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Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors
Open accessAbstract
Rat renal interlobar arteries express heme oxygenase 2 (HO-2) and manufacture carbon monoxide (CO), which is released into the headspace gas. CO release falls to 30% and 54% of control, respectively, after inhibition of HO activity with chromium mesoporphyrin (CrMP) or of HO-2 expression with antisense oligodeoxynucleotides (HO-2 AS-ODN). Patch-clamp studies revealed that CrMP decreases the open probability of a tetraethylammonium-sensitive (TEA-sensitive) 105 pS K channel in interlobar artery smooth muscle cells, and that this effect of CrMP is reversed by CO. Assessment of phenylephrine-induced tension development revealed reduction of the EC(50) in vessels treated with HO-2 AS-ODN, CrMP, or TEA. Exogenous CO greatly minimized the sensitizing effect on agonist-induced contractions of agents that decrease vascular CO production, but not the sensitizing effect of K channel blockade with TEA. Collectively, these data suggest that vascular CO serves as an inhibitory modulator of vascular reactivity to vasoconstrictors via a mechanism that involves a TEA-sensitive K channel.
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Citations
Cited by
Pharmacological and Clinical Aspects of Heme Oxygenase
Abraham, N. G., & Kappas, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07104 · Cited by 1,115
Self-citationCarbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Wu, L., & Wang, R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.3 · Cited by 962
CO AS A CELLULAR SIGNALING MOLECULE
Kim, H. P., Ryter, S. W., & Choi, A. M. K. (2006) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141053 · Cited by 426
Turkseven, S., Kruger, A., Mingone, C. J., Kaminski, P., Inaba, M., Rodella, L. F., Ikehara, S., Wolin, M. S., & Abraham, N. G. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00024.2005 · Cited by 256
Self-citationBarone, E., Di Domenico, F., Mancuso, C., & Butterfield, D. A. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.09.018 · Cited by 127
Metadata
- Authors
- Kaide, J.-I., Zhang, F., Wei, Y., Jiang, H., Yu, C., Wang, W., Balazy, M., Abraham, N. G., & Nasjletti, A.
- Venue
- Journal of Clinical Investigation
- Published
- 2001-05-01
- Volume
- 107
- Issue
- 9
- Pages
- 1163-1171
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2170431734
- Cited by
- 184
- References
- 0
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kaide, J.-I., Zhang, F., Wei, Y., Jiang, H., Yu, C., Wang, W., Balazy, M., Abraham, N. G., & Nasjletti, A. (2001). Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors. Journal of Clinical Investigation. https://doi.org/10.1172/jci11218
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