Cited by 341Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

Open access

Caro, J F, Sinha, M K, Raju, S M, Ittoop, O, Pories, W J, Flickinger, E G, Meelheim, D, Dohm, G L·1987·Journal of Clinical Investigation

DOI 10.1172/jci112958PMC PMC424378

Open this paper in CoChat — free account Open PDF

Abstract

We have studied the structure and function of the insulin receptors in obese patients with and without noninsulin dependent diabetes mellitus (NIDDM) and in nonobese controls using partially purified receptors from muscle biopsies. Insulin binding was decreased in obesity due to reduced number of binding sites but no differences were observed in insulin binding between obese subjects with or without NIDDM. The structural characteristics of the receptors, as determined by affinity labeling methods and electrophoretic mobility of the beta-subunit, were not altered in obese or NIDDM compared to normal weight subjects. Furthermore, the ability of insulin to stimulate the autophosphorylation of the beta-subunit and the phosphoamino acid composition of the phosphorylated receptor were the same in all groups. However, insulin receptor kinase activity was decreased in obesity using Glu4:Tyr1 as exogenous phosphoacceptor without any appreciable additional defect when obesity was associated with NIDDM. Thus, our data are supportive of the hypothesis that in muscle of obese humans, insulin resistance is partially due to decreased insulin receptors and insulin receptor kinase activity. In NIDDM the defect(s) in muscle is probably distal to the insulin receptor kinase.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci112958

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Insulin Sensitivity and Insulin Binding to Monocytes in Maturity-Onset Diabetes
Defronzo, R., Deibert, D., Hendler, R., Felig, P., & Soman, V. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109394 · Cited by 188
Retracted
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311
Immunoassay of endogenous plasma insulin in man
Yalow, R. S., & Berson, S. A. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104130 · Cited by 3,041
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
Hunter, T. R., & Sefton, B. M. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1311 · Cited by 2,333
Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.
Krotkiewski, M., Björntorp, P. A., Sjöström, L., & Smith, U. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111040 · Cited by 1,475
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.
DeFronzo, R. A., Gunnarsson, R., Björkman, O., Olsson, M., & Wahren, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111938 · Cited by 1,167
Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*
Perley, M. J., & Kipnis, D. M. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105685 · Cited by 917
Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system
Kasuga, M., Zick, Y., Blithe, D., Crettaz, M., & Kahn, C. R. (1982) · Nature · doi:10.1038/298667a0 · Cited by 680

Flagged first, then by citations

Show all 60 references

Research works printed but not linked: 3

Sinha, M. K., W. J. Pories, E. G. Flickinger, D. Meelheim, and J. F. Caro. 1987. Insulin receptor kinase activity of adipose tissue from morbidly obese humans with and without noninsulin-dependent diabetes. Diabetes. In press.
Freidenberg, G. R., R. R. Henry, H. H. Klein, D. R. Reichert, and J. M. Olefsky. 1987. Decreased kinase activity of insulin receptors from adipocytes of non-insulin dependent diabetic (NIDDM) subjects. J Clin. Invest. In press.
Avruch, J., R. A. Nemenoff, M. Pierce, Y. C. Kwok, and P. J. Blackshear. 1985. Protein phosphorylation as a mode of insulin action. In Molecular Basis of Insulin Action. M. P. Czech, editor. Plenum Press, New York and London. 263-296.

Sorted by citations

Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Who Would Have Thought It? An Operation Proves to Be the Most Effective Therapy for Adult-Onset Diabetes Mellitus
Pories, W. J., Swanson, M. S., MacDonald, K. G., Long, S. B., Morris, P. G., Brown, B. M., Barakat, H. A., deRamon, R. A., Israel, G., Dolezal, J. M., et al. (1995) · Annals of Surgery · doi:10.1097/00000658-199509000-00011 · Cited by 2,293
Self-citation
Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342
A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance
Brüning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Hörsch, D., Accili, D., Goodyear, L. J., & Kahn, C. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80155-0 · Cited by 1,173
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study
Martin, B. C., Warram, J. H., Krolewski, A. S., Soeldner, J. S., Kahn, C. R., Martin, B. C., & Bergman, R. N. (1992) · The Lancet · doi:10.1016/0140-6736(92)92814-v · Cited by 1,158
Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes
Kulkarni, R., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., & Kahn, C. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80546-2 · Cited by 1,148
Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome: A Pilot Study
Tjønna, A. E., Lee, S. J., Rognmo, Ø., Stølen, T. O., Bye, A., Haram, P. M., Loennechen, J. P., Al-Share, Q. Y., Skogvoll, E., Slørdahl, S. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.772822 · Cited by 1,145
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939
Insulin Action and the Insulin Signaling Network*
Cheatham, B., & Kahn, C. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-2-117 · Cited by 885
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
DeFronzo, R. A. (2010) · Diabetologia · doi:10.1007/s00125-010-1684-1 · Cited by 908
Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
Virkamäki, A., Ueki, K., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6609 · Cited by 854
Insulin Resistance — Mechanisms, Syndromes, and Implications
Epstein, F. H., Moller, D. E., & Flier, J. S. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109263251307 · Cited by 807
The aetiology and molecular landscape of insulin resistance
James, D. E., Stöckli, J., & Birnbaum, M. J. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00390-6 · Cited by 736
Pathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5971 · Cited by 604
Non-Insulin-Dependent Diabetes Mellitus — A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance
Polonsky, K. S., Sturis, J., & Bell, G. I. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341207 · Cited by 595
Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.
Dunaif, A., Xia, J., Book, C. B., Schenker, E., & Tang, Z. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118126 · Cited by 561
Plasma Adiponectin Concentration Is Associated With Skeletal Muscle Insulin Receptor Tyrosine Phosphorylation, and Low Plasma Concentration Precedes a Decrease in Whole-Body Insulin Sensitivity in Humans
Stefan, N., Vozarova, B., Funahashi, T., Matsuzawa, Y., Weyer, C., Lindsay, R. S., YOUNGREN, J. F., Havel, P. J., Pratley, R. E., Bogardus, C., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1884 · Cited by 557
Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles
Brüning, J. C., Winnay, J. N., Bonner‐Weir, S., Taylor, S. I., Accili, D., & Kahn, C. R. (1997) · Cell · doi:10.1016/s0092-8674(00)81896-6 · Cited by 539
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.
Goodyear, L. J., Giorgino, F., Sherman, L., Carey, J., Smith, R. J., & Dohm, G. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117909 · Cited by 527
Self-citation
Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice
Klover, P. J., Zimmers, T. A., Koniaris, L. G., & Mooney, R. A. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2784 · Cited by 488
Pathophysiology and Pharmacological Treatment of Insulin Resistance
Matthaei, S., Stümvoll, M., Kellerer, M., & Häring, H. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0413 · Cited by 375
AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise
Musi, N., Fujii, N., Hirshman, M. F., Ekberg, I., Fröberg, S., Ljungqvist, O., Thorell, A., & Goodyear, L. J. (2001) · Diabetes · doi:10.2337/diabetes.50.5.921 · Cited by 371
Role of Exercise Training in the Prevention and Treatment of Insulin Resistance and Non-Insulin-Dependent Diabetes Mellitus
Ivy, J. L. (1997) · Sports Medicine · doi:10.2165/00007256-199724050-00004 · Cited by 369
Obesity and insulin resistance in humans: A dose-response study
Bonadonna, R. C., Leif, G., Kraemer, N., Ferrannini, E., Prato, S. D., & DeFronzo, R. A. (1990) · Metabolism · doi:10.1016/0026-0495(90)90002-t · Cited by 363
Recent Advances in Our Understanding of Insulin Action and Insulin Resistance
Roith, D. L., & Zick, Y. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.588 · Cited by 347
Evidence Against Altered Expression of GLUT1 or GLUT4 in Skeletal Muscle of Patients With Obesity or NIDDM
Pedersen, O., Bak, J. F., Andersen, P. H., Lund, S., Moller, D. E., Flier, J. S., & Kahn, B. B. (1990) · Diabetes · doi:10.2337/diab.39.7.865 · Cited by 329
Tissue-Specific Expression of Two Alternatively Spliced Insulin Receptor mRNAs in Man
Moller, D. E., Yokota, A., Caro, J. F., & Flier, J. S. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-8-1263 · Cited by 323
Self-citation
Lipid and lipoprotein dysregulation in insulin resistant states
Avramoglu, R. K., Basciano, H., & Adeli, K. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.026 · Cited by 326
Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans
Hickey, M. S., Carey, J. O., Azevedo, J. L., Houmard, J. A., Pories, W. J., Israel, R. G., & Dohm, G. L. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.3.e453 · Cited by 305
Self-citation
Rad: a Member of the Ras Family Overexpressed in Muscle of Type II Diabetic Humans
Reynet, C., & Kahn, C. R. (1993) · Science · doi:10.1126/science.8248782 · Cited by 300
An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
Dohm, G. L., Tapscott, E. B., Pories, W. J., Dabbs, D. J., Flickinger, E. G., Meelheim, D., Fushiki, T., Atkinson, S., Elton, C. W., & Caro, J. F. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113622 · Cited by 296
Self-citation
Pathophysiology of insulin resistance
Sesti, G. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.09.007 · Cited by 297
The impact of ethnicity on type 2 diabetes
Abate, N. I., & Chandalia, M. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(02)00190-3 · Cited by 282
Modulation of insulin action
Pirola, L., Johnston, A., & OBBERGHEN, E. V. (2004) · Diabetologia · doi:10.1007/s00125-003-1313-3 · Cited by 286
Insulin Resistance with Aging
Ryan, A. S. (2000) · Sports Medicine · doi:10.2165/00007256-200030050-00002 · Cited by 294
Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction
Byon, J. C. H., Kusari, A. B., & Kusari, J. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006868409841 · Cited by 271
Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines
Kulkarni, R., Winnay, J. N., Daniels, M. S., Brüning, J. C., Flier, S. N., Hanahan, D., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8339 · Cited by 268
Obesity and Insulin Resistance
Després, J., & Marette, A. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-716-1_4 · Cited by 254
Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans
Fröjdö, S., Vidal, H., & Pirola, L. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.019 · Cited by 247
Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.
Itani, S. I., Zhou, Q., Pories, W. J., MacDonald, K. G., & Dohm, G. L. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1353 · Cited by 234
Self-citation
A two-step model for development of non-insulin-dependent diabetes
Saad, M. F., Knowler, W. C., Pettitt, D. J., Nelson, R. G., Charles, M.-A. A., & Bennett, P. H. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)80165-i · Cited by 233
AMP‐activated protein kinase: role in metabolism and therapeutic implications
Schimmack, G., DeFronzo, R. A., & Musi, N. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00561.x · Cited by 231
Brown adipose tissue–specific insulin receptor knockout shows diabetic phenotype without insulin resistance
Guerra, C. E., Navarro, P., Valverde, Á. M., Arribas, M., Brüning, J. C., Kozak, L. P., Kahn, C. R., & Benito, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13103 · Cited by 226
Regulation of insulin receptor function
YOUNGREN, J. F. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6359-9 · Cited by 224
Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling.
Kroder, G., Bossenmaier, B., Kellerer, M., Capp, E., Stoyanov, B., Mühlhöfer, A., Berti, L., Horikoshi, H., Ullrich, A., & Häring, H.-U. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118569 · Cited by 225
Reduced glycogen synthase activity in skeletal muscle from obese patients with and without Type 2 (non-insulin-dependent) diabetes mellitus
Damsbo, P., Vaag, A., Hother-Nielsen, O., & Beck-Nielsen, H. (1991) · Diabetologia · doi:10.1007/bf00405082 · Cited by 203
PTP1B and TCPTP – nonredundant phosphatases in insulin signaling and glucose homeostasis
Tiganis, T. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08563.x · Cited by 209
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.
Freidenberg, G. R., Reichart, D. R., Olefsky, J. M., & Henry, R. R. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113744 · Cited by 196
Obesity and cardiovascular disease: From pathophysiology to risk stratification
Marinou, K., Tousoulis, D., Antonopoulos, A. S., Stefanadi, E., & Stefanadis, C. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.03.135 · Cited by 191
The Control of Diabetes Mellitus (NIDDM) in the Morbidly Obese with the Greenville Gastric Bypass
Pories, W. J., CARD, J. F., Flickinger, E. G., MEELHEIM, H. D., & Swanson, M. S. (1987) · Annals of Surgery · doi:10.1097/00000658-198709000-00009 · Cited by 185
Self-citation
Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.
Friedman, J. E., Dohm, G. L., Leggett-Frazier, N., Elton, C. W., Tapscott, E. B., Pories, W., & Caro, J. F. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115638 · Cited by 185
Self-citation
Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice
Otani, K., Kulkarni, R. N., Baldwin, A. C., Krutzfeldt, J., Ueki, K., Stoffel, M., Kahn, C. R., & Polonsky, K. S. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00533.2001 · Cited by 185
Diabetes Reduces Basal Retinal Insulin Receptor Signaling
Reiter, C. E. N., Wu, X., Sandirasegarane, L., Nakamura, M., Gilbert, K. A., Singh, R. S., Fort, P. E., Antonetti, D. A., & Gardner, T. W. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-0744 · Cited by 174
Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus.
Del Prato, S., Bonadonna, R. C., Bonora, E., Gulli, G., Solini, A., Shank, M., & DeFronzo, R. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116226 · Cited by 170
Dietary Zinc Supplementation Attenuates Hyperglycemia in db/db Mice
Simon, S. F., & Taylor, C. G. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600107 · Cited by 170
Ethnicity and type 2 diabetes
Abate, N. I., & Chandalia, M. (2001) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00161-1 · Cited by 172
Insulin signaling and glucose transport in insulin resistant human skeletal muscle
Karlsson, H. K. R., & Zierath, J. R. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-0030-9 · Cited by 159
Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes
Caro, J. F., Dohm, L. G., Pories, W. J., & Sinha, M. K. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050804 · Cited by 165
Self-citation
Obesity and its surgical management
Livingston, E. H. (2002) · The American Journal of Surgery · doi:10.1016/s0002-9610(02)00914-5 · Cited by 164
The biochemistry of diabetes
Taylor, R., & Agius, L. (1988) · Biochemical Journal · doi:10.1042/bj2500625 · Cited by 166
Relative effects of calorie restriction and weight loss in noninsulin- dependent diabetes mellitus
Kelley, D. E. (1993) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.5.1287 · Cited by 303
Regulation of glucose transport into skeletal muscle
Holloszy, J. O., & Hansen, P. A. (1996) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/3-540-61343-9_8 · Cited by 151
Ethnicity, type 2 diabetes & migrant Asian Indians.
Abate, N., & Chandalia, M. (2007) · PubMed · Cited by 150
Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway
Ding, L., Li, J., Song, B., Xu, X., Zhang, B., Qi, M., Huang, W., Yang, L., & Wang, Z. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.05.011 · Cited by 149
AMP‐activated protein kinase and muscle glucose uptake
Musi, N., & Goodyear, L. J. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01168.x · Cited by 149
Diverse signaling pathways in the cellular actions of insulin
Saltiel, A. R. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.3.e375 · Cited by 142
Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.
Considine, R. V., Nyce, M. R., Allen, L. E., Morales, L. M., Triester, S., Serrano, J., Colberg, J., Lanza-Jacoby, S., & Caro, J. F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118001 · Cited by 141
Self-citation
Obesity and cardiovascular disease
Abate, N. I. (2000) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(00)00067-2 · Cited by 144
A High Fat Diet Impairs Stimulation of Glucose Transport in Muscle
Hansen, P. A., Han, D. H., Marshall, B. A., Nolte, L. A., Chen, M. M., Mueckler, M. M., & Holloszy, J. O. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.26157 · Cited by 142
The Insulin Receptor - A Critical Link in Glucose Homeostasis and Insulin Action
Patti, M., & Kahn, C. R. (1998) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp.1998.9.2-4.89 · Cited by 138
Sedentary Death Syndrome
Lees, S. J., & Booth, F. W. (2004) · Canadian Journal of Applied Physiology · doi:10.1139/h04-029 · Cited by 142
The Role of Membrane Glycoprotein Plasma Cell Antigen 1/Ectonucleotide Pyrophosphatase Phosphodiesterase 1 in the Pathogenesis of Insulin Resistance and Related Abnormalities
Goldfine, I. D., Maddux, B. A., YOUNGREN, J. F., Reaven, G. M., Accili, D., Trischitta, V., Vigneri, R., & Frittitta, L. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0004 · Cited by 137
Role of diet and exercise in the management of hyperinsulinemia and associated atherosclerotic risk factors
Barnard, R. J., Ugianskis, E. J., Martin, D. A., & Inkeles, S. B. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90981-4 · Cited by 134
The insulin receptor: signalling mechanism and contribution to the pathogenesis of insulin resistance
H�ring, H. U. (1991) · Diabetologia · doi:10.1007/bf00400192 · Cited by 133
Protein tyrosine phosphatase-1B in diabetes
Kennedy, B. P., & Ramachandran, C. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00305-1 · Cited by 132
Metabolic and molecular basis of insulin resistance
Bajaj, M., & DeFronzo, R. A. (2003) · Journal of Nuclear Cardiology · doi:10.1016/s1071-3581(03)00520-8 · Cited by 131
Increased abundance of specific skeletal muscle protein-tyrosine phosphatases in a genetic model of insulin-resistant obesity and diabetes mellitus
Ahmad, F., & Goldstein, B. J. (1995) · Metabolism · doi:10.1016/0026-0495(95)90012-8 · Cited by 127
Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues.
Benecke, H., Flier, J. S., & Moller, D. E. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115819 · Cited by 126
Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms
Olefsky, J. M., & Nolan, J. J. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.4.980s · Cited by 124
Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance.
Kusari, J., Kenner, K. A., Suh, K. I., HILL, D. E., & Henry, R. R. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117068 · Cited by 123
Regulation of glucose transport in human skeletal muscle
Koistinen, H. A., & Zierath, J. R. (2002) · Annals of Medicine · doi:10.1080/078538902321012351 · Cited by 124
AMP activated protein kinase: a next generation target for total metabolic control
Misra, P. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.1.91 · Cited by 117
A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance.
Moller, D. E., Yokota, A., White, M. F., Pazianos, A. G., & Flier, J. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77212-8 · Cited by 119
Vitamin D and pancreas: The role of sunshine vitamin in the pathogenesis of diabetes mellitus and pancreatic cancer
Altieri, B., Grant, W. B., Della Casa, S., Orio, F., Pontecorvi, A., Colao, A., Sarno, G., & Muscogiuri, G. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1136922 · Cited by 113
Effect of metformin treatment on insulin action in diabetic rats: In vivo and in vitro correlations
Rossetti, L., DeFronzo, R. A., Gherzi, R., Stein, P., Andraghetti, G., Falzetti, G., Shulman, G. I., Klein-Robbenhaar, E., & Cordera, R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90259-f · Cited by 111
Phosphoinositide 3-Kinase-mediated Reduction of Insulin Receptor Substrate-1/2 Protein Expression via Different Mechanisms Contributes to the Insulin-induced Desensitization of Its Signaling Pathways in L6 Muscle Cells
Pirola, L., Bonnafous, S., Johnston, A., Chaussade, C., Portis, F., & OBBERGHEN, E. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208984200 · Cited by 110
Dietary omega-3 and polyunsaturated fatty acids modify fatty acyl composition and insulin binding in skeletal-muscle sarcolemma.
Liu, S., Baracos, V. E., Quinney, H. A., & Clandinin, M. T. (1994) · Biochemical Journal · doi:10.1042/bj2990831 · Cited by 108
Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity
Nolan, J. J. (1994) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.2.471 · Cited by 108
A defective Intramolecular Autoactivation Cascade May Cause the Reduced Kinase Activity of the Skeletal Muscle Insulin Receptor from Patients with Non-insulin-dependent Diabetes Mellitus
Obermaier-Kusser, B., White, M. F., Pongratz, D. E., Su, Z., Ermel, B., Mühlbacher, C., & Häring, H.-U. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60559-9 · Cited by 107
Morphological changes and hypoglycemic effects of Annona muricata linn. (annonaceae) leaf aqueous extract on pancreatic β-cells of streptozotocin-treated diabetic rats
Adewole, S., & Caxton-Martins, E. A. (2009) · African Journal of Biomedical Research · doi:10.4314/ajbr.v9i3.48903 · Cited by 110
Insulin Resistance and Improvements in Signal Transduction
Musi, N., & Goodyear, L. J. (2006) · Endocrine · doi:10.1385/endo:29:1:73 · Cited by 104
Regulation of glucose transport in skeletal muscle 1
Barnard, R. J., & YOUNGREN, J. F. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.14.1426762 · Cited by 100
Protein kinase C modulates insulin action in human skeletal muscle
Cortright, R. N., Azevedo, J. L., Zhou, Q., Sinha, M. K., Pories, W. J., Itani, S. I., & Dohm, G. L. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.3.e553 · Cited by 100
Self-citation
Effects of Exercise Training on Abdominal Obesity and Related Metabolic Complications
Buemann, B., & Tremblay, A. (1996) · Sports Medicine · doi:10.2165/00007256-199621030-00004 · Cited by 98
The molecular mechanism linking muscle fat accumulation to insulin resistance
Hulver, M. W., & Dohm, G. L. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004351 · Cited by 98
Self-citation
Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-a gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity
Frittitta, L., YOUNGREN, J. F., Sbraccia, P., D’Adamo, M., Buongiorno, A. M., Vigneri, R., Goldfine, I. D., & Trischitta, V. (1997) · Diabetologia · doi:10.1007/s001250050675 · Cited by 98
Emergence of the metabolic syndrome in childhood: an epidemiological overview and mechanistic link to dyslipidemia
Avramoglu, R. K., Theriault, A., & Adeli, K. (2003) · Clinical Biochemistry · doi:10.1016/s0009-9120(03)00038-9 · Cited by 96
Reversal of Insulin Resistance Postpartum Is Linked to Enhanced Skeletal Muscle Insulin Signaling
Kirwan, J. P., Varastehpour, A., Jing, M. X., Presley, L. H., Shao, J., Friedman, J. E., & Catalano, P. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0749 · Cited by 97
The Insulin Receptor and Its Substrate: Molecular Determinants of Early Events in Insulin Action
Kahn, C. R., White, M. F., Shoelson, S. E., Backer, J., Araki, E., Cheatham, B., Csermely, P., Folli, F. B., Goldstein, B. J., Huertas, P. E., et al. (1993) · Elsevier eBooks · doi:10.1016/b978-0-12-571148-7.50015-4 · Cited by 91

Authors: Caro, J. F., Sinha, M. K., Raju, S. M., Ittoop, O., Pories, W. J., Flickinger, E. G., Meelheim, D., & Dohm, G. L.
Affiliations: East Carolina University (US)
ORCID: Pories, W J
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1987-05-01
Volume: 79
Issue: 5
Pages: 1330-1337
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci112958
PMC: PMC424378
OpenAlex: W2104713078
Cited by: 341
References: 60
Citations by year: 2026: 1 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 6
FWCI: 7.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2r01am032585-03)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: insulin receptor kinase, insulin receptor, skeletal muscle, obesity, type 2 diabetes, insulin resistance, insulin binding, receptor autophosphorylation, receptor beta-subunit, affinity labeling
MeSH terms: Adult, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Insulin Resistance, Male, Muscles, Obesity, Phosphorylation, Protein-Tyrosine Kinases, Receptor, Insulin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks