The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.
Open accessAbstract
To study exogenous fat metabolism, we used the vitamin A-fat loading test, which specifically labels intestinally derived lipoproteins with retinyl palmitate (RP). Postprandial RP concentrations were followed in total plasma, and chylomicron (Sf greater than 1,000) and nonchylomicron (Sf less than 1,000) fractions. In normal subjects postprandial lipoproteins were present for more than 14 h, and chylomicron levels correlated inversely with lipoprotein lipase activity and fasting high density lipoprotein (HDL) cholesterol levels and nonchylomicron levels correlated inversely with hepatic triglyceride lipase activity. The main abnormality in type IV patients was a 5.6-fold increase in the chylomicron fraction, whereas in type III patients it was a 6.4-fold increase in nonchylomicrons. Type IIa patients had abnormally low chylomicron fractions. In type IV patients gemfibrozil decreased, whereas in type IIa patients cholestyramine increased the chylomicron fraction 66 and 88%, respectively. This study demonstrates an unexpectedly large magnitude and long duration of postprandial lipemia in normal subjects and patients. These particles are potentially atherogenic, and their role in human atherosclerosis warrants further study.
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“Increased concentrations of circulating chylomicron-remnant particles are then preferentially taken up by the liver by means of a receptor-mediated process,18–22 resulting in non-alcoholic fatty liver disease and hepatic insulin resistance.”
From Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease (2010) · cites this paper as [22]
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Cites
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Frick, M. H., Elo, O., Haapa, K., Heinonen, O. P., Heinsalmi, P., Helo, P., Huttunen, J. K., Kaitaniemi, P., Koskinen, P., Manninen, V., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711123172001 · Cited by 3,881
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Self-citationRelation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state
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Hypertriglyceridemia as a Result of Human apo CII Gene Expression in Transgenic Mice
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Metadata
- Authors
- Weintraub, M. S., Eisenberg, S., & Breslow, J. L.
- Affiliations
- Rockefeller University (US)
- Hadassah Medical Center (IL)
- ORCID
- Breslow, J L
- Venue
- Journal of Clinical Investigation
- Published
- 1987-04-01
- Volume
- 79
- Issue
- 4
- Pages
- 1110-1119
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC424291
- OpenAlex
- W2156066000
- Cited by
- 261
- References
- 60
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 5 · 2020: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pew Charitable Trusts
- American Heart Association
- National Institutes of Health
- National Institute on Aging (AG 04727)
- National Heart, Lung, and Blood Institute (HL 33714, HL32435)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- postprandial lipemia, lipoprotein metabolism, chylomicrons, type IV hyperlipoproteinemia, type III hyperlipoproteinemia, type IIa hyperlipoproteinemia, cholestyramine, gemfibrozil, lipoprotein lipase, hepatic lipase, atherosclerosis, atherogenic lipoproteins
- MeSH terms
- Cholestyramine Resin, Chylomicrons, Dietary Fats, Female, Humans, Hyperlipoproteinemia Type II, Hyperlipoproteinemia Type III, Hyperlipoproteinemia Type IV, Lipoproteins, Male, Pentanoic Acids, Triglycerides, Valerates, Vitamin A, Gemfibrozil
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