Cited by 341Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

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Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

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Caro, J F, Sinha, M K, Raju, S M, Ittoop, O, Pories, W J, Flickinger, E G, Meelheim, D, Dohm, G L·1987·Journal of Clinical Investigation

DOI 10.1172/jci112958PMC PMC424378

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Abstract

We have studied the structure and function of the insulin receptors in obese patients with and without noninsulin dependent diabetes mellitus (NIDDM) and in nonobese controls using partially purified receptors from muscle biopsies. Insulin binding was decreased in obesity due to reduced number of binding sites but no differences were observed in insulin binding between obese subjects with or without NIDDM. The structural characteristics of the receptors, as determined by affinity labeling methods and electrophoretic mobility of the beta-subunit, were not altered in obese or NIDDM compared to normal weight subjects. Furthermore, the ability of insulin to stimulate the autophosphorylation of the beta-subunit and the phosphoamino acid composition of the phosphorylated receptor were the same in all groups. However, insulin receptor kinase activity was decreased in obesity using Glu4:Tyr1 as exogenous phosphoacceptor without any appreciable additional defect when obesity was associated with NIDDM. Thus, our data are supportive of the hypothesis that in muscle of obese humans, insulin resistance is partially due to decreased insulin receptors and insulin receptor kinase activity. In NIDDM the defect(s) in muscle is probably distal to the insulin receptor kinase.

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Sinha, M. K., W. J. Pories, E. G. Flickinger, D. Meelheim, and J. F. Caro. 1987. Insulin receptor kinase activity of adipose tissue from morbidly obese humans with and without noninsulin-dependent diabetes. Diabetes. In press.
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Authors: Caro, J. F., Sinha, M. K., Raju, S. M., Ittoop, O., Pories, W. J., Flickinger, E. G., Meelheim, D., & Dohm, G. L.
Affiliations: East Carolina University (US)
ORCID: Pories, W J
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1987-05-01
Volume: 79
Issue: 5
Pages: 1330-1337
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci112958
PMC: PMC424378
OpenAlex: W2104713078
Cited by: 341
References: 60
Citations by year: 2026: 1 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 6
FWCI: 7.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2r01am032585-03)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: insulin receptor kinase, insulin receptor, skeletal muscle, obesity, type 2 diabetes, insulin resistance, insulin binding, receptor autophosphorylation, receptor beta-subunit, affinity labeling
MeSH terms: Adult, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Insulin Resistance, Male, Muscles, Obesity, Phosphorylation, Protein-Tyrosine Kinases, Receptor, Insulin

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Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

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