The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions.
Open accessAbstract
To characterize glucose counterregulatory mechanisms in patients with noninsulin-dependent diabetes mellitus (NIDDM) and to test the hypothesis that the increase in glucagon secretion during hypoglycemia occurs primarily via a paracrine islet A-B cell interaction, we examined the effects of a subcutaneously injected therapeutic dose of insulin (0.15 U/kg) on plasma glucose kinetics, rates of glucose production and utilization, and their relationships to changes in the circulating concentrations of neuroendocrine glucoregulatory factors (glucagon, epinephrine, norepinephrine, growth hormone, and cortisol), as well as to changes in endogenous insulin secretion in 13 nonobese NIDDM patients with no clinical evidence of autonomic neuropathy. Compared with 11 age-weight matched nondiabetic volunteers in whom euglycemia was restored primarily by a compensatory increase in glucose production, in the diabetics there was no compensatory increase in glucose production (basal 2.08 +/- 0.04----1.79 +/- 0.07 mg/kg per min at 21/2 h in diabetics vs. basal 2.06 +/- 0.04----2.32 +/- 0.11 mg/kg per min at 21/2 h in nondiabetics, P less than 0.01) despite the fact that plasma insulin concentrations were similar in both groups (peak values 22 +/- 2 vs. 23 +/- 2 microU/ml in diabetics and nondiabetics, respectively). This abnormality in glucose production was nearly completely compensated for by a paradoxical decrease in glucose utilization after injection of insulin (basal 2.11 +/- 0.03----1.86 +/- 0.06 mg/kg per min at 21/2 h in diabetics vs. basal 2.08 +/- 0.04----2.39 +/- 0.11 mg/kg per min at 21/2 h nondiabetics, P less than 0.01), which could not be accounted for by differences in plasma glucose concentrations; the net result was a modest prolongation of hypoglycemia. Plasma glucagon (area under the curve [AUC] above base line, 12 +/- 3 vs. 23 +/- 3 mg/ml X 12 h in nondiabetics, P less than 0.05), cortisol (AUC 2.2 +/- 0.5 vs. 4.0 +/- 0.7 mg/dl X 12 h in nondiabetics, P less than 0.05), and growth hormone (AUC 1.6 +/- 0.4 vs. 2.9 +/- 0.4 micrograms/ml X 12 h in nondiabetics, P less than 0.05) responses in the diabetics were decreased 50% while their plasma norepinephrine responses (AUC 49 +/- 12 vs. 21 +/- 5 ng/ml X 12 h in nondiabetics, P less than 0.05) were increased twofold (P less than 0.05) and their plasma epinephrine responses were similar to those of the nondiabetics (AUC 106 +/- 17 vs. 112 +/- 10 ng/ml X 12 h in nondiabetics). In both groups of subjects, increases in plasma glucagon were inversely correlated with plasma glucose concentrations (r = -0.80 in both groups, P less than 0.01) and suppression of endogenous insulin secretion (r = -0.57 in nondiabe
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In type 2 diabetes, the glucagon response to hypoglycemia has been diversely reported as being either modestly diminished (16, 30,50) or preserved (33,34,37,38).”
From Hypoglycemia in Type 2 Diabetes (2005) · cites this paper as [30]
In the citing paper
“Interpretation of the early studies is limited by heterogeneity of study design (29), differences in blood glucose nadir between the diabetic and control groups (30,31), a lack of agematched control subjects (31), and the disparate methods used to induce hypoglycemia (30 -35).”
From Hypoglycemia in Type 2 Diabetes (2005) · cites this paper as [30]
In the citing paper
“Plasma free fatty acids increase in response to hypoglycemia in type 2 diabetes (30,33,50) but do not in type 1 diabetes (54).”
From Hypoglycemia in Type 2 Diabetes (2005) · cites this paper as [30]
Citations
Cites
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*
Perley, M. J., & Kipnis, D. M. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105685 · Cited by 917
Effects of arterial versus venous sampling on analysis of glucose kinetics in man
McGuire, E. A., Helderman, J. H., Tobin, J. D., Andres, R., & Berman, M. D. (1976) · Journal of Applied Physiology · doi:10.1152/jappl.1976.41.4.565 · Cited by 704
RIZZA, R. A., MANDARINO, L. J., & GERICH, J. E. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-1-131 · Cited by 696
Self-citationGerich, J. E., Langlois, M., Noacco, C., Karam, J. H., & Forsham, P. H. (1973) · Science · doi:10.1126/science.182.4108.171 · Cited by 688
Self-citationKolterman, O., Gray, R. S., Griffin, J., BURSTEIN, P. J., Insel, J. R., Scarlett, J. A., & Olefsky, J. M. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110350 · Cited by 628
ON THE HORMONAL REGULATION OF CARBOHYDRATE METABOLISM; STUDIES WITH C14 GLUCOSE.
DeBodo, R. C., Steele, R., ALTSZULER, N., Dunn, A., & Bishop, J. (1963) · PubMed · Cited by 532
Rizza, R. A., Mandarino, L. J., & Gerich, J. E. (1982) · Diabetes · doi:10.2337/diab.31.8.663 · Cited by 440
Self-citationBolli, G., Feo, P. D., Compagnucci, P., Cartechini, M. G., Angeletti, G., Santeusanio, F., Brunetti, P., & Gerich, J. E. (1983) · Diabetes · doi:10.2337/diab.32.2.134 · Cited by 433
Self-citationRole of Glucagon, Catecholamines, and Growth Hormone in Human Glucose Counterregulation
Rizza, R. A., Cryer, P. E., & Gerich, J. E. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109464 · Cited by 421
Self-citation
Cited by
Sorted by citations
Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes.
Cryer, P. (2002) · Diabetologia · doi:10.1007/s00125-002-0822-9 · Cited by 794
Self-citationHypoglycemia in Type 2 Diabetes
Zammitt, N. N., & Frier, B. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.12.2948 · Cited by 435
Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes
Quesada, I., Tudurí, E., Ripoll, C., & Nadal, Á. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0290 · Cited by 447
Dunning, B. E., & Gerich, J. E. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0026 · Cited by 369
Self-citationHypoglycemia-associated autonomic failure in advanced type 2 diabetes.
Segel, S. A., Paramore, D. S., & Cryer, P. E. (2002) · Diabetes · doi:10.2337/diabetes.51.3.724 · Cited by 337
Self-citationGlucose counterregulation, hypoglycemia, and intensive insulin therapy in diabetes mellitus
Epstein, F. H., Cryer, P. E., & Gerich, J. E. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507253130405 · Cited by 273
Self-citationAlpha cell function in health and disease: influence of glucagon-like peptide-1
Dunning, B. E., Foley, J. E., & Åhrén, B. (2005) · Diabetologia · doi:10.1007/s00125-005-1878-0 · Cited by 276
Degn, K., Brock, B., Juhl, C. B., Djurhuus, C., Grubert, J., Kim, D. S., Han, J., Taylor, K., Fineman, M. S., & Schmitz, O. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2397 · Cited by 255
MacDonald, P. E., Marinis, Y. Z. D., Ramracheya, R. D., Salehi, A. A., Ma, X., Johnson, P., Cox, R., Eliasson, L., & Rorsman, P. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050143 · Cited by 250
Gerich, J. E. (1993) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80207-1 · Cited by 224
Self-citationInsulin therapy and hypoglycemia
McCall, A. L. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.03.001 · Cited by 177
Neuroendocrine responses to hypoglycemia
Tesfaye, N., & Seaquist, E. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05820.x · Cited by 164
Taylor, R., & Agius, L. (1988) · Biochemical Journal · doi:10.1042/bj2500625 · Cited by 166
2 Intra-islet insulin—glucagon—somatostatin relationships
Samols, E., Bonner‐Weir, S., & Weir, G. C. (1986) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(86)80041-x · Cited by 156
Hepburn, D. A., MacLeod, K. M., Pell, A. C. H., Scougal, I. J., & Frier, B. M. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb00050.x · Cited by 154
Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes.
Weir, G. C., & Bonner‐Weir, S. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114574 · Cited by 148
Spyer, G., Hattersley, A. T., MacDonald, I., Amiel, S., & MacLeod, K. M. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03322-5 · Cited by 126
Hypoglycemia in Patients with Diabetes and Renal Disease
Alsahli, M., & Gerich, J. E. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4050948 · Cited by 127
Self-citationEarly Loss of the Glucagon Response to Hypoglycemia in Adolescents With Type 1 Diabetes
Siafarikas, A., Johnston, R. J., Bulsara, M. K., O’Leary, P., Jones, T. W., & Davis, E. A. (2012) · Diabetes Care · doi:10.2337/dc11-2010 · Cited by 120
TURK, J. W. (1987) · Progress in Lipid Research · doi:10.1016/0163-7827(87)90010-5 · Cited by 117
Hypoglycaemia and Cardiac Arrhythmias in Patients with Type 2 Diabetes Mellitus
Lindström, T., Jorfeldt, L., Tegler, L., & Arnqvist, H. J. (1992) · Diabetic Medicine · doi:10.1111/j.1464-5491.1992.tb01834.x · Cited by 113
Torlone, E., Rambotti, A. M., Perriello, G., Botta, G., Santeusanio, F., Brunetti, P., & Bolli, G. B. (1991) · Diabetologia · doi:10.1007/bf00500383 · Cited by 113
Self-citationNocturnal Blood Glucose Control in Type I Diabetes Mellitus
Bolli, G. B., Perriello, G., Fanelli, C. G., & Feo, P. D. (1993) · Diabetes Care · doi:10.2337/diacare.16.3.71 · Cited by 87
Self-citationBolli, G. B., Gottesman, I. S., Campbell, P. J., Haymond, M. W., Cryer, P. E., & Gerich, J. E. (1984) · New England Journal of Medicine · doi:10.1056/nejm198411083111904 · Cited by 84
Self-citationHypoglycemia, Chronic Kidney Disease, and Diabetes Mellitus
Alsahli, M., & Gerich, J. E. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.07.013 · Cited by 81
Self-citationAkram, K., Pedersen‐Bjergaard, U., Borch‐Johnsen, K., & Thorsteinsson, B. (2006) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2005.08.005 · Cited by 74
Åhrén, B., & Foley, J. E. (2016) · Diabetologia · doi:10.1007/s00125-016-3899-2 · Cited by 77
Effects of Glycemic Control on Protective Responses Against Hypoglycemia in Type 2 Diabetes
Korzon-Burakowska, A., Hopkins, D., Matyka, K., Lomas, J., Pernet, A., Macdonald, I., & Amiel, S. (1998) · Diabetes Care · doi:10.2337/diacare.21.2.283 · Cited by 71
Schweizer, A., Hassanein, M. M., & Abdallah, K. (2014) · Vascular Health and Risk Management · doi:10.2147/vhrm.s64038 · Cited by 72
Landstedt‐Hallin, L., Adamson, U., & Lins, P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.6002 · Cited by 67
Overview of counterregulation and its abnormalities in diabetes mellitus and other conditions
Gerich, J. E., & Campbell, P. J. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040202 · Cited by 65
Self-citationPedersen, M. G., Ahlstedt, I., El Hachmane, M. F., & Göpel, S. O. (2016) · Scientific Reports · doi:10.1038/srep31214 · Cited by 64
Regulation of Counterregulatory Hormone Secretion in Man During Exercise and Hypoglycemia*
SOTSKY, M. J., SHILO, S., & Shamoon, H. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-1-9 · Cited by 64
van Haeften, T. W., Bolli, G. B., Dimitriadis, G., Gottesman, I. S., Horwitz, D. L., & Gerich, J. E. (1986) · Metabolism · doi:10.1016/0026-0495(86)90173-3 · Cited by 58
Self-citationShamoon, H., Friedman, S., Canton, C., Zacharowicz, L., Hu, M., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117267 · Cited by 57
Hypoglycaemia in Type 2 diabetes
Heller, S. R. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.09.026 · Cited by 55
Koeslag, J. H., Saunders, P. T., & Terblanche, E. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.037895 · Cited by 54
Sulphonylurea‐induced hypoglycaemia in type 2 diabetes mellitus: a review
Burge, M. R., Sood, V., Sobhy, T. A., Rassam, A. G., & Schade, D. S. (1999) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.1999.00031.x · Cited by 51
Renal Compensation for Impaired Hepatic Glucose Release During Hypoglycemia in Type 2 Diabetes
Woerle, H. J., Meyer, C., Popa, E. M., Cryer, P. E., & Gerich, J. E. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1386 · Cited by 54
Self-citationBottini, P., Tantucci, C., Scionti, L., Dottorini, M., Puxeddu, E., Reboldi, G., Bolli, G. B., Casucci, G., Santeusanio, F., Sorbini, C., et al. (1995) · Diabetologia · doi:10.1007/bf00400101 · Cited by 51
Self-citationHemmings, S. J., & Spafford, D. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00019-4 · Cited by 49
Farngren, J., Persson, M., Schweizer, A., Foley, J. E., & Åhrén, B. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12284 · Cited by 49
Alsahli, M., & Gerich, J. E. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.07.002 · Cited by 45
Self-citationHeller, S. R., Macdonald, I. A., & Tattersall, R. B. (1987) · Diabetologia · doi:10.1007/bf00295875 · Cited by 43
CRYER, P. E., WHITE, N. H., & SANTIAGO, J. V. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-2-131 · Cited by 43
Self-citationJun, H., Bae, H. Y., Lee, B. R., Koh, K. S., Kim, Y., Lee, K. W., Kim, H., & Yoon, J. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00071-4 · Cited by 40
Hypoglycaemia and counterregulation in type 2 diabetes
Gerich, J. E. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03303-1 · Cited by 36
Self-citationGlucagon, cyclic AMP, and hepatic glucose mobilization: A half‐century of uncertainty
Rodgers, R. L. (2022) · Physiological Reports · doi:10.14814/phy2.15263 · Cited by 34
The physiological basis of insulin therapy in people with diabetes mellitus
Bolli, G. B., Porcellati, F., Lucidi, P., & Fanelli, C. G. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108839 · Cited by 34
Self-citationMultiple defects in counterregulation of hypoglycemia in modestly advanced type 2 diabetes mellitus
Israelian, Z., Szoke, E., Woerle, J., Bokhari, S. M. N. A., Schorr, M., Schwenke, D. C., Cryer, P. E., Gerich, J. E., & Meyer, C. (2006) · Metabolism · doi:10.1016/j.metabol.2005.11.013 · Cited by 33
Self-citationHypoglycaemia and gastric emptying
Marathe, C. S., Marathe, J. A., Rayner, C. K., Kar, P., Jones, K. L., & Horowitz, M. (2019) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13570 · Cited by 32
Hompesch, M., Jones-Leone, A. R., Carr, M. C., Matthews, J., Zhi, H., Young, M. A., Morrow, L., & Reinhardt, R. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12398 · Cited by 31
Mumme, L., Breuer, T. G. K., Rohrer, S., Schenker, N., Menge, B. A., Holst, J. J., Nauck, M. A., & Meier, J. J. (2017) · Diabetes Care · doi:10.2337/dc17-0792 · Cited by 29
Clinical Measures of Islet Function: Usefulness to Characterize Defects in Diabetes
Åhrén, B., Pratley, R. E., Soubt, M., Dunning, B. E., & Foley, J. E. (2008) · Current Diabetes Reviews · doi:10.2174/157339908784220714 · Cited by 30
Muneer, M. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2020_534 · Cited by 28
Lundqvist, M., Pereira, M. J., Almby, K. E., Hetty, S., & Eriksson, J. W. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad549 · Cited by 29
Dimitriadis, G. K., Cryer, P., & Gerich, J. E. (1985) · Diabetologia · doi:10.1007/bf00279917 · Cited by 30
Self-citationDawn Phenomenon and Somogyi Effect in IDDM
Stephenson, J., & Schernthaner, G. (1989) · Diabetes Care · doi:10.2337/diacare.12.4.245 · Cited by 27
Glucagon, Catecholamine, and Symptom Responses to Hypoglycemia in Living Donors of Pancreas Segments
Robertson, R. P., Sutherland, D. E. R., Seaquist, E. R., & Lanz, K. J. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1689 · Cited by 27
Regulation of Carbohydrate Metabolism and Response to Hypoglycemia
Butler, P. C., & Rizza, R. A. (1989) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30386-4 · Cited by 27
Bell, D. S. H., & Yumuk, V. (1997) · Endocrine Practice · doi:10.4158/ep.3.5.281 · Cited by 26
Decreased hepatic glucagon responses in Type 1 (insulin-dependent) diabetes mellitus
�rskov, L., Alberti, K. G. M. M., Mengel, A., M⊘ller, N., Pedersen, O. B., Rasmussen, O., Seefeldt, T., & Schmitz, O. (1991) · Diabetologia · doi:10.1007/bf00403290 · Cited by 24
Insulin in the Somogyi Phenomenon
Wallaert, B., Aerts, C., Bonniere, P., Cortot, A., Tonnel, A., Paris, J., & Voisin, C. (1985) · New England Journal of Medicine · doi:10.1056/nejm198502143120715 · Cited by 23
Kennedy, F. P., Bolli, G. B., Go, V. L. W., Cryer, P. E., & Gerich, J. E. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-3-602 · Cited by 23
Self-citationLiver or kidney: Who has the oar in the gluconeogenesis boat and when?
Sahoo, B., Srivastava, M., Katiyar, A., ECELBARGER, C. A., & Tiwari, S. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i7.1049 · Cited by 22
Hypoglycemia Unawareness in Noninsulin-Dependent Diabetes Mellitus
Veneman, T. F., & Erkelens, D. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3972 · Cited by 20
Gerich, J. E. (1989) · Aufklärung und Einwilligung im Arztrecht, ESA · doi:10.1007/978-3-642-74255-2_10 · Cited by 20
Self-citationLandgraf, W., Owens, D. R., Frier, B. M., Zhang, M., & Bolli, G. B. (2019) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13897 · Cited by 19
Self-citationBurge, M. R., Sobhy, T. A., Qualls, C. R., & Schade, D. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.7993 · Cited by 17
Literature Review: Drug and Alcohol-Induced Hypoglycaemia
Kalaria, T., Ko, Y. L., & Issuree, K. K. J. (2021) · Journal of Laboratory and Precision Medicine · doi:10.21037/jlpm-21-16 · Cited by 17
Bell, D. S. H., & Ovalle, F. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.00357.x · Cited by 15
Adverse Effects of Exogenous Insulin
Patrick, A. W., & Williams, G. (1993) · Drug Safety · doi:10.2165/00002018-199308060-00004 · Cited by 14
Åhrén, B., Foley, J. E., Dejager, S., Akacha, M., Shao, Q., Heimann, G., Dworak, M., & Schweizer, A. (2014) · Diabetes Therapy · doi:10.1007/s13300-014-0082-y · Cited by 13
Porcellati, F., Mauro, S. D., Mazzieri, A., Scamporrino, A., Filippello, A., Fano, M. D., Fanelli, C. G., Purrello, F., Malaguarnera, R., & Piro, S. (2021) · Biomolecules · doi:10.3390/biom11091281 · Cited by 15
Somogyi and dawn phenomena: Mechanisms
Feo, P. D., Perriello, G., & Bolli, G. B. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040106 · Cited by 13
Self-citationHypoglycaemia unawareness in insulin‐dependent diabetes mellitus
Veneman, T. F., & van Haeften, T. W. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb02020.x · Cited by 13
Glucose counterregulation in Type 2 diabetes mellitus
de Galan, B. E., & Hoekstra, J. B. L. (2001) · Diabetic Medicine · doi:10.1046/j.1464-5491.2001.00610.x · Cited by 11
The Genetics and Pathophysiology of Type II and Gestational Diabetes
Csorba, T. R., Edwards, A. L., & Tan, M. H. (1995) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369509082593 · Cited by 9
Hypoglycaemia in Type 2 Diabetes and in Elderly People
Zammitt, N. N., & Frier, B. M. (2013) · Wiley eBooks · doi:10.1002/9781118695432.ch12 · Cited by 8
Thomas, R. L., BOEDER, S. C., Hamidi, V., Giovannetti, E. R., Gregory, J. M., & Pettus, J. (2024) · Diabetes Care · doi:10.2337/dc23-2501 · Cited by 7
Autonomic nervous system responses to hypo- and hyperglycemia in type 2 diabetes and prediabetes
Lundqvist, M., Pereira, M. J., Wiklund, U., Hetty, S., & Eriksson, J. W. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae130 · Cited by 7
A reappraisal of the role of cyclic AMP in the physiological action of glucagon
Rodgers, R. L. (2022) · Peptides · doi:10.1016/j.peptides.2022.170906 · Cited by 7
Hoffman, E. G., D’Souza, N. C., Aiken, J., ATHERLEY, S. C., Liggins, R., & Riddell, M. C. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15002 · Cited by 8
The signification of stress in the aetiopathogenesis of type2 diabetes mellitus
Ionescu-Tirgoviste, C., Pruna, S., Mariana, C., Dan, C. M., & Mincu, I. (1987) · Stress Medicine · doi:10.1002/smi.2460030408 · Cited by 7
Low-dose epinephrine supports plasma glucose in fasted elderly patients with type 2 diabetes
Burge, M. R., Kamin, J., Timm, C., Qualls, C., & Schade, D. S. (2000) · Metabolism · doi:10.1016/s0026-0495(00)91273-3 · Cited by 5
Glucose Counterregulation in Advanced Type 2 Diabetes: Effect of β-Adrenergic Blockade
Bokhari, S. M. N. A., Plummer, E., Emmerson, P., Gupta, A., & Meyer, C. (2014) · Diabetes Care · doi:10.2337/dc14-0782 · Cited by 4
Fowelin, J., Attvall, S., von Schenck, H., Smith, U., & Lager, I. (1990) · Metabolism · doi:10.1016/0026-0495(90)90126-w · Cited by 4
Glucose counterregulation in normal and diabetic man
Cryer, P. E. (1985) · Clinical Physiology · doi:10.1111/j.1365-2281.1985.tb00012.x · Cited by 4
Self-citationKodl, C. T., & Seaquist, E. R. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0065-3 · Cited by 3
Dietary sugars and carbohydrate metabolism in type II diabetes.
Hallfrisch, J. (1987) · Journal of the American College of Nutrition · doi:10.1080/07315724.1987.10720203 · Cited by 3
Pancreatic morphology in normal and diabetic states
Hull, R. L., & Kahn, S. E. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch5 · Cited by 2
Carbohydrate Metabolism and Aging
McDonald, R. B., & Ruhe, R. C. (2000) · Modern nutrition · doi:10.1201/9781420039047.ch14 · Cited by 2
Hypoglycemia in Diabetes Mellitus
Alsahli, M., & Gerich, J. E. (2009) · Springer eBooks · doi:10.1007/978-0-387-09841-8_19 · Cited by 1
Self-citationHypoglycemia — mechanisms and prevention in NIDDM treatment with insulin
Zahnd, G. R. (1988) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(88)90016-2 · Cited by 1
ON THE ORIGIN OF NON-INSULIN DEPENDENT DIABETES MELLITUS
O'Hare, J. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90310-1 · Cited by 1
Atypical mycobacterial infection of a finger
Leung, D., & Venkatesan, P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03309-2
Mohan, N., P, G. K. K., Jayachandran, A. K., P, S. T., Ajith, V., Bharath Prasad, S., Karunanithi, K., Arun Kumar, K., Manohar, V., & Nandu., M. (2015) · Universal Journal of Medical Science · doi:10.13189/ujmsj.2015.030402
Diabetische Notfallsituationen – die Hypoglykämie
Siegmund, T., & Schumm‐Draeger, P. (2014) · Der Diabetologe · doi:10.1007/s11428-014-1264-y
Hypoglycemia with New Generation Basal Analog Insulins: A Descriptive Critical Review
Thrasher, M. A. J. R. (2015) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000576
Somatostatin Receptor Type 2 (SSTR2) Antagonism and Hypoglycemia in Diabetes
Yue, J. T. Y. (2012) · TSpace (University of Toronto)
Metadata
- Authors
- Bolli, G. B., Tsalikian, E., Haymond, M. W., Cryer, P. E., & Gerich, J. E.
- Affiliations
- Mayo Clinic (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1984-06-01
- Volume
- 73
- Issue
- 6
- Pages
- 1532-1541
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC437063
- OpenAlex
- W2010800358
- Semantic Scholar
- 786d58ad6f63ba856c5f63459c3b3032b1cf5333
- Cited by
- 108
- References
- 57
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 7 · 2013: 2 · 2012: 3
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fogarty International Center
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, glucose counterregulation, hypoglycemia, glucagon secretion, insulin resistance, glucose production, glucose utilization, neuroendocrine response, epinephrine, norepinephrine, growth hormone, cortisol, endogenous insulin secretion, subcutaneous insulin
- MeSH terms
- Adult, Blood Glucose, Blood Pressure, C-Peptide, Diabetes Mellitus, Type 2, Female, Glucose, Glycolysis, Heart Rate, Glycated Hemoglobin, Hormones, Humans, Injections, Subcutaneous, Insulin, Kinetics, Male, Middle Aged, Reference Values
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
