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Cited by 454

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Study of the molecular mechanism of decreased liver synthesis of albumin in inflammation.

Open access
Moshage, H J, Janssen, J A, Franssen, J H, Hafkenscheid, J C, Yap, S H·1987·Journal of Clinical Investigation
DOI 10.1172/jci113000
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Abstract

Hypoalbuminemia in inflammatory disorders is not an infrequent finding. However, little is known about albumin synthesis in these patients. In the present study we have measured the albumin synthesis in four patients with inflammatory diseases using the [14C]carbonate technique. Because inflammation causes a decreased albumin synthesis and this decreased synthesis could not be related to a reduced amino acid supply, we have also examined the possible molecular mechanisms of reduced albumin synthesis during inflammation using in vivo and in vitro experiments in rats. In rats with turpentine-induced inflammation, serum albumin concentration and liver albumin mRNa level were markedly decreased. These changes could not be reproduced by administration of fibrinogen-, or fibrin-degradation products, or several hormones, such as corticosteroids, growth hormone, and adrenaline. However, monocytic products, especially interleukin 1, postulated to be important mediators of the inflammatory response, reduced albumin synthesis and liver albumin messenger RNA content but not total protein synthesis in rats in vivo and in primary cultures of rat hepatocytes. These findings suggest that monocytic products play an important role in reduced albumin synthesis during inflammation.

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Metadata

Authors
Moshage, H. J., Janssen, J. A., Franssen, J. H., Hafkenscheid, J. C., & Yap, S. H.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1987-06-01
Volume
79
Issue
6
Pages
1635-1641
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci113000
OpenAlex
W1989431810
Cited by
454
References
15
FWCI
8.51
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Study of the molecular mechanism of decreased liver synthesis of albumin in inflammation. https://app.cochat.ai/papers/10.1172/jci113000
The paper
Moshage, H. J., Janssen, J. A., Franssen, J. H., Hafkenscheid, J. C., & Yap, S. H. (1987). Study of the molecular mechanism of decreased liver synthesis of albumin in inflammation. Journal of Clinical Investigation. https://doi.org/10.1172/jci113000

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.