The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause.
Open accessAbstract
We made longitudinal measurements of bone mineral density (BMD) in 139 normal women (ages 20-88 yr) at midradius (99% cortical bone) and lumbar spine (approximately 70% trabecular bone) by single- and dual-photon absorptiometry. BMD was measured 2-6 (median, 3) times over an interval of 0.8-3.4 yr (median, 2.1 yr). For midradius, BMD did not change (+0.48%/yr, NS) before menopause but decreased (-1.01%/yr, P less than 0.001) after menopause. For lumbar spine, there was significant bone loss both before (-1.32%/yr, P less than 0.001) and after (-0.97%/yr, P = 0.006) menopause; these rates did not differ significantly from each other. Our data show that before menopause little, if any, bone is lost from the appendicular skeleton but substantial amounts are lost from the axial skeleton. Thus, factors in addition to estrogen deficiency must contribute to pathogenesis of involutional osteoporosis in women because about half of overall vertebral bone loss occurs premenopausally.
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Citations
Cites
Prevention of spinal osteoporosis in oophorectomised women
Lindsay, R., Hart, D. M., Forrest, C., & Baird, C. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92592-1 · Cited by 706
JUDD, H. L., JUDD, G. E., LUCAS, W. E., & YEN, S. S. C. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-6-1020 · Cited by 511
Self-citation
Cited by
Sex Steroids and the Construction and Conservation of the Adult Skeleton
Riggs, B. L., Khosla, S., & Melton, L. J. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0465 · Cited by 1,846
Self-citationRiggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Peterson, J. M., Rouleau, P. A., McCollough, C. H., Bouxsein, M. L., & Khosla, S. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040916 · Cited by 925
Self-citationPathogenesis of bone fragility in women and men
Seeman, E. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08706-8 · Cited by 909
Matkovic, V, Jelic, T., Wardlaw, G. M., Ilich, J. Z., Goel, P. K., Wright, J. K., Andon, M. B., Smith, K. T., & Heaney, R. P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117034 · Cited by 806
Wolff, I., van Croonenborg, J. J., Kemper, H. C. G., Kostense, P. J., & Twisk, J. W. R. (1999) · Osteoporosis International · doi:10.1007/s001980050109 · Cited by 589
Metadata
- Authors
- Riggs, B. L., Wahner, H. W., Melton, L. J., Richelson, L. S., Judd, H. L., & Offord, K. P.
- Venue
- Journal of Clinical Investigation
- Published
- 1986-05-01
- Volume
- 77
- Issue
- 5
- Pages
- 1487-1491
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2079088427
- Cited by
- 510
- References
- 2
- FWCI
- 39.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause. https://app.cochat.ai/papers/10.1172/jci112462
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- Riggs, B. L., Wahner, H. W., Melton, L. J., Richelson, L. S., Judd, H. L., & Offord, K. P. (1986). Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause. Journal of Clinical Investigation. https://doi.org/10.1172/jci112462
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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