrinology · doi:10.1210/endo-79-2-328 · Cited by 132
Giguère, V., & Labrie, F. (1982) · Endocrinology · doi:10.1210/endo-111-5-1752 · Cited by 128
Substances modulating the secretion of ACTH by cultured anterior pituitary cells.
Vale, W., & River, C. (1977) · PubMed · Cited by 101
Self-citationTHE ACTH-RELEASING ACTIVITY OF EXTRACTS OF THE POSTERIOR LOBE OF THE PITUITARY IN VIVO1
McCann, S. M. (1957) · Endocrinology · doi:10.1210/endo-60-5-664 · Cited by 92
Roth, K. A., Weber, E., & Barchas, J. D. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90228-4 · Cited by 73
DEBOLD, C. R., DECHERNEY, G. S., JACKSON, R. V., SHELDON, W. R., ALEXANDER, A. N., ISLAND, D. P., RIVIER, J., VALE, W., & ORTH, D. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-2-294 · Cited by 71
Self-citationGillies, G. E., Greidanus, T. B. V. W., & Lowry, P. J. (1978) · Endocrinology · doi:10.1210/endo-103-2-528 · Cited by 60
Isolated Pituitary Cells: CRF-Like Activity of Neurohypophysial and Related Polypeptides
Portanova, R. P., & Sayers, G. (1973) · Experimental Biology and Medicine · doi:10.3181/00379727-143-37386 · Cited by 55
Nicholson, W. E., DeCherney, G. S., Jackson, R. V., DEBOLD, C. R., Uderman, H. D., ALEXANDER, A. N., Rivier, J., Vale, W., & Orth, D. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-6-1263 · Cited by 50
Self-citationAdrenocorticotropin,β-Endorphin, and Corticosterone Secretion in Brattleboro Rats*
Conte‐Devolx, B., Giraud, P., Oliver, C., Castanas, E., Boudouresque, F., Gillioz, P., & MILLET, Y. (1982) · Endocrinology · doi:10.1210/endo-110-6-2097 · Cited by 46
Staub, J. J., Jenkins, J. S., Ratcliffe, J. G., & Landon, J. (1973) · BMJ · doi:10.1136/bmj.1.5848.267 · Cited by 42
Studies on the Site of Action of Vasopressin in Inducing Adrenocorticotropin Secretion*
YASUDA, N., Greer, M. A., Greer, S. E., & Panton, P. (1978) · Endocrinology · doi:10.1210/endo-103-3-906 · Cited by 42
A Semi-Automated in vitro Assay for CRF: Activities of Peptides Related to Oxytocin and Vasopressin
Pearlmutter, A. F., Rapino, E., & Saffran, M. (2008) · Neuroendocrinology · doi:10.1159/000122299 · Cited by 37
CORTICOTROPHIN RELEASING ACTIVITY IN EXTRACTS OF THE STALK MEDIAN EMINENCE OF BRATTLEBORO RATS
Gillies, G. E., & Lowry, P. J. (1980) · Journal of Endocrinology · doi:10.1677/joe.0.0840065 · Cited by 37
Spiess, J., Rivier, J., & Vale, W. (1983) · Biochemistry · doi:10.1021/bi00287a027 · Cited by 34
Self-citationBuckingham, J. C. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013612 · Cited by 27
Is corticotropin releasing factor modulated vasopressin?
Pearlmutter, A. F., Dokas, L. A., Kong, A., Miller, R. E., & Saffran, M. (1980) · Nature · doi:10.1038/283697b0 · Cited by 15
McDonald, R. K., & Weise, V. K. (1956) · Experimental Biology and Medicine · doi:10.3181/00379727-92-22518 · Cited by 12
RIVIER, C. L., Vale, W. W., & Guillemin, R. (1973) · Experimental Biology and Medicine · doi:10.3181/00379727-142-37129 · Cited by 10
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [4]4. Vale, W. W., C. Rivier, J. Spiess, M. R. Brown, and J. Rivier. 1983. Corticotropin-releasing factor. In Brain Peptides. D. Krieger, M. Brownstein, and J. Martin, editors. John Wiley & Sons, Inc., New York. 961-974.
Cited by
Sorted by citations
CRF and CRF receptors: role in stress responsivity and other behaviors
Bale, T. L., & Vale, W. W. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121410 · Cited by 1,270
Self-citationThe Diagnosis and Differential Diagnosis of Cushing’s Syndrome and Pseudo-Cushing’s States
Newell-Price, J., Trainer, P., Besser, M., & Grossman, A. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.5.0346 · Cited by 833
Hostinar, C. E., Sullivan, R. M., & Gunnar, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0032671 · Cited by 739
Orth, D. N. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503233321207 · Cited by 563
Self-citationRole of stress in the pathogenesis of the metabolic syndrome
Rosmond, R. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.05.007 · Cited by 533
Metadata
- Authors
- DeBold, C. R., Sheldon, W. R., DeCherney, G. S., Jackson, R. V., Alexander, A. N., Vale, W., Rivier, J., & Orth, D. N.
- Affiliations
- Vanderbilt University (US)
- Salk Institute for Biological Studies (US)
- ORCID
- Vale, W
- Venue
- Journal of Clinical Investigation
- Published
- 1984-02-01
- Volume
- 73
- Issue
- 2
- Pages
- 533-538
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC425045
- OpenAlex
- W2007636157
- Cited by
- 189
- References
- 31
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 3
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2t32am007061-12)
- Medical Research Council (19429)
- National Health and Medical Research Council
- National Cancer Institute
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, ACTH, ACTH release, corticotropin-releasing factor, ovine CRF, synergistic hormone interaction, cortisol, insulin-induced hypoglycemia, hypothalamic-pituitary-adrenal axis, stress response, plasma ACTH, plasma cortisol, human volunteers, dose-response relationship
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Arginine Vasopressin, Corticotropin-Releasing Hormone, Drug Synergism, Humans, Hydrocortisone, Insulin, Kinetics, Male, Peptides, Vasopressins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
