Arginine Vasopressin Is a Much More Potent Stimulus to ACTH Release from Ovine Anterior Pituitary Cells than Ovine Corticotropin-Releasing Factor

Familari, Mary; Smith, Ian; Smith, Robin; Funder, John W.

doi:10.1159/000125214

Cited by 117Stress Responses and CortisolNeuropeptides and Animal PhysiologyAdrenal Hormones and Disorders

Arginine Vasopressin Is a Much More Potent Stimulus to ACTH Release from Ovine Anterior Pituitary Cells than Ovine Corticotropin-Releasing Factor

Familari, Mary, Smith, Ian, Smith, Robin, Funder, John W.·2008·Neuroendocrinology

DOI 10.1159/000125214

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Abstract

Cultured rat and ovine anterior pituitary cells were treated with a range of doses (0.01-1,000 nM) of arginine vasopressin (AVP) and ovine corticotropin-releasing factor (CRF), alone or in combination, and medium and cell content of immunoreactive (ir-)ACTH determined. In rat cells, a dose-response curve to CRF was obtained, with a threshold dose of 0.1 nM; AVP was much less effective alone, but augmented CRF responses when administered with CRF. In ovine pituitary cells AVP markedly stimulated ACTH release in a dose-dependent fashion, and with a threshold of 0.1 nM; in contrast, CRF increased ACTH release over basal only at doses greater than 100 nM. In combination, subthreshold doses of AVP potentiated rat pituitary cell responses to CRF; addition of 1 nM of AVP to varying doses of CRF was more effective in terms of ACTH release than addition of 1 nM of CRF to increasing doses of AVP. In contrast, in ovine cells the addition of 1 nM CRF to increasing doses of AVP elicited a larger ACTH response than the addition of 1 nM AVP to increasing doses of CRF. Dexamethasone pretreatment (5 nM) for 48 h significantly decreased CRF potentiation of AVP-stimulated ACTH release in ovine cells. These studies confirm that CRF is a more potent stimulus of ACTH release than AVP in the rat, and establish that in contrast AVP is a much more potent stimulus of ACTH secretion than CRF in isolated ovine pituitary cells.

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CRH and AVP are capable of potentiating each other's activity.
“Moreover, CRH and AVP are also capable of potentiating each other’s activity (37, 38).”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [37]
Synergistic stimulation of ACTH production and secretion by corticotrope cells by CRH and AVP could yield a several-fold higher output than either one individually.
“Their synergistic stimulation of ACTH production and secretion by corticotrope cells could yield a several-fold higher output than due to the action of either one individually (26, 34–41, 43–47).”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [37]
Both in human and in rat, the CRH reaction pathway is considered to be dominant in pituitary-adrenal regulation.
“Namely, both in human (39, 43–47, 55) and in rat (26, 36–38, 40, 41), CRH reaction pathway is considered to be dominant in pituitary-adrenal regulation.”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [37]

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Authors: Familari, M., Smith, I., Smith, R., & Funder, J. W.
ORCID: Familari, Mary
Funder, John W.
Venue: Neuroendocrinology
Publisher: S. Karger AG
Published: 2008-04-02
Volume: 50
Issue: 2
Pages: 152-157
ISSN: 0028-3835 (ISSN-L)
1423-0194
DOI: 10.1159/000125214
OpenAlex: W2042841775
Cited by: 116
References: 0
Citations by year: 2025: 2 · 2024: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 3
FWCI: 0.74
Type: journal article
Language: en
Open access: closed
Licence: karger.com/pages/terms-and-conditions (vor)
karger.com/pages/terms-and-conditions (tdm)
Locations: Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: vasopressin, corticotropin-releasing factor, ACTH secretion, anterior pituitary cells, ovine pituitary, rat pituitary, hormone potentiation, dexamethasone
MeSH terms: Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Cells, Cultured, Corticotropin-Releasing Hormone, Dexamethasone, Dose-Response Relationship, Drug, Drug Synergism, Female, Male, Pituitary Gland, Anterior, Rats, Inbred Strains, Sheep, Stress, Physiological, Rats

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Arginine Vasopressin Is a Much More Potent Stimulus to ACTH Release from Ovine Anterior Pituitary Cells than Ovine Corticotropin-Releasing Factor

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