Prehepatic Insulin Production in Man: Kinetic Analysis Using Peripheral Connecting Peptide Behavior*

EATON, R. PHILIP; ALLEN, R. C.; SCHADE, D. S.; ERICKSON, K. M.; STANDEFER, J.

doi:10.1210/jcem-51-3-520

Cited by 363Pancreatic function and diabetesDiabetes Management and ResearchDiabetes and associated disorders

Prehepatic Insulin Production in Man: Kinetic Analysis Using Peripheral Connecting Peptide Behavior*

EATON, R. PHILIP, ALLEN, R. C., SCHADE, D. S., ERICKSON, K. M., STANDEFER, J.·1980·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-51-3-520

Open this paper in CoChat — free account

Abstract

The prehepatic production of insulin in normal man was evaluated by kinetic analysis of connecting peptide (C-peptide) behavior in the plasma in men and women. Studies were performed during suppression of endogenous insulin secretion (induced by both fasting and exogenous insulin injection) as well as during stimulation of secretion (induced by oral glucose ingestion) and iv glucose injection. Least squares spline fitting of the C-peptide data by interactive computer analysis permitted evaluation of the precursor production of insulin using a two-compartment model for C-peptide removal. Basal prehepatic insulin production averaged 15-4 mU/70 kg.min in 20 subjects and was reduced to 0.9 +/- 2.2 mU/70 kg.min after 84 h of fasting. The injection of exogenous iv insulin resulted in suppression of endogenous production to 0 +/- 2.5 mU/70 kg.min. Maximum prehepatic insulin production induced by a 100-g oral glucose tolerance test was 91 +/- 1.2 mU/70 kg.min, with a cumulative hormone secretion of 11.4 +/- 2.0 U over the 5 h of observation. After the acute iv injection of 25 g glucose, production rose to 465 +/- 108 mU/70 kg.min at 2 min post injection and rapidly returned toward basal. Levels of insulin in the portal vein calculated from this analysis were markedly elevated relative to simultaneous peripheral venous levels. These results quantitate prehepatic insulin production and portal venous insulin concentration from an analysis of the behavior of C-peptide within the plasma in both the steady state and the nonsteady state in man.

Integrity signals

Registry

Crossref · 10.1210/jcem-51-3-520

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

C-peptide and insulin are secreted in equimolar fashion and C-peptide is not extracted by the liver.
“given that both are secreted in an equimolar fashion and C-peptide is not extracted by the liver.”
From A model of GLP-1 action on insulin secretion in nondiabetic subjects (2010) · cites this paper as [12]
Peripheral insulin concentrations do not represent insulin secretion but rather the sum of pancreatic insulin secretion, hepatic insulin extraction, and distribution into the circulating compartment.
“However, peripheral insulin concentrations do not represent insulin secretion but rather the sum of pancreatic insulin secretion, hepatic insulin extraction, and distribution into the circulating compartment.”
From A model of GLP-1 action on insulin secretion in nondiabetic subjects (2010) · cites this paper as [12]

A Practical Guide to Splines
de Boor, C. (1978) · Applied mathematical sciences · doi:10.1007/978-1-4612-6333-3 · Cited by 12,089 · see citing works
Reappraisal of the role of insulin in hypertriglyceridemia
Olefsky, J. M., Farquhar, J. W., & Reaven, G. M. (1974) · The American Journal of Medicine · doi:10.1016/0002-9343(74)90006-0 · Cited by 483 · see citing works
Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood.
Horwitz, D. L., Starr, J. I., Mako, M. E., Blackard, W. G., & Rubenstein, A. H. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108047 · Cited by 473 · see citing works
A model of the kinetics of insulin in man
Sherwin, R. S., Kramer, K. J., Tobin, J. D., Insel, P. A., Liljenquist, J. E., Berman, M., & Andres, R. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107697 · Cited by 460 · see citing works
Secretion of Proinsulin C-Peptide by Pancreatic β Cells and its Circulation in Blood
Rubenstein, A. H., Clark, J. L., Melani, F., & Steiner, D. F. (1969) · Nature · doi:10.1038/224697a0 · Cited by 295 · see citing works
Direct Measurement of Hepatic Blood Flow in Surgical Patients
Schenk, W. G., McDonald, J. C., McDonald, K. E., & Drapanas, T. (1962) · Annals of Surgery · doi:10.1097/00000658-196209000-00013 · Cited by 271 · see citing works
Metabolism of Proinsulin, Insulin, and C-Peptide in the Rat
Katz, A. I., & Rubenstein, A. H. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107277 · Cited by 266 · see citing works
Portal and Peripheral Vein Immunoreactive Insulin Concentrations Before and After Glucose Infusion
Blackard, W. G., & Nelson, N. C. (1970) · Diabetes · doi:10.2337/diab.19.5.302 · Cited by 247 · see citing works
THE EARLY RECOGNITION OF DIABETES MELLITUS*
Fajans, S. S., & Conn, J. W. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44901.x · Cited by 244 · see citing works
Kinetics of human connecting peptide in normal and diabetic subjects.
Faber, O., Hagen, C., Binder, C., Markussen, J., Naithani, V., Blix, P., Kuzuya, H., Horwitz, D. L., Rubenstein, A., & Rossing, N. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109106 · Cited by 229 · see citing works
DETERMINATION OF THE HEPATIC ARTERIAL BLOOD FLOW AND OXYGEN SUPPLY IN MAN BY CLAMPING THE HEPATIC ARTERY DURING SURGERY
Tygstrup, N., WINKLER, K., Mellemgaard, K., & Andreassen, M. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104497 · Cited by 176 · see citing works
Identification of Proinsulin and C-Peptide in Human Serum by a Specific Immunoassay
Melani, F., Rubenstein, A. H., Oyer, P. E., & Steiner, D. F. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.67.1.148 · Cited by 164 · see citing works
Insulin production rate following glucose ingestion estimated by splanchnic C-peptide output in normal man
Waldh�usl, W., Bratusch-Marrain, P. R., Gasic, S., Korn, A., & Nowotny, P. (1979) · Diabetologia · doi:10.1007/bf01235858 · Cited by 149 · see citing works
"Big insulin": a new component of plasma insulin detected by immunoassay.
Roth, J., Görden, P., & Pastan, I. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.61.1.138 · Cited by 147 · see citing works
STUDIES ON TISSUE UPTAKE OF INSULIN IN MAN USING A DIFFERENTIAL IMMUNOASSAY FOR ENDOGENOUS AND EXOGENOUS INSULIN*
Samols, E., & Ryder, J. A. (1961) · Journal of Clinical Investigation · doi:10.1172/jci104435 · Cited by 140 · see citing works
Extraction of Insulin by Liver
Field, J. B. (1973) · Annual Review of Medicine · doi:10.1146/annurev.me.24.020173.001521 · Cited by 137 · see citing works
Effect of Intraduodenal Glucose Administration on Hepatic Extraction of Insulin in the Anesthetized Dog
Kaden, M., Harding, P., & Field, J. B. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107386 · Cited by 131 · see citing works
Measurement of the Insulin Delivery Rate in Man
Turner, R. C., Grayburn, J. A., Newman, G. B., & Nabarro, J. D. N. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-2-279 · Cited by 121 · see citing works
EVIDENCE FOR PROINSULIN IN HUMAN URINE AND SERUM
Rubenstein, A. H., Cho, S., & Steiner, D. F. (1968) · The Lancet · doi:10.1016/s0140-6736(68)92040-0 · Cited by 111 · see citing works
Effects of anti-insulin serum, insulin, and glucose on output of triglycerides and on ketogenesis by the perfused rat liver.
Woodside, W. F., & Heimberg, M. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33920-0 · Cited by 92 · see citing works
Clearance of Porcine Insulin, Proinsulin, and Connecting Peptide by the Isolated Rat Liver
Stoll, R., TOUBER, J. L., Menahan, L. A., & Williams, R. H. (1970) · Experimental Biology and Medicine · doi:10.3181/00379727-133-34589 · Cited by 91 · see citing works
Prolonged Suppression of Insulin Release by Insulin-Induced Hypoglycemia: Demonstration by C-Peptide Assay
Horwitz, D. L., Rubenstein, A. H., Reynolds, C., Molnar, G. D., & Yanaihara, N. (1975) · Hormone and Metabolic Research · doi:10.1055/s-0028-1093701 · Cited by 90 · see citing works
Studies of the metabolism and distribution of albumin with autologous I131-albumin in healthy men.
Takeda, Y., & Reeve, E. B. (1963) · PubMed · Cited by 81 · see citing works
Kinetic Analysis of Plasma Insulin Disappearance in Nonketotic Diabetic Patients and in Normal Subjects
Navalesi, R., PILO, A., Ferrannini, E., Cecchetti, P., & Masoni, A. (1978) · Journal of Clinical Investigation · doi:10.1172/jci108918 · Cited by 77 · see citing works
Kinetics of Native Insulin in Diabetic, Obese, and Aged Men
McGuire, E. A., Tobin, J. D., Berman, M., & Andres, R. (1979) · Diabetes · doi:10.2337/diab.28.2.110 · Cited by 75 · see citing works
C-peptide Metabolism and the Liver
Kuhl, C. K., FABER, O. K., HORNNES, P. J., & Jensen, S. L. (1978) · Diabetes · doi:10.2337/diab.27.1.s197 · Cited by 75 · see citing works
Metabolic clearance of insulin in man
Genuth, S. M. (1972) · Diabetes · doi:10.2337/diab.21.10.1003 · Cited by 72 · see citing works
Proinsulin and C-Peptide in Blood
Rubenstein, A. H., Block, M. B., Starr, J. I., Melani, F., & Steiner, D. F. (1972) · Diabetes · doi:10.2337/diab.21.2.s661 · Cited by 70 · see citing works
Direct Effect of Insulin on Secretion of Insulin, Glucagon, Gastric Inhibitory Polypeptide, and Gastrin during Maintenance of Normoglycemia*
Service, F. J., NELSON, R. L., Rubenstein, A. H., & Go, V. L. W. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-47-3-488 · Cited by 68 · see citing works
Insulin removal by isolated perfused rat liver
Misbin, R. I., Tj, M., & Lowenstein, J. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.230.1.171 · Cited by 59 · see citing works
Untitled work
(1973) · PubMed · Cited by 57 · see citing works
C-Peptide and Insulin Secretion in Pima Indians and Caucasians: Constant Fractional Hepatic Extraction over a Wide Range of Insulin Concentrations and in Obesity*
Savage, P. J., Flock, E. V., Mako, M. E., BLIX, P. M., Rubenstein, A. H., & BENNETT, P. H. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-4-594 · Cited by 56 · see citing works
Estimation of hepatic arterial and portal venous blood flow by direct catheterization of the vena porta through the umbilical cord in man. Preliminary results.
Chiandussi, L., Greco, F., Sardi, G., Vaccarino, A., Cm, F., & Curti, B. D. (1968) · PubMed · Cited by 53 · see citing works
Regulation of insulin secretion by the intestinal hormone, secretin: studies in man via transumbilical portal vein catheterization.
Jj, W., & Dupré, J. (1968) · PubMed · Cited by 48 · see citing works
Insulin Concentrations in Portal Venous and Peripheral Venous Blood in Man Following Administration of Glucose, Galactose, Xylitol and Tolbutamide
Berger, W., Göschke, H., Moppert, J., & Künzli, H. (1973) · Hormone and Metabolic Research · doi:10.1055/s-0028-1093991 · Cited by 30 · see citing works
Control of insulin secretion during fasting in man
Lilavivathana, U., Campbell, R. G., & Brodows, R. G. (1978) · Metabolism · doi:10.1016/0026-0495(78)90216-0 · Cited by 30 · see citing works
Electrophoretic characterization of circulating human proinsulin and insulin
Gutman, R. A., Lazarus, N. R., & Recant, L. (1972) · Diabetologia · doi:10.1007/bf01235639 · Cited by 24 · see citing works
Symposium I: hormone-fuel interactions in normal and diabetic man. The liver as site of insulin and glucagon action in normal, diabetic and obese humans.
Felig, P., & Wahren, J. (1975) · PubMed · Cited by 23 · see citing works
Characterisation of the effect of intravenous infusion of glucose and tolbutamide on the insulin delivery rate in man
Asano, T., Sasaki, H., & Okumura, M. (1978) · Diabetologia · doi:10.1007/bf00421232 · Cited by 6 · see citing works

Flagged first, then by citations

Sorted by citations

Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
NAUCK, M. A., HOMBERGER, E., SIEGEL, E. G., ALLEN, R. C., EATON, R. P., EBERT, R., & CREUTZFELDT, W. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-2-492 · Cited by 874 · see citing works
Self-citation
Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.
Polonsky, K. S., Given, B. D., & Van Cauter, E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113339 · Cited by 763 · see citing works
Effects of Glucagon-Like Peptide 1 on Counterregulatory Hormone Responses, Cognitive Functions, and Insulin Secretion during Hyperinsulinemic, Stepped Hypoglycemic Clamp Experiments in Healthy Volunteers
Nauck, M. A., Heimesaat, M. M., Behle, K., Holst, J. J., Nauck, M. S., Ritzel, R., Hüfner, M., & Schmiegel, W. H. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8355 · Cited by 605 · see citing works
Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.
Polonsky, K. S., Given, B. D., Hirsch, L. J., Tillil, H., Shapiro, E. T., Beebe, C., Frank, B. H., Galloway, J. A., & Van Cauter, E. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805123181903 · Cited by 567 · see citing works
Diabetes: Models, Signals, and Control
Cobelli, C., Dalla Man, C., Sparacino, G., Magni, L., De Nicolao, G., & Kovatchev, B. P. (2009) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2009.2036073 · Cited by 511 · see citing works
“Since the secretion model is identified on C-peptide measurements taken in plasma, it must be integrated into a model of whole-body C-peptide kinetics, which has two compartments [88].”
C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve β-Cell Function
Palmer, J. P., Fleming, G. A., Greenbaum, C. J., Herold, K. C., Jansa, L. D., Kolb, H., Lachin, J. M., Polonsky, K. S., Pozzilli, P., Skyler, J. S., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.1.250 · Cited by 491 · see citing works
Quantitative study of insulin secretion and clearance in normal and obese subjects
Polonsky, K. S., Given, B. D., Hirsch, L., Shapiro, E. T., Tillil, H., Beebe, C., Galloway, J. A., Frank, B. H., Karrison, T., & Van Cauter, E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113338 · Cited by 444 · see citing works
Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.
Ehrmann, D. A., Sturis, J., Byrne, M. M., Karrison, T., Rosenfield, R. L., & Polonsky, K. S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118064 · Cited by 426 · see citing works
Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients.
Polonsky, K. S., Licinio-Paixao, J., Given, B. D., Pugh, W., Rue, P., Galloway, J., Karrison, T., & Frank, B. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112308 · Cited by 359 · see citing works
Splanchnic insulin metabolism in obesity. Influence of body fat distribution.
Peiris, A. N., Mueller, R. A., Smith, G. A., Struve, M. F., & Kissebah, A. H. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112758 · Cited by 346 · see citing works
Oral Glucose Tolerance Test Minimal Model Indexes of β-Cell Function and Insulin Sensitivity
Breda, E., Cavaghan, M. K., Toffolo, G., Polonsky, K. S., & Cobelli, C. (2001) · Diabetes · doi:10.2337/diabetes.50.1.150 · Cited by 320 · see citing works
Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes
Fehse, F., Trautmann, M., Holst, J. J., Halseth, A. E., Nanayakkara, N., Nielsen, L. L., Fineman, M. S., Kim, D. D., & Nauck, M. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1093 · Cited by 297 · see citing works
Evidence for a circadian rhythm of insulin secretion
Boden, G., Ruiz, J., Urbain, J. L., & Chen, X. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e246 · Cited by 261 · see citing works
Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.
Cavaghan, M. K., Ehrmann, D. A., Byrne, M. M., & Polonsky, K. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119562 · Cited by 216 · see citing works
A low–glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans
Solomon, T. P., Haus, J. M., Kelly, K. R., Cook, M. D., Filion, J., Rocco, M., Kashyap, S. R., Watanabe, R. M., Barkoukis, H., & Kirwan, J. P. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29771 · Cited by 165 · see citing works
Metabolism of C-peptide in the dog. In vivo demonstration of the absence of hepatic extraction.
Polonsky, K., Jaspan, J., Pugh, W., Cohen, D., Schneider, M., Schwartz, T., Moossa, A. R., Tager, H., & Rubenstein, A. H. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111036 · Cited by 158 · see citing works
The impact of mathematical modeling on the understanding of diabetes and related complications
Ajmera, I., Swat, M., Laibe, C., Le Novère, N., & Chelliah, V (2013) · CPT: Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.30 · Cited by 153 · see citing works
Counterregulatory adaptation to recurrent hypoglycemia in normal humans
DAVIS, M. R., & SHAMOON, H. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-995 · Cited by 143 · see citing works
Loss of beta cell function as fasting glucose increases in the non-diabetic range
Godsland, I. F., Jeffs, J. A. R., & Johnston, D. G. (2004) · Diabetologia · doi:10.1007/s00125-004-1454-z · Cited by 131 · see citing works
Quantitative indexes of β-cell function during graded up&down glucose infusion from C-peptide minimal models
Toffolo, G., Breda, E., Cavaghan, M. K., Ehrmann, D. A., Polonsky, K. S., & Cobelli, C. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.1.e2 · Cited by 112 · see citing works
Favourable metabolic effects of a eucaloric lower‐carbohydrate diet in women with <scp>PCOS</scp>
Gower, B. A., Chandler‐Laney, P. C., Ovalle, F., Goree, L. L., Azziz, R., Desmond, R. A., Granger, W. M., Goss, A. M., & Bates, G. W. (2013) · Clinical Endocrinology · doi:10.1111/cen.12175 · Cited by 108 · see citing works
Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions.
Bolli, G. B., Tsalikian, E., Haymond, M. W., Cryer, P. E., & Gerich, J. E. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111359 · Cited by 108 · see citing works
Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans
Tillil, H., Shapiro, E. T., Miller, M. A., Karrison, T., Frank, B. H., Galloway, J. A., Rubenstein, A. H., & Polonsky, K. S. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.3.e349 · Cited by 105 · see citing works
Development of hyperinsulinemia and insulin resistance during the early stage of weight gain
Erdmann, J., Kallabis, B., Oppel, U., Sypchenko, O., Wagenpfeil, S., & Schusdziarra, V. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00560.2007 · Cited by 103 · see citing works
A stochastic deconvolution method to reconstruct insulin secretion rate after a glucose stimulus
Sparacino, G., & Cobelli, C. (1996) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.488799 · Cited by 76 · see citing works
Mechanisms of glucagon secretion during insulin-induced hypoglycemia in man. Role of the beta cell and arterial hyperinsulinemia.
Bolli, G., De Feo, P., Perriello, G., De Cosmo, S., Compagnucci, P., Santeusanio, F., Brunetti, P., & Unger, R. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111315 · Cited by 64 · see citing works
Insulins
Burge, M. R., & Schade, D. S. (1997) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70268-1 · Cited by 48 · see citing works
Self-citation
Advancing Our Understanding of the Glucose System via Modeling: A Perspective
Cobelli, C., Dalla Man, C., Pedersen, M. G., Bertoldo, A., & Toffolo, G. (2014) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2014.2310514 · Cited by 46 · see citing works
A model of GLP-1 action on insulin secretion in nondiabetic subjects
Dalla Man, C., Micheletto, F., Sathananthan, A., Rizza, R. A., Vella, A., & Cobelli, C. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00705.2009 · Cited by 45 · see citing works
Clinical Pharmacology of Albiglutide, a GLP-1 Receptor Agonist
Young, M. A., Wald, J. A., Matthews, J. E., Scott, R., Hodge, R. J., Zhi, H., & Reinhardt, R. R. (2014) · Postgraduate Medicine · doi:10.3810/pgm.2014.11.2836 · Cited by 41 · see citing works
Incretin effect potentiates β-cell responsivity to glucose as well as to its rate of change: OGTT and matched intravenous study
Campioni, M., Toffolo, G., Shuster, L. T., Service, F. J., Rizza, R. A., & Cobelli, C. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00033.2006 · Cited by 40 · see citing works
Model-Based Quantification of Glucagon-Like Peptide-1–Induced Potentiation of Insulin Secretion in Response to a Mixed Meal Challenge
Dalla Man, C., Micheletto, F., Sathananthan, M., Vella, A., & Cobelli, C. (2016) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2015.0146 · Cited by 24 · see citing works
Acute hyperglycemia alters the ability of the normal β-cell to sense and respond to glucose
Meyer, J., Sturis, J., Katschinski, M., Arnold, R., Göke, B., & Byrne, M. M. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00427.2001 · Cited by 25 · see citing works
Increased Prevalence of Beta-Cell Dysfunction despite Normal HbA1c in Youth and Young Adults with Turner Syndrome
Sheanon, N., Elder, D., Khoury, J., Casnellie, L., Gutmark-Little, I., Cernich, J., & Backeljauw, P. F. (2021) · Hormone Research in Paediatrics · doi:10.1159/000520233 · Cited by 12 · see citing works

A Simple and Rational Twice Daily Insulin Regime
PHILLIPS, M., Simpson, R., Holman, R. R., et al. (1979) · QJM · doi:10.1093/oxfordjournals.qjmed.a067589 · Cited by 37 · see citing works
Use of c-peptide as a measure of cephalic phase insulin release in humans
Pullicin, A. J., Newsom, S. A., Robinson, M. M., & Lim, J. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113940 · Cited by 9 · see citing works
Use of c-peptide as a measure of cephalic phase insulin release in humansPreprint
Pullicin, A. J., Newsom, S. A., Robinson, M. M., et al. (2022) · medRxiv · doi:10.1101/2022.05.03.22274582 · Cited by 1 · see citing works
Determination of Free and Total Insulin and C-Peptide in Insulin-treated Diabetics
Kuzuya, H., BLIX, P. M., Horwitz, D. L., Steiner, D. F., & Rubenstein, A. H. (1977) · Diabetes · doi:10.2337/diab.26.1.22 · Cited by 603 · see citing works
Residual Beta-Cell Function in Type II Diabetes and Evaluation of the Hepatic Insulin Extraction
Souza, I. T. D. T. E., WAJCHENBERG, B. L., Cesar, F., et al. (1983) · Hormone and Metabolic Research · doi:10.1055/s-2007-1018797

Authors: EATON, R. P., ALLEN, R. C., SCHADE, D. S., ERICKSON, K. M., & STANDEFER, J.
Affiliations: University of New Mexico (US)
ORCID: EATON, R. PHILIP
ALLEN, R. C.
SCHADE, D. S.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1980-09
Volume: 51
Issue: 3
Pages: 520-528
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-51-3-520
OpenAlex: W2070862761
Cited by: 363
References: 39
Citations by year: 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 13 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 12 · 2014: 12 · 2013: 15 · 2012: 7
FWCI: 4.98
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: C-peptide kinetics, insulin secretion, fasting, oral glucose tolerance test, intravenous glucose, two-compartment model, sex differences
MeSH terms: Adult, C-Peptide, Fasting, Female, Glucose Tolerance Test, Humans, Infusions, Parenteral, Insulin, Kinetics, Male, Pancreas, Peptides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prehepatic Insulin Production in Man: Kinetic Analysis Using Peripheral Connecting Peptide Behavior*

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks