The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.
Open accessAbstract
The pathogenesis and progression of rheumatoid arthritis involves the production of biologically active lymphokines and monokines. Of these, interleukin 1 (IL-1) has been somewhat of a controversial molecule because it seems to evoke various biological responses in several different tissues. In these studies we demonstrate that three biological properties of human monocyte-derived IL-1 (T-lymphocyte activation and human synovial cell prostaglandin E2 and collagenase production) co-purify. The complementary DNA for the prominent pI 7 form of human IL-1 was expressed, purified, and tested. Any controversy now appears resolved since homogeneous recombinant human IL-1 stimulates prostaglandin E2 and collagenase from human synovial cells as well as activates T cells in vitro.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cloning and expression of murine interleukin-1 cDNA in Escherichia coli
Lomedico, P. T., Gubler, U., Hellmann, C. P., Dukovich, M., Giri, J. G., Pan, Y.-C. E., Collier, K., Semionow, R., Chua, A. O., & Mizel, S. B. (1984) · Nature · doi:10.1038/312458a0 · Cited by 816
Mizel, S. B., Dayer, J. M., Krane, S. M., & Mergenhagen, S. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.4.2474 · Cited by 612
Self-citationKaye, J., Gillis, S., Mizel, S. B., Shevach, E. M., Malek, T. R., Dinarello, C. A., Lachman, L. B., & Janeway, C. A. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.3.1339 · Cited by 519
Self-citationDayer, J. M., Bréard, J., Chess, L., & Krane, S. M. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109596 · Cited by 281
Self-citationFontana, A., Weber, E., & Dayer, J. M. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.4.1696 · Cited by 280
Self-citationHuman leukocytic pyrogen: purification and development of a radioimmunoassay.
Dinarello, C. A., Renfer, L., & Wolff, S. M. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.10.4624 · Cited by 272
Self-citationMolecular basis of fever in humans
A. Dinarello, C., & M. Wolff, S. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90548-4 · Cited by 249
Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1
Van Damme, J., De Ley, M., Opdenakker, G., Billiau, A., De Somer, P., & Beeumen, J. V. (1985) · Nature · doi:10.1038/314266a0 · Cited by 236
Hanson, D. F., & Murphy, P. A. (1984) · Infection and Immunity · doi:10.1128/iai.45.2.483-490.1984 · Cited by 45
Cited by
Interleukin-1 and interleukin-1 antagonism
Dinarello, C. (1991) · Blood · doi:10.1182/blood.v77.8.1627.1627 · Cited by 2,304
Self-citationEdwards, D. R., Murphy, G., Reynolds, J. J., Whitham, S. E., Docherty, A. J., Angel, P., & Heath, J. K. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02449.x · Cited by 1,221
Interleukin 1 of the central nervous system is produced by ameboid microglia.
Giulian, D., Baker, T. J., Shih, L. C., & Lachman, L. B. (1986) · The Journal of experimental medicine · doi:10.1084/jem.164.2.594 · Cited by 859
Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis.
Koch, A. E., Kunkel, S. L., Harlow, L. A., Johnson, B., Evanoff, H. L., Haines, G. K., Burdick, M. D., Pope, R. M., & Strieter, R. M. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115950 · Cited by 668
Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.
HE, C. S., Wilhelm, S. M., Pentland, A. P., Marmer, B. L., Grant, G. A., Eisen, A. Z., & Goldberg, G. I. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2632 · Cited by 572
Metadata
- Authors
- Dayer, J. M., de Rochemonteix, B., Burrus, B., Demczuk, S., & Dinarello, C. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1986-02-01
- Volume
- 77
- Issue
- 2
- Pages
- 645-648
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2150876596
- Cited by
- 624
- References
- 9
- FWCI
- 39.94
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells. https://app.cochat.ai/papers/10.1172/jci112350
- The paper
- Dayer, J. M., de Rochemonteix, B., Burrus, B., Demczuk, S., & Dinarello, C. A. (1986). Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells. Journal of Clinical Investigation. https://doi.org/10.1172/jci112350
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
