Cited by 444Pancreatic function and diabetesDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Quantitative study of insulin secretion and clearance in normal and obese subjects

Open access

Polonsky, K S, Given, B D, Hirsch, L, Shapiro, E T, Tillil, H, Beebe, C, Galloway, J A, Frank, B H, Karrison, T, Van Cauter, E·1988·Journal of Clinical Investigation

DOI 10.1172/jci113338PMC PMC329588

Open this paper in CoChat — free account Open PDF

Abstract

The secretion and hepatic extraction of insulin were compared in 14 normal volunteers and 15 obese subjects using a previously validated mathematical model of insulin secretion and rate constants for C-peptide derived from analysis of individual decay curves after intravenous bolus injections of biosynthetic human C-peptide. Insulin secretion rates were substantially higher than normal in the obese subjects after an overnight fast (86.7 +/- 7.1 vs. 50.9 +/- 4.8 pmol/m2 per min, P less than 0.001, mean +/- SEM), over a 24-h period on a mixed diet (279.6 +/- 24.2 vs. 145.8 +/- 8.8 nmol/m2 per 24 h, P less than 0.001), and during a hyperglycemic intravenous glucose infusion (102.2 +/- 10.8 vs. 57.2 +/- 2.8 nmol/m2 per 180 min, P less than 0.001). Linear regression analysis revealed a highly significant relationship between insulin secretion and body mass index. Basal hepatic insulin extraction was not significantly different in the normal and obese subjects (53.1 +/- 3.8 vs. 51.6 +/- 4.0%). In the normal subjects, fasting insulin did not correlate with basal hepatic insulin extraction, but a significant negative correlation between fasting insulin and hepatic insulin extraction was seen in obesity (r = -0.63, P less than 0.02). This finding reflected a higher extraction in the six obese subjects with fasting insulin levels within the range of the normal subjects than in the nine subjects with elevated fasting insulin concentrations (61 +/- 3 vs. 45 +/- 6%, P less than 0.05). During the hyperglycemic clamp, the insulin secretion rate increased to an average maximum of 6.2-fold over baseline in the normal subjects and 5.8-fold in the obese subjects. Over the same time, the peripheral insulin concentration increased 14.1-fold over baseline in the normals and 16.6-fold over baseline in the obese, indicating a reduction in the clearance of endogenously secreted insulin. Although the fall in insulin clearance tended to be greater in the obese subjects, the differences between the two groups were not statistically significant. Thus, under basal, fasting conditions and during ingestion of a mixed diet, the hyperinsulinemia of obesity results predominantly from increased insulin secretion. In patients with more marked basal hyperinsulinemia and during intense stimulation of insulin secretion, a reduction in insulin clearance may contribute to the greater increase in peripheral insulin concentrations that are characteristic of the obese state.+

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci113338

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Robust Locally Weighted Regression and Smoothing Scatterplots
Cleveland, W. S. (1979) · Journal of the American Statistical Association · doi:10.1080/01621459.1979.10481038 · Cited by 11,594
Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
Morgan, C. R., & Lazarow, A. (1963) · Diabetes · doi:10.2337/diab.12.2.115 · Cited by 2,197
Robust Locally Weighted Regression and Smoothing Scatterplots
Cleveland, W. S. (1979) · Journal of the American Statistical Association · doi:10.2307/2286407 · Cited by 2,063
Relation of Body Fat Distribution to Metabolic Complications of Obesity*
KISSEBAH, A. H., VYDELINGUM, N., MURRAY, R., EVANS, D. J., KALKHOFF, R. K., & ADAMS, P. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-2-254 · Cited by 1,909
C-Peptide as a Measure of the Secretion and Hepatic Extraction of Insulin: Pitfalls and Limitations
Polonsky, K. S., & Rubenstein, A. H. (1984) · Diabetes · doi:10.2337/diab.33.5.486 · Cited by 473
Self-citation
Prehepatic Insulin Production in Man: Kinetic Analysis Using Peripheral Connecting Peptide Behavior*
EATON, R. P., ALLEN, R. C., SCHADE, D. S., ERICKSON, K. M., & STANDEFER, J. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-3-520 · Cited by 363
Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients.
Polonsky, K. S., Licinio-Paixao, J., Given, B. D., Pugh, W., Rue, P., Galloway, J., Karrison, T., & Frank, B. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112308 · Cited by 359
Self-citation
Splanchnic insulin metabolism in obesity. Influence of body fat distribution.
Peiris, A. N., Mueller, R. A., Smith, G. A., Struve, M. F., & Kissebah, A. H. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112758 · Cited by 346
Characterization of Seven C-peptide Antisera
FABER, O. K., Binder, C., Markussen, J., Hedïng, L. G., Naithani, V. K., Kuzuya, H., BLIX, P. M., Horwitz, D. L., & Rubenstein, A. H. (1978) · Diabetes · doi:10.2337/diab.27.1.s170 · Cited by 230
Splanchnic and renal metabolism of insulin in human subjects: a dose-response study
Ferrannini, E., Wahren, J., FABER, O. K., Felig, P., Binder, C., & DeFronzo, R. A. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.244.6.e517 · Cited by 214

Flagged first, then by citations

Show all 27 references

Sorted by citations

Items 301–400 of 441

Linearity of β-cell response across the metabolic spectrum and to pharmacology: insights from a graded glucose infusion-based investigation series
Shankar, S. S., Shankar, R. R., Mixson, L. A., Miller, D. L., Chung, C., Cilissen, C., Beals, C. R., Stoch, S. A., Steinberg, H. O., & Kelley, D. E. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00527.2015 · Cited by 10
Insulin therapy for type 2 diabetes – are we there yet? The d-Nav® story
Hodish, I. (2018) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-018-0056-5 · Cited by 9
Insulin requirement profiles and related factors of insulin pump therapy in patients with type 2 diabetes
Yang, X., Deng, H., Zhang, X., Yang, D., Yan, J., Yao, B., Weng, J., & Xu, W. (2019) · Science China Life Sciences · doi:10.1007/s11427-018-9530-3 · Cited by 9
Relationship between Insulin Secretion and Arterial Stiffness in Essential Hypertension
Sun, Y., Zhu, Y., Zhang, L., Lu, Y., Liu, Y., Zhang, Y., Song, W., Jiang, Y., & Cheng, Y. (2021) · International Journal of Hypertension · doi:10.1155/2021/5015797 · Cited by 9
Glucokinase-Linked Hypoglycemia
Christesen, H. T., Herold, K. C., Noordam, C., & Gloyn, A. L. (2004) · KARGER eBooks · doi:10.1159/000079008 · Cited by 9
In nondiabetic, human immunodeficiency virus–infected patients with lipodystrophy, hepatic insulin extraction and posthepatic insulin clearance rate are decreased in proportion to insulin resistance
Haugaard, S. B., Andersen, O., Hansen, B. R., Andersen, U. B., Vølund, A., Iversen, J., Nielsen, J. O., & Madsbad, S. (2005) · Metabolism · doi:10.1016/j.metabol.2004.08.009 · Cited by 9
Abnormalities of Insulin Secretion and β‐Cell Defects in Type 2 Diabetes
Alsahli, M., & Gerich, J. E. (2010) · Wiley eBooks · doi:10.1002/9781444324808.ch10 · Cited by 11
Insulin sensitivity and kinetics in African American and White people with obesity: Insights from different study protocols
Koh, H. E., Patterson, B. W., Reeds, D. N., & Mittendorfer, B. (2022) · Obesity · doi:10.1002/oby.23363 · Cited by 8
Intracranial Transplantation of Pancreatic Islets Attenuates Cognitive and Peripheral Metabolic Dysfunctions in a Rat Model of Sporadic Alzheimer’s Disease
Bloch, K. O., Gil‐Ad, I., Vanichkin, A., Hornfeld, S. H., Taler, M., Dar, S., Azarov, D., Vardi, P., & Weizman, A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180623 · Cited by 8
Lack of insulin feedback inhibition in non-obese and obese men
Peiris, A. N., Stagner, J. I., Vogel, R. L., Samols, E., & Nakagawa, A. (1993) · Metabolism · doi:10.1016/0026-0495(93)90089-7 · Cited by 8
Increased Plasma Oxidizability in Subjects with Severe Obesity
Pipek, R., Dankner, G., Ben‐Amotz, A., Aviram, M., & Levy, Y. (1996) · Journal of Nutritional & Environmental Medicine · doi:10.3109/13590849609007253 · Cited by 8
Determinants of hepatic insulin clearance – Results from a Mendelian Randomization study
Lamprinou, A., Willmann, C., Machann, J., Schick, F., Eckstein, S. S., Man, C. D., VISENTIN, R., Birkenfeld, A. L., Peter, A., Stefan, N., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154776 · Cited by 7
An adipoincretin effect links adipostasis with insulin secretion
Solinas, G., & Becattini, B. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.10.009 · Cited by 6
Long-term Remission of Type 2 Diabetes and Patient Survival After Biliopancreatic Diversion with Duodenal Switch
Frenken, M., Kemmet, O., Frenken, M., Röhrig, I., Fischer, L., & Hellinger, A. (2022) · Obesity Surgery · doi:10.1007/s11695-022-06223-5 · Cited by 7
Quantitative and qualitative differences in basal and glucose- and arginine-stimulated insulin secretion in healthy subjects and different stages of NIDDM
Ratheiser, K., Reitgruber, W., Komjati, M., Bratusch-Marrain, P. R., Vierhapper, H., & Waldhäusl, W. K. (1990) · Acta Diabetologica · doi:10.1007/bf02581332 · Cited by 7
Chronic kidney disease and obesity bias surrogate estimates of insulin sensitivity compared with the hyperinsulinemic euglycemic clamp
Ahmad, I., Zelnick, L. R., Robinson, N., Hung, A. M., Kestenbaum, B. R., Utzschneider, K. M., Kahn, S. E., & de Boer, I. H. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00394.2016 · Cited by 8
Surgical removal of insulinoma restores glucose recovery from hypoglycaemia but does not normalize insulin action
de Kreutzenberg, S. V., RICCIO, A., Dorella, M., Avogaro, A., Marescotti, M. C., Tiengo, A., & Prato, S. D. (1995) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1995.tb01714.x · Cited by 7
The Effects of Body Fat Distribution on Glucose Tolerance in Overweight Subjects
Yamada, T., & Yanagisawa, K. (1991) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.67.11_1240 · Cited by 6
Insulin and Glucagon Secretion in vivo and its Neural Control
Taborsky, G. J. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070206 · Cited by 7
Spleen, as an Optimal Site for Islet Transplantation and a Source of Mesenchymal Stem CellsPreprint
Sakata, N., Yoshimatsu, G., & Kodama, S. (2018) · Preprints.org · doi:10.20944/preprints201802.0101.v2 · Cited by 6
Oestradiol levels may differ between premenopausal women, ages 18–50, with type 1 diabetes and matched controls
Hassan, L. S., Monson, R. S., & Danielson, K. K. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2829 · Cited by 6
Body Mass Dynamics Is Determined by the Metabolic Ohm's Law and Adipocyte-Autonomous Fat Mass Homeostasis
Wang, G. (2020) · iScience · doi:10.1016/j.isci.2020.101176 · Cited by 6
Modeling of insulin secretion and insulin mass balance during hemodialysis in patients with and without type 2 diabetes
Schneditz, D., Niemczyk, L., & Niemczyk, S. (2021) · Journal of Applied Biomedicine · doi:10.1016/j.bbe.2021.02.009 · Cited by 6
Simultaneous pancreas-kidney (SPK) and pancreas living-donor kidney (SPLK) transplantation at the University of Maryland.
Philosophe, B., Farney, A. C., Schweitzer, E. J., Colonna, J. O., Jarrell, B. E., Foster, C., Wiland, A., & Bartlett, S. T. (2000) · PubMed · Cited by 6
Energetics and life-history of olive baboons (Papio hamadryas anubis) in the Gashaka Gumti National Park
Lodge, E. J. (2012) · Cited by 6
Decline in the acute insulin response in relationship to plasma glucose concentrations
Heinitz, S., Piaggi, P., Bogardus, C., & Krakoff, J. A. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2953 · Cited by 6
Insulin Clearance at the Pubertal Transition in Youth with Obesity and Steatosis Liver Disease
Franceschi, R., Fintini, D., Ravà, L., Mariani, M., Aureli, A., Inzaghi, E., Pedicelli, S., Deodati, A., Bizzarri, C., Cappa, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914963 · Cited by 5
Direct rosiglitazone-induced modifications in insulin secretion, action and clearance: a single-dose hyperglycaemic clamp study
Farret, A., Chevassus, H., Roux, B., Petit, P., & Galtier, F. (2007) · Diabetologia · doi:10.1007/s00125-007-0682-4 · Cited by 5
Metabolic abnormalities among free‐ranging Macaca mulatta on Cayo Santiago: Comparisons with Macaca mulatta at Sabana Seca
Howard, C. F., Kessler, M., & Schwartz, S. M. (1990) · American Journal of Primatology · doi:10.1002/ajp.1350210303 · Cited by 5
Urinary C‐peptide Is Not an Accurate Bioindicator of Energy Balance in Humans
Bergouignan, A., Habold, C., Rudwill, F., Gauquelin‐Koch, G., Normand, S., Simon, C., & Blanc, S. (2011) · Obesity · doi:10.1038/oby.2011.116 · Cited by 5
Predicting Diabetes Using Measures of β-Cell Function
Vella, A. V., & Zinsmeister, A. R. (2012) · Diabetes · doi:10.2337/db11-1785 · Cited by 5
Human insulin dynamics in women: a physiologically based model
Weiß, M., Tura, A., Kautzky‐Willer, A., Pacini, G., & D’Argenio, D. Z. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00113.2015 · Cited by 5
Introduction and commentary to: M.I. Mityushov (1954) “Conditioned reflex secretion of insulin”
Overduin, J., Dworkin, B. R., & Jansen, A. T. M. (1997) · Integrative Psychological and Behavioral Science · doi:10.1007/bf02688621 · Cited by 5
Inside out the Ragbag of Glucose Intolerance in Obese Adolescents
Brufani, C., Tura, A., Bedogni, G., Luciano, R., Sbrignadello, S., Fintini, D., Cappa, M., Weiss, R., & Manco, M. (2017) · Hormone Research in Paediatrics · doi:10.1159/000464144 · Cited by 5
Regulation of Food Intake and Body Weight
Schwartz, M. W., Baskin, D. G., Kaiyala, K. J., Woods, S. C., & Porte, D. (1997) · Humana Press eBooks · doi:10.1007/978-1-4757-3906-0_3 · Cited by 6
Peripheral influences on central melanocortin neurons
Murphy, K. G., & Bloom, S. R. (2005) · Peptides · doi:10.1016/j.peptides.2004.12.027 · Cited by 5
Human proinsulin and insulin : antibody production, assay development and clinical application
Dorrian, C. A. (1989) · Enlighten: Theses (The University of Glasgow) · Cited by 5
The β-cell burden index of food: A proposal
Scazzina, F., Dei, A., Rio, D. D., Brighenti, F., & Bonadonna, R. C. (2016) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.04.015 · Cited by 4
A one-health approach to identifying and mitigating the impact of endocrine disorders on human and equine athletes
Manfredi, J. M., Jacob, S. I., Boger, B. L., & Norton, E. M. (2022) · American Journal of Veterinary Research · doi:10.2460/ajvr.22.11.0194 · Cited by 6
How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats
Leahy, J. L., Chen, C., & Rhodes, C. J. (1998) · Diabetologia · doi:10.1007/s001250050999 · Cited by 4
The Influence of Obesity on the Development of Non-Insulin-Dependent Diabetes Mellitus
Kolaczynski, J. W., & Goldstein, B. J. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-59651-3_4 · Cited by 4
Normal β‐cell function
Natali, A., Prato, S. D., & Mari, A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch8 · Cited by 4
Insulin as an Accelerator and Brake of Aging: From Molecular Landscape to Clinical Interventions
Chen, S., Sun, X., & Zhang, Y. (2025) · Comprehensive physiology · doi:10.1002/cph4.70079 · Cited by 4
Plasma acyl ghrelin and nonesterified fatty acids are the best predictors for hunger status in pregnant gilts1
Ren, P., Yang, X., Kim, J. S., Menon, D., Pangeni, D., Manu, H., Tekeste, A., & Baidoo, S. K. (2017) · Journal of Animal Science · doi:10.2527/jas2017.1785 · Cited by 3
Separation and Purification of Bioactive Molecules by Ion Exchange
Alam, R. (2022) · Materials research foundations · doi:10.21741/9781644902219-5 · Cited by 3
One Hundred and One Years of Insulin Delivery with Transition from Syringes to User-Friendly Technologies
Kesavadev, J., Saboo, B., Benny, N., Basanth, A., Krishnan, G., Shankar, A., & Jothydev, S. (2022) · International Journal of Diabetes and Technology · doi:10.4103/ijdt.ijdt_5_22 · Cited by 3
Comorbidities of Childhood Obesity
Banerjee, A., & Dara, P. (2012) · InTech eBooks · doi:10.5772/33612 · Cited by 3
Categorization of β-cell capacity in patients with obesity via OGTT using K-means clustering
Li, L., Song, Q., & Yang, X. (2020) · Endocrine Connections · doi:10.1530/ec-19-0476 · Cited by 4
Methodology for Quantifying Fasting Glucose Homeostasis in Type 2 Diabetes: Observed Variability and Lability
Hill, N. R., Τσάπας, Α., Hindmarsh, P. C., & Matthews, D. R. (2013) · Journal of Diabetes Science and Technology · doi:10.1177/193229681300700308 · Cited by 3
Structure and properties of insulin
Gupta, A. (2022) · Understanding Insulin and Insulin Resistance · doi:10.1016/b978-0-12-820234-0.00004-4
Neuropeptides and the Control of Energy Homeostasis
Woods, S. C., Rushing, P. A., & Seeley, R. J. (2001) · KARGER eBooks · doi:10.1159/000061847 · Cited by 3
Alternative insulin delivery systems: how demanding should the patient be?
Polonsky, K. S., Byrne, M. M., & Sturis, J. (1997) · Diabetologia · doi:10.1007/s001250051417 · Cited by 3
Self-citation
Molecular investigation of genetic factors associated with insulin resistance and obesity in a South African population
Vergotine, Z. (2015) · SUNScholar (Stellenbosch University) · Cited by 3
Studies on insulin secretion and clearance in obese and diabetic children (7-11 years old) and adolescents (12-16 years old) Investigation by oral glucose tolerance tests(O-GTT).
Tsunoda, M., Ohki, Y., Mineda, T., & Teshirogi, T. (1992) · Journal of Nippon Medical School · doi:10.1272/jnms1923.59.9 · Cited by 3
How evolution draws trade-offsPreprint
Bourg, S., Jacob, L., Menu, F., & Rajon, É. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/169904 · Cited by 3
Advancements in Insulin Delivery Technology: A Journey of Evolution
Joshi, S., Kesavadev, J., Saboo, B., Parikh, R. M., Chawla, M. S., Gupta, A. S., Bhartia, M., Shankar, A., Basanth, A., & Krishnan, G. (2023) · International Journal of Diabetes and Technology · doi:10.4103/ijdt.ijdt_24_23 · Cited by 2
Cardioprotective effect of genetic ablation of the G-protein-coupled receptor kinase GRK2 in adult pancreatic β-cells during high-fat diet
Snyder, J. E., Jiang, C., Choi, R. H., Morgan, T., Roman, J., Underwood, L., Lucchese, A. M., Montgomery, S. E., Grisanti, L. A., Doliba, N. M., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108388 · Cited by 2
Assessment of Islet Alpha- and Beta-Cell Function
Madsbad, S., & Holst, J. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-11748-1_2 · Cited by 2
Insulin Requirement Profiles of Short‐Term Continuous Subcutaneous Insulin Infusion Therapy in Patients With Type 2 Diabetic Nephropathy
Feng, Q., Li, B., Lin, J., Zou, L., Xu, W., Zeng, L., Li, P., & Lin, S. (2025) · International Journal of Endocrinology · doi:10.1155/ije/8403917 · Cited by 2
Paradoxical inhibition of insulin secretion by glucose in non-insulin-dependent diabetic patients
Linstow, M., Mikines, K. J., Dela, F., & Galbo, H. (1995) · Acta Diabetologica · doi:10.1007/bf00581036 · Cited by 2
First phase release coefficient of insulin in subjects with normal glucose tolerance on glucose infusion analyzed by computer simulation
Huang, C., Chou, W.-C., Lin, L.-Y., Peng, C.-C., Chyau, C.-C., Chen, K., & Peng, R. Y. (2007) · Biosystems · doi:10.1016/j.biosystems.2007.08.005 · Cited by 2
The Role of Surface-Layer Proteins in Ovine Campylobacter Abortion
Grogono‐Thomas, R., Woodland, R. M., & Newell, D. G. (1996) · Springer eBooks · doi:10.1007/978-1-4757-9558-5_109 · Cited by 2
Obesity and Diabetes
Fatouros, I. G., & Mitrakou, A. (2012) · CRC Press eBooks · doi:10.1201/b12085-16 · Cited by 2
Insulin Secretion
Meier, J. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00032-9 · Cited by 3
Effects of accelerometry-derived physical activity energy expenditure on urinary C-peptide levels in a wild primate (Papio ursinus)
Morgan, A. R., Christensen, C., Bracken, A. M., O'Riain, M. J., King, A. J., & Fürtbauer, I. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105355 · Cited by 2
Insulin Delivery: An Evolution in the Technology
Kesavadev, J., Krishnan, G., & Benny, N. (2023) · Springer eBooks · doi:10.1007/978-3-031-25519-9_69 · Cited by 2
Altered metabolism in pulmonary hypertension: fuelling the fire or just smoke?
Duan, D., Gu, C., & Jun, J. C. (2020) · European Respiratory Journal · doi:10.1183/13993003.00447-2020 · Cited by 2
Developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model
Jamaludin, U. K. (2013) · UMP Institutional Repository (Universiti Malaysia Pahang) · doi:10.26021/3488 · Cited by 2
Desenvolvimento de biomarcador específico de células beta pancreáticas (incretina radiomarcada) para imagem da massa beta funcional em diabéticos e obesos: estudo em modelo animal
Seo, D. (2017) · doi:10.11606/t.85.2017.tde-23032017-153731 · Cited by 2
Postprandial Metabolic Responses to Macronutrient in Healthy, Hyperinsulinemic and Type 2 Diabetic Subjects
Lan‐Pidhainy, X. (2012) · TSpace (University of Toronto) · Cited by 2
Metabolic clearance rate of insulin across the glucose tolerance spectrum by race and ethnicity in youth with obesity
Cho, W., Bacha, F. F., Tfayli, H. M., Lee, S., Michaliszyn, S. F., Kim, J. Y., & Arslanian, S. A. (2025) · Obesity · doi:10.1002/oby.24317 · Cited by 1
Development of a computational model of glucose toxicity in the progression of diabetes mellitus
Pérez-Rivera, D. T., Torres-Torres, V. L., Torres-Colón, A. E., & Cruz-Aponte, M. (2016) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2016029 · Cited by 1
Physiologic changes in obesity and patient preparation for bariatric surgery
Şahin, T. T. (2017) · Laparoscopic Endoscopic Surgical Science · doi:10.14744/less.2014.33042 · Cited by 1
Diabetes in the Pediatric Surgical Patient
Wassner, A. J., & Agus, M. S. D. (2017) · Springer eBooks · doi:10.1007/978-3-662-54256-9_15 · Cited by 1
Glucagon-Like Peptide 1 and Human Obesity
Anandhakrishnan, A., & Korbonits, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-48559-3.00003-8 · Cited by 1
Insulin Resistance and the Metabolic Syndrome
Chaiken, R. L. (2004) · Springer eBooks · doi:10.1007/978-1-4757-6260-0_39 · Cited by 1
Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals
Ahmadpour, S., Habibi, M. A., & Hosseinimehr, S. J. (2022) · Current Drug Metabolism · doi:10.2174/1389200223666220919121354 · Cited by 1
Peptide C : un coproduit de la biosynthèse de l’insuline ou une hormone peptidique active ?
Mavrakanas, T. A., & Bastide, D. (2008) · La Presse Médicale · doi:10.1016/j.lpm.2008.07.015 · Cited by 1
Urinary C‐peptide Excretion in Obese and Anorectic Children
Wallensteen, M., GINSBURG, B. ‐., PERSSON, B., & Dahlquist, G. G. (1991) · Acta Paediatrica · doi:10.1111/j.1651-2227.1991.tb11896.x · Cited by 1
Insulinoterapia
Pérez, A., & Mendoza, L. C. (2015) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2015.12.004 · Cited by 3
The Kinetics of Insulin, C-Peptide, and Proinsulin in Normal and Diabetic Man
Polonsky, K. S. (1989) · Aufklärung und Einwilligung im Arztrecht, ESA · doi:10.1007/978-3-642-74255-2_7 · Cited by 1
Self-citation
Mathematical studies of the glucose-insulin regulatory system models.
Wang, M. (2015) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2242 · Cited by 1
Changes in Glut4 and Glut1 in feline obesity
Brennan, C. L. (2003) · Cited by 1
Spleen, as an Optimal Site for Islet TransplantationPreprint
Sakata, N., Yoshimatsu, G., & Kodama, S. (2018) · Preprints.org · doi:10.20944/preprints201802.0101.v1 · Cited by 1
Metabolic Syndrome
Chaiken, R. L., & Banerji, M. A. (2006) · Humana Press eBooks · doi:10.1007/978-1-59259-985-1_9 · Cited by 1
The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects
Manco, M., BERTUZZI, A., Salinari, S., Scarfone, A., Calvani, M., Greco, A. V., & Mingrone, G. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041268 · Cited by 28
Stability of the insulin–glucose feedback loop in Glucosafe: A comparison of pancreas models
Rousing, M. L., Pielmeier, U., & Andreassen, S. (2015) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2015.06.013
Ruokahalun säätely ja lihavuuden lääkehoito : lihavuuslääkkeiden tehoseulontamenetelmä seeprakalalla
Heine, S. (2014) · Työväentutkimus Vuosikirja
O exercício físico agudo reduz a insulinemia através da redução da secreção e aumento do clearance de insulina em camundongos obesos
Kurauti, M. A. (2015) · doi:10.47749/t/unicamp.2015.943073
Islet Xenotransplantation: toward a cure for diabetes
van der Windt, D. J. (2011)
Serum Osteoprotegerin, a Potential Novel Marker of Systemic Inflammation: The Influence of Obesity, Insulin Sensitivity and Oral Glucose Loading on its Circulating Concentrations
Ashley, D. T. (2010) · Dublin City University Open Access Institutional Repository (Dublin City University)
The Role of the Hypothalamus in the Maintenance of Energy Balance and Peripheral Glucose Control
Seeley, R. J., Clegg, D. J., Schwartz, M. W., & Woods, S. C. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0505
Serine/Threonine Protein Phosphatase 5 - a Double-edged Sword - in the Progression towards Diabetes
Grankvist, N. (2012) · Figshare
LIVER FAT IN THE METABOLIC SYNDROME AND TYPE 2 DIABETES
Kotronen, A. (2008) · Työväentutkimus Vuosikirja
Lifestyle intervention strategies for type 2 diabetes management.
Wycherley, T. P. (2011) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Role of gastrointestinal hormones in the metabolic dysfunction in obesity and associated diseases
Rudovich, N. N. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-7245
Effect of nifedipine retard on glucose-induced insulin response in patients with and without non—insulin-dependent diabetes mellitus and hypertension
Kazumi, T., Hozumi, T., Ishida, Y., Ikeda, Y., Miyaji, J., Suzuki, K., & Yoshino, G. (1998) · Current Therapeutic Research · doi:10.1016/s0011-393x(98)85002-9
Alteration in Pancreatic Islet Function in Human Immunodeficiency Virus
Haugaard, S. B. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2014.06.004
Islet Transplantation in Bone Marrow
Piemonti, L. (2010) · Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele · doi:10.2174/1996327001003010035
Insulin receptor and IGF-I receptor Bioactivity in Health and Disease
Varewijck, A. J. (2013) · EUR Research Repository (Erasmus University Rotterdam)

Authors: Polonsky, K. S., Given, B. D., Hirsch, L., Shapiro, E. T., Tillil, H., Beebe, C., Galloway, J. A., Frank, B. H., Karrison, T., & Van Cauter, E.
Affiliations: University of Chicago (US)
Université Libre de Bruxelles (BE)
ORCID: Given, B D
Hirsch, L
Tillil, H
Karrison, T
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1988-02-01
Volume: 81
Issue: 2
Pages: 435-441
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci113338
PMC: PMC329588
OpenAlex: W2132705610
Cited by: 444
References: 27
Citations by year: 2026: 3 · 2025: 5 · 2024: 1 · 2023: 9 · 2022: 18 · 2021: 17 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 24 · 2016: 19 · 2015: 24 · 2014: 13 · 2013: 21 · 2012: 20
FWCI: 9.68
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Eli Lilly and Company
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK-31842, DK 20595)
National Center for Research Resources (RR-00055)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: insulin secretion, insulin clearance, hepatic insulin extraction, obesity, hyperinsulinemia, C-peptide, body mass index, hyperglycemic clamp, fasting insulin, mixed diet, insulin secretion rate, endogenous insulin secretion, type 2 diabetes risk, insulin sensitivity index
MeSH terms: Insulin Secretion, Blood Glucose, C-Peptide, Humans, Hyperglycemia, Insulin, Liver, Metabolic Clearance Rate, Obesity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Quantitative study of insulin secretion and clearance in normal and obese subjects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks