Cited by 341Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

Open access

Caro, J F, Sinha, M K, Raju, S M, Ittoop, O, Pories, W J, Flickinger, E G, Meelheim, D, Dohm, G L·1987·Journal of Clinical Investigation

DOI 10.1172/jci112958PMC PMC424378

Open this paper in CoChat — free account Open PDF

Abstract

We have studied the structure and function of the insulin receptors in obese patients with and without noninsulin dependent diabetes mellitus (NIDDM) and in nonobese controls using partially purified receptors from muscle biopsies. Insulin binding was decreased in obesity due to reduced number of binding sites but no differences were observed in insulin binding between obese subjects with or without NIDDM. The structural characteristics of the receptors, as determined by affinity labeling methods and electrophoretic mobility of the beta-subunit, were not altered in obese or NIDDM compared to normal weight subjects. Furthermore, the ability of insulin to stimulate the autophosphorylation of the beta-subunit and the phosphoamino acid composition of the phosphorylated receptor were the same in all groups. However, insulin receptor kinase activity was decreased in obesity using Glu4:Tyr1 as exogenous phosphoacceptor without any appreciable additional defect when obesity was associated with NIDDM. Thus, our data are supportive of the hypothesis that in muscle of obese humans, insulin resistance is partially due to decreased insulin receptors and insulin receptor kinase activity. In NIDDM the defect(s) in muscle is probably distal to the insulin receptor kinase.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci112958

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Insulin Sensitivity and Insulin Binding to Monocytes in Maturity-Onset Diabetes
Defronzo, R., Deibert, D., Hendler, R., Felig, P., & Soman, V. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109394 · Cited by 188
Retracted
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311
Immunoassay of endogenous plasma insulin in man
Yalow, R. S., & Berson, S. A. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104130 · Cited by 3,041
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
Hunter, T. R., & Sefton, B. M. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1311 · Cited by 2,333
Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.
Krotkiewski, M., Björntorp, P. A., Sjöström, L., & Smith, U. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111040 · Cited by 1,475
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.
DeFronzo, R. A., Gunnarsson, R., Björkman, O., Olsson, M., & Wahren, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111938 · Cited by 1,167
Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*
Perley, M. J., & Kipnis, D. M. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105685 · Cited by 917
Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system
Kasuga, M., Zick, Y., Blithe, D., Crettaz, M., & Kahn, C. R. (1982) · Nature · doi:10.1038/298667a0 · Cited by 680

Flagged first, then by citations

Show all 60 references

Research works printed but not linked: 3

Sinha, M. K., W. J. Pories, E. G. Flickinger, D. Meelheim, and J. F. Caro. 1987. Insulin receptor kinase activity of adipose tissue from morbidly obese humans with and without noninsulin-dependent diabetes. Diabetes. In press.
Freidenberg, G. R., R. R. Henry, H. H. Klein, D. R. Reichert, and J. M. Olefsky. 1987. Decreased kinase activity of insulin receptors from adipocytes of non-insulin dependent diabetic (NIDDM) subjects. J Clin. Invest. In press.
Avruch, J., R. A. Nemenoff, M. Pierce, Y. C. Kwok, and P. J. Blackshear. 1985. Protein phosphorylation as a mode of insulin action. In Molecular Basis of Insulin Action. M. P. Czech, editor. Plenum Press, New York and London. 263-296.

Sorted by citations

Items 201–300 of 341

Heterogeneity of human liver, muscle, and adipose tissue insulin receptor
Caro, J., Raju, S. M., Sinha, M. K., Goldfine, I. D., & Dohm, G. L. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90567-0 · Cited by 26
Self-citation
Small-Molecule Insulin Mimetic Reduces Hyperglycemia and Obesity in a Nongenetic Mouse Model of Type 2 Diabetes
Strowski, M. Z., Li, Z., Szalkowski, D., Shen, X., Guan, X.-M., Jüttner, S., Moller, D. E., & Zhang, B. B. (2004) · Endocrinology · doi:10.1210/en.2004-0610 · Cited by 25
Guanine nucleotide binding regulatory proteins in liver from obese humans with and without type II diabetes: Evidence for altered “cross‐talk” between the insulin receptor and Gi‐proteins
Caro, J. F., Raju, M. S., Caro, M., Lynch, C. J., Poulos, J., Exton, J. H., & Thakkar, J. K. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240540307 · Cited by 25
Self-citation
Dephosphorylation increases insulin-stimulated receptor kinase activity in skeletal muscle of obese Zucker rats
Zhou, Q., Dolan, P. L., & Dohm, G. L. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006942831223 · Cited by 25
Self-citation
Insulin receptor tyrosine kinase activity is reduced in monocytes from non-obese normoglycaemic insulin-resistant subjects
Frittitta, L., Grasso, G., Munguira, M. E., Vigneri, R., & Trischitta, V. (1993) · Diabetologia · doi:10.1007/bf00401061 · Cited by 25
Insulin resistance in skeletal muscles of patients with diabetes mellitus
Beck‐Nielsen, H. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050602 · Cited by 25
Regulation of gene expression during severe caloric restriction: lack of induction of p85alpha phosphatidylinositol 3-kinase mRNA in skeletal muscle of patients with Type II (non-insulin-dependent) diabetes mellitus
Andréelli, F., Laville, M., Véga, N., Riou, J. P., & Vidal, H. (2000) · Diabetologia · doi:10.1007/s001250050054 · Cited by 25
Characterisation of insulin-like growth factor I receptor in skeletal muscles of normal and insulin resistant subjects
Livingston, N., Pollare, T., Lithell, H., & Arner, P. (1988) · Diabetologia · doi:10.1007/bf00265369 · Cited by 25
Insulin action 1991
Taylor, R. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb00287.x · Cited by 25
Insulin resistance in non-insulin-dependent diabetes mellitus
Alzaid, A. (1996) · Acta Diabetologica · doi:10.1007/bf00569416 · Cited by 25
Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator
Ding, V. D. H., Qureshi, S. A., Szalkowski, D., Li, Z., Biazzo-Ashnault, D. E., Xie, D., Liu, K., Jones, A. B., Moller, D. E., & Zhang, B. B. (2002) · Biochemical Journal · doi:10.1042/bj20020708 · Cited by 24
Effect of a high-fat-sucrose diet on in vivo insulin receptor kinase activation
Boyd, J. J., Contreras, I., Kern, M., Tapscott, E. B., Downes, D. L., Frisell, W. R., & Dohm, G. L. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.1.e111 · Cited by 24
Self-citation
Behavioral, metabolic, and molecular correlates of lower insulin sensitivity in Mexican-Americans
Ho, R. C., Davy, K. P., Hickey, M. S., Summers, S. A., & Melby, C. L. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00105.2002 · Cited by 23
Effects of hyperinsulinemia and hyperglycemia on insulin receptor function and glycogen synthase activation in skeletal muscle of normal man
Bak, J. F., Møller, N., Schmitz, O., Richter, E. A., & Pedersen, O. B. (1991) · Metabolism · doi:10.1016/0026-0495(91)90011-k · Cited by 23
The impact of obesity on the pathogenesis of non‐insulin‐dependent diabetes mellitus: A review of current hypotheses
Pedersen, O. B. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050603 · Cited by 23
Effects of Intensive Dietary Treatment on Insulin‐stimulated Skeletal Muscle Glycogen Synthase Activation and Insulin Secretion in Newly Presenting Type 2 Diabetic Patients
Johnson, A. B., Argyraki, M., Thow, J. C., Broughton, D., Jones, I. R., & Taylor, R. (1990) · Diabetic Medicine · doi:10.1111/j.1464-5491.1990.tb01417.x · Cited by 23
Decreased muscle insulin receptor kinase correlates with insulin resistance in normoglycemic Pima Indians
YOUNGREN, J. F., Goldfine, I. D., & Pratley, R. E. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.2.e276 · Cited by 23
High Glucose-Induced Abnormal Epidermal Growth Factor Signaling
Obata, T., Maegawa, H., Kashiwagi, A., Pillay, T. S., & Kikkawa, R. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022009 · Cited by 21
Effect of a thermogenic agent, BRL 26830A, on insulin receptors in obese mice
Rochet, N., Tanti, J., Grémeaux, T., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.2.e101 · Cited by 21
The Effect of Sulphonylurea Therapy on Skeletal Muscle Glycogen Synthase Activity and Insulin Secretion in Newly Presenting Type 2 (Non‐insulin‐dependent) Diabetic Patients
Johnson, A. B., Argyraki, M., Thow, J. C., Jones, I. R., Broughton, D., Miller, M. A., & Taylor, R. (1991) · Diabetic Medicine · doi:10.1111/j.1464-5491.1991.tb01580.x · Cited by 21
Type 2 diabetes and atherosclerosis
Donnelly, R., & Davis, K. R. (2000) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2000.00019.x · Cited by 20
Role of kinases in insulin stimulation of glucose transport
Klip, A., & Douen, A. G. (1989) · The Journal of Membrane Biology · doi:10.1007/bf01869205 · Cited by 20
The case for metabolic hypertension: Is it time to restructure the hypertension paradigm?
Pool, P. E. (1993) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(93)90020-e · Cited by 20
Protein-tyrosine Phosphatase-1B acts as a negative regulator of insulin signal transduction
Byon, J. C. H., Kusari, A. B., & Kusari, J. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5647-3_11 · Cited by 19
Tyrosine-Kinase Defect of the Insulin Receptor in Cultured Fibroblasts from Patients with Lipoatropic Diabetes*
Magré, J., Grigorescu, F., Reynet, C., Caron, M., Capony, J., White, M. F., Picard, J., Mirouze, J., & Capeau, J. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-1-142 · Cited by 19
Complementary measures for promoting insulin sensitivity in skeletal muscle
McCarty, M. F. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90065-2 · Cited by 19
Regulation of Muscle Glucose Uptake In Vivo
Mandarino, L. J., Bonadonna, R. C., McGuinness, O. P., Halseth, A. E., & Wasserman, D. H. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070227 · Cited by 19
A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle
Maegawa, H., Obata, T., Shibata, T., Fujita, T., Ugi, S., Morino, K., Nishio, Y., Kojima, H., Hidaka, H., Haneda, M., et al. (1999) · Diabetologia · doi:10.1007/s001250051133 · Cited by 18
Where All the Glucose Doesn't Go in Non-Insulin-Dependent Diabetes Mellitus
Bogardus, C., & Lillioja, S. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220409 · Cited by 18
Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insulin resistance
Maddux, B. A., Sbraccia, P., Reaven, G. M., Moller, D. E., & Goldfine, I. D. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.1.7686917 · Cited by 17
Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch25 · Cited by 17
Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance
Wang, G., Yu, Y., Cai, W., Batista, T. M., Suk, S., Noh, H. L., Hirshman, M. F., Nigro, P., Li, M. E., Softic, S., et al. (2020) · Diabetes · doi:10.2337/db20-0439 · Cited by 16
Kinetics of insulin binding and kinase activity of the partially purified insulin receptor from human skeletal muscle
Bak, J. F., Handberg, A., Beck‐Nielsen, H., & Pedersen, O. B. (1990) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(90)90226-4 · Cited by 16
Insulin receptor dephosphorylation by phosphotyrosine phosphatases obtained from insulin-resistant obese mice
Olichon‐Berthe, C., Mouzon, S. H., Peraldi, P., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1994) · Diabetologia · doi:10.1007/bf00428778 · Cited by 16
Effect of an α-glycosidase inhibitor on experimentally-induced obesity in mice
MARCHAND‐BRUSTEL, Y. L., Rochet, N., Grémeaux, T., Marot, I., & OBBERGHEN, E. V. (1990) · Diabetologia · doi:10.1007/bf00586457 · Cited by 15
Abnormal messenger ribonucleic acid (mRNA) transcribed from a mutant insulin receptor gene in a patient with type A insulin resistance
Shimada, F., Suzuki, Y., Taira, M., Hashimoto, N., Nozaki, O., Makino, H., & Yoshida, S. (1992) · Diabetologia · doi:10.1007/bf00400255 · Cited by 15
Effects of adenovirus‐mediated liver‐selective overexpression of protein tyrosine phosphatase‐1b on insulin sensitivity in vivo
Wang, J., Cheung, A. T., Kolls, J. K., Starks, W. W., Martinez‐Hernandez, A., Dietzen, D. J., & Bryer‐Ash, M. (2001) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2001.00173.x · Cited by 15
Effect Of Altered Nutritional States On Insulin Receptors
Adamo, M. L., LeRoith, D., Simon, J., & Roth, J. (1988) · Annual Review of Nutrition · doi:10.1146/annurev.nu.08.070188.001053 · Cited by 15
Metabolic and Molecular Pathogenesis of Type 2 Diabetes Mellitus
DeFronzo, R. A., Mandarino, L. J., & Ferrannini, E. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0310 · Cited by 15
Insulin resistance and noninsulin‐dependent diabetes mellitus: Which horse is pulling the cart?
Garvey, W. T. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050807 · Cited by 15
miR-10a/b-5p-NCOR2 Regulates Insulin-Resistant Diabetes in Female Mice
Ha, S. E., Singh, R., Jin, B., Baek, G., Jorgensen, B. G., Zogg, H., Debnath, S., Park, H. S., Cho, H., Watkins, C. M., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810147 · Cited by 14
Insulin receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians
YOUNGREN, J. F., Goldfine, I. D., & Pratley, R. E. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e990 · Cited by 14
Studies on the mechanism of action of sulphonylureas in type II diabetic subjects: gliquidone
Bonora, E., Moghetti, P., Querena, M., Zenere, M. B., Cacciatori, V., Tosi, F., Travia, D., Zoppini, G., & Muggeo, M. (1992) · Journal of Endocrinological Investigation · doi:10.1007/bf03348644 · Cited by 14
Pathogenesis of Type 2 Diabetes Mellitus
DeFronzo, R. A. (2018) · Endocrinology · doi:10.1007/978-3-319-45015-5_8 · Cited by 14
Pathophysiology of Diabetes
Shamoon, H. (1992) · Drugs · doi:10.2165/00003495-199200443-00002 · Cited by 14
What is the role of the insulin receptor tyrosine kinase?
Espinal, J. (1988) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(88)90170-3 · Cited by 14
Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys
Pender, C., Ortmeyer, H. K., HANSEN, B. C., Goldfine, I. D., & YOUNGREN, J. F. (2002) · Metabolism · doi:10.1053/meta.2002.31327 · Cited by 14
Defect in Tyrosine Kinase Activity of the Insulin Receptor from a Patient with Insulin Resistance and Acanthosis Nigricans*
Yamamoto, R., Shiba, T., Tobe, K., Shibasaki, Y., Koshio, O., Izumi, T., Odawara, M., Mikami, Y., Matsuura, N., Akanuma, Y., et al. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-4-869 · Cited by 14
Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP
Asthana, P., & Wong, H. L. X. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167081 · Cited by 13
Genetic variation in insulin receptor ?-chain exons among members of familial Type 2 (non-insulin-dependent) diabetic pedigrees
Elbein, S. C., & Sorensen, L. K. (1991) · Diabetologia · doi:10.1007/bf00401521 · Cited by 13
Orally active insulin mimics: where do we stand now?
Balasubramanyam, M., & Mohan, V. (2001) · Journal of Biosciences · doi:10.1007/bf02703748 · Cited by 12
Effect of short- and long-term experimental hyperthyroidism on plasma glucose level and insulin secretion during an intravenous glucose load and on insulin binding, insulin receptor kinase activity, and insulin action in adipose tissue
Casla, A., Arrieta, F., Grant, C., Casanova, B., & Rovira, A. (1993) · Metabolism · doi:10.1016/0026-0495(93)90052-p · Cited by 12
Glyburide but not ciglitazone enhances insulin action in the liver independent of insulin receptor kinase activation
Caro, J., Ittoop, O. R. R., & Sinha, M. K. (1989) · Metabolism · doi:10.1016/0026-0495(89)90095-4 · Cited by 12
Self-citation
Insulin stimulated protein phosphorylation in human plasma liver membranes: Detection of endogenous or plasma membrane associated substrates for insulin receptor kinase
Caro, J., Shafer, J. A., Taylor, S. I., Raju, S. M., Perrotti, N., & Sinha, M. K. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90509-2 · Cited by 12
Self-citation
A review: Mechanism and prospect of gastrodin in prevention and treatment of T2DM and COVID-19
Li, Y., Ji, Y., & Li, F. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21218 · Cited by 11
Pathogenesis of Type 2 Diabetes Mellitus
DeFronzo, R. A. (2018) · Endocrinology · doi:10.1007/978-3-319-27317-4_8-1 · Cited by 11
Impaired insulin-like growth factor I-mediated stimulation of glucose incorporation into glycogen in vivo in the ob/ob mouse
Cascieri, M. A., Slater, E. E., Vicario, P. P., Green, B. G., BAYNE, M. L., & Saperstein, R. (1989) · Diabetologia · doi:10.1007/bf00277256 · Cited by 11
Stimulation of glucose uptake by insulin-like growth factor II in human muscle is not mediated by the insulin-like growth factor II/mannose 6-phosphate receptor
Burguera, B. G., Elton, C. W., Caro, J. F., Tapscott, E. B., Pories, W. J., DiMarchi, R. D., Sakano, K.-I., & Dohm, G. L. (1994) · Biochemical Journal · doi:10.1042/bj3000781 · Cited by 11
Self-citation
Insulin resistance of glucose metabolism in isolated brown adipocytes of lactating rats. Evidence for a post-receptor defect in insulin action
Burnol, A., Ebner, S., Kandé, J., & Girard, J. R. (1990) · Biochemical Journal · doi:10.1042/bj2650511 · Cited by 11
Amino acids influence the glucose uptake through GLUT4 in CHO-K1 cells under high glucose conditions
Selvi, R., Angayarkanni, N., Asma, B., Seethalakshmi, T. S., & Srinivasan, V. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0527-1 · Cited by 10
Advances in the development of AMPK-activating compounds
Sriwijitkamol, A., & Musi, N. (2008) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.3.10.1167 · Cited by 10
Insulin binding and insulin receptor tyrosine kinase activity are not altered in the liver of rats with non-insulin-dependent diabetes
Kergoat, M., Simon, J., & Portha, B. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80385-1 · Cited by 10
Insulin receptor binding and kinase activity in liver and skeletal muscles of lactating goats
Balage, M., Sornet, C., & Grizard, J. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.5.e561 · Cited by 10
Molecular Mechanisms Involved in Insulin Resistance: Recent Updates and Future Challenges
Singh, A., Ghai, N., & Bedi, P. M. S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104806 · Cited by 9
Pathogenesis of Type 2 Diabetes
Alsahli, M., & Gerich, J. E. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1028-7_7 · Cited by 8
Relationships between urinary inositol excretions and whole-body glucose tolerance and skeletal muscle insulin receptor phosphorylation
Stull, A. J., Thyfault, J. P., Haub, M. D., Ostlund, R. E., & Campbell, W. W. (2008) · Metabolism · doi:10.1016/j.metabol.2008.06.009 · Cited by 8
Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans
Love, K. M., Jahn, L. A., Hartline, L. M., Patrie, J. T., Barrett, E. J., & Liu, Z. (2021) · Scientific Reports · doi:10.1038/s41598-021-90935-8 · Cited by 8
Effects of adenosine receptor antagonism on protein tyrosine phosphatase in rat skeletal muscle
Crist, G. B. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00051-6 · Cited by 8
Effect of Mazindol on Body Weight and Insulin Sensitivity in Severely Obese Patients after a Very-Low-Calorie Diet Therapy.
Nishikawa, T., Iizuka, T., Omura, M., Kuramoto, N., Miki, T., Itô, H., & Chiba, S. (1996) · Endocrine Journal · doi:10.1507/endocrj.43.671 · Cited by 8
The effect of nitric oxide on glucose metabolism
Ragoobirsingh, D., McGrowder, D. A., Dasgupta, T. P., & Brown, P. D. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000041846.99698.5d · Cited by 8
Ethnicity and type 2 diabetes in Asian Indian migrants in Auckland, New Zealand
Jowitt, L. M. (2014) · SANAMED · doi:10.5937/sanamed1403253j · Cited by 7
Pancreatic Polypeptide and Glucose Metabolism
Seymour, N. E., & Andersen, D. K. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-695-9_13 · Cited by 7
Lipogenic potential of liver from morbidly obese patients with and without non-insulin-dependent diabetes
Barakat, H. A., McLendon, V. D., Carpenter, J. W., Marks, R. H. L., Leggett-Frazier, N., O'Brien, K. F., & Caro, J. F. (1991) · Metabolism · doi:10.1016/0026-0495(91)90110-i · Cited by 7
Self-citation
Contribution of defects in glucose production and uptake to carbohydrate intolerance in insulin-resistant subjects.
Nielsen, M. F. (2008) · PubMed · Cited by 6
Reduced insulin binding to liver plasma membranes in inherently obese diabetic CBA/CA mice
Taberner, P. V., & Connelly, D. M. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90073-e · Cited by 6
Evaluation of common variants in MG53 and the risk of type 2 diabetes and insulin resistance in Han Chinese
Yang, S., Zhao, H., Xu, K., Qian, Y., Wu, M., Yang, T., Chen, Y., Zhao, X., Chen, J., Wen, J., et al. (2016) · SpringerPlus · doi:10.1186/s40064-016-2218-1 · Cited by 6
Twin Conception in Sheep Leads to Impaired Insulin Sensitivity and Sexually Dimorphic Adipose Tissue and Skeletal Muscle Phenotypes in Adulthood
Donovan, E. L., Buckels, E. J., Hancock, S. N., Smeitink, D., Oliver, M. H., Bloomfield, F. H., & Jaquiery, A. L. (2016) · Reproductive Sciences · doi:10.1177/1933719116670516 · Cited by 6
Lettuce-avicularin treatment reverses insulin resistance through stimulation of glycolytic kinases and insulin signaling molecules.
Amadi, J. A., Amadi, P. U., Njoku, U. C., & Onitchi, C. L. (2021) · PubMed Central · doi:10.22038/ijbms.2020.49770.11368 · Cited by 6
The Male Obese Wistar Diabetic Fatty Rat Is a New Model of Extreme Insulin Resistance
Greene, S. F., Johnson, P. R., Eiffert, K. C., Greenwood, M., & Stern, J. S. (1994) · Obesity Research · doi:10.1002/j.1550-8528.1994.tb00090.x · Cited by 6
Insulin resitance and diabetes, mechanism and possible intervention
Koffler, M., Ramirez, L. C., & Raskin, P. (1989) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(89)90098-3 · Cited by 6
Insulin receptor kinase activity in muscles and white adipose tissue during course of VMH obesity
Pujol, A., Cousin, B., Burnol, A., Loizeau, M., Picon, L., Girard, J. R., & Pénicaud, L. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.2.e161 · Cited by 6
Membrane glycoprotein PC-1 and insulin resistance
Goldfine, I. D., Maddux, B. A., YOUNGREN, J. F., Frittitta, L., Trischitta, V., & Dohm, G. L. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5647-3_19 · Cited by 6
Self-citation
Erythrocyte insulin receptor tyrosine kinase activity is increased in glyburide‐treated patients with type 2 diabetes in good glycaemic control
Santos, R. F., Nomizo, R., de Oliveira, E. M., Ursich, M. J. M., WAJCHENBERG, B. L., Reaven, G. M., & Azhar, S. (2000) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2000.00091.x · Cited by 6
Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice
Zhang, Y., Lan, M., Liu, C., Wang, T., Liu, C., Wu, S., & Meng, Q. (2023) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2023.106420 · Cited by 5
Whole Egg Consumption Impairs Insulin Sensitivity in a Rat Model of Obesity and Type 2 Diabetes
Saande, C. J., Steffes, M. A., Webb, J. L., Valentine, R. J., Rowling, M. J., & Schalinske, K. L. (2019) · Current Developments in Nutrition · doi:10.1093/cdn/nzz015 · Cited by 5
Culprits or consequences: Understanding the metabolic dysregulation of muscle in diabetes
O’Reilly, C. L., Uranga, S., & Fluckey, J. D. (2021) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v12.i5.70 · Cited by 5
Effects of diabetes and sex steroid hormones on insulin receptor tyrosine kinase activity in R3230AC mammary adenocarcinomas.
Hilf, R., Livingston, J. N., & CROFTON, D. H. (1988) · PubMed · Cited by 5
Impairment of glucose tolerance: Mechanism of action and impact on the cardiovascular system
Beck-Nielsen, H., Nielsen, O. H., Damsbo, P., Vaag, A. A., Handberg, A., & Henriksen, J. E. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90570-w · Cited by 5
Pathogenesis of Type 2 Diabetes
Cusi, K. J., & DeFronzo, R. A. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070237 · Cited by 5
The role of PYY in improving insulin resistance
Liu, C., Na, R., Zhang, H., & Ma, J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1784709 · Cited by 4
Resistance to Injection: 1991 RD Lawrence Lecture
Taylor, R. (1992) · Diabetic Medicine · doi:10.1111/j.1464-5491.1992.tb01744.x · Cited by 4
Insulin binding in non-insulin-dependent diabetes mellitus (NIDDM) is correlated with glycemic control: Clinical evidence for abnormal receptor regulation in NIDDM
Kelly, C. M., & Fantus, I. G. (1995) · Metabolism · doi:10.1016/0026-0495(95)90059-4 · Cited by 4
Diabetes and Aging
Musi, N., & Bartke, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_12 · Cited by 5
Dietary and lifestyle factors contributing to insulin resistance
Bell, P. M. (1997) · Proceedings of The Nutrition Society · doi:10.1017/s002966519700102x · Cited by 4
Relationship between insulin receptor tyrosine kinase activity and internalization in monocytes of non-insulin-dependent diabetes mellitus patients
Trischitta, V., Giorgino, F., Frittitta, L., Scalisi, R., & Vigneri, R. (1993) · Metabolism · doi:10.1016/0026-0495(93)90064-u · Cited by 4
The effect of fasting on the activation in vivo of the insulin receptor kinase
Contreras, I., Dohm, G. L., Abdallah, S., Wells, J. A., Mooney, N., Rovira, A., & Caro, J. F. (1990) · Biochemical Journal · doi:10.1042/bj2650887 · Cited by 4
Self-citation
Dephosphorylation of Insulin and Epidermal Growth Factor Receptors in Normal and Alloxan Diabetic Rats
Gruppuso, P. A., Boylan, J. M., Faure, R. L., & Brautigan, D. L. (1990) · Cited by 4
Effects of troglitazone on skeletal muscle and liver protein tyrosine phosphatase activity in insulin-resistant otsuka long-evans tokushima fatty rats
Seiichi, T., Sakaue, S., Honda, T., Haruhiko, Y., Homma, H., Ohno, K., Nishimura, M., & Hajime, I. (2002) · Current Therapeutic Research · doi:10.1016/s0011-393x(02)80062-5 · Cited by 3
Evaluation of Antidiabetic Effects of Saponins Extracted from Methanol Leaf Extract of Commiphora kerstingii Engl.
Yerima, M., & Alkali, Y. I. (2019) · Asian Journal of Applied Sciences · doi:10.3923/ajaps.2019.180.184 · Cited by 3
[Recent concepts in gestational diabetes' etiopathogenesis].
Valencia, M. H., & Zárate, A. (2005) · PubMed · Cited by 3

Authors: Caro, J. F., Sinha, M. K., Raju, S. M., Ittoop, O., Pories, W. J., Flickinger, E. G., Meelheim, D., & Dohm, G. L.
Affiliations: East Carolina University (US)
ORCID: Pories, W J
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1987-05-01
Volume: 79
Issue: 5
Pages: 1330-1337
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci112958
PMC: PMC424378
OpenAlex: W2104713078
Cited by: 341
References: 60
Citations by year: 2026: 1 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 6
FWCI: 7.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2r01am032585-03)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: insulin receptor kinase, insulin receptor, skeletal muscle, obesity, type 2 diabetes, insulin resistance, insulin binding, receptor autophosphorylation, receptor beta-subunit, affinity labeling
MeSH terms: Adult, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Insulin Resistance, Male, Muscles, Obesity, Phosphorylation, Protein-Tyrosine Kinases, Receptor, Insulin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks