Cited by 346Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

Open access

Peiris, A N, Mueller, R A, Smith, G A, Struve, M F, Kissebah, A H·1986·Journal of Clinical Investigation

DOI 10.1172/jci112758PMC PMC423938

Open this paper in CoChat — free account

Abstract

The effects of obesity and body fat distribution on splanchnic insulin metabolism and the relationship to peripheral insulin sensitivity were assessed in 6 nonobese and 16 obese premenopausal women. When compared with the nonobese women, obese women had significantly greater prehepatic production and portal vein levels of insulin both basally and following glucose stimulation. This increase correlated with the degree of adiposity but not with waist-to-hip girth ratio (WHR). WHR, however, correlated inversely with the hepatic extraction fraction and directly with the posthepatic delivery of insulin. The latter correlated with the degree of peripheral insulinemia. The decline in hepatic insulin extraction with increasing WHR also correlated with the accompanying diminution in peripheral insulin sensitivity. Increasing adiposity is thus associated with insulin hypersecretion. The pronounced hyperinsulinemia of upper body fat localization, however, is due to an additional defect in hepatic insulin extraction. This defect is closely allied with the decline in peripheral insulin sensitivity.

Integrity signals

Registry

Crossref · 10.1172/jci112758

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 Years
Durnin, J. V. G. A., & Womersley, J. (1974) · British Journal Of Nutrition · doi:10.1079/bjn19740060 · Cited by 6,343
Relation of Body Fat Distribution to Metabolic Complications of Obesity*
KISSEBAH, A. H., VYDELINGUM, N., MURRAY, R., EVANS, D. J., KALKHOFF, R. K., & ADAMS, P. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-2-254 · Cited by 1,909
Self-citation
The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function.
CAESAR, J., Shaldon, S., Chiandussi, L., Guevara, L., & Sherlock, S. (1961) · PubMed · Cited by 761
Relationship of Androgenic Activity to Body Fat Topography, Fat Cell Morphology, and Metabolic Aberrations in Premenopausal Women*
EVANS, D. J., Hoffmann, R. G., Kalkhoff, R. K., & Kissebah, A. H. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-2-304 · Cited by 582
Self-citation
Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood.
Horwitz, D. L., Starr, J. I., Mako, M. E., Blackard, W. G., & Rubenstein, A. H. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108047 · Cited by 473
C-Peptide as a Measure of the Secretion and Hepatic Extraction of Insulin: Pitfalls and Limitations
Polonsky, K. S., & Rubenstein, A. H. (1984) · Diabetes · doi:10.2337/diab.33.5.486 · Cited by 473
Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women
Evans, D. J., Hoffman, R. G., Kalkhoff, R. K., & Kissebah, A. H. (1984) · Metabolism · doi:10.1016/0026-0495(84)90164-1 · Cited by 389
Self-citation
Prehepatic Insulin Production in Man: Kinetic Analysis Using Peripheral Connecting Peptide Behavior*
EATON, R. P., ALLEN, R. C., SCHADE, D. S., ERICKSON, K. M., & STANDEFER, J. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-3-520 · Cited by 363
Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients.
Polonsky, K. S., Licinio-Paixao, J., Given, B. D., Pugh, W., Rue, P., Galloway, J., Karrison, T., & Frank, B. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112308 · Cited by 359
Relationship between degree of obesity and in vivo insulin action in man
BOGARDUS, C., Lillioja, S., Mott, D. M., Hollenbeck, C. B., & Reaven, G. M. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.248.3.e286 · Cited by 347
Secretion of Proinsulin C-Peptide by Pancreatic β Cells and its Circulation in Blood
Rubenstein, A. H., Clark, J. L., Melani, F., & Steiner, D. F. (1969) · Nature · doi:10.1038/224697a0 · Cited by 295
Insulin Receptor Deficiency in Genetic and Acquired Obesity
Soli, A. H., Kahn, C. R., Neville, D. M., & Roth, J. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108155 · Cited by 260
The islands of langerhans in 19 cases of obesity
OGILVIE, R. F. (1933) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700370314 · Cited by 243
Splanchnic and renal metabolism of insulin in human subjects: a dose-response study
Ferrannini, E., Wahren, J., FABER, O. K., Felig, P., Binder, C., & DeFronzo, R. A. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.244.6.e517 · Cited by 214
Kinetics of human connecting peptide in normal and diabetic subjects.
FABER, O. K., Hagen, C., Binder, C., Markussen, J., Naithani, V. K., BLIX, P. M., Kuzuya, H., Horwitz, D. L., Rubenstein, A. H., & Rossing, N. N. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109106 · Cited by 201
Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography.
Evans, D. J., Murray, R., & Kissebah, A. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111565 · Cited by 199
Self-citation
Metabolism of C-peptide in the dog. In vivo demonstration of the absence of hepatic extraction.
Polonsky, K., Jaspan, J., Pugh, W., Cohen, D., Schneider, M., Schwartz, T., Moossa, A. R., Tager, H., & Rubenstein, A. H. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111036 · Cited by 158
Insulin production rate following glucose ingestion estimated by splanchnic C-peptide output in normal man
Waldh�usl, W., Bratusch-Marrain, P. R., Gasic, S., Korn, A., & Nowotny, P. (1979) · Diabetologia · doi:10.1007/bf01235858 · Cited by 149
Decreased Insulin Removal Contributes to Hyperinsulinemia in Obesity
FABER, O. K., Christensen, K. C., Kehlet, H., Madsbad, S., & Binder, C. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-3-618 · Cited by 148
Retention and degradation of 125I-insulin by perfused livers from diabetic rats.
Terris, S., & Steiner, D. F. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108365 · Cited by 138
Extraction of Insulin by Liver
Field, J. B. (1973) · Annual Review of Medicine · doi:10.1146/annurev.me.24.020173.001521 · Cited by 137
Hyperinsulinemia of obesity is due to decreased clearance of insulin
Meistas, M. T., Margolis, S., & Kowarski, A. A. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.245.2.e155 · Cited by 116
Characterization of a Rat Liver Protease with Specificity for Insulin1
Burghen, G. A., Kitabchi, A. E., & Brush, J. S. (1972) · Endocrinology · doi:10.1210/endo-91-3-633 · Cited by 109
C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog.
Polonsky, K. S., Pugh, W., Jaspan, J. B., Cohen, D. M., Karrison, T. G., Tager, H. S., & Rubenstein, A. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111601 · Cited by 107
C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations
Polonsky, K. S., & Rubenstein, A. H. (1984) · Diabetes · doi:10.2337/diabetes.33.5.486 · Cited by 104
Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis.
Chideckel, E. W., Palmer, J. P., Koerker, D. J., Ensinck, J. W., Davidson, M. B., & Goodner, C. J. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107986 · Cited by 103
Clearance of Porcine Insulin, Proinsulin, and Connecting Peptide by the Isolated Rat Liver
Stoll, R., TOUBER, J. L., Menahan, L. A., & Williams, R. H. (1970) · Experimental Biology and Medicine · doi:10.3181/00379727-133-34589 · Cited by 91
Regulation of insulin receptors in normal and abnormal physiology in humans.
Bar, R. S., Harrison, L. C., Muggeo, M., Görden, P., Kahn, C. R., & Roth, J. (1979) · PubMed · Cited by 89
Reduced Hepatic Insulin Extraction in Obesity: Relationship with Plasma Insulin Levels
Rossell, R., Gomis, R., Casamitjana, R., Segura, R., Vilardell, E., & Rivera, F. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-3-608 · Cited by 85
Hepatic disposal of biosynthetic human insulin and porcine C-peptide in humans
Bratusch-Marrain, P. R., Waldhäusl, W. K., Gasic, S., & Hofer, A. (1984) · Metabolism · doi:10.1016/0026-0495(84)90128-8 · Cited by 83
Estimation of the Secretion Rate of Insulin from the Urinary Excretion Rate of C-Peptide: Study in Obese and Diabetic Subjects
Meistas, M. T., Rendell, M., Margolis, S., & Kowarski, A. A. (1982) · Diabetes · doi:10.2337/diab.31.5.449 · Cited by 76
Kinetics of Native Insulin in Diabetic, Obese, and Aged Men
McGuire, E. A., Tobin, J. D., Berman, M., & Andres, R. (1979) · Diabetes · doi:10.2337/diab.28.2.110 · Cited by 75
Removal of insulin by perfused rat liver: Effect of concentration
Mondon, C. E., Olefsky, J. M., Dolkas, C. B., & Reaven, G. M. (1975) · Metabolism · doi:10.1016/0026-0495(75)90016-5 · Cited by 72
Hyperinsulinemia in obesity syndromes: Its metabolic consequences and possible etiology
Jeanrenaud, B. (1978) · Metabolism · doi:10.1016/s0026-0495(78)80006-7 · Cited by 72
Peripheral Hyperinsulinemia of Simple Obesity: Pancreatic Hypersecretion or Impaired Insulin Metabolism?*
Bonora, E., Zavaroni, I., Bruschi, F., Alpi, O., Pezzarossa, A., GUERRA, L., Dall’Aglio, E., Coscelli, C., & BUTTURINI, U. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-6-1121 · Cited by 66
Insulin removal by isolated perfused rat liver
Misbin, R. I., Tj, M., & Lowenstein, J. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.230.1.171 · Cited by 59
C-Peptide and Insulin Secretion in Pima Indians and Caucasians: Constant Fractional Hepatic Extraction over a Wide Range of Insulin Concentrations and in Obesity*
Savage, P. J., Flock, E. V., Mako, M. E., BLIX, P. M., Rubenstein, A. H., & BENNETT, P. H. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-4-594 · Cited by 56
Amelioration of insulin resistance in obese mice
Mahler, R. J., & Szabó, O. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.4.980 · Cited by 52
Regulation of insulin secretion by the intestinal hormone, secretin: studies in man via transumbilical portal vein catheterization.
Jj, W., & Dupré, J. (1968) · PubMed · Cited by 48
Intravascular volume, extracellular fluid volume, and total body water in obese and nonobese hypertensive patients
Raison, J., Achimastos, A. D., Bouthier, J., London, G. M., & Safar, M. E. (1983) · The American Journal of Cardiology · doi:10.1016/s0002-9149(83)80030-7 · Cited by 44
Insulin Removal in Man:In VivoEvidence for a Receptor-Mediated Process*
Eaton, R. P., Friedman, N. M., Allen, R. C., & Schade, D. S. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-3-555 · Cited by 35
Dynamics of insulin hypersecretion by obese Zucker rats
CURRY, D. L., & Stern, J. S. (1985) · Metabolism · doi:10.1016/0026-0495(85)90100-3 · Cited by 32
Insulin Concentrations in Portal Venous and Peripheral Venous Blood in Man Following Administration of Glucose, Galactose, Xylitol and Tolbutamide
Berger, W., Göschke, H., Moppert, J., & Künzli, H. (1973) · Hormone and Metabolic Research · doi:10.1055/s-0028-1093991 · Cited by 30
Kinetics of native insulin in diabetic, obese, and aged men
McGuire, E. A., Tobin, J. D., Berman, M. K., et al. (1979) · Diabetes · doi:10.2337/diabetes.28.2.110 · Cited by 23
Portal and peripheral vein concentrations of insulin and glucagon after arginine infusion in morbidly obese subjects
Walter, R. M., Gold, E. M., Michas, C. A., & Ensinck, J. W. (1980) · Metabolism · doi:10.1016/0026-0495(80)90213-9 · Cited by 22
Insulin a Possible Inducer of the Biosynthesis of Rat Liver Insulinase
Morgan, C. R., Spahn, J., Frazier, V., & Fleitz, S. (1968) · Experimental Biology and Medicine · doi:10.3181/00379727-128-33125 · Cited by 13
The Pathogenesis of Pancreatic Islet Cell Hyperplasia and Insulin Insensitivity in Obesity
Mahler, R. J. (1974) · Advances in metabolic disorders · doi:10.1016/b978-0-12-027307-2.50016-5 · Cited by 12
Portal and peripheral vein concentrations of insulin after glucose and arginine infusions in morbidly obese subjects
Walter, R. M., Gold, E. M., & Michas, C. A. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90335-5 · Cited by 2

Sorted by citations

Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166
The Deadly Quartet
Kaplan, N. M. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.7.1514 · Cited by 1,672
Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., Retzlaff, B. M., Knopp, R. H., Brunzell, J. D., & Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-003-1074-z · Cited by 1,483
"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes.
Björntorp, P. A. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.4.493 · Cited by 1,115

See all 346

Authors: Peiris, A. N., Mueller, R. A., Smith, G. A., Struve, M. F., & Kissebah, A. H.
Affiliations: Froedtert Hospital (US)
ORCID: Peiris, A N
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1986-12-01
Volume: 78
Issue: 6
Pages: 1648-1657
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci112758
PMC: PMC423938
OpenAlex: W2163235578
Cited by: 346
References: 49
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 7 · 2012: 8
FWCI: 9.67
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Yale University
National Institutes of Health (RR00058)
National Heart, Lung, and Blood Institute (HL32060)
National Center for Research Resources (RR00058)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: obesity, body fat distribution, waist-to-hip ratio, hepatic insulin extraction, insulin hypersecretion, peripheral insulin sensitivity, premenopausal women
MeSH terms: Adipose Tissue, Adult, C-Peptide, Female, Glucose, Humans, Insulin, Kinetics, Liver, Obesity, Viscera

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks